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114 条记录 (耗时 0.053 秒)

    Calcium phosphate cements and methods for using the same
    81.
    发明授权
    Calcium phosphate cements and methods for using the same 有权
    磷酸钙水泥及其使用方法

    公开(公告)号：US08419803B2

    公开(公告)日：2013-04-16

    申请号：US11189555

    申请日：2005-07-25

    申请人： Brent R. Constantz ,  David Delaney ,  Duran Yetkinler

    发明人： Brent R. Constantz ,  David Delaney ,  Duran Yetkinler

    IPC分类号： A61K9/14 ,  A61K33/42 ,  A61K33/06 ,  A61F2/28 ,  C04B12/02 ,  C04B7/00

    CPC分类号： A61L27/12 ,  Y10S514/951 ,  Y10S514/955

    摘要： Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

    摘要翻译： 用于生产可流动组合物的方法和组合物，例如 提供了设置成磷酸钙产品的糊剂。 在本发明方法中，包括钙源和磷酸盐源的干燥反应物与固化流体组合以产生可流动组合物。 本发明方法的特征在于干燥的反应物包括平均粒径小于约8μm并且尺寸分布窄的粒状钙和/或磷酸盐反应物。 还提供了组合物本身以及用于实践本发明方法的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

    Methods and devices for the in situ dissolution of renal calculi
    83.
    发明授权
    Methods and devices for the in situ dissolution of renal calculi 有权
    用于原位溶解肾结石的方法和装置

    公开(公告)号：US07906152B2

    公开(公告)日：2011-03-15

    申请号：US11295716

    申请日：2005-12-05

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K33/18 ,  A01M37/00 ,  A61B17/221 ,  A61M25/00 ,  A01N59/00 ,  A01M31/00

    CPC分类号： A61K33/00 ,  A61B17/22 ,  A61B2017/22084 ,  Y10S514/891

    摘要： Methods and devices for at least reducing the mass of, if not dissolving, renal calculi in situ are provided. In the subject methods, a renal calculus is contacted, e.g. flushed, with an acidic dissolution solution in situ, where the acidic dissolution solution is a solution of a strong, inorganic acid, e.g. hydrochloric acid. In many embodiments, the renal calculus is first enclosed in an isolated local environment of a device prior contact with the dissolution solution. Also provided are novel devices and kits for practicing the subject invention.

    摘要翻译： 提供了用于至少减少原位肾结石质量（如不溶解）的方法和装置。 在本发明的方法中，使肾结石接触。 用酸性溶解溶液原位冲洗，其中酸性溶解溶液是强无机酸（例如，无机酸）的溶液。 盐酸。 在许多实施方案中，肾结石首先在与溶解溶液接触之前封闭在器件的隔离局部环境中。 还提供了用于实施本发明的新颖的装置和试剂盒。

    Methods and devices for reducing the mineral content of vascular calcified lesions
    84.
    发明授权
    Methods and devices for reducing the mineral content of vascular calcified lesions 有权

    公开(公告)号：US06622732B2

    公开(公告)日：2003-09-23

    申请号：US10091133

    申请日：2002-03-04

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61B1900

    CPC分类号： A61B17/22 ,  A61B2017/22067 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2017/22098

    摘要： Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are systems and kits for practicing the subject methods. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.

    Kits for use in the treatment of vascular calcified lesions
    85.
    发明授权
    Kits for use in the treatment of vascular calcified lesions 有权
    用于治疗血管钙化病变的试剂盒

    公开(公告)号：US06562020B1

    公开(公告)日：2003-05-13

    申请号：US09483634

    申请日：2000-01-14

    申请人： Brent R. Constantz ,  Peter Johansson

    发明人： Brent R. Constantz ,  Peter Johansson

    IPC分类号： A61M2500

    CPC分类号： A61M29/02 ,  A61B17/22 ,  A61B2017/22084 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/1052 ,  A61M2025/1093 ,  A61M2025/1095

    摘要： Kits for use in the treatment of vascular calcified lesions are provided. The subject kits include at least one of: (a) a fluid delivery means for conveying fluid to and from a vascular site; and (b) a dissolution fluid for at least partially dissolving the target lesion. In many embodiments, the kits include both of these components. The subject kits further include instructions for treating vascular calcified lesions with the contents of the kit, where the instructions are typically recorded on a recording medium, e.g. printed on a substrate, such as paper.

    摘要翻译： 提供了用于治疗血管钙化病变的试剂盒。 主题套件包括以下中的至少一个：（a）用于将流体输送到血管部位和从血管部位输送流体的流体输送装置; 和（b）用于至少部分溶解靶病变的溶解流体。 在许多实施方案中，试剂盒包括这两种组分。 主题试剂盒还包括用试剂盒内容物治疗血管钙化损伤的说明，其中指令通常记录在记录介质上，例如 印刷在诸如纸的基底上。

    Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
    86.
    发明授权
    Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same 有权
    通过阻塞血管部位增强流体流动的方法，以及用于实施血管部位的系统和试剂盒

    公开(公告)号：US06488671B1

    公开(公告)日：2002-12-03

    申请号：US09528576

    申请日：2000-03-20

    申请人： Brent R. Constantz ,  Dave Delaney ,  Christine Hankermeyer

    发明人： Brent R. Constantz ,  Dave Delaney ,  Christine Hankermeyer

    IPC分类号： A61M3100

    CPC分类号： A61B17/22 ,  A61B5/14539 ,  A61B2017/22084 ,  A61M29/02 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/1052 ,  A61M2025/1093 ,  A61M2025/1095

    摘要： Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.

    摘要翻译： 提供了通过血管闭塞所占据的血管部位增强流体流动的方法以及用于实施血管闭塞的系统和试剂盒。 在实施本发明方法时，血管部位与第一溶解流体和第二溶解流体衰减流体同时冲洗，其中冲洗以仅使血管闭塞的表面与非减毒溶解物接触的方式进行 流体。 以这种方式进行冲洗一段足以使流体流过血管部位以增强的时间，例如， 增加或建立 用于实践相同的主题方法，系统和试剂盒可用于治疗各种不同血管疾病，其特征在于存在血管闭塞，包括部分和全部闭塞。

    Methods and devices for reducing the mineral content of vascular calcified lesions
    87.
    发明授权
    Methods and devices for reducing the mineral content of vascular calcified lesions 有权
    减少血管钙化病变矿物质含量的方法和装置

    公开(公告)号：US06387071B1

    公开(公告)日：2002-05-14

    申请号：US09195291

    申请日：1998-11-18

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61M300

    CPC分类号： A61B17/22 ,  A61B2017/22084 ,  A61B2017/22098

    摘要： Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are catheters for use in performing the subject methods, where the catheters at least include a first lumen capable of delivering fluid to a vascular site and a second lumen capable of removing fluid from a vascular site. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.

    摘要翻译： 提供了至少减少血管钙化病变的矿物质含量的方法和装置，即存在于宿主血管组织上的钙化损伤。 在本方法中，病变的局部环境在亚生物pH下保持足以使损伤的矿物质含量降低的时间，例如， 通过用能够局部增加病变区域中的质子浓度的流体冲洗病变。 还提供了用于执行本发明方法的导管，其中导管至少包括能够将流体输送到血管部位的第一腔和能够从血管部位去除流体的第二腔。 本发明的方法和装置特别用于治疗与血管组织上的钙化损伤相关的血管疾病。