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213 条记录 (耗时 0.055 秒)

    System for neural control of respiration
    81.
    发明授权
    System for neural control of respiration 有权

    公开(公告)号：US08401651B2

    公开(公告)日：2013-03-19

    申请号：US13229211

    申请日：2011-09-09

    申请人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

    发明人： Anthony V. Caparso ,  Imad Libbus ,  M. Jason Brooke ,  Kent Lee ,  Jonathan Kwok ,  Yachuan Pu

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3601 ,  A61N1/36114

    摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

    Automatic activation of medical processes
    82.
    发明授权
    Automatic activation of medical processes 失效
    自动激活医疗过程

    公开(公告)号：US08380296B2

    公开(公告)日：2013-02-19

    申请号：US12649753

    申请日：2009-12-30

    申请人： Kent Lee ,  Jeffrey E. Stahmann ,  Jesse W. Hartley ,  Quan Ni

    发明人： Kent Lee ,  Jeffrey E. Stahmann ,  Jesse W. Hartley ,  Quan Ni

    IPC分类号： A61B5/04

    CPC分类号： A61N1/3601 ,  A61B5/04012 ,  A61B5/1107 ,  A61B5/4094 ,  A61B5/4818 ,  A61B5/6869 ,  A61B2505/09 ,  A61M16/024 ,  A61M16/10 ,  A61M2016/0039 ,  A61M2016/0042 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2230/04 ,  A61M2230/10 ,  A61M2230/63 ,  A61N1/3611 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/36514

    摘要： Systems and methods involve automatic activation, de-activation or modification of therapies or other medical processes based on brain state. A medical system includes a sensor system having one or more sensors configured to sense signals related to the brain state of the patient. A brain state analyzer detects various brain states, including sleep stage and/or brain seizures. A controller uses the brain state detection information to control a medical system configured to perform at least one respiratory or cardiac process. Methods involve sensing signals related to brain state and determining the brain state of a patient based on the sensed signals. At least one respiratory or cardiac medical process is controlled based on the patient's brain state.

    摘要翻译： 系统和方法涉及基于脑状态的治疗或其他医疗过程的自动激活，去激活或修饰。 医疗系统包括具有一个或多个传感器的传感器系统，该传感器被配置为感测与患者的脑状态相关的信号。 脑状态分析仪检测各种脑状态，包括睡眠阶段和/或脑癫痫发作。 控制器使用脑状态检测信息来控制被配置为执行至少一个呼吸或心脏过程的医疗系统。 方法涉及感测与脑状态相关的信号，并且基于感测到的信号来确定患者的大脑状态。 至少一个呼吸或心脏医疗过程是根据患者的大脑状态进行控制的。

    RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE
    83.
    发明申请
    RESPIRATION MONITORING FOR HEART FAILURE USING IMPLANTABLE DEVICE 失效
    使用可移植设备进行心脏衰竭的呼吸监测

    公开(公告)号：US20120283527A1

    公开(公告)日：2012-11-08

    申请号：US13553098

    申请日：2012-07-19

    申请人： Yachuan Pu ,  Kent Lee ,  Jonathan Kwok ,  Quan Ni

    发明人： Yachuan Pu ,  Kent Lee ,  Jonathan Kwok ,  Quan Ni

    IPC分类号： A61B5/0205 ,  A61B5/11 ,  A61B5/08

    CPC分类号： A61B5/0816 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/4818 ,  A61N1/3627 ,  A61N1/36521

    摘要： An implantable respiration monitor can be used to detect disordered breathing or periodic breathing events that can be categorized, such as according to one or more of sleep, exercise, and resting awake states. The categorized frequency of such events can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with detection of one or more other congestive heart failure (CHF) symptoms to generate a CHF status indicator or to trigger an alarm or responsive therapy or to display one or more trends. The alert can notify the patient or a caregiver, such as via remote monitoring. The sleep state information can be further categorized according to central sleep apnea (CSA) or obstructive sleep apnea (OSA) events.

    摘要翻译： 可植入式呼吸监测器可用于检测可分类的无序呼吸或定期呼吸事件，例如根据睡眠，运动和休眠状态中的一种或多种。 这些事件的分类频率可以与独立指定的阈值进行比较，例如触发警报或响应治疗，或显示一个或多个趋势。 该信息还可以与一种或多种其他充血性心力衰竭（CHF）症状的检测相结合，以产生CHF状态指示器或触发警报或反应性治疗或显示一种或多种趋势。 该警报可以通过远程监视来通知病人或看护者。 睡眠状态信息可以根据中枢性睡眠呼吸暂停（CSA）或阻塞性睡眠呼吸暂停（OSA）事件进一步分类。

    Methods and systems for control of gas therapy
    84.
    发明授权
    Methods and systems for control of gas therapy 有权
    气体治疗方法和系统

    公开(公告)号：US08251061B2

    公开(公告)日：2012-08-28

    申请号：US10929306

    申请日：2004-08-30

    申请人： Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Quan Ni

    发明人： Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Quan Ni

    IPC分类号： A61M15/00 ,  A61M16/00 ,  A61M15/08 ,  A62B7/00 ,  A62B9/02

    CPC分类号： A61M16/024 ,  A61M2016/0039 ,  A61M2230/04 ,  A61M2230/08 ,  A61M2230/205 ,  A61M2230/63

    摘要： A gas therapy system involves sensing the blood gas concentration of the patient and adapting a gas therapy based on the sensed gas concentration. Disordered breathing may be detected bases on blood gas concentration, and gas or cardiac electrical therapy may be adapted to treat the detected disordered breathing. One or more of sensing the blood gas concentration, detecting disordered breathing, or adapting the therapy may be performed at least in part implantably. The gas therapy is delivered to the patient through an external respiratory device, such as a positive airway pressure device.

    摘要翻译： 气体治疗系统包括感测患者的血液气体浓度，并根据检测到的气体浓度调整气体治疗。 可能会根据血气浓度检测到无效呼吸，气体或心脏电疗可适用于治疗检测到的无序呼吸。 感测血气浓度，检测无序呼吸或适应治疗的一种或多种可以至少部分地可植入地进行。 气体治疗通过外部呼吸装置（例如气道正压装置）输送给患者。

    Method and apparatus for morphology-based arrhythmia classification using cardiac and other physiological signals
    88.
    发明授权
    Method and apparatus for morphology-based arrhythmia classification using cardiac and other physiological signals 有权
    使用心脏和其他生理信号进行形态学心律失常分类的方法和装置

    公开(公告)号：US07912545B2

    公开(公告)日：2011-03-22

    申请号：US12536828

    申请日：2009-08-06

    申请人： Dan Li ,  Shelley M. Cazares ,  Jaeho Kim ,  Kent Lee

    发明人： Dan Li ,  Shelley M. Cazares ,  Jaeho Kim ,  Kent Lee

    IPC分类号： A61N1/362 ,  A61B5/04

    CPC分类号： A61B5/0464 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3925 ,  A61N1/3962

    摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal, a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.

    摘要翻译： 快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。 快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板的形态特征之间的相关性的相关系数 波形 通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

    THORACIC OR INTRACARDIAC IMPEDANCE DETECTION WITH AUTOMATIC VECTOR SELECTION
    89.
    发明申请
    THORACIC OR INTRACARDIAC IMPEDANCE DETECTION WITH AUTOMATIC VECTOR SELECTION 有权
    用自动矢量选择进行THORACIC或INTRACARDIAC阻抗检测

    公开(公告)号：US20100056884A1

    公开(公告)日：2010-03-04

    申请号：US12612204

    申请日：2009-11-04

    申请人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

    发明人： Jonathan Kwok ,  Kent Lee ,  Jesse W. Hartley ,  Jeffrey E. Stahmann ,  Yinghong Yu ,  Jiang Ding

    IPC分类号： A61B5/0205 ,  A61B5/02

    CPC分类号： A61B5/0205 ,  A61B5/053 ,  A61B5/0538 ,  A61N1/36185 ,  A61N1/36521 ,  A61N1/3686

    摘要： This document discusses, among other things, a cardiac function management device or other implantable medical device that includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

    摘要翻译： 本文件还讨论了包括测试模式和诊断模式的心脏功能管理装置或其它可植入医疗装置。 在测试模式期间，器件循环通过各种电极配置来收集胸部阻抗数据。 从每个这样的电极配置的阻抗数据计算至少一个品质因数。 在一个例子中，仅使用非心律失常节拍来计算品质因数。 使用品质因数自动选择特定的电极配置。 在诊断模式下，设备使用所选择的电极配置收集阻抗数据。 在一个示例中，品质因数包括心搏幅度和呼吸振幅的比值。 还描述了品质因数的其它实例。

    Neural stimulator to treat sleep disordered breathing
    90.
    发明授权
    Neural stimulator to treat sleep disordered breathing 有权

    公开(公告)号：US07672728B2

    公开(公告)日：2010-03-02

    申请号：US11320500

    申请日：2005-12-28

    申请人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

    发明人： Imad Libbus ,  Anthony Caparso ,  M. Jason Brooke ,  Jonathan Kwok ,  Kent Lee ,  Yachuan Pu

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36185 ,  A61N1/3611

    摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.