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    Modified oligoribonucleotide analogs with enhanced immunostimulatory activity
    82.
    发明申请
    Modified oligoribonucleotide analogs with enhanced immunostimulatory activity 审中-公开
    具有增强的免疫刺激活性的修饰的寡核糖核苷酸类似物

    公开(公告)号：US20060241076A1

    公开(公告)日：2006-10-26

    申请号：US11411975

    申请日：2006-04-26

    申请人： Eugen Uhlmann ,  Arthur Krieg ,  Grayson Lipford

    发明人： Eugen Uhlmann ,  Arthur Krieg ,  Grayson Lipford

    IPC分类号： A61K48/00

    CPC分类号： C07H21/00 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/3183 ,  C12N2310/321 ,  C12N2310/3515 ,  C12N2310/3529

    摘要： The invention provides immunostimulatory compositions and methods for their use. In particular, the immunostimulatory compositions of the invention include RNA-like polymers that incorporate an immunostimulatory sequence motif and at least one chemical modification to confer improved stability against nuclease degradation and improved activity. Specific modifications involving phosphate linkages, nucleotide analogs, and combinations thereof are provided. Compositions of the invention optionally include an antigen and can be used to stimulate an immune response. Also provided are compositions and methods useful for treating a subject having an infection, a cancer, an allergic condition, or asthma. Modified oligoribonucleotide analogs of the invention are believed to stimulate Toll-like receptors TLR7 and TLR8.

    摘要翻译： 本发明提供免疫刺激组合物及其使用方法。 特别地，本发明的免疫刺激组合物包括纳入免疫刺激序列基序的RNA样聚合物和至少一种化学修饰，以提供改善的对核酸酶降解的稳定性和改善的活性。 提供了涉及磷酸键，核苷酸类似物及其组合的具体修饰。 本发明的组合物任选地包括抗原并且可以用于刺激免疫应答。 还提供了可用于治疗感染，癌症，过敏性疾病或哮喘的受试者的组合物和方法。 据信本发明的修饰的寡核糖核苷酸类似物刺激Toll样受体TLR7和TLR8。

    Mini-proinsulin, its preparation and use
    85.
    发明授权
    Mini-proinsulin, its preparation and use 失效
    迷你胰岛素原，其制备和用途

    公开(公告)号：US06875589B1

    公开(公告)日：2005-04-05

    申请号：US08402394

    申请日：1995-03-10

    申请人： Michael Dörschug ,  Paul Habermann ,  Gerhard Seipke ,  Eugen Uhlmann

    发明人： Michael Dörschug ,  Paul Habermann ,  Gerhard Seipke ,  Eugen Uhlmann

    IPC分类号： A61K38/00 ,  C07K14/62 ,  C12N1/21 ,  C12N15/17 ,  A61K38/28 ,  C12N1/16

    CPC分类号： C07K14/62 ,  A61K38/00

    摘要： A mini-proinsulin, in which the amino acid Arg bridges the A and the B chain instead of the C chain, shows insulin activity and is suitable for the preparation of pharmaceuticals for the treatment of diabetes mellitus. It can furthermore be converted into an insulin derivative simply using trypsin, the B chain of which is lengthened by Arg. This can be converted into insulin using carboxypeptidase B. Advantageously, however, the mini-proinsulin can also be converted to insulin directly in a one-pot process.

    摘要翻译： 其中氨基酸Arg桥接A和B链而不是C链的微型胰岛素原显示胰岛素活性，并且适用于制备用于治疗糖尿病的药物。 胰蛋白酶可以简单地转化为胰岛素衍生物，其中B链被Arg延长。 这可以使用羧肽酶B转化成胰岛素。然而，有益的是，微型胰岛素原也可以在一锅法中直接转化为胰岛素。