公开(公告)号：US20080031404A1

公开(公告)日：2008-02-07

申请号：US11831090

申请日：2007-07-31

Applicant: Ali Khamene ,  Charles Florin ,  Juan Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

Inventor： Ali Khamene ,  Charles Florin ,  Juan Celi ,  Barbara Ofstad ,  Mikael Rousson ,  Frank Sauer ,  Christian Schaller

IPC: A61B6/00

CPC classification number: A61N5/1049 ,  A61B5/113 ,  A61B5/1135 ,  A61B6/032 ,  A61B6/541 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1068 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1062

Abstract: A method for four-dimensional (4D) image verification in respiratory gated radiation therapy, includes: acquiring 4D computed tomography (CT) images, each of the 4D CT images representing a breathing phase of a patient and tagged with a corresponding time point of a first surrogate signal; acquiring fluoroscopic images of the patient under free breathing, each of the fluoroscopic images tagged with a corresponding time point of a second surrogate signal; generating digitally reconstructed radiographs (DRRs) for each breathing phase represented by the 4D CT images; generating a similarity matrix to assess a degree of resemblance in a region of interest between the DRRs and the fluoroscopic images; computing a compounded similarity matrix by averaging values of the similarity matrix across different time points of the breathing phase during a breathing period of the patient; determining an optimal time point synchronization between the DRRs and the fluoroscopic images by using the compounded similarity matrix; and acquiring a third surrogate signal and turning a treatment beam on or off according to the optimal time point synchronization.

Abstract translation: 呼吸门控放射治疗中四维（4D）图像验证的方法包括：获取4D计算机断层摄影（CT）图像，每个4D CT图像代表患者的呼吸阶段，并用相应的时间点标记 第一替代信号; 在自由呼吸下获取患者的透视图像，每个透视图像标记有第二替代信号的相应时间点; 为由4D CT图像表示的每个呼吸阶段生成数字重建X射线照片（DRR）; 生成相似性矩阵以评估DRR和荧光透视图像之间的感兴趣区域中的相似程度; 通过在患者的呼吸期间在呼吸阶段的不同时间点平均相似性矩阵的值来计算复合相似性矩阵; 通过使用复合相似度矩阵确定DRR和荧光透视图像之间的最佳时间点同步; 并根据最佳时间点同步获取第三替代信号并打开或关闭治疗束。

公开(公告)号：US20070274582A1

公开(公告)日：2007-11-29

申请号：US11695096

申请日：2007-04-02

Applicant: Liron Yatziv ,  Yiyong Sun ,  Chenyang Xu ,  Frank Sauer

Inventor： Liron Yatziv ,  Yiyong Sun ,  Chenyang Xu ,  Frank Sauer

IPC: G06K9/60

CPC classification number: G06T7/30 ,  G06T2207/30004

Abstract: A computer-implemented method is disclosed for comparing three dimensional (3D) digital medical images. The method uses a reference MPR to position subsequent MPRs in one or more other 3D digital medical images so their content matches the reference MPR. The matched MPRs may then be used by a medical professional to diagnose a patient condition. The ability to quickly and automatically position matching MPRs for multiple 3D images eases the medical staff workload and shortens diagnostics time. Matching MPRs provides an effective way to view the 3D volumes for anatomical changes over time and to monitor medical conditions such as stenosis and tumors.

Abstract translation: 公开了一种用于比较三维（3D）数字医学图像的计算机实现的方法。 该方法使用参考MPR将一个或多个其他3D数字医学图像中的后续MPR定位，使得其内容与参考MPR匹配。 然后，医疗专业人员可以使用匹配的MPR来诊断患者状况。 快速，自动地为多个3D图像定位匹配的MPR的能力可以减轻医务人员的工作量，缩短诊断时间。 匹配MPR提供了一种有效的方式来查看3D体积，以便随着时间的推移进行解剖学变化，并监测诸如狭窄和肿瘤之类的医学状况。

公开(公告)号：US20070267850A1

公开(公告)日：2007-11-22

申请号：US11798337

申请日：2007-05-11

Applicant: Nick Eckert ,  Patrick Isermann ,  Milan Bachraty ,  Matthias Liebetrau ,  Frank Sauer

Inventor： Nick Eckert ,  Patrick Isermann ,  Milan Bachraty ,  Matthias Liebetrau ,  Frank Sauer

IPC: B60R21/217

CPC classification number: B60R21/217 ,  B60R21/201

Abstract: A module assembly for an airbag device for protecting occupants of motor vehicles includes a carrier for the assembly, an inflatable airbag packet, a flexible protective envelope, and a fixing mechanism. The airbag packet is fixed to the carrier. The airbag packet is accommodated in the flexible protective envelope. The protective enveloped can be closed off in a gastight manner. The fixing mechanism fixes the airbag packet to the carrier. The fixing mechanism includes a holding element. The holding element, which includes a securing mechanism provided on the carrier to fix the airbag packet to the carrier, extends along an edge of the airbag packet. The securing mechanism is formed integrally on the carrier and is resiliently pivotable with respect to a lateral section of the carrier. Alternatively, the securing mechanism is fixed on the carrier as a separate assembly.

Abstract translation: 用于保护机动车辆乘客的安全气囊装置的模块组件包括用于组装的载体，可充气安全气囊包，柔性保护套和固定机构。 安全气囊包固定在载体上。 安全气囊包被容纳在柔性保护外壳中。 保护膜可以气密的方式封闭。 固定机构将气囊包固定到托架上。 固定机构包括保持元件。 保持元件包括设置在载体上以将气囊包固定到载体上的固定机构，沿安全气囊包的边缘延伸。 固定机构一体地形成在载体上并且能够相对于载体的横向部分弹性地枢转。 或者，固定机构作为单独的组件固定在载体上。

公开(公告)号：US20070248251A1

公开(公告)日：2007-10-25

申请号：US11686533

申请日：2007-03-15

Applicant: Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

Inventor： Rui Liao ,  Christoph Guetter ,  Chenyang Xu ,  Yiyong Sun ,  Ali Khamene ,  Frank Sauer

IPC: G06K9/00 ,  G06T11/00

CPC classification number: G06K9/00208 ,  G06K9/6212 ,  G06T7/33 ,  G06T7/35 ,  G06T2207/30101

Abstract: A method of registering 3-dimensional digitized images to 2-dimensional digitized images during a medical procedure includes providing a pair of correctly-registered training images L={lr, lf} and their joint intensity distribution pl(ir, if), wherein ir and if are reference and floating images, respectively, providing a pair of observed images O={or, of} and their joint intensity distribution po(ir, if), mapping a marginal intensity distribution of the observed pair O={or, of} to a marginal intensity distribution of the training pair L={lr, lf}, and estimating a set of parameters T that registers image of to image or by maximizing a weighted sum of a Jensen-Shannon divergence (JSD) of a joint intensity distribution of the observed pair and a joint intensity distribution of the training pair and a similarity measure between the observed images.

Abstract translation: 在医疗过程中将三维数字化图像记录到二维数字化图像的方法包括提供一对正确注册的训练图像L =（1/2） >}和它们的联合强度分布p（i），其中i i和i i f分别是提供一对观察图像的参考和浮动图像，它们的联合强度分布 映射所观察到的对的边缘强度分布O = {o 以及训练对的边缘强度分布L = {1> 1，...，...），并且估计一组 通过最大化所观察到的对的联合强度分布的Jensen-Shannon发散（JSD）的加权和来加权对照图像的参数T，以使图像o 训练对的联合强度分布 以及观察到的图像之间的相似性度量。

公开(公告)号：US07251352B2

公开(公告)日：2007-07-31

申请号：US10222308

申请日：2002-08-16

Applicant: Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

Inventor： Frank Sauer ,  Ali Khamene ,  Benedicte Bascle

IPC: G06K9/00 ,  G09G5/00

CPC classification number: A61B8/467 ,  A61B8/00 ,  A61B8/462 ,  A61B8/466 ,  A61B8/483 ,  A61B8/5238 ,  A61B17/3403 ,  A61B90/37 ,  A61B2017/3413 ,  G01S7/52034 ,  G01S7/52036 ,  G01S7/52068 ,  G01S7/52084 ,  G01S15/8993

Abstract: A method for marking three-dimensional (3D) locations from images obtained from an ultrasound imaging system including a transducer, comprising the steps of: tracking the pose of the transducer with respect to an external 3D coordinate system; obtaining a two-dimensional (2D) ultrasound image from the transducer; marking a desired target with a marker on the 2D ultrasound image; and calculating the 3D position of the marker utilizing data from the step of tracking.

Abstract translation: 一种用于从包括换能器的超声成像系统获得的图像中标记三维（3D）位置的方法，包括以下步骤：跟踪所述换能器相对于外部3D坐标系的姿态; 从换能器获得二维（2D）超声图像; 在2D超声波图像上用标记标记所需目标; 以及利用来自跟踪步骤的数据计算标记的3D位置。

公开(公告)号：US20060281971A1

公开(公告)日：2006-12-14

申请号：US11383598

申请日：2006-05-16

Applicant: Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

Inventor： Frank Sauer ,  Ali Khamene ,  Sebastian Vogt

IPC: A61B1/04

CPC classification number: A61B34/20 ,  A61B1/0005 ,  A61B1/04 ,  A61B90/36 ,  A61B2090/364 ,  A61B2090/376 ,  G16H50/50

Abstract: A method and apparatus for presenting three-dimensional data to a physician is provided to facilitate the flexible navigation of an endoscope and surgical instruments with respect to anatomical structures. In accordance with a first embodiment a first set of data corresponding to a three dimensional model of a patient's anatomy is received. This three-dimensional model may be rendered from images taken in CT or MRI scanning, as discussed above In accordance with this embodiment, this model is then combined with a second set of data corresponding to a view obtained from an endoscope. In another embodiment, the view from the illustrative endoscope is displayed as an inset image on the display of the three-dimensional image. In yet another embodiment, the three-dimensional image comprises a graphical representation of at least a first surgical instrument, such as said endoscope. The surgeon may select among various combinations of views and may zoom in or out from any particular view.

Abstract translation: 提供了一种用于向医师呈现三维数据的方法和装置，以便于内窥镜和外科器械相对于解剖结构的灵活导航。 根据第一实施例，接收对应于患者解剖结构的三维模型的第一组数据。 这种三维模型可以从CT或MRI扫描中拍摄的图像呈现，如上所述根据本实施例，该模型然后与对应于从内窥镜获得的视图的第二组数据组合。 在另一个实施例中，来自说明性内窥镜的视图作为插入图像被显示在三维图像的显示器上。 在另一个实施例中，三维图像包括至少第一外科器械（例如所述内窥镜）的图形表示。 外科医生可以在各种视图组合中进行选择，并且可以放大或缩小任何特定视图。

公开(公告)号：US20060276709A1

公开(公告)日：2006-12-07

申请号：US11405304

申请日：2006-04-17

Applicant: Ali Khamene ,  Martin Masters ,  Frank Sauer ,  Therese Velde

Inventor： Ali Khamene ,  Martin Masters ,  Frank Sauer ,  Therese Velde

IPC: A61B5/05

CPC classification number: A61B5/1077 ,  A61B5/0066 ,  H04R25/652 ,  H04R25/658 ,  H04R2225/77

Abstract: A method for reconstructing an ear canal from optical coherence tomography (OCT) scan data of an ear comprises extracting frame numbers and line numbers of interference intensities corresponding to one or more markers on an OCT scan guide, receiving reference frame numbers and lines numbers for one or more markers, determining a starting position and direction for the OCT ear scan from the ear scan marker frame and line numbers and the reference marker frame and line numbers, for each scan line, finding a pixel number of a maximum interference intensity value, and determining an offset distance of said pixel from said scan guide, and reconstructing a surface of the ear canal from the distance offset data.

Abstract translation: 用于从耳朵的光学相干断层扫描（OCT）扫描数据重建耳道的方法包括在OCT扫描引导件上提取对应于一个或多个标记的干扰强度的帧号和干扰强度的行号，接收参考帧编号和一个 或更多的标记，为每个扫描线确定来自耳朵扫描标记帧和线号以及参考标记帧和线号的OCT耳朵扫描的起始位置和方向，找到最大干扰强度值的像素数，以及 确定所述像素与所述扫描引导件的偏移距离，以及从所述距离偏移数据重建所述耳道的表面。

公开(公告)号：US20060152434A1

公开(公告)日：2006-07-13

申请号：US10863414

申请日：2004-06-08

Applicant: Frank Sauer ,  Yakup Genc ,  Nassir Navab

Inventor： Frank Sauer ,  Yakup Genc ,  Nassir Navab

IPC: G09G5/00

CPC classification number: G06F3/012 ,  G02B27/0101 ,  G02B27/0189 ,  G02B2027/0138 ,  G02B2027/0187

Abstract: A method for calibrating real and virtual views includes tracking a calibration screen, wherein a real reference point, generated by a real reference point generator, is projected on the calibration screen, aligning a view of a virtual reference point to a view of the real reference point in a display, wherein the real reference point generator and the display have a fixed relative position, determining a point correspondence between the virtual reference point and the real reference point, and determining one or more parameters for rendering a virtual object in the real scene.

Abstract translation: 用于校准实际和虚拟视图的方法包括跟踪校准屏幕，其中由实际参考点发生器生成的实际参考点被投影在校准屏幕上，将虚拟参考点的视图与真实参考图像的视图对准 指向显示器，其中所述实际参考点发生器和所述显示器具有固定的相对位置，确定所述虚拟参考点和所述实际参考点之间的点对应，以及确定用于在所述真实场景中呈现虚拟对象的一个​​或多个参数 。

公开(公告)号：US20050272991A1

公开(公告)日：2005-12-08

申请号：US11104831

申请日：2005-04-13

Applicant: Chenyang Xu ,  Nassir Navab ,  Frank Sauer ,  Ali Khamene

Inventor： Chenyang Xu ,  Nassir Navab ,  Frank Sauer ,  Ali Khamene

IPC: A61B5/05 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B19/00 ,  G06F17/30 ,  G06F19/00

CPC classification number: A61B5/055 ,  A61B6/032

Abstract: A system and method for registering pre-operative images of an object with an intra-operative image of the object is disclosed. Prior to an operative procedure, Digitally Reconstructed Radiographs (DRRs) are generated for the pre-operative images of each individual patient. Signatures are extracted from the DRRs. The signatures are stored in a knowledge base. During the operative procedure, a signature is extracted from the intra-operative image. The intra-operative signature is compared to the stored pre-operative signatures. A pre-operative image having a best signature match to the intra-operative signature is retrieved. The retrieved pre-operative image is registered with the intra-operative image.

Abstract translation: 公开了一种用于登记具有对象的手术内图像的对象的术前图像的系统和方法。 在手术过程之前，为每个患者的术前图像生成数字重建放射照片（DRR）。 从DRR中提取签名。 签名存储在知识库中。 在手术过程中，从手术中的图像中提取出一个签名。 术中签名与存储的术前签名进行比较。 检索与手术内签名具有最佳签名匹配的术前图像。 检索到的术前图像与手术内图像一起登记。

公开(公告)号：US20050251029A1

公开(公告)日：2005-11-10

申请号：US11110156

申请日：2005-04-20

Applicant: Ali Khamene ,  Frank Sauer

Inventor： Ali Khamene ,  Frank Sauer

IPC: A61B5/05 ,  A61N5/10 ,  G06F19/00 ,  G06K9/00

CPC classification number: A61B8/4245 ,  A61B8/4254 ,  A61N5/103 ,  A61N5/1049 ,  G06F19/3481

Abstract: A method and system for modifying a radiation therapy treatment plan are disclosed. In one embodiment, a radiation therapy treatment plan based on a first medical diagnostic image of a target in a patient is provided. A second medical diagnostic image of the target is generated while the patient is disposed on a treatment surface of a radiation therapy device. A deformation of the target is determined using the second medical diagnostic image, and the radiation therapy treatment plan is modified based on the determined deformation. Other embodiments are provided, and each of the embodiments described herein can be used alone or in combination with one another.

Abstract translation: 公开了一种用于修改放射治疗治疗计划的方法和系统。 在一个实施例中，提供了基于患者中的目标的第一医疗诊断图像的放射治疗处理计划。 当患者被放置在放射线治疗装置的治疗表面上时，产生靶的第二医疗诊断图像。 使用第二医疗诊断图像确定目标的变形，并且基于确定的变形来修改放射治疗处理计划。 提供了其它实施例，并且本文所述的每个实施例可以单独使用或彼此组合使用。