公开(公告)号：US12006350B2

公开(公告)日：2024-06-11

申请号：US16760329

申请日：2018-10-30

申请人： Bret Ulery ,  Rui Zhang ,  Caitlin Leeper ,  Josiah Smith ,  Logan Morton

发明人： Bret Ulery ,  Rui Zhang ,  Caitlin Leeper ,  Josiah Smith ,  Logan Morton

IPC分类号： C07K14/77 ,  A61P29/00 ,  A61P31/16 ,  C07K14/575 ,  A61K38/00

CPC分类号： C07K14/77 ,  A61P29/00 ,  A61P31/16 ,  C07K14/57563 ,  A61K38/00

摘要： One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwitterion-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.

公开(公告)号：US20230008022A1

公开(公告)日：2023-01-12

申请号：US17295497

申请日：2019-11-25

申请人： Dane CLAUSEN ,  Ping CHEN ,  Xavier FRADERA ,  Liangqin GUO ,  Yongxin HAN ,  Shuwen HE ,  Xianhai HUANG ,  Joseph KOZLOWSKI ,  Guoqing LI ,  Theodore A. MARTINOT ,  Alexander PASTERNAK ,  Andreas VERRAS ,  Li XIAO ,  Wensheng YU ,  Rui ZHANG ,  Merck Sharp & Dohme Corp.

发明人： Dane Clausen ,  Ping Chen ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Xianhai Huang ,  Joseph Kozlowski ,  Guoqing Li ,  Theodore A. Martinot ,  Alexander Pasternak ,  Andreas Verras ,  Li Xiao ,  Feng Ye ,  Wensheng Yu ,  Rui Zhang

IPC分类号： C07D231/56 ,  C07D491/052 ,  C07D231/54 ,  A61K31/496 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  A61K31/5377 ,  C07D498/10 ,  C07D491/107 ,  C07D498/08 ,  C07D471/10 ,  C07D403/12 ,  C07D405/12 ,  C07D498/04 ,  C07D487/04 ,  C07D487/10 ,  A61K31/541 ,  C07D413/14

摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10394787B2

公开(公告)日：2019-08-27

申请号：US15065710

申请日：2016-03-09

申请人： HUBEI UNIVERSITY OF EDUCATION ,  Rui Zhang

发明人： Rui Zhang

IPC分类号： G06F17/30 ,  G06F16/22 ,  G06F16/28 ,  G06F16/29 ,  G06F16/901

摘要： The present application provides indexing methods and systems for indexing spatial data objects of a data space, and methods and systems for performing an operation on an index of spatial data. One of the methods includes: associating each spatial data object with one of a plurality of separations according to a size of the respective spatial data object; and mapping each spatial data object to an index key based on the separation with which the spatial data object is associated. The methods and systems for performing an operation on an index of spatial data can facilitate efficient selection or manipulation of the spatial data objects.

公开(公告)号：US10051381B2

公开(公告)日：2018-08-14

申请号：US15416980

申请日：2017-01-26

申请人： Jinyu Zhang ,  Rui Zhang ,  Zhenkui Meng

发明人： Jinyu Zhang ,  Rui Zhang ,  Zhenkui Meng

IPC分类号： H04R25/00 ,  H04R19/04 ,  H04R7/04 ,  H04R19/00 ,  B81B3/00

摘要： A MEMS microphone, includes a base with a back cavity and a capacitor system fixed to the base. The capacitor system includes a back plate above the base and a diaphragm opposite to the back plate for forming an insulated gap. The back plate includes a body part and multiple spaced fixation parts extending from the body part, and the diaphragm includes a vibrating part and a connecting part extending from the vibrating part. An orthographic projection of the body part of the back plate along a vibration direction of the diaphragm is completely located on the diaphragm; and at least a part of an orthographic projection of the fixation parts along the vibration direction is located on the diaphragm.

公开(公告)号：US09986319B2

公开(公告)日：2018-05-29

申请号：US15417184

申请日：2017-01-26

申请人： Rui Zhang ,  Ting Kang

发明人： Rui Zhang ,  Ting Kang

IPC分类号： H04R19/04 ,  H04R1/02 ,  H04R19/00 ,  H04R1/22 ,  H04R1/38

CPC分类号： H04R1/02 ,  B81B2201/0257 ,  H04R1/04 ,  H04R1/086 ,  H04R1/222 ,  H04R1/38 ,  H04R19/005 ,  H04R19/04 ,  H04R2201/003 ,  H04R2499/11

摘要： A MEMS sensor is disclosed. The MEMS sensor includes a housing having an acoustic port, a base plate forming an accommodation cavity together with the housing, a MEMS chip accommodated in the accommodation cavity, and a control mechanism having a first working position and a second working position. At the first working position, the acoustic port communicates the accommodation cavity with an external space of the housing, while at the second working position, the control mechanism isolates the accommodation cavity from the external space of the housing.

公开(公告)号：US20180115810A1

公开(公告)日：2018-04-26

申请号：US15417184

申请日：2017-01-26

申请人： Rui Zhang ,  Ting Kang

发明人： Rui Zhang ,  Ting Kang

IPC分类号： H04R1/02 ,  H04R19/04 ,  H04R19/00

CPC分类号： H04R1/02 ,  B81B2201/0257 ,  H04R1/04 ,  H04R1/086 ,  H04R1/222 ,  H04R1/38 ,  H04R19/005 ,  H04R19/04 ,  H04R2201/003 ,  H04R2499/11

摘要： A MEMS sensor is disclosed. The MEMS sensor includes a housing having an acoustic port, a base plate forming an accommodation cavity together with the housing, a MEMS chip accommodated in the accommodation cavity, and a control mechanism having a first working position and a second working position. At the first working position, the acoustic port communicates the accommodation cavity with an external space of the housing, while at the second working position, the control mechanism isolates the accommodation cavity from the external space of the housing.

公开(公告)号：US09813819B2

公开(公告)日：2017-11-07

申请号：US15080364

申请日：2016-03-24

申请人： Rui Zhang ,  Long Zhang

发明人： Rui Zhang ,  Long Zhang

IPC分类号： H04R11/02 ,  H04R9/04 ,  H04R9/06 ,  H04R1/28 ,  H04S7/00

CPC分类号： H04R9/045 ,  H04R1/2803 ,  H04R9/06 ,  H04R2499/11 ,  H04S7/00 ,  H04S2420/01

摘要： A speaker is provided in the present disclosure. The speaker includes a membrane, a voice coil connected to the membrane, and a vibration part attached on the membrane. The membrane includes a main body and a periphery portion surrounding the main body. One of the vibration part and the main body includes a protrusion protruding away from the voice coil, and the other one of the vibration part and the main body includes a recess portion recessed towards the voice coil and corresponding to the protrusion.

公开(公告)号：US09215869B1

公开(公告)日：2015-12-22

申请号：US13090830

申请日：2011-04-20

申请人： Michael J. Adang ,  Rui Zhang ,  Gang Hua

发明人： Michael J. Adang ,  Rui Zhang ,  Gang Hua

IPC分类号： A01N37/18

CPC分类号： A01N37/18 ,  A01N63/02 ,  A01N37/46

摘要： The subject invention relates in part to fragments of non-cadherin Cry toxin binding proteins, wherein the fragments potentiate, or act as synergists with, the insecticidal activity of Cry proteins. In some preferred embodiments, the binding protein (a Cry protein receptor on insect midgut cells) is an aminopeptidase. In preferred embodiments, the fragment comprises a Cry protein binding region.

摘要翻译： 本发明部分涉及非钙粘蛋白Cry毒素结合蛋白的片段，其中片段加强Cry蛋白的杀虫活性，或作为增效剂。 在一些优选的实施方案中，结合蛋白（昆虫中肠细胞上的Cry蛋白受体）是氨基肽酶。 在优选的实施方案中，片段包含Cry蛋白结合区。

公开(公告)号：US20150274708A1

公开(公告)日：2015-10-01

申请号：US14434348

申请日：2013-10-03

申请人： Michael W. SEGANISH ,  Jennifer HANISAK ,  Guoqing LI ,  Rui ZHANG ,  Haiqun TANG ,  MERCK SHARP & DOHME CORP.

发明人： W. Michael Seganish ,  Jennifer Hanisak ,  Guoqing Li ,  Rui Zhang ,  Haiqun Tang

IPC分类号： C07D409/14 ,  A61K31/444 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496 ,  C07D405/14 ,  A61K31/497 ,  C07D401/14 ,  C07D401/12

CPC分类号： C07D409/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  A61K2300/00

摘要： The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.

摘要翻译： 本发明涉及式（I）的IRAK4的抑制剂，并提供包含这些抑制剂的组合物，以及其用于治疗IRAK4介导的或相关的病症或疾病的方法。

公开(公告)号：US09118944B2

公开(公告)日：2015-08-25

申请号：US12366599

申请日：2009-02-05

申请人： Jim Chen Chou ,  Rui Zhang

发明人： Jim Chen Chou ,  Rui Zhang

IPC分类号： H04N7/12 ,  H04N21/24 ,  H04N21/2343 ,  H04N19/147 ,  H04N19/115 ,  H04N19/132 ,  H04N19/156 ,  H04N19/174 ,  H04N19/187 ,  H04N19/36

CPC分类号： H04N21/2402 ,  H04N19/115 ,  H04N19/132 ,  H04N19/147 ,  H04N19/156 ,  H04N19/174 ,  H04N19/187 ,  H04N19/36 ,  H04N21/234327

摘要： A method is provided in one example embodiment and includes receiving video data and gathering statistics associated with the video data. At least some of the video data is broken into slices, each of the slices representing a partition in a video frame within the video data. Each frame is encoded with one or more quality layers based on an outgoing rate and based on a number of central processing unit (CPU) cycles, wherein one or more quality layers of the frames are dropped in the encoding process. In more specific embodiments, the statistics relate to how many bits are used for encoding the quality layers of the video data and how much complexity is required for encoding the quality layers of the video data. After the statistics gathering, adjustments to a network rate are executed.

摘要翻译： 在一个示例实施例中提供了一种方法，并且包括接收视频数据并收集与视频数据相关联的统计信息。 视频数据中的至少一些被分解为片，每个片表示视频数据内的视频帧中的分区。 基于输出速率并且基于多个中央处理单元（CPU）周期，每帧对一个或多个质量层进行编码，其中帧的一个或多个质量层在编码处理中被丢弃。 在更具体的实施例中，统计信息涉及用于对视频数据的质量层进行编码的多少位以及对视频数据的质量层进行编码所需的复杂度。 统计采集后，执行网络速率调整。