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公开(公告)号:US5705658A
公开(公告)日:1998-01-06
申请号:US800671
申请日:1997-02-14
申请人: Richard Goschke , Jurgen Klaus Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim Claude Cohen , Peter Herold
发明人: Richard Goschke , Jurgen Klaus Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim Claude Cohen , Peter Herold
IPC分类号: C07D295/14 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/27 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4245 , A61K31/44 , A61K31/445 , A61K31/4468 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/20 , A61P27/02 , A61P43/00 , C07C213/00 , C07C229/36 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07C237/24 , C07C255/13 , C07C255/16 , C07C255/60 , C07C271/16 , C07C271/18 , C07C271/22 , C07C311/30 , C07C311/32 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/10 , C07C323/12 , C07D207/27 , C07D207/40 , C07D211/32 , C07D211/88 , C07D213/30 , C07D213/40 , C07D213/65 , C07D213/89 , C07D233/64 , C07D233/76 , C07D239/10 , C07D241/08 , C07D257/04 , C07D263/20 , C07D263/26 , C07D263/38 , C07D265/30 , C07D271/06 , C07D277/14 , C07D277/18 , C07D277/28 , C07D295/13 , C07D295/18 , C07D295/22 , C07D307/32 , C07D307/33 , C07D317/64 , C07D319/18 , C07D319/20 , C07D413/06 , C07D521/00 , C07F7/18
CPC分类号: C07D307/33 , C07C229/36 , C07C237/20 , C07C255/13 , C07C271/16 , C07C271/18 , C07C271/22 , C07D241/08
摘要: .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
摘要翻译: 式I(Ⅰ)的α-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺及其盐具有肾素抑制性质,可用作抗高血压药用活性成分。
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公开(公告)号:US5654445A
公开(公告)日:1997-08-05
申请号:US674555
申请日:1996-07-02
申请人: Richard Goschke , Jurgen Klaus Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim Claude Cohen , Peter Herold
发明人: Richard Goschke , Jurgen Klaus Maibaum , Walter Schilling , Stefan Stutz , Pascal Rigollier , Yasuchika Yamaguchi , Nissim Claude Cohen , Peter Herold
IPC分类号: C07D295/14 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/27 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/395 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4245 , A61K31/44 , A61K31/445 , A61K31/4468 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/20 , A61P27/02 , A61P43/00 , C07C213/00 , C07C229/36 , C07C235/34 , C07C235/36 , C07C237/20 , C07C237/22 , C07C237/24 , C07C255/13 , C07C255/16 , C07C255/60 , C07C271/16 , C07C271/18 , C07C271/22 , C07C311/30 , C07C311/32 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/10 , C07C323/12 , C07D207/27 , C07D207/40 , C07D211/32 , C07D211/88 , C07D213/30 , C07D213/40 , C07D213/65 , C07D213/89 , C07D233/64 , C07D233/76 , C07D239/10 , C07D241/08 , C07D257/04 , C07D263/20 , C07D263/26 , C07D263/38 , C07D265/30 , C07D271/06 , C07D277/14 , C07D277/18 , C07D277/28 , C07D295/13 , C07D295/18 , C07D295/22 , C07D307/32 , C07D307/33 , C07D317/64 , C07D319/18 , C07D319/20 , C07D413/06 , C07D521/00 , C07F7/18
CPC分类号: C07D307/33 , C07C229/36 , C07C237/20 , C07C255/13 , C07C271/16 , C07C271/18 , C07C271/22 , C07D241/08
摘要: .delta.-Amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.
摘要翻译: 式I(Ⅰ)的α-氨基-γ-羟基-ω-芳基 - 链烷酸酰胺及其盐具有肾素抑制性质,可用作抗高血压药用活性成分。
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公开(公告)号:US08969341B2
公开(公告)日:2015-03-03
申请号:US14361068
申请日:2012-11-28
申请人: Pascal Furet , Vito Guagnano , Philipp Holzer , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
发明人: Pascal Furet , Vito Guagnano , Philipp Holzer , Robert Mah , Keiichi Masuya , Achim Schlapbach , Stefan Stutz , Andrea Vaupel
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/517 , A61K31/519 , A61K31/505 , A61K31/4709 , A61K31/4523 , A61K31/4155 , C07D413/14 , C07D487/14 , C07D239/02 , C07D403/14 , C07D215/00 , C07D211/80 , C07D401/14 , C07D257/02 , C07D487/04 , A61K31/41 , A61K31/4162 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506
CPC分类号: C07D487/04 , A61K31/41 , A61K31/4162 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/5377
摘要: The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
摘要翻译: 本发明涉及本文所述的式(I)化合物,包含这些化合物的药物制剂,用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的化合物的用途和用途,以及组合 包括这样的化合物。
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84.
公开(公告)号:US06319917B1
公开(公告)日:2001-11-20
申请号:US09655170
申请日:2000-09-05
IPC分类号: A61K3155
CPC分类号: C07D403/12 , C07C237/22 , C07D209/20 , C07D209/24 , C07D223/12
摘要: Compounds of formula I wherein R1, R1-R3, R4′, R4″ and R5 are as defined in the description, have valuable pharmaceutical properties and are effective especially as NK1 and NK2 antagonists. They are prepared in a manner known per se.
摘要翻译: 在R1,R1-R3,R4',R4“和R5中的式I化合物如说明书中所定义,具有有价值的药物性质,特别是作为NK1和NK2拮抗剂是有效的。 它们是以本身已知的方式准备的。
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85.
公开(公告)号:US20110039831A1
公开(公告)日:2011-02-17
申请号:US12849642
申请日:2010-08-03
申请人: Pascal Furet , Clive McCarthy , Joseph Schoepfer , Stefan Stutz
发明人: Pascal Furet , Clive McCarthy , Joseph Schoepfer , Stefan Stutz
IPC分类号: A61K31/5025 , C07D487/04 , A61K31/551 , A61P35/00
CPC分类号: C07D487/04
摘要: The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
摘要翻译: 本发明涉及式(I)化合物及其盐,其中取代基如本说明书中所定义,式(I)化合物在治疗人或动物体的方法中的应用,特别是关于 对C-Met酪氨酸激酶介导的疾病; 使用式(I)化合物制备用于治疗这些疾病的药物; 包含式(I)化合物的药物组合物,任选地在组合配偶体存在下; 制备式(I)化合物的方法。
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公开(公告)号:US20140275158A1
公开(公告)日:2014-09-18
申请号:US14127159
申请日:2012-06-19
申请人: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号: C07D217/24 , C07D405/08 , A61K31/4725 , A61K31/472 , C07D401/08
CPC分类号: C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/04 , C07D401/08 , C07D405/08
摘要: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)化合物:如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号:US20140135306A1
公开(公告)日:2014-05-15
申请号:US14127155
申请日:2012-06-19
申请人: Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人: Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号: C07D409/10 , A61K31/472 , C07D401/04 , A61K31/4725 , C07D401/10 , C07D405/10 , C07D405/14 , C07D217/24 , C07D401/14
CPC分类号: A61K31/4725 , A61K31/472 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/08 , C07D451/02 , C07D451/14 , C07D491/08 , C07D493/08
摘要: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)化合物:如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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公开(公告)号:US20120165310A1
公开(公告)日:2012-06-28
申请号:US13394534
申请日:2010-09-10
申请人: Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
发明人: Bei Chen , Robin Alec Fairhurst , Andreas Floersheimer , Pascal Furet , Vito Guagnano , Jiang Songchun , Wenshuo Lu , Thomas H. Marsilje, III , Clive McCarthy , Pierre-Yves Michellys , Frederic Stauffer , Stefan Stutz , Andrea Vaupel
IPC分类号: A61K31/519 , A61K31/541 , C07D493/08 , A61K31/5377 , A61K31/554 , A61P19/00 , A61K31/5386 , C07D495/08 , A61P35/00 , A61P11/00 , A61P1/16 , C07D487/04 , C07D487/08
CPC分类号: C07D487/04 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K9/4858
摘要: The invention relates to compounds of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.
摘要翻译: 本发明涉及式I化合物,其中取代基如说明书中所定义; 制备这些化合物的方法; 包含这些化合物的药物组合物; 诸如药物的化合物; 这种化合物用于治疗增殖性疾病。
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公开(公告)号:US5283498A
公开(公告)日:1994-02-01
申请号:US770408
申请日:1991-10-03
申请人: Christoph von Arx , Stefan Stutz
发明人: Christoph von Arx , Stefan Stutz
IPC分类号: H01J61/30 , H01J61/35 , H01J61/52 , H01J61/54 , H01J65/00 , H01J65/04 , H01S3/03 , H01S3/038 , H01S3/097 , H05H1/24 , H01J17/04
CPC分类号: H01J65/046
摘要: In a UV high-power radiator, a plurality of dielectric tubes (6) having internal electrodes (7) are disposed in the interior of a quartz housing having rectangular cross section. The interior of the housing is filled with a filling gas which emits UV radiation under discharge conditions. The electrical supply is provided in such a way that the discharges (17) develop between adjacent dielectric tubes (6). A notable feature of this construction is its compactness, economical nature and service friendliness.
摘要翻译: 在UV大功率散热器中,具有内部电极(7)的多个电介质管(6)设置在具有矩形截面的石英壳体的内部。 外壳的内部填充有在放电条件下发出紫外线的填充气体。 以这样的方式提供电源,使得放电(17)在相邻的电介质管(6)之间形成。 这个结构的一个显着特点是其紧凑性,经济性和服务友好性。
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公开(公告)号:US08859535B2
公开(公告)日:2014-10-14
申请号:US14127155
申请日:2012-06-19
申请人: Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
发明人: Nicole Buschmann , Pascal Furet , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC分类号: C07D409/10 , A61K31/472 , A61K31/4725 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D491/08 , C07D493/08 , C07D451/14 , C07D413/08 , C07D451/02
CPC分类号: A61K31/4725 , A61K31/472 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/08 , C07D451/02 , C07D451/14 , C07D491/08 , C07D493/08
摘要: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
摘要翻译: 本发明涉及式(I)化合物:如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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