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81.发明授权Method of generating an immune response in a subject using fusion proteins comprising CD4 minimal modules and HIV Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 失效使用包含CD4最小模块和HIV Tat支架多肽的融合蛋白在受试者中产生免疫应答的方法，其能够结合HIV包膜并暴露神经中和表位公开(公告)号：US08637044B2
公开(公告)日：2014-01-28
申请号：US13427234
申请日：2012-03-22
IPC分类号： A61K39/21 , A61K39/00 , A61K39/385 , C07K1/00
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
摘要翻译： 描述了包含结合HIV Env多肽与一种或多种HIV Tat多肽结合的CD4最小模块或模拟物的杂合分子。 还描述了这些杂合分子与Env的复合物以及使用多核苷酸和多肽进行诊断，治疗和预防的方法。
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公开(公告)号：US08524251B2
公开(公告)日：2013-09-03
申请号：US13359471
申请日：2012-01-26
申请人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , A61K39/02 , A61K38/00 , C07K1/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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83.发明授权Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing CG motifs 失效用含有CG基序的寡核苷酸增强奈瑟菌抗原的杀菌活性公开(公告)号：US08221761B1
公开(公告)日：2012-07-17
申请号：US09914454
申请日：2000-02-09
CPC分类号： C07K14/22 , A61K39/095 , A61K39/39 , A61K2039/55561 , A61K2039/55566
摘要： Immunogenic compositions (e.g. vaccines) comprising: (a) an immunostimulating amount of a Neisseria antigen (preferably N. meningitidis serogroup B); and (b) an immunostimulating amount of an adjuvant composition comprising an oligonucleotide comprising at least one CG motif. Component (b) may further comprise a second adjuvant. Component (a) may be selected from a variety of antigens. Adjuvant compositions comprising an oligonucleotide having at least one CG motif, and complete Freund's adjuvant (CFA) are also provided.
摘要翻译： 免疫原性组合物（例如疫苗）包含：（a）免疫刺激量的奈瑟氏球菌抗原（优选脑膜炎奈瑟球菌血清群B）; 和（b）免疫刺激量的包含至少一个CG基序的寡核苷酸的佐剂组合物。 组分（b）还可以包含第二种佐剂。 组分（a）可以选自多种抗原。 还提供了包含具有至少一个CG基序的寡核苷酸和完全弗氏佐剂（CFA）的佐剂组合物。
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84.发明授权Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 有权包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和人免疫缺陷病毒（HIV）Tat支架多肽的融合蛋白公开(公告)号：US08168194B2
公开(公告)日：2012-05-01
申请号：US11883696
申请日：2006-02-03
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
摘要翻译： 描述了包含结合HIV Env多肽与一种或多种HIV Tat多肽结合的CD4最小模块或模拟物的杂合分子。 还描述了这些杂合分子与Env的复合物以及使用多核苷酸和多肽进行诊断，治疗和预防的方法。
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公开(公告)号：US20110180430A1
公开(公告)日：2011-07-28
申请号：US12092285
申请日：2006-11-06
IPC分类号： B65D71/00 , A61K39/145 , A61K39/385 , A61P31/16 , A61P31/04 , A61P37/04
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： While oil-in-water emulsions are excellent adjuvants for influenza vaccines, their efficacy can be improved by additionally including other immunostimulating agent(s) to improve cytokine responses, such as γ-interferon response. Thus, a vaccine comprises (i) an influenza virus antigen; (ii) an oil-in-water emulsion adjuvant; and (iii) a cytokine-inducing agent.
摘要翻译： 虽然水包油乳剂是用于流感疫苗的优异佐剂，但是通过另外包括其它免疫刺激剂来改善细胞因子应答（例如γ-干扰素应答）可以改善其功效。 因此，疫苗包含（i）流感病毒抗原; （ii）水包油乳剂佐剂; 和（iii）细胞因子诱导剂。
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公开(公告)号：US20100285062A1
公开(公告)日：2010-11-11
申请号：US12225653
申请日：2007-03-29
申请人： Rino Rappuoli , David L.M. Lewis , Susan Barnett
发明人： Rino Rappuoli , David L.M. Lewis , Susan Barnett
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , A61K2039/55566 , C07K14/005 , C12N2740/16122 , C12N2740/16134
摘要： HIV antigens are mucosally administered in one or more priming immunization(s), and then HIV antigens are parenterally administered in one or more boosting immunization(s). Thus the invention provides a method for raising an immune response in a patient, comprising: (i) administering a HIV antigen to the patient via a mucosal route; and then (ii) administering a HIV antigen to the patient via a parenteral route. The antigens will typically be adjuvanted. Preferred mucosal immunizations are via the intranasal route using a detoxified mutant of E. coli heat labile toxin as the adjuvant. Preferred parenteral immunizations are via the intramuscular route using an oil-in-water emulsion adjuvant.
摘要翻译： HIV抗原在一次或多次引发免疫中粘膜施用，然后HIV抗原在一次或多次加强免疫中肠胃外给药。 因此，本发明提供了一种提高患者免疫应答的方法，包括：（i）通过粘膜途径向患者施用HIV抗原; 然后（ii）通过胃肠外途径向患者施用HIV抗原。 抗原通常将被佐剂化。 优选的粘膜免疫是通过使用大肠杆菌热不稳定毒素的解毒突变体作为佐剂的鼻内途径。 优选的肠胃外免疫是通过肌内途径使用水包油乳剂佐剂。
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87.发明申请BLOCKING INTERACTION BETWEEN PATHOGEN FACTORS AND FACTOR H TO INHIBIT HEMORRHAGIC SYNDROMES 审中-公开致病因素与因子H之间的阻断相互作用以抑制HEMORRHAGIC综合征公开(公告)号：US20100150912A1
公开(公告)日：2010-06-17
申请号：US12450697
申请日：2008-04-11
申请人： Rino Rappuoli
发明人： Rino Rappuoli
CPC分类号： C07K16/1217 , A61K2039/505 , C07K16/1081 , Y02A50/386 , Y02A50/394
摘要： If pathogen factors such as meningococcal NMB 1870 or flaviviral NS1 are able to sequester factor H in the blood then its inhibitory effect on complement may be disturbed, thereby permitting C3 to initiate a dramatic attack on host endothelial tissue. In combination with a strong inflammatory response, this attack can result in sever damage to the endothelium, with resulting hemorrhagic syndrome. Blocking the interaction between pathogen factors and factor H may thus be used to treat and/or prevent these pathogen-induced hemorrhagic syndromes. The interaction may, for instance, be blocked by antibodies, either delivered endogenously (passive immunisation) or produced by a patient's immune system (active immunisation).
摘要翻译： 如果病原体因子如脑膜炎球菌NMB1870或黄病毒NS1能够在血液中螯合因子H，则其对补体的抑制作用可能受到干扰，从而允许C3引发对宿主内皮组织的剧烈攻击。 结合强烈的炎症反应，这种攻击可能导致对内皮的严重损伤，导致出血综合征。 因此，阻断病原体因子和因子H之间的相互作用因此可用于治疗和/或预防这些病原体诱导的出血综合征。 例如，相互作用可被抗体阻断，内源性递送（被动免疫）或由患者的免疫系统产生（主动免疫）。
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公开(公告)号：US07714121B2
公开(公告)日：2010-05-11
申请号：US10695499
申请日：2003-10-28
IPC分类号： C07H21/04
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供来自脑膜炎奈瑟菌（A＆B）菌株的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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公开(公告)号：US07700755B2
公开(公告)日：2010-04-20
申请号：US10615668
申请日：2003-07-08
CPC分类号： C07K14/195 , A61K38/00 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12Q1/689
摘要： This invention provides polynucleotides encoding Helicobacter pylori cytotoxin associated immunodominant antigen. The polynucleotides can be used as probes to identify the presence of complementary target nucleotide sequences. The invention also provides kits and vectors containing the polynucleotides of the invention.
摘要翻译： 本发明提供编码幽门螺杆菌细胞毒素相关免疫显性抗原的多核苷酸。 多核苷酸可用作探针以鉴定互补靶核苷酸序列的存在。 本发明还提供了含有本发明的多核苷酸的试剂盒和载体。
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公开(公告)号：US07700119B2
公开(公告)日：2010-04-20
申请号：US11264676
申请日：2005-11-01
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K39/00 , Y02A50/466
摘要： An 85 kDa antigen from Neisseria meningitidis and Neisseria gonorrhoeae has been cloned, sequenced and expressed. The antigen is common to diverse strains, serogroups and serotypes of N. meningitidis, and also to N. gonorrhoeae, N. polysaccharia and N. lactamica. The protein sequences of N. meningitidis (serogroups A and B) and N. gonorrhoeae are highly homologous.
摘要翻译： 来自脑膜炎奈瑟氏球菌和淋病奈瑟氏球菌的85kDa抗原已被克隆，测序和表达。 该抗原对于脑膜炎奈瑟氏球菌的不同菌株，血清型和血清型以及淋病奈瑟氏球菌，多糖和内酰胺酶是常见的。 脑膜炎奈瑟氏球菌（血清群A和B）和淋病奈瑟氏球菌的蛋白质序列高度同源。
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