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公开(公告)号：US09669088B2
公开(公告)日：2017-06-06
申请号：US12744920
申请日：2008-11-25
申请人： Audino Podda , Rino Rappuoli
发明人： Audino Podda , Rino Rappuoli
IPC分类号： A61K39/145 , C07K14/11 , A61K39/12 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , C12N2710/10343 , C12N2760/16134
摘要： H5N1 influenza viruses isolated from animals and humans since 2003 separate into distinct clades based on hemagglutinin amino acid sequences. According to the invention, multiple clades are used in influenza immunization. Thus there is a prime-boost immunization schedule where a subject receives a priming dose of a first clade of H5 influenza A virus and a boosting dose of a second clade of H5 influenza A virus. There is also an immunogenic composition comprising hemagglutinin antigens from more than one clade of H5 influenza A virus.
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公开(公告)号：US09636393B2
公开(公告)日：2017-05-02
申请号：US10148533
申请日：2000-11-29
IPC分类号： A61K39/095 , A61K39/00 , A61K39/42 , A61K47/48 , A61K39/116
CPC分类号： A61K39/095 , A61K39/116 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55566 , A61K2039/6037 , A61K2039/6068
摘要： International patent application WO99/61053 discloses immunogenic compositions that comprise N. meningitidis serogroup C oligosaccharide conjugated to a carrier, in combination with N. meningitidis serogroup B outer membrane protein. These are disclosed in the present application in combination with further Neisserial proteins and/or protective antigens against other pathogenic organisms (e.g. Haemophilus influenzae, DTP, HBV, etc.).
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公开(公告)号：US08858958B2
公开(公告)日：2014-10-14
申请号：US12870708
申请日：2010-08-27
申请人： Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
发明人： Michele Pallaoro , Derek O'Hagan , Rino Rappuoli
IPC分类号： A61K39/095 , A61K39/39 , A61K39/00 , A61K39/108 , A61K39/085 , A61K39/09 , A61K39/155
CPC分类号： A61K39/39 , A61K39/0002 , A61K39/0258 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/155 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/18534 , Y02A50/474
摘要： An immunological adjuvant comprises an aluminum salt, an immunostimulatory oligonucleotide and a polycationic polymer, wherein the oligonucleotide and the polymer ideally associate with each other to form a complex. The adjuvant can be included in a composition with an immunogen e.g. to elicit an immune response that protects against a bacterial disease or a fungal disease.
摘要翻译： 免疫佐剂包括铝盐，免疫刺激寡核苷酸和聚阳离子聚合物，其中寡核苷酸和聚合物理想地相互结合以形成络合物。 佐剂可以包括在具有免疫原的组合物中。 以引发免疫应答，防止细菌性疾病或真菌性疾病。
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4.发明授权Method for generating immune responses utilizing nucleic acids encoding fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 失效使用编码融合蛋白的核酸产生免疫应答的方法，其包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽公开(公告)号：US08568734B2
公开(公告)日：2013-10-29
申请号：US13426295
申请日：2012-03-21
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W Barnett , Indresh K. Srivastava , Rino Rappuoli
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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公开(公告)号：US08398999B2
公开(公告)日：2013-03-19
申请号：US13556139
申请日：2012-07-23
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
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公开(公告)号：US20130064846A1
公开(公告)日：2013-03-14
申请号：US13593464
申请日：2012-08-23
IPC分类号： A61K39/095 , A61P31/04 , A61P37/04 , C07K14/22
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟菌（A＆B）菌株和来自淋病奈瑟氏球菌的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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7.发明授权公开(公告)号：US08226960B2
公开(公告)日：2012-07-24
申请号：US12085413
申请日：2006-11-27
IPC分类号： A61K39/095 , C07H21/04 , C12P21/04 , C07K14/00
CPC分类号： C07K14/22 , A61K38/164 , A61K39/095 , C07K2319/00
摘要： NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other.
摘要翻译： NMB1870是脑膜炎奈瑟氏球菌中的蛋白质。 NMB1870的三个家族是已知的。 为了增加NMB1870蛋白质引起家族之间交叉反应的抗体的能力，NMB1870被设计。 序列可以从一个NMB1870家族代替到另一个家族的相应位置。 来自不同家族的NMB1870序列的蛋白质可以彼此连接。
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公开(公告)号：US20120135024A1
公开(公告)日：2012-05-31
申请号：US13070448
申请日：2011-03-23
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US07928192B2
公开(公告)日：2011-04-19
申请号：US10472681
申请日：2002-03-28
申请人： Vega Masignani , Mariagrazia Pizza , Rino Rappuoli
发明人： Vega Masignani , Mariagrazia Pizza , Rino Rappuoli
IPC分类号： C07K1/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , C07K14/255 , C07K14/315 , C07K14/36 , C12N2799/021 , Y02A50/472
摘要： ADP-ribosylating toxins from Neisseria meningitidis, Streptomyces coelicolor, Mycoplasma pneumoniae, Salmonella typhimurium, Salmonella paratyphi, and Streptococcus pyogenes are disclosed, together with mutant toxins and uses therefor. There is only a low level of sequence identity between these toxins and toxins such as cholera toxin and E. coli heat labile toxin.
摘要翻译： 公开了脑膜炎奈瑟氏球菌，天蓝色链霉菌，肺炎支原体，鼠伤寒沙门氏菌，副伤寒沙门氏菌和化脓性链球菌的ADP-核糖基化毒素，以及突变毒素及其用途。 这些毒素和毒素如霍乱毒素和大肠杆菌热不稳定毒素之间只存在低水平的序列同一性。
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公开(公告)号：US07655245B2
公开(公告)日：2010-02-02
申请号：US10864684
申请日：2004-06-08
IPC分类号： A61K39/095 , C07K14/195 , C12P21/04 , C07H21/04
摘要： The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics.
摘要翻译： 本发明提供脑膜炎奈瑟菌（A＆B）菌株和来自淋病奈瑟氏球菌的蛋白质，包括氨基酸序列，相应的核苷酸序列，表达数据和血清学数据。 蛋白质是疫苗，免疫原性组合物和/或诊断的有用的抗原。
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