Abstract:
The present invention relates to compounds of formula (I), wherein Ra, Rb, Rc, Rd, Re and Rf are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR), Signal transducer and activator of transcription 3 (STAT 3), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) or a combination thereof particularly in the treatment of cancer and inflammation.
Abstract:
The present invention provides the compounds of formula (I): The present invention relates to imidazo[4,5-c]quinoline derivatives of formula (I), process for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PBK) and/or mammalian target of rapamycin (mTOR) and/or tumor necrosis factor-α (TNF-oc) and/or interleukin-6 (IL-6), particularly in the treatment of cancer and inflammation.
Abstract:
A method for performing virtualization, includes managing data between a virtual machine and a bus controller by transmitting an input output (IO) request from the virtual machine to a service virtual machine that owns the bus controller. According to an alternate embodiment, the method for performing virtualization includes managing isochronous data between a virtual machine and a bus controller. Other embodiments are described and claimed.
Abstract:
The present invention relates to cloning of novel gene sequences expressed and repressed during winter dormancy in the apical buds of Camellia sinesis L. (O.) Kuntze (hereinafter, referred to tea) bush, particularly, relates to identification, cloning and analysis of novel 3 prime (hereinafter called as 3′) ends of the genes (gene in the present invention refers to the deoxyribonucleic acid (hereinafter known as, DNA) sequences that are expressed and repressed in winter-dormant apical buds of tea. 3′ end refers to that end of DNA which has free hydroxyl group at 3rd position of the carbohydrate moiety of the DNA molecule.
Abstract:
Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme cleavage activity compared to the unmodified enzyme. Activities associated with the modified DNA cleaving enzyme that can be modulated in different reaction conditions include at least one of: (a) non-sequence specific nicking activity; (b) cleaving the second strand of a duplex DNA at a preexisting nick site to produce a linear duplex with a single strand overhang; (c) non-sequence specific DNA cleavage; (d) cleaving DNA flanking a mismatch; and (e) cleavage at a cruciform structure in a DNA duplex.
Abstract:
The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.
Abstract:
A method and system for assigning a role within an enterprise. The method and system can include a requester selecting a role to which he wishes to be assigned, selecting an administrator authorized to grant the selected role, and submitting a request for the selected role to the selected administrator. The administrator can then approve or deny the request. These actions can be done in a web-based computer program. The selection of the role or the administrator can be made from a list of one or more roles or administrators available to the requester. The submittal of the request can be done by the interaction of the web-based computer program with an e-mail program. Records of the submittal of the request and of the approval or denial of the request can be maintained in an archive data store coupled to the web-based computer program.
Abstract:
The present invention relates to crystalline forms of Atorvastatin magnesium and processes for their preparation. The crystalline forms of the present invention are designated as form X, form Y, form Z and form P of atorvastatin magnesium. The present invention further relates to pharmaceutical compositions comprising form X, form Y, form Z and form P of atorvastatin magnesium and method of using the crystalline forms.
Abstract:
A multi-core system including cores and voltage sources supplying power to the cores. The cores are divided into clusters based on the particular voltage source supplying power to each core. Power management is performed in the multi-core system based on one or more of core utilization and a management policy.
Abstract:
According to an aspect of the present invention, a scheduler balances the load on the microengines comprising one or more threads allocated to execute a corresponding microblock. The scheduler determines the load on each microengine at regular time intervals. The scheduler balances the load of a heavily loaded microengine by distributing the corresponding load among one or more lightly loaded microengines.