公开(公告)号：US09726114B2

公开(公告)日：2017-08-08

申请号：US14379279

申请日：2013-02-19

Applicant: The Regents of the University of California

Inventor： Joseph Wang ,  Sadik C. Esener ,  Daniel Kagan ,  Michael Benchimol ,  Jonathan Claussen

IPC: F02K7/00 ,  F03G7/00 ,  B82B1/00 ,  A61M37/00 ,  B82Y30/00 ,  B82Y5/00 ,  F02K7/02

CPC classification number: F02K7/02 ,  A61M37/0092 ,  B82B1/006 ,  B82Y5/00 ,  B82Y30/00 ,  F03G7/005

Abstract: Techniques, devices and systems are disclosed for implementing acoustically triggered propulsion of nano- and micro-scale structures. In one aspect, an ultrasound responsive propulsion device includes a tube that includes one or more layers including an inner layer having an electrostatic surface, and an ultrasound-responsive substance coupled to the inner layer and configured to form gaseous bubbles in a fluid in response to an ultrasound pulse, in which the bubbles exit the tube to propel the tube to move in the fluid.

公开(公告)号：US20160095541A1

公开(公告)日：2016-04-07

申请号：US14965755

申请日：2015-12-10

Applicant: The Regents of the University of California ,  North Carolina State University ,  Sandia Corporation

Inventor： Joseph Wang ,  Joshua Ray Windmiller ,  Roger Narayan ,  Philip Miller ,  Ronen Polsky ,  Thayne L. Edwards

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/150984 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7282 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2562/028 ,  A61B2562/046 ,  A61M5/158 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/003 ,  G01N33/48785

Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Abstract translation: 公开了用于生物传感和药物递送技术的方法，结构和系统。 在一个方面，用于检测分析物和/或将生物化学物质释放到生物流体中的装置可以包括中空针阵列，其中每个针包括突出的针结构，其包括形成中空内部的外壁和在 暴露中空内部的突出针结构的末端以及外壁内的探针与通过开口与探针接触以产生探针感测信号的一种或多种化学或生物物质相互作用，并产生阵列 分别耦合到中空针阵列的探针的导线，每根线都是导电的，以传输由相应探针产生的探针感测信号。

公开(公告)号：US20150293048A1

公开(公告)日：2015-10-15

申请号：US14439641

申请日：2013-10-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITAT AUTONOMA DE BARCELONA

Inventor： Joseph Wang ,  Joshua Ray Windmiller ,  Aoife O'Mahony ,  Xavier Cetó ,  Manel Del Valle

IPC: G01N27/30

CPC classification number: G01N27/307 ,  G01N27/48 ,  G01N33/0057

Abstract: Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that the chemical agent transfers on the electrode, detecting an electrochemical signal of the chemical agent on the electrode to transduce chemical information associated with the chemical agent to an electrical signal, processing the electrical signal to obtain electrochemical spectral signature data to identify the chemical agent and generating a series of coefficients of the electrochemical spectral signature data to reduce the data, and classifying the chemical information based on the series of coefficients among preselected data sets to determine a level of exposure to the chemical agent.

Abstract translation: 公开了用于鉴定化学试剂的方法，系统和装置，并且使用电化学检测和先进的信号处理来确定其暴露程度。 一方面，一种方法包括将样品从含有化学试剂的表面收集到传感器上的电极上，使得化学试剂在电极上转移，检测电极上的化学试剂的电化学信号，以转移与 将化学试剂转化为电信号，处理电信号以获得电化学光谱特征数据，以鉴定化学试剂并产生电化学光谱特征数据的一系列系数以减少数据，并根据该系列的化学信息进行分类 预选数据集中的系数，以确定暴露于化学试剂的水平。

公开(公告)号：US20150148667A1

公开(公告)日：2015-05-28

申请号：US14407450

申请日：2013-06-11

Applicant: The Regents of the University of California

Inventor： Robert Mattrey ,  Zhe Wu ,  Emilia Olson ,  Joseph Wang ,  Wei Gao ,  Chris Malone

IPC: A61B8/08 ,  A61M25/01 ,  A61B8/00 ,  A61F2/00 ,  A61F2/02 ,  A61K49/22 ,  A61B19/00

CPC classification number: A61B8/481 ,  A61B8/0841 ,  A61B8/4483 ,  A61B90/39 ,  A61B2090/3925 ,  A61F2/0063 ,  A61F2/02 ,  A61F2250/0096 ,  A61K49/223 ,  A61K49/225 ,  A61M25/0108

Abstract: A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or micro sphere, or an implantable device.

Abstract translation: 提供了一种方法和系统，用于通过将含有过氧化氢酶的材料引入感兴趣的位置来检测组织内的局部过氧化氢，将超声换能器定位在该位置上，并产生超声图像以检测微泡，其中微泡的存在指示 局部过氧化氢的存在。 过氧化氢酶包被的表面可以是微管的内表面，在纳米球或微球体的表面或纳入微球体或可植入装置中。