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    External Charger with Customizable Magnetic Charging Field
    81.
    发明申请
    External Charger with Customizable Magnetic Charging Field 有权
    带定制磁场的外部充电器

    公开(公告)号：US20110276111A1

    公开(公告)日：2011-11-10

    申请号：US13099906

    申请日：2011-05-03

    申请人： Rafael Carbunaru ,  Andrew DiGiore ,  Todd Whitehurst

    发明人： Rafael Carbunaru ,  Andrew DiGiore ,  Todd Whitehurst

    IPC分类号： A61N1/36

    CPC分类号： A61N1/37229 ,  A61N1/08 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/378 ,  A61N1/3787

    摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include a plurality of field customization coils for customizing the magnetic charging field generated by the external charger such that the magnetic charging field is not radially symmetric. For example, one embodiment includes a primary coil with a plurality of field customization coils distributed radially with respect to the coil. The generated magnetic charging field can be rendered radially asymmetric by selectively activating or disabling the field customization coils in response to data quantifying the coupling between the various implants and the field customization coils in the charger. If there is a relatively high coupling between a particular implant and a particular customization coil for example, that customization coil can be activated to counter the magnetic charging field at that location, while still maintaining a relatively high magnetic charging field at the location of other implants that may have lower couplings.

    摘要翻译： 公开了改进的用于对植入式医疗装置进行充电的外部充电器，并且对于多个这种装置的充电特别有用。 各种实施例中的每一个包括用于定制由外部充电器产生的磁充电场的多个场定制线圈，使得磁充电场不是径向对称的。 例如，一个实施例包括具有相对于线圈径向分布的多个场定制线圈的初级线圈。 响应于量化各种种植体和充电器中的野外定制线圈之间的耦合的数据，通过选择性地激活或禁用场定制线圈，可以使产生的磁充电场呈径向不对称。 例如，如果特定植入物和特定定制线圈之间存在相对较高的耦合，则该定制线圈可以被激活以抵抗该位置处的磁充电场，同时在其它植入物的位置保持相对高的磁充电场 这可能会降低联轴器。

    METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT
    82.
    发明申请
    METHODS TO AVOID FREQUENCY LOCKING IN A MULTI-CHANNEL NEUROSTIMULATION SYSTEM USING PULSE PLACEMENT 有权
    使用脉冲放置在多通道神经元系统中避免频率锁定的方法

    公开(公告)号：US20110054568A1

    公开(公告)日：2011-03-03

    申请号：US12550237

    申请日：2009-08-28

    申请人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K.L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    发明人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K.L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

    IPC分类号： A61N1/08 ,  A61N1/36

    CPC分类号： A61N1/08 ,  A61N1/36071 ,  A61N1/36082

    摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the electrical waveforms that will potentially overlap temporally are predicted. Each of the potentially overlapping pulse sets is substituted with a replacement stimulation pulse, such that each replacement stimulation pulse is delivered within at least one of the respective timing channels, thereby preventing temporal overlap between the stimulation pulses of the respective electrical waveforms while preventing frequency locking between the timing channels.

    摘要翻译： 提供了一种用于治疗患者的方法和神经刺激系统。 多个脉冲电波形分别在神经刺激系统的多个定时通道内递送，从而治疗患者。 预测可能在时间上潜在重叠的电波形内的一组刺激脉冲。 每个可能重叠的脉冲组被替换刺激脉冲代替，使得每个替换刺激脉冲在相应的定时通道中的至少一个内递送，从而防止各个电波形的刺激脉冲之间的时间重叠，同时防止频率锁定 在定时通道之间。

    AUTOMATIC EVALUATION TECHNIQUE FOR DEEP BRAIN STIMULATION PROGRAMMING
    83.
    发明申请
    AUTOMATIC EVALUATION TECHNIQUE FOR DEEP BRAIN STIMULATION PROGRAMMING 有权
    自动评估技术用于深层脑刺激编程

    公开(公告)号：US20110160796A1

    公开(公告)日：2011-06-30

    申请号：US12976658

    申请日：2010-12-22

    申请人： Courtney Lane ,  Rafael Carbunaru ,  David K.L. Peterson ,  Andrew DiGiore

    发明人： Courtney Lane ,  Rafael Carbunaru ,  David K.L. Peterson ,  Andrew DiGiore

    IPC分类号： A61N1/08 ,  A61N1/36

    CPC分类号： A61N1/36139 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/37282

    摘要： Neurostimulation systems and methods for providing therapy to a patient suffering from a symptom of a disease that latently responds to electrical stimulation therapy are provided. First electrical stimulation energy is conveyed to or from a tissue region of the patient in accordance with a first set of stimulation parameters, thereby affecting the symptom. A predetermined period of time estimated for the symptom to resolve in response to electrical stimulation therapy is allowed to elapse. Second electrical stimulation energy is conveyed to or from the tissue region in accordance with a second set of stimulation parameters different from the first set of stimulation parameters.

    摘要翻译： 提供了神经刺激系统和用于向患有潜在的电刺激治疗反应的疾病症状的患者提供治疗的方法。 根据第一组刺激参数将第一电刺激能量传送到患者的组织区域或从患者的组织区域传送，从而影响症状。 对于电刺激治疗反应的症状的预定时间段被允许经过。 根据与第一组刺激参数不同的第二组刺激参数将第二电刺激能量传送到组织区域或从组织区域传送。

    NEUROSTIMULATION SYSTEM AND METHOD FOR COMBINING CURRENT USING RECONFIGURABLE CURRENT SOURCES
    84.
    发明申请
    NEUROSTIMULATION SYSTEM AND METHOD FOR COMBINING CURRENT USING RECONFIGURABLE CURRENT SOURCES 审中-公开
    使用可重构电流源组合电流的神经网络系统和方法

    公开(公告)号：US20110125224A1

    公开(公告)日：2011-05-26

    申请号：US12952845

    申请日：2010-11-23

    申请人： Rafael Carbunaru ,  Kristen Jaax ,  Andrew DiGiore

    发明人： Rafael Carbunaru ,  Kristen Jaax ,  Andrew DiGiore

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36071

    摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. One of the electrical sources is reconfigured from a second polarity to a first polarity. A first electrical current is generated with the one electrical source when configured in the first polarity. A second electrical current is generated with another one of the electrical sources. At least a portion of the first electrical current and at least a portion of the second electrical current is combined in one of an additive manner and a subtractive manner to produce a first combined electrical current. The first combined electrical current is conveyed to or from one or more of the electrodes.

    摘要翻译： 提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。 电源中的一个从第二极性重新配置为第一极性。 当以第一极性配置时，利用一个电源产生第一电流。 与另一个电源产生第二电流。 第一电流的至少一部分和第二电流的至少一部分以加法方式和减法方式之一组合以产生第一组合电流。 第一组合电流被传送到一个或多个电极或从一个或多个电极传送。

    External Charger for an Implantable Medical Device Having at Least One Moveable Charging Coil
    86.
    发明申请
    External Charger for an Implantable Medical Device Having at Least One Moveable Charging Coil 有权
    具有至少一个可移动充电线圈的可植入医疗设备的外部充电器

    公开(公告)号：US20120119699A1

    公开(公告)日：2012-05-17

    申请号：US13277522

    申请日：2011-10-20

    申请人： Rafael Carbunaru ,  Andrew DiGiore ,  Todd Whitehurst

    发明人： Rafael Carbunaru ,  Andrew DiGiore ,  Todd Whitehurst

    IPC分类号： H02J7/00

    CPC分类号： H02J50/40 ,  A61N1/3787 ,  H01F38/14 ,  H02J7/0042 ,  H02J7/025 ,  H02J50/12 ,  H02J50/90

    摘要： Improved external chargers for charging an implantable medical device, and particularly useful in charging a plurality of such devices, are disclosed. Each of the various embodiments include design elements for mechanically manipulating the position of one or more charging coils within the external charger to customize the magnetic charging field as appropriate for the charger/implantable device environment. For example, a single charging coil may be moved within a housing of the external charger to direct the charging field of the coil towards the currently “coldest” implant, i.e., the implant with the lowest coupling to the external charger. The one or more charging coils may be mechanically manipulated within the external charger housing in a number of ways, including by using linear actuators, by inflatable bladders, or even by hand.

    摘要翻译： 公开了改进的用于对植入式医疗装置进行充电的外部充电器，并且对于多个这种装置的充电特别有用。 各种实施例中的每一个都包括用于机械地操纵外部充电器内的一个或多个充电线圈的位置的设计元件，以适应充电器/可植入装置环境来定制磁充电场。 例如，单个充电线圈可以在外部充电器的壳体内移动以将线圈的充电场引向当前“最冷”的植入物，即具有与外部充电器的最低耦合的植入物。 一个或多个充电线圈可以以多种方式在外部充电器壳体内机械地操作，包括通过使用线性致动器，可膨胀气囊，或甚至手动操作。

    NEUROSTIMULATION SYSTEM AND METHOD FOR COMPOUNDING CURRENT TO MINIMIZE CURRENT SOURCES
    87.
    发明申请
    NEUROSTIMULATION SYSTEM AND METHOD FOR COMPOUNDING CURRENT TO MINIMIZE CURRENT SOURCES 有权
    用于组合电流以最小化电流源的神经网络系统和方法

    公开(公告)号：US20110125223A1

    公开(公告)日：2011-05-26

    申请号：US12952738

    申请日：2010-11-23

    申请人： Rafael Carbunaru ,  Kristen Jaax ,  Andrew DiGiore

    发明人： Rafael Carbunaru ,  Kristen Jaax ,  Andrew DiGiore

    IPC分类号： A61N1/08

    CPC分类号： A61N1/08 ,  A61N1/0551 ,  A61N1/36185 ,  A61N1/37223 ,  A61N1/37241 ,  A61N1/37288 ,  A61N2001/083

    摘要： A neurostimulation system and method of providing therapy to a patient implanted with a plurality of electrodes using a plurality of electrical sources is provided. A source-electrode coupling configuration is determined from the electrical sources and electrodes. Electrical current is respectively conveyed between active ones of the plurality of electrical sources and active subsets of the plurality of electrodes in accordance with the determined source-electrode coupling configuration. The total number of the electrodes in the active electrode subsets is greater than the total number of the active electrical sources.

    摘要翻译： 提供了一种使用多个电源向注入多个电极的患者提供治疗的神经刺激系统和方法。 源电极耦合配置由电源和电极确定。 根据所确定的源电极耦合配置，电流分别在多个电源中的有效电源和多个电极的有效子集之间传送。 有源电极子集中的电极总数大于有源电源的总数。

    METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE
    88.
    发明申请
    METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
    使用噪声共振方法来提高实际和有效的传输

    公开(公告)号：US20110009919A1

    公开(公告)日：2011-01-13

    申请号：US12501170

    申请日：2009-07-10

    申请人： Rafael Carbunaru ,  Michael Moffitt ,  Kristen Jaax ,  Andrew DiGiore ,  Courtney Lane

    发明人： Rafael Carbunaru ,  Michael Moffitt ,  Kristen Jaax ,  Andrew DiGiore ,  Courtney Lane

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0551 ,  A61N1/0529 ,  A61N1/36057 ,  A61N1/36071 ,  A61N1/36114 ,  A61N1/36128 ,  A61N1/36164

    摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.

    摘要翻译： 提供了向患者提供治疗的方法。 在一种方法中，患者具有应用亚阈值生物电刺激的神经元。 该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。 在另一种方法中，患者具有应用超临界生物电刺激的神经元。 该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。 另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。