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    METHODS AND MATERIALS FOR ASSESSING PROSTATE CANCER THERAPIES AND COMPOUNDS
    83.
    发明申请
    METHODS AND MATERIALS FOR ASSESSING PROSTATE CANCER THERAPIES AND COMPOUNDS 有权
    用于评估前列腺癌治疗和化合物的方法和材料

    公开(公告)号：US20080090888A2

    公开(公告)日：2008-04-17

    申请号：US10590445

    申请日：2006-08-24

    申请人： Michael Jung ,  Samedy Ouk ,  Charles Sawyers ,  Charlie Chen ,  Derek Welsbie

    发明人： Michael Jung ,  Samedy Ouk ,  Charles Sawyers ,  Charlie Chen ,  Derek Welsbie

    IPC分类号： A61K31/4166 ,  C07D233/84

    CPC分类号： A61K31/426

    摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.

    摘要翻译： 雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。 增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。 本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。

    Processes and reagents for oligonucleotide synthesis and purification
    84.
    发明申请
    Processes and reagents for oligonucleotide synthesis and purification 审中-公开
    寡核苷酸合成和纯化的方法和试剂

    公开(公告)号：US20050267300A1

    公开(公告)日：2005-12-01

    申请号：US11099430

    申请日：2005-04-05

    申请人： Muthiah Manoharan ,  Michael Jung ,  Kallanthottathil Rajeev ,  Rajendra Pandey ,  Gang Wang

    发明人： Muthiah Manoharan ,  Michael Jung ,  Kallanthottathil Rajeev ,  Rajendra Pandey ,  Gang Wang

    IPC分类号： C07D285/00 ,  C07D285/01 ,  C07H21/00 ,  C07H21/04

    CPC分类号： C07H21/00 ,  C07H21/04 ,  Y02P20/55

    摘要： The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups. In a preferred embodiment, the acrylonitrile scavenger is a polymer-bound thiol. Another aspect of the present invention relates to agents used to oxidize a phosphite to a phosphate. In a preferred embodiment, the oxidizing agent is sodium chlorite, chloroamine, or pyridine-N-oxide. Another aspect of the present invention relates to methods of purifying an oligonucleotide by annealing a first single-stranded oligonucleotide and second single-stranded oligonucleotide to form a double-stranded oligonucleotide; and subjecting the double-stranded oligonucleotide to chromatographic purification. In a preferred embodiment, the chromatographic purification is high-performance liquid chromatography.

    摘要翻译： 本发明涉及寡核苷酸合成和纯化的方法和试剂。 本发明的一个方面涉及可用于在寡核苷酸合成中活化亚磷酰胺的化合物。 本发明的另一方面涉及使用本发明的活化剂通过亚磷酰胺方法制备寡核苷酸的方法。 本发明的另一方面涉及硫转移剂。 在优选的实施方案中，硫转移剂是3-氨基-1,2,4-二噻唑烷-5-酮。 本发明的另一方面涉及通过用本发明的硫转移试剂处理亚磷酸酯制备硫代磷酸酯的方法。 在优选的实施方案中，硫转移剂是3-氨基-1,2,4-二噻唑烷-5-酮。 本发明的另一方面涉及清除在带有乙腈基保护基团的磷酸酯基团去保护过程中产生的丙烯腈的化合物。 在优选的实施方案中，丙烯腈清除剂是聚合物结合的硫醇。 本发明的另一方面涉及用于将亚磷酸盐氧化成磷酸盐的试剂。 在优选的实施方案中，氧化剂是亚氯酸钠，氯胺或吡啶-N-氧化物。 本发明的另一方面涉及通过使第一单链寡核苷酸和第二单链寡核苷酸退火以形成双链寡核苷酸来纯化寡核苷酸的方法; 并对双链寡核苷酸进行色谱纯化。 在优选的实施方案中，色谱纯化是高效液相色谱法。

    Laminated packet for a plastic substrate and method for producing such a laminated packet
    85.
    发明授权
    Laminated packet for a plastic substrate and method for producing such a laminated packet 失效
    用于塑料基材的层压包装及其制造方法

    公开(公告)号：US06610393B1

    公开(公告)日：2003-08-26

    申请号：US09301454

    申请日：1999-04-29

    申请人： Michael Jung

    发明人： Michael Jung

    IPC分类号： B32B702

    CPC分类号： C08J7/045 ,  G02B1/105 ,  G02B1/111 ,  G02B1/14 ,  Y10T428/2495 ,  Y10T428/24967 ,  Y10T428/24975 ,  Y10T428/30 ,  Y10T428/31663

    摘要： A laminated packet or layered coating system is applied onto plastic eyeglasses which is composed of several superposed coating sequences of a coating of TMDS of approximately 1 &mgr;, a hardened TMDS coating of approximately 0.2 &mgr;m and a separating coating of approximately 3-5 nm. The laminated composite contains on the outside a non-hardened coating of TMDS and a cover coating approximately 10-15 nm thick on it. The separating coating is produced in a plasma using methanol. The deposition of the hardened coating of TMDS takes place in the presence of oxygen bound in alcohol.

    摘要翻译： 层压包或分层涂层系统被施加到塑料眼镜上，塑料眼镜由几个大约1微米的TMDS涂层的叠加涂层序列，约0.2μm的硬化TMDS涂层和约3-5nm的分离涂层组成。 层压复合材料在外部含有TMDS的非硬化涂层和其上约10-15nm厚的覆盖层。 使用甲醇在等离子体中产生分离涂层。 TMDS的硬化涂层的沉积在酒精结合的氧气存在下进行。

    Drawing device for a press with control device for maintaining pressure during press stoppage
    89.
    发明授权
    Drawing device for a press with control device for maintaining pressure during press stoppage 失效
    用于压力机的牵引装置，用于在压力停止期间保持压力的控制装置

    公开(公告)号：US5979210A

    公开(公告)日：1999-11-09

    申请号：US40414

    申请日：1998-03-18

    申请人： Siegfried Baur ,  Michael Jung

    发明人： Siegfried Baur ,  Michael Jung

    IPC分类号： B21D24/14 ,  B21D22/00

    CPC分类号： B21D24/14

    摘要： A drawing device for a press is provided with a drawing slide, with a sheet holder having a sheet held therein, and with a pressure cheek which is arranged under the sheet holder and is connected with a piston rod which can be displaced in parallel to the drawing direction. The piston rod is operatively connected with a preacceleration piston of a preacceleration cylinder. The drawing cylinders are applied to the pressure cheek by way of drawing rods, in which case the drawing cylinders have drawing pistons with first and second piston spaces. The first piston space directed to the drawing rod is pressure controlled during the drawing operation for the sheet forming. In the event of a press stoppage during a sheet forming, a control valve device can be activated so that, for maintaining the pressure existing in the first piston space at the start of the press stoppage during the time of the press stoppage, pressure medium can be charged into the first piston space by way of a pressure medium generator.

    摘要翻译： 一种用于压力机的拉丝装置设置有一个牵引滑块，一个带有一个保持在其中的片材的片材夹持器，并且一个压力面板被布置在片材夹持器的下面，并与活塞杆连接，该活塞杆可以与 绘图方向。 活塞杆与预加速缸的预加速活塞可操作地连接。 拉伸圆筒通过拉杆施加到压力面颊，在这种情况下，拉伸圆柱体具有带有第一和第二活塞空间的拉伸活塞。 在用于片材成形的拉拔操作期间，引导到拉杆的第一活塞空间被压力控制。 在片材成型期间发生压力停止的情况下，可以启动控制阀装置，使得为了在压力停止期间在压力停止开始时保持存在于第一活塞空间中的压力，压力介质可以 通过压力介质发生器装入第一活塞空间。

    Monitoring system for representing vibration conditions of a multiplicity of blades on a rotating disc
    90.
    发明授权
    Monitoring system for representing vibration conditions of a multiplicity of blades on a rotating disc 失效
    用于表示旋转盘上的多个叶片的振动条件的监视系统

    公开(公告)号：US5736643A

    公开(公告)日：1998-04-07

    申请号：US589399

    申请日：1996-01-22

    申请人： Hans-Jochen Bores ,  Meinrad Gloger ,  Michael Jung

    发明人： Hans-Jochen Bores ,  Meinrad Gloger ,  Michael Jung

    IPC分类号： G01H11/02 ,  F01D25/00 ,  G01H1/00 ,  G01H17/00 ,  G07C3/00

    CPC分类号： G01H1/006

    摘要： A monitoring system for representing vibration conditions of a multiplicity of blades on a rotating disc in a turbomachine includes at least one sensor which is associated with the disc and which is connected to a pulse generator that delivers sensor pulses which respectively mark an instant at which a blade passes the sensor, a mark pick-up which always delivers a mark pulse when the disc is in a certain zero position, and an analysis device. The latter has an allocation module which takes account of the mark pulses and associates each sensor pulse with the blade which has caused it when passing a sensor. The allocation module calculates vibration data from the associated sensor pulses, which characterize the vibration conditions of the blade. A memory module has access to a working memory to which the vibration data are supplied and the memory module stores the vibration data in the working memory. In addition, the monitoring system has a representation device through the use of which the vibration data can be called up from the working memory and can be represented on at least one representation medium.

    摘要翻译： 用于表示涡轮机中的旋转盘上的多个叶片的振动条件的监视系统包括至少一个与盘相关联的传感器，其连接到脉冲发生器，脉冲发生器分别传送传感器脉冲，其分别标记一个 刀片通过传感器，当光盘处于一定零位置时总是传送标记脉冲的标记拾取器和分析装置。 后者具有分配模块，其考虑标记脉冲并且将每个传感器脉冲与通过传感器时引起的叶片相关联。 分配模块从相关的传感器脉冲计算振动数据，其表征叶片的振动条件。 存储器模块可访问提供振动数据的工作存储器，并且存储器模块将振动数据存储在工作存储器中。 此外，监视系统具有通过使用可以从工作存储器调用振动数据并且可以在至少一个表示介质上表示的表示设备。