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81.发明授权Methods and materials relating to alpha-2-macroglobulin-like polypeptides and polynucleotides 失效与α-2-巨球蛋白样多肽和多核苷酸有关的方法和材料公开(公告)号：US06806254B2
公开(公告)日：2004-10-19
申请号：US09756247
申请日：2001-01-08
申请人： Shubhada D. Godbole , Bryan J. Boyle , Nancy K. Mize , Cenhua Deng , Ryle W. Goodrich , Matthew C. Arterburn , Ping Zhou , Y. Tom Tang , Chenghua Liu , George Yeung , Radoje T. Drmanac
发明人： Shubhada D. Godbole , Bryan J. Boyle , Nancy K. Mize , Cenhua Deng , Ryle W. Goodrich , Matthew C. Arterburn , Ping Zhou , Y. Tom Tang , Chenghua Liu , George Yeung , Radoje T. Drmanac
IPC分类号： A61K3800
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/8107 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted alpha-2-macroglobulin-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal brain mRNA (Clontech) (SEQ ID NO: 1) and uterus mRNA (Clontech) (SEQ ID NO: 26). Other aspects of the invention include vectors containing processes for producing novel human secreted alpha-2-macroglobulin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由这样的多核苷酸编码的新的多核苷酸和多肽，其对应于新型人分泌的α-2-巨球蛋白样多肽的突变体或其变体。 这些多核苷酸包含从胎儿脑mRNA（Clontech）（SEQ ID NO：1）和子宫mRNA（Clontech）（SEQ ID NO：26）的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有产生新的人分泌的α-2-巨球蛋白样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US06667391B1
公开(公告)日：2003-12-23
申请号：US09764325
申请日：2001-01-16
申请人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Cheng-Chi Chao , Nancy K. Mize , John Childs
发明人： Radoje T. Drmanac , Ivan Labat , Y. Tom Tang , Cheng-Chi Chao , Nancy K. Mize , John Childs
IPC分类号： C07K200
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/505 , C07K14/47 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human fetal liver spleen (Hyseq clone identification number 6118092), ovary (Hyseq clone identification number 8375786), adult brain (Hyseq clone identification numbers 701734, 15327638, 15741682, 15954941, 15955015), lung tumor (Hyseq clone identification number 11047146 and 10280328), spinal cord (Hyseq clone identification number 10102150), cervix (Hyseq clone identification numbers 10022437 and 14029194), ovary (Hyseq clone identification number 8319153), endothelial cells (Hyseq clone identification number 13815744), umbilical cord (Hyseq clone identification number 18568149), lymphocyte (Hyseq clone identification number 10257378), lung fibroblast (Hyseq clone identification number 17116257), fetal brain (Hyseq clone identification number 15266959), and testis. Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿肝脏脾脏（Hyseq克隆鉴定号6118092），卵巢（Hyseq克隆鉴定号8375786），成年脑（Hyseq克隆鉴定号701734,15327638,15741682,15954941,15955015）分离的核酸序列， 肺癌（Hyseq克隆鉴定号11047146和10280328），脊髓（Hyseq克隆鉴定号10102150），宫颈（Hyseq克隆鉴定号10022437和14029194），卵巢（Hyseq克隆鉴定号8319153），内皮细胞（Hyseq克隆鉴定号13815744 ），脐带（Hyseq克隆鉴定号18568149），淋巴细胞（Hyseq克隆鉴定号10257378），肺成纤维细胞（Hyseq克隆鉴定号17116257），胎儿脑（Hyseq克隆鉴定号码15266959）和睾丸。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US06590089B1
公开(公告)日：2003-07-08
申请号：US09603552
申请日：2000-06-22
IPC分类号： C07H2104
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47
摘要： The invention provides a mammalian cDNA which encodes a mammalian an RVP-1 variant. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of Crohn's disease. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
摘要翻译： 本发明提供编码哺乳动物RVP-1变体的哺乳动物cDNA。 它还提供cDNA，片段，补体和变体以及编码的蛋白质，其部分及其抗体用于克罗恩氏病的诊断和治疗。 本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统。
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公开(公告)号：US06436703B1
公开(公告)日：2002-08-20
申请号：US09668680
申请日：2000-09-22
申请人： Y. Tom Tang , Chenghua Liu , Ping Zhou , Vinod Asundi , Jie Zhang , Jian-Rui Wang , Aidong J. Xue , Chongjun Xu , Radoje T. Drmanac
发明人： Y. Tom Tang , Chenghua Liu , Ping Zhou , Vinod Asundi , Jie Zhang , Jian-Rui Wang , Aidong J. Xue , Chongjun Xu , Radoje T. Drmanac
IPC分类号： C12N1512
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译： 本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。
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公开(公告)号：US06232459B1
公开(公告)日：2001-05-15
申请号：US08904234
申请日：1997-07-31
申请人： Preeti Lal , Y. Tom Tang
发明人： Preeti Lal , Y. Tom Tang
IPC分类号： C07H2104
摘要： The invention provides a human synaptojanin isoform (NSYN-1) and polynucleotides which identify and encode NSYN-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NSYN-1.
摘要翻译： 本发明提供了人类synaptojanin同种型（NSYN-1）和识别和编码NSYN-1的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与NSYN-1表达相关的疾病的方法。
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公开(公告)号：US06171790B2
公开(公告)日：2001-01-09
申请号：US09071709
申请日：1998-05-01
申请人： Jennifer L. Hillman , Y. Tom Tang , Preeti Lal , Neil C. Corley , Karl J. Guegler , Chandra Patterson
发明人： Jennifer L. Hillman , Y. Tom Tang , Preeti Lal , Neil C. Corley , Karl J. Guegler , Chandra Patterson
IPC分类号： C12N1557
CPC分类号： C07K14/8114 , A61K38/00 , C12N9/48 , C12N9/6421
摘要： The invention provides human protease associated proteins (HPRAP) and polynucleotides which identify and encode HPRAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HPRAP.
摘要翻译： 本发明提供了人类蛋白酶相关蛋白（HPRAP）和识别和编码HPRAP的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HPRAP表达相关的障碍的方法。
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公开(公告)号：US6156523A
公开(公告)日：2000-12-05
申请号：US153939
申请日：1998-09-16
申请人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
发明人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K14/00 , C12N9/00 , C12N15/52 , G01N23/53
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译： 本发明提供人丝氨酸/苏氨酸蛋白激酶（HSTK）和识别和编码HSTK的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HSTK表达相关的病症的方法。
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公开(公告)号：US06036954A
公开(公告)日：2000-03-14
申请号：US373029
申请日：1999-08-11
申请人： Y. Tom Tang , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn
发明人： Y. Tom Tang , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P21/00 , A61P25/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/46
摘要： The invention provides a human ATP synthase subunit homolog (ASYNT) and polynucleotides which identify and encode ASYNT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of ASYNT.
摘要翻译： 本发明提供了人ATP合酶亚基同源物（ASYNT）和识别和编码ASYNT的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了用于诊断，治疗或预防与ASYNT表达相关的病症的方法。
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公开(公告)号：US6017744A
公开(公告)日：2000-01-25
申请号：US129055
申请日：1998-08-04
申请人： Jennifer L. Hillman , Y. Tom Tang , Neil C. Corley
发明人： Jennifer L. Hillman , Y. Tom Tang , Neil C. Corley
CPC分类号： C12N9/104 , C12Q1/6883 , A61K38/00 , C12Q2600/158
摘要： The invention provides a human N-acetyl transferase (NACTH) and polynucleotides which identify and encode NACTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NACTH.
摘要翻译： 本发明提供了人N-乙酰转移酶（NACTH）和鉴定和编码NACTH的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与NACTH表达相关的疾病的方法。
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公开(公告)号：US5989822A
公开(公告)日：1999-11-23
申请号：US154802
申请日：1998-09-17
申请人： Y. Tom Tang , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn
发明人： Y. Tom Tang , Neil C. Corley , Karl J. Guegler , Mariah R. Baughn
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P21/00 , A61P25/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/14 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/00 , C12N15/00
摘要： The invention provides a human ATP synthase subunit homolog (ASYNT) and polynucleotides which identify and encode ASYNT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of ASYNT.
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