公开(公告)号：US07540082B2

公开(公告)日：2009-06-02

申请号：US10595127

申请日：2004-08-19

申请人： Kohichi Ohsumi ,  Kaoru Kobayashi

发明人： Kohichi Ohsumi ,  Kaoru Kobayashi

IPC分类号： H01K3/10 ,  H05K1/03

CPC分类号： H05K3/426 ,  H05K3/0094 ,  H05K3/108 ,  H05K3/427 ,  H05K3/4602 ,  H05K2201/0347 ,  H05K2201/0959 ,  H05K2201/096 ,  H05K2203/1461 ,  Y10T29/49155 ,  Y10T29/49165

摘要： A printed wiring board having a through hole conductor formed on the surface of a through hole formed in a copper-clad laminate board, and on the surface of the copper-clad laminate board 1 in the vicinity of an opening of the through hole. The through hole conductor is filled with a positive photosensitive resin. A capped conductor is formed on the positive photosensitive resin and is coupled to the through hole conductor. Further, a circuit pattern is formed on the surface of the copper-clad laminate board. An insulating layer is formed on the surface of the copper-clad laminate board, capped conductor, and the circuit pattern, and formed with a via hole extending from the surface of the insulating layer to the capped conductor. A via conductor is formed inside the via hole and on the surface of the insulating layer in the vicinity of an opening of the via hole.

摘要翻译： 一种印刷电路板，具有形成在覆铜层压板上形成的通孔的表面上的通孔导体，以及覆铜层压板1的通孔附近的表面。 通孔导体填充有正性感光性树脂。 在正性感光性树脂上形成有帽状导体，并与通孔导体连接。 此外，在覆铜层压板的表面上形成电路图案。 在覆铜层压板，封盖导体和电路图案的表面上形成绝缘层，并且形成有从绝缘层的表面延伸到封盖导体的通孔。 通孔导体形成在通孔内部以及在通孔的开口附近的绝缘层的表面上。

公开(公告)号：US07491748B2

公开(公告)日：2009-02-17

申请号：US10486220

申请日：2002-08-08

申请人： Kousuke Tani ,  Masaki Asada ,  Kaoru Kobayashi ,  Masami Narita ,  Mikio Ogawa

发明人： Kousuke Tani ,  Masaki Asada ,  Kaoru Kobayashi ,  Masami Narita ,  Mikio Ogawa

IPC分类号： A61K31/195 ,  C07C229/02

CPC分类号： C07D231/12 ,  C07C59/68 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C229/34 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73 ,  C07C311/06 ,  C07C311/08 ,  C07C311/19 ,  C07C311/29 ,  C07C311/51 ,  C07C317/18 ,  C07C317/22 ,  C07C317/40 ,  C07C317/50 ,  C07C323/19 ,  C07C323/42 ,  C07C323/59 ,  C07C323/60 ,  C07D233/56 ,  C07D249/08

摘要： A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic ring; Q is alkylnene-Cyc2, etc.; D is a linking chain; and R3 is alkyl, a carbocyclic ring or a heterocyclic ring, or a non-toxic salt thereof. The compound of formula (I) binds to PGE2 receptor, especially subtypes EP3 and/or EP4 and show the antagonizing activity, are useful for the prevention and/or treatment of diseases induced pain, itch, urticaria, allergy, urinary frequency, urinary disturbance, Alzheimer's disease, cancer, dysmenorrhea, endometriosis, etc.

摘要翻译： 式（I）的羧酸衍生物：其中R 1是-COOH，-COOR 6等; A是单键，亚烷基等; R2是烷基，烷氧基等; B是碳环或杂环; Q是亚烷基-Si 2等; D是连接链; 和R 3是烷基，碳环或杂环，或其无毒盐。 式（I）化合物与PGE2受体结合，特别是亚型EP3和/或EP4并显示拮抗活性，可用于预防和/或治疗疾病诱发的疼痛，瘙痒，荨麻疹，过敏，尿频，尿紊乱 ，阿尔茨海默病，癌症，痛经，子宫内膜异位症等

公开(公告)号：US20090034587A1

公开(公告)日：2009-02-05

申请号：US12213881

申请日：2008-06-25

申请人： Kaoru Kobayashi ,  Shigeru Takegishi ,  Nobuo Tsukamoto

发明人： Kaoru Kobayashi ,  Shigeru Takegishi ,  Nobuo Tsukamoto

IPC分类号： H04B1/69

CPC分类号： H04B1/707

摘要： There is provided a signal processing device and a wireless apparatus capable of not erroneously determining polarity, appropriately performing a spread modulation process, a carrier modulation process, and reception data demodulation process, improving reception accuracy, and miniaturizing a circuit, even when IF carrier frequency shift occurs. The signal processing device and the wireless apparatus includes a spread modulation unit which includes a first differential encoding process section for performing a differential encoding process on a reception data, a differential encoding process section for performing a second differential encoding process on the output, and a spread modulation process section for performing a spread modulation process on the output using a spread code; a carrier modulation unit which quadrature-modulates a transmission data spread modulation signal and a continuous wave; and a reception data decoding unit which performs a correlation process twice and a delay detection process twice.

摘要翻译： 提供一种能够不错误地确定极性的信号处理装置和无线装置，适当地执行扩频调制处理，载波调制处理和接收数据解调处理，提高接收精度，并且使电路小型化，即使在IF载波频率 班次发生。 信号处理装置和无线装置包括扩展调制部，其包括对接收数据进行差分编码处理的第一差分编码处理部，对输出进行第二差分编码处理的差分编码处理部， 扩展调制处理部分，用于使用扩展码对输出进行扩展调制处理; 载波调制单元，对发送数据扩展调制信号和连续波进行正交调制; 以及接收数据解码单元，其执行两次相关处理和延迟检测处理两次。

公开(公告)号：US20090010363A1

公开(公告)日：2009-01-08

申请号：US12213983

申请日：2008-06-26

申请人： Kaoru Kobayashi ,  Shigeru Takegishi

发明人： Kaoru Kobayashi ,  Shigeru Takegishi

IPC分类号： H04B1/00

CPC分类号： H04B1/7093 ,  H04B1/7075

摘要： Provided is a matched filter whose circuit scale can be made significantly smaller by reducing the number of multipliers for a despreading process and the number of adders for an accumulating process. For each in-phase/orthogonal component, the matched filter includes a dual-port RAM that separates written samples into 128 groups each of 32 samples which are collectively read out group by group in order at a speed faster than a write speed in write mode, a bit separating section that separates data read group by group into 32 samples and simultaneously outputs the 32 samples, and 32 despreading/accumulating circuits that, with 16 samples sequentially input from 16 groups being taken as one block, sequentially despread individual samples, accumulate despreading results, and output accumulated values for each block. The matched filter further includes an accumulating section that accumulates absolute values for each block from in-phase/orthogonal outputs of the despreading/accumulating circuits, and outputs correlation value data.

摘要翻译： 提供了一种匹配滤波器，其通过减少用于解扩处理的乘法器的数量和用于累积处理的加法器的数量，可以使其电路规模显着更小。 对于每个同相/正交分量，匹配滤波器包括双端口RAM，其将写入样本分成128组，每组32个采样中的每一个采样速率比写入模式的速度快 ，将数据逐个分组分离成32个样本并同时输出32个样本的位分离部分，以及从16个组顺序输入的16个样本作为一个块的32个解扩/累加电路，依次解扩个别样本，累积 解扩结果，并输出每个块的累积值。 匹配滤波器还包括累积部分，其累加解扩/累积电路的同相/正交输出中的每个块的绝对值，并输出相关值数据。

公开(公告)号：US07353186B2

公开(公告)日：2008-04-01

申请号：US09933738

申请日：2001-08-22

申请人： Kaoru Kobayashi

发明人： Kaoru Kobayashi

IPC分类号： G06Q99/00 ,  H04K1/00

CPC分类号： G06Q30/02 ,  G06F17/30867 ,  G06F17/3087 ,  G06Q20/3674 ,  G06Q30/0264 ,  G06Q30/0267 ,  G06Q30/0272 ,  G06Q30/0277

摘要： An advertising system is disclosed which is capable of balancing the degree of specifying geographical areas for advertisements and the number of advertisements being displayed, in accordance with content of the advertisements. A database stores the advertisements, after gradually fractionalizing the advertisement areas into increasingly more specific geographic regions, categorizing the advertisements according to levels of fractionalization and the area sections within the levels, and further categorizing the advertisements according to the content thereof. A data receiving means receives from a computer x “perusal data” indicating the levels of fractionalization of the areas, the area sections within the levels and the content of the advertisements. A retrieving means retrieves from the advertisements stored in the database advertisements categorized according to the levels of fractionalization of the areas, the area sections and the content of the advertisements, all of which are concerned with the “perusal data,” and a data transmitting means 4 transmits “advertisement data” of the retrieved advertisements to the computer x.

摘要翻译： 公开了一种广告系统，其能够根据广告的内容平衡指定广告的地理区域的程度和正在显示的广告的数量。 数据库存储广告，在将广告区域逐渐分级为越来越多的特定地理区域之后，根据分数级别和级别内的区域部分对广告进行分类，并根据其内容进一步对广告进行分类。 数据接收装置从计算机接收指示区域的分数级别，级别内的区域部分和广告内容的“读取数据”。 检索装置从存储在数据库中的广告中检索出根据区域，区域部分和广告内容的分数级别分类的广告，所有这些广告涉及“读取数据”，数据发送装置 4将检索到的广告的“广告数据”发送到计算机x。

公开(公告)号：US07291644B2

公开(公告)日：2007-11-06

申请号：US11412879

申请日：2006-04-28

申请人： Kazuhiko Torisu ,  Maki Iwahashi ,  Kaoru Kobayashi ,  Fumio Nambu

发明人： Kazuhiko Torisu ,  Maki Iwahashi ,  Kaoru Kobayashi ,  Fumio Nambu

IPC分类号： A61K31/335 ,  C07D265/36 ,  C07D405/00 ,  C07D209/02 ,  C07D209/04

CPC分类号： C07D405/12 ,  A61K31/405 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/538 ,  C07D209/22 ,  C07D401/12 ,  C07D413/12

摘要： Compounds represented by formula (I) wherein all symbols represent the same meanings as described in specification and salts thereof. Since the compound represented by the formula (I) binds and antagonizes to DP receptor, it is useful for the prevention or treatment against the disease such as allergic disorder, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, pleuritis complicated by rheumatoid arthritis, cerebrovascular disease, and ulcerative colitis.

摘要翻译： 由式（I）表示的化合物，其中所有符号表示与说明书及其盐中所述相同的含义。 由于式（I）表示的化合物与DP受体结合并拮抗，因此可用于预防或治疗诸如过敏性疾病，伴有瘙痒的疾病，由瘙痒引起的行为引起的继发性疾病，炎症，慢性 阻塞性肺病，局部缺血再灌注障碍，类风湿关节炎并发的胸膜炎，脑血管疾病和溃疡性结肠炎。

公开(公告)号：US20050065353A1

公开(公告)日：2005-03-24

申请号：US10779049

申请日：2004-02-13

申请人： Amos Smith ,  Yuping Qin ,  Michael Kaufman ,  Hirokazu Arimoto ,  David Jones ,  Kaoru Kobayashi ,  Thomas Beauchamp

发明人： Amos Smith ,  Yuping Qin ,  Michael Kaufman ,  Hirokazu Arimoto ,  David Jones ,  Kaoru Kobayashi ,  Thomas Beauchamp

IPC分类号： C07C271/12 ,  C07D213/30 ,  C07D263/22 ,  C07D303/16 ,  C07D309/10 ,  C07D309/30 ,  C07D309/32 ,  C07D319/06 ,  C07D339/08 ,  C07D407/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07F7/18 ,  C07F9/54

CPC分类号： C07C271/12 ,  C07B2200/07 ,  C07D213/30 ,  C07D263/22 ,  C07D303/16 ,  C07D309/10 ,  C07D309/30 ,  C07D309/32 ,  C07D319/06 ,  C07D339/08 ,  C07D407/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07F7/1804 ,  C07F7/1892 ,  C07F9/5428 ,  C07F9/5442

摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

摘要翻译： 提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。

公开(公告)号：US06565032B1

公开(公告)日：2003-05-20

申请号：US09914930

申请日：2001-09-05

申请人： Kaoru Kobayashi ,  Kenichi Kanda ,  Kazuo Arai

发明人： Kaoru Kobayashi ,  Kenichi Kanda ,  Kazuo Arai

IPC分类号： H02K1509

CPC分类号： H02K15/09 ,  Y10T29/49009

摘要： A wire is wound in a plurality of core slots 15 on an armature core, and thereby a plurality of coils 18 is formed. In the case.where each coil end portion of the coils is formed in a predetermined shape by a shaping-winding method, a coil end portion of a coil wound in each core slot is formed to be close to an end surface of the armature core 12 as it is directed outside of a radius direction of the shaft 11. In the case where coil end portions are formed by a shaping-winding and direct-winding methods, some of coil end portions are formed between the first winding to the predetermined number-th winding coils by a shaping winding method, and the remaining coil end portions are formed between the predetermined number-th winding and the last winding coils by a direct-winding method.

摘要翻译： 电线被缠绕在电枢铁芯上的多个铁芯槽15中，从而形成多个线圈18。 在这种情况下，线圈的每个线圈端部通过整形绕组形成为预定的形状，卷绕在每个芯槽中的线圈的线圈端部形成为靠近电枢芯的端面 它指向轴11的半径方向外侧。在通过成形绕组和直接缠绕方法形成线圈端部的情况下，在第一绕组与预定数量之间形成一些线圈端部 通过成形绕组方法将剩余的线圈端部通过直线缠绕法形成在预定的第n绕组和最后的绕组线圈之间。

公开(公告)号：US06451796B1

公开(公告)日：2002-09-17

申请号：US09554166

申请日：2000-05-10

申请人： Kaoru Kobayashi ,  Tadashi Tatsumi ,  Kiyoyuki Sato ,  Hiroyuki Ohno

发明人： Kaoru Kobayashi ,  Tadashi Tatsumi ,  Kiyoyuki Sato ,  Hiroyuki Ohno

IPC分类号： A01N4358

CPC分类号： C07D487/14 ,  A61K31/4985 ,  C07D471/04 ,  C07D487/04 ,  C07D495/14

摘要： The compound of the formula (I): wherein all the symbols are meaning the same as descriptions of the specification; and salts thereof. The compounds of the formula (I) have inhibitory activity of adhesion molecules expression, and are useful for prevention and/or treatment of inflammation, rheumatoid arthritis, allergies, asthma, atopic dermatitis, psoriasis, suppression of ischemia reperfusion injury, nephritis, hepatitis, multiple sclerosis, ulcerative colitis, adult respiratory distress syndrome (ARDS), suppression of transplant rejection, sepsis, diabetes, autoimmune diseases, tumor metastasis, arteriosclerosis and AIDS.

摘要翻译： 式（I）的化合物：其中所有符号与说明书的描述相同; 式（I）的化合物具有粘附分子表达的抑制活性，可用于预防和/或治疗炎症，类风湿性关节炎，过敏，哮喘，特应性皮炎，牛皮癣，局部缺血再灌注损伤的抑制， 肾炎，肝炎，多发性硬化，溃疡性结肠炎，成人呼吸窘迫综合征（ARDS），移植排斥抑制，败血症，糖尿病，自身免疫性疾病，肿瘤转移，动脉硬化和艾滋病。

公开(公告)号：US06309864B1

公开(公告)日：2001-10-30

申请号：US09402162

申请日：1999-12-22

申请人： Toyoo Ohda ,  Tomoshi Ohya ,  Shinobu Kuwae ,  Masao Ohyama ,  Kaoru Kobayashi ,  Yahiro Uemura

发明人： Toyoo Ohda ,  Tomoshi Ohya ,  Shinobu Kuwae ,  Masao Ohyama ,  Kaoru Kobayashi ,  Yahiro Uemura

IPC分类号： C12P2106

CPC分类号： C12N1/16 ,  C12P21/02

摘要： A production method of a heterologous protein, comprising culturing a heterologous protein-producing host prepared by gene manipulation in a medium containing a fatty acid or a salt thereof, and a surfactant and harvesting the heterologous protein from the culture. The production amount of the heterologous protein produced by a heterologous protein-producing host can be increased. Moreover, since decomposition of the heterologous protein by an enzyme derived from the host can be inhibited, enabling large scale production of a heterologous protein.

摘要翻译： 一种异源蛋白质的制备方法，包括在含有脂肪酸或其盐的介质和表面活性剂的培养基中培养通过基因操作制备的异源蛋白质生产宿主，并从培养物中收获异源蛋白质。 可以增加异源蛋白质生产宿主产生的异源蛋白质的产生量。 此外，由于可以抑制来自宿主的酶分解异源蛋白质，能够大规模生产异源蛋白质。