公开(公告)号：US20210000849A1

公开(公告)日：2021-01-07

申请号：US17026616

申请日：2020-09-21

Applicant: GLYCOM A/S

Inventor： Bruce MCCONNELL ,  Emma ELISON ,  Louise Kristine VIGSNÆS

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/15 ,  A61P25/22 ,  A61P25/24

Abstract: A synthetic composition for use in treating or improving one or more emotion and/or mood disorders in a patient, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.

公开(公告)号：US10800802B2

公开(公告)日：2020-10-13

申请号：US15703551

申请日：2017-09-13

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Markus Jondelius Hederos

IPC: A23L33/195 ,  B01D15/36 ,  B01D61/02 ,  B01D61/14 ,  B01D61/16 ,  B01D61/58 ,  C07H1/06 ,  C07H1/08 ,  C07H13/02 ,  C07H13/04 ,  C07H23/00 ,  C08B37/00 ,  C12P19/04 ,  C12P19/18

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US10780103B2

公开(公告)日：2020-09-22

申请号：US15771652

申请日：2016-10-28

Applicant: GLYCOM A/S

Inventor： Bruce McConnell ,  Emma Elison ,  Louise Kristine Vigsnæs

IPC: A61K31/702 ,  A23L33/00 ,  A23L33/15 ,  A61P25/22 ,  A61P25/24

Abstract: A synthetic composition for use in treating or improving one or more emotion and/or mood disorders in a patient, characterised in that the composition contains an effective amount of one or more neutral human milk oligosaccharides, is disclosed.

公开(公告)号：US10415021B2

公开(公告)日：2019-09-17

申请号：US15521580

申请日：2015-10-23

Applicant: Glycom A/S

Inventor： Elise Champion ,  Andreas Vogel ,  Sebastian Bartsch ,  Gyula Dekany

IPC: C12N9/26 ,  C12N15/00 ,  C12P19/18 ,  C07H21/04 ,  C12P21/06 ,  C12P21/04 ,  C12N9/10 ,  C12N9/24 ,  C12P19/04

Abstract: Mutated fucosidases are provided demonstrating improved properties in terms of thermal stability and transfucosidase synthetic performance compared with a wild type transfucosidase isolated from Bifidobacterium longum subsp. infantis.

公开(公告)号：US10407516B2

公开(公告)日：2019-09-10

申请号：US15799386

申请日：2017-10-31

Applicant: Glycom A/S

Inventor： Pierre Chassagne ,  Nikolay Khanzhin ,  Agnese Maggi

IPC: C08B37/00 ,  A23L33/125 ,  A23L33/00

Abstract: Crystalline pLNnH, useful in a pharmaceutical or nutritional composition, is disclosed.

公开(公告)号：US10314852B2

公开(公告)日：2019-06-11

申请号：US15521582

申请日：2015-10-23

Applicant: Glycom A/S

Inventor： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

IPC: C12P19/18 ,  C12P19/26 ,  A61K31/702 ,  C07H5/06 ,  A61K31/715 ,  A61K31/7016

Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

公开(公告)号：US09834574B2

公开(公告)日：2017-12-05

申请号：US14442017

申请日：2013-09-19

Applicant: Glycom A/S

Inventor： Martin Matwiejuk ,  Gyula Dekany

IPC: C07H3/06 ,  C07H1/06 ,  A23L33/10 ,  A23L33/00

CPC classification number: C07H3/06 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/06

Abstract: Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.

公开(公告)号：US09816122B2

公开(公告)日：2017-11-14

申请号：US14430930

申请日：2013-09-25

Applicant: Glycom A/S

Inventor： Pauline Peltier-Pain ,  Gyula Dekany ,  Christophe Pain ,  Pierre Chassagne ,  Nicolas Fierfort ,  Dóra Molnàr-Gàbor

IPC: C12P19/18 ,  C12P19/44 ,  C07H15/08 ,  C07H13/04 ,  C07H15/04 ,  C07H15/26

CPC classification number: C12P19/44 ,  C07H13/04 ,  C07H15/04 ,  C07H15/08 ,  C07H15/26 ,  C12P19/18

Abstract: The invention relates to a method for producing a glycoconjugate comprising an oligosaccharide part covalently linked to a non-sugar moiety selected from the group consisting of amino acids, peptides, proteins, lipids, longer alkyl groups, polyethylene glycols, α,β-unsaturated amido group and polyvinyl alcohols, using a genetically modified cell.

公开(公告)号：US09815862B2

公开(公告)日：2017-11-14

申请号：US14653086

申请日：2013-12-18

Applicant: Glycom A/S

Inventor： Benjámin Podányi ,  Gyula Dekany

IPC: C07H15/12 ,  A23L33/10 ,  A61K31/702 ,  C07H13/04 ,  A23L33/00

CPC classification number: C07H15/12 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H13/04

Abstract: A crystalline LNnT polymorph IV, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuKα radiation, at 8.16, 15.41, 39.14, 23.77, 7.77 and 31.15 2Θ angles, and a crystalline LNnT polymorph V, characterized in that it displays X-ray powder diffraction reflections, based on a measurement using CuKα radiation, at 9.15, 10.26, 19.68, 26.06, 20.61 and 1 1.89 2Θ angles, are provided.

公开(公告)号：US09234225B2

公开(公告)日：2016-01-12

申请号：US14117348

申请日：2012-05-14

Applicant: Gyula Dekany ,  Elise Champion ,  Andreas Schroven ,  Markus Hederos

Inventor： Gyula Dekany ,  Elise Champion ,  Andreas Schroven ,  Markus Hederos

IPC: C12P19/04 ,  C12P19/12 ,  C12P19/14 ,  C07H17/02 ,  C07H17/04 ,  C07H9/06 ,  C08B37/00 ,  A23L1/29 ,  C12P19/18 ,  C07H17/075 ,  C07H19/01

CPC classification number: C12P19/14 ,  A23L33/40 ,  C07H9/06 ,  C07H17/02 ,  C07H17/04 ,  C07H17/075 ,  C07H19/01 ,  C08B37/006 ,  C12P19/04 ,  C12P19/12 ,  C12P19/18 ,  C12Y302/0114

Abstract: A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).

Abstract translation: 一种生产人乳寡糖（HMO）或其前体的方法，可通过该方法获得的化合物，以及涉及这些化合物的用途和组合物。 所述方法包括以下步骤：a）提供至少一种选自式5至10中任一项的化合物的供体，b）从乳糖，LNT，LNnT及其衍生物组中提供至少一种受体，c）提供 至少一种酶，其包含转糖苷酶活性和/或糖基转移酶活性，d）制备所述至少一种供体，至少一种受体和至少一种在步骤a），b）和c）中提供的酶的混合物; 和e）培养根据步骤d）制备的混合物。