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公开(公告)号:US20190169125A1
公开(公告)日:2019-06-06
申请号:US16321137
申请日:2016-09-28
Inventor: Fujie TANAKA , Feng YIN
IPC: C07D209/54 , C07D207/16 , C07C205/51
Abstract: The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present invention relates to a novel pyrrolidine carboxylic acid derivative, its manufacture, pharmaceutical compositions containing it and its use as a catalyst.
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公开(公告)号:US20190086876A1
公开(公告)日:2019-03-21
申请号:US16130469
申请日:2018-09-13
Inventor: Tomotake Sasaki , Eiji Uchibe , Kenji Doya , Hirokazu Anai , Hitoshi Yanami , Hidenao Iwane
Abstract: A non-transitory, computer-readable recording medium stores a program of reinforcement learning by a state-value function. The program causes a computer to execute a process including calculating a TD error based on an estimated state-value function, the TD error being calculated by giving a perturbation to each component of a feedback coefficient matrix that provides a policy; calculating based on the TD error and the perturbation, an estimated gradient function matrix acquired by estimating a gradient function matrix of the state-value function with respect to the feedback coefficient matrix for a state of a controlled object, when state variation of the controlled object in the reinforcement learning is described by a linear difference equation and an immediate cost or an immediate reward of the controlled object is described in a quadratic form of the state and an input; and updating the feedback coefficient matrix using the estimated gradient function matrix.
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公开(公告)号:US20190033527A1
公开(公告)日:2019-01-31
申请号:US16036517
申请日:2018-07-16
Inventor: Rafino Miguel James Murphy , Fuchuan Lei , Jonathan Ward , Sile Nic Chormaic , Yong Yang
IPC: G02B6/26 , C03B37/15 , B23K26/00 , B23K26/073 , B23K26/0622 , B23K26/04 , B23K26/354 , B23K26/352 , B23K26/06
Abstract: A tunable, all-optical, coupling method for a high-Q silica microsphere and an optical waveguide is disclosed. By means of a novel optical nanopositioning method, induced thermal expansion of an asymmetric microsphere stem for laser powers up to 211 mW is observed and used to fine tune the microsphere-waveguide coupling. Microcavity displacements ranging from (0.61±0.13)−(3.49±0.13) μm and nanometer scale sensitivities varying from (2.81±0.08)−(17.08±0.76) nm/mW are obtained. Additionally, an apparent linear dependency of coupling distance on stem laser heating is achieved. Using these methods, coupling can be altered such that the differing and customizable coupling regimes can be achieved.
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公开(公告)号:US10125074B2
公开(公告)日:2018-11-13
申请号:US15560868
申请日:2016-02-01
Inventor: Fujie Tanaka , Dongxin Zhang
IPC: C07C49/00 , C07C69/00 , C07C227/30 , C07C49/753 , C07C69/738 , C07D333/22 , C07D333/24 , C07C227/10 , C07C229/34 , C07C49/255 , C07C49/747 , C07C227/34 , C07C227/42 , A61K31/02 , A61K31/045
Abstract: The present invention relates to novel tertiary alcohol derivatives substituted with aryl and trifluoromethyl, and optical isomers thereof. In addition, the present invention also relates to methods for the preparation and use as enantiomer recognition agent thereof. The present invention provides pharmaceutical composition and use as therapeutically active substance thereof.
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公开(公告)号:US20180193820A1
公开(公告)日:2018-07-12
申请号:US15736721
申请日:2016-06-28
Inventor: Mukhles Ibrahim SOWWAN , Cathal CASSIDY , Vidya Dhar SINGH
Abstract: A novel catalyst includes a plurality of nanoparticles, each nanoparticle including a core made of a catalytic metal and a porous shell surrounding the core, made of metal oxide, the porous shell preserving a catalytic function of the core and reducing reduction of the core and coalescence of the nanoparticles.
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公开(公告)号:US20180178207A1
公开(公告)日:2018-06-28
申请号:US15754091
申请日:2016-08-18
Inventor: Stephan STEINHAUER , Vidya Dhar SINGH , Mukhles Ibrahim SOWWAN
CPC classification number: B01J37/0226 , B01J23/892 , B01J23/8926 , B01J35/0013 , B01J35/06 , B01J37/14 , B01J37/347 , B82Y30/00 , B82Y40/00 , C01G3/02 , C01P2004/03 , C01P2004/04 , C01P2004/16 , C01P2004/80 , C23C16/40 , C30B29/16 , C30B29/60 , C30B33/00
Abstract: A method for manufacturing nanoparticle decorated nanowires by a vacuum deposition system having a deposition chamber and an aggregation chamber connected thereto includes: mounting a metal member in the deposition chamber; performing thermal oxidization of the metal member in the deposition chamber in an oxygen atmosphere so as to grow metal oxide nanowires on a surface of the metal member; without breaking vacuum in the vacuum deposition system, generating a vapor of a catalytic metal particles clusters in the aggregation chamber that is connected to the deposition chamber; and without breaking vacuum in the vacuum deposition system, transporting the generated catalytic metal particles clusters to the deposition chamber so as to decorate the metal oxide nanowires with catalytic metal nanoparticles made of the catalytic metal particles.
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公开(公告)号:US20180118703A1
公开(公告)日:2018-05-03
申请号:US15560858
申请日:2016-02-01
Inventor: Fujie TANAKA , Sherida JOHNSON
IPC: C07D307/22 , C07D309/14
CPC classification number: C07D307/22 , C07D309/14
Abstract: The present invention can provide novel C-glycoside derivatives which are biologically important under high stereoselective, mild, atom economical condition.
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公开(公告)号:US20170338430A1
公开(公告)日:2017-11-23
申请号:US15523500
申请日:2015-11-05
Inventor: Yabing Qi , Min-Cherl Jung , Sonia Ruiz Raga
CPC classification number: H01L51/4246 , H01L51/001 , H01L51/002 , H01L51/0083 , H01L51/4226 , H01L51/4293 , Y02E10/549 , Y02P70/521
Abstract: An optoelectronic device is provided, the p-doped HTL device comprising an active layer comprising organometal halide perovskite and a hole transport layer (HTL) formed by vacuum evaporation and configured to transport hole carriers. The HTL includes a first sublayer comprising a hole transport material (HTM) doped with an n-dopant and disposed adjacent to the active layer, a second sublayer comprising the HTM that is undoped and disposed adjacent to the first sublayer, and a third sublayer comprising the HTM doped with a p-dopant and disposed adjacent to the second sublayer. The doping concentration of the n-dopant for the n-doped sublayer is determined to match the highest occupied molecular orbital energy level of the n-doped sublayer with the valence band maximum energy level of the perovskite active layer.
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公开(公告)号:US20170216924A1
公开(公告)日:2017-08-03
申请号:US15501309
申请日:2015-08-06
Inventor: Jerome VERNIERES , Maria BENELMEKKI ERRETBY , Jeong-Hwan KIM , Rosa Estela DIAZ RIVAS , Mukhles Ibrahim SOWWAN
CPC classification number: B22F9/12 , B22F1/0018 , B22F1/0044 , B22F1/0062 , B22F1/02 , B22F2201/11 , B22F2202/05 , B22F2301/35 , B22F2302/253 , B22F2302/45 , B22F2998/10 , B22F2999/00 , C22C38/06 , H01F1/0054 , H01F1/153 , H01F1/15341
Abstract: A soft magnetic nanoparticle comprising an iron aluminide nanoalloy of the DO3 phase as a core encapsulated in an inert shell made of alumina.
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公开(公告)号:US20170213151A1
公开(公告)日:2017-07-27
申请号:US15329690
申请日:2015-08-07
Inventor: Eiji UCHIBE , Kenji DOYA
Abstract: A method of inverse reinforcement learning for estimating cost and value functions of behaviors of a subject includes acquiring data representing changes in state variables that define the behaviors of the subject; applying a modified Bellman equation given by Eq. (1) to the acquired data: q(x)+gV(y)−V(x)=−1n{pi(y|x))/(p(y|x)} (1) where q(x) and V(x) denote a cost function and a value function, respectively, at state x, g represents a discount factor, and p(y|x) and pi(y|x) denote state transition probabilities before and after learning, respectively; estimating a density ratio pi(y|x)/p(y|x) in Eq. (1); estimating q(x) and V(x) in Eq. (1) using the least square method in accordance with the estimated density ratio pi(y|x)/p(y|x), and outputting the estimated q(x) and V(x).
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