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91 条记录 (耗时 0.017 秒)

    Sheet-shape adhesive preparation
    81.
    发明授权
    Sheet-shape adhesive preparation 失效
    片状粘合剂制备

    公开(公告)号：US4594240A

    公开(公告)日：1986-06-10

    申请号：US530070

    申请日：1983-09-07

    申请人： Terushige Kawata ,  Shinsuke Yamashita

    发明人： Terushige Kawata ,  Shinsuke Yamashita

    IPC分类号： A61K6/00 ,  A61K6/02 ,  A61K9/00 ,  A61K31/557 ,  A61F13/00 ,  A61K9/70 ,  A61L15/03

    CPC分类号： A61K9/0063 ,  A61K31/557 ,  A61K6/0061 ,  A61K6/0067

    摘要： A sheet-shape adhesive preparation for promoting tooth-movement in orthodontics comprising a layer of a pharmaceutical composition containing as the active ingredient a prostaglandin (e.g. prostaglandin E.sub.1, prostaglandin E.sub.2, and prostaglandin F.sub.2.alpha.) in admixture with one or more high molecular weight compounds and a flexible base sheet, a process for the preparation thereof, and a method for promoting tooth-movement in orthodontics by applying the sheet-shape adhesive preparation to the mucous membrane of gingiva. Said preparation can be kept for a long period of time without being dissolved in saliva and without irritation or unpleasant feeling when applied to the mucous membrane of gingiva and hence can show the tooth-movement activity of the active prostaglandin for a long period of time.

    摘要翻译： 一种用于促进口腔正畸的牙齿移动的片状粘合剂制剂，其包含与一种或多种高分子量化合物混合的含有作为活性成分的前列腺素（例如前列腺素E1，前列腺素E2和前列腺素F2α）的药物组合物层 和柔性基片，其制备方法以及通过将片状粘合剂施用于牙龈粘膜来促进正畸矫正中的牙齿移动的方法。 所述制剂可以长时间保存而不会溶解在唾液中，并且当施用到牙龈粘膜时没有刺激或不愉快的感觉，因此可以长时间显示活性前列腺素的牙齿运动活性。

    Nitroglycerin-containing polymeric matrix for sustained release on topical application
    83.
    发明授权
    Nitroglycerin-containing polymeric matrix for sustained release on topical application 失效
    含有硝酸甘油的聚合物基质用于局部施用时持续释放

    公开(公告)号：US4533540A

    公开(公告)日：1985-08-06

    申请号：US646001

    申请日：1984-08-30

    申请人： Izhak Blank

    发明人： Izhak Blank

    IPC分类号： A61K9/06 ,  A61K9/70 ,  A61K31/21 ,  A61K47/32 ,  A61P9/08 ,  A61P9/10 ,  A61F13/00 ,  A61K31/79 ,  A61L15/03

    CPC分类号： A61K9/7053 ,  A61K31/21 ,  A61K47/32 ,  A61K9/7061 ,  Y10S514/947 ,  Y10S514/969 ,  Y10S514/97

    摘要： A mixture of nitroglycerin and a water-insoluble vinylpyrrolidone polymer provides a polymeric matrix which gradually releases nitroglycerin upon application to the skin of a patient in the form of a film, gel or ointment. The water-insoluble vinylpyrrolidone polymer may be an uncrosslinked copolymer or a crosslinked homopolymer or copolymer. The polymer provides increased stability and reduced volatility of the nitroglycerin while permitting slow and sustained release of the drug upon topical application to the skin.

    摘要翻译： 硝酸甘油和水不溶性乙烯基吡咯烷酮聚合物的混合物提供了一种聚合物基体，其在以薄膜，凝胶或软膏形式施用于患者皮肤时逐渐释放硝酸甘油。 水不溶性乙烯基吡咯烷酮聚合物可以是未交联的共聚物或交联的均聚物或共聚物。 该聚合物提供了硝酸甘油的增加的稳定性和降低的挥发性，同时在局部施用于皮肤时缓慢且持续释放药物。

    Virucidal wipe and method
    85.
    发明授权
    Virucidal wipe and method 失效
    病毒擦拭和方法

    公开(公告)号：US4355021A

    公开(公告)日：1982-10-19

    申请号：US201960

    申请日：1980-10-29

    申请人： Mearl C. Mahl ,  Elliot C. Dick ,  George R. Walter, Jr.

    发明人： Mearl C. Mahl ,  Elliot C. Dick ,  George R. Walter, Jr.

    IPC分类号： A01N59/12 ,  A61L15/18 ,  A61K9/70 ,  A61F13/00 ,  A61L15/03 ,  A61K33/18

    CPC分类号： A61L15/18 ,  A01N59/12

    摘要： A substantially dry, impregnated wipe having therein iodine and means for retaining the iodine from escape therefrom, the iodine being present in an amount from about 1% to about 15% by weight of the wipe and in an amount sufficient to provide virucidal activity. The iodine is preferably present in an amount of from about 2% to about 5%. A flexible paper substrate is preferred, and the most preferred substrate is facial tissue. The iodine retaining means is preferably a suitable stabilizing surfactant present in an amount sufficient to complex the iodine, but preferably not substantially in excess of an amount sufficient to complex the iodine. A highly preferred stabilizing surfactant is polyoxyethylene (40) sorbitol septaoleate, present in weight ratio to iodine of from about 1:3 to about 2:1, and most preferably about 1:2.A method of reducing transmission of respiratory viral infections, which includes providing a substantially dry nasal wipe material of the type described and contacting such material with nasal surfaces in the presence of nasal discharge, and, preferably, thereafter wiping to dry hand surfaces with such material.

    摘要翻译： 其中具有碘的基本上干燥的浸渍擦拭物和用于保持碘从其中逸出的装置，碘以擦拭物重量的约1％至约15％的量存在并且以足以提供杀病毒活性的量存在。 碘优选以约2％至约5％的量存在。 优选柔性纸基材，最优选的基材是面巾纸。 碘保存装置优选是以足以使碘复合的量的合适的稳定表面活性剂，但优选基本上不超过足以使碘复合的量。 高度优选的稳定化表面活性剂是聚氧乙烯（40）山梨醇间苯二甲酸酯，其与碘的重量比为约1:3至约2:1，最优选约1:2。 一种减少呼吸道病毒感染传播的方法，其包括提供所述类型的基本上干燥的鼻拭子材料，并且在鼻放电存在下将这种材料与鼻表面接触，并且优选地随后用这种材料擦干手表面 。

    Polymeric diffusion matrix containing a vasodilator
    87.
    发明授权
    Polymeric diffusion matrix containing a vasodilator 失效
    含有血管扩张剂的聚合物扩散基质

    公开(公告)号：US4291015A

    公开(公告)日：1981-09-22

    申请号：US163262

    申请日：1980-06-26

    申请人： Alec D. Keith ,  Wallace Snipes

    发明人： Alec D. Keith ,  Wallace Snipes

    IPC分类号： A45C3/00 ,  A61K9/70 ,  A61K31/135 ,  A61K31/415 ,  A61K31/565 ,  A61L15/03 ,  A61K31/21 ,  A61K31/79

    CPC分类号： A61K9/7084 ,  A61K31/135 ,  A61K31/415 ,  A61K31/565 ,  A61K9/70 ,  Y10S514/929

    摘要： A polymeric diffusion matrix containing a vasodilator is provided comprising from about 2 to about 60% of a polar plasticizer, e.g., glycerol, from about 2 to about 15% of a matrix component, e.g., polyvinylalcohol, from about 2 to about 10% of a water-soluble polymer with hydration sites, e.g., polyvinylpyrrolidone, which in combination with the remaining ingredients yields a matrix capable of sustained release of a vasodilator drug dispersed therein, and the balance water, the percentages being by weight.

    摘要翻译： 提供了含有血管扩张剂的聚合物扩散基质，其包含约2-约60％的极性增塑剂，例如甘油，约2至约15％的基质组分，例如聚乙烯醇，约2至约10％ 具有水合位点的水溶性聚合物，例如聚乙烯吡咯烷酮，其与剩余成分组合产生能够持续释放其中分散的血管扩张剂药物的基质，余量水的重量百分数。

    Dosage form
    89.
    发明授权
    Dosage form 失效
    剂型

    公开(公告)号：US3972995A

    公开(公告)日：1976-08-03

    申请号：US567788

    申请日：1975-04-14

    申请人： Andrew G. Tsuk ,  Frederick H. Martin

    发明人： Andrew G. Tsuk ,  Frederick H. Martin

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61M31/00 ,  A61F7/02 ,  A61L15/03 ,  A61M35/00

    CPC分类号： A61M31/002 ,  A61K9/006 ,  A61K9/70

    摘要： The disclosure is directed to dosage forms for buccal administration of a drug and are directly applicable to the interior surfaces of the mouth. The dosage form is comprised of a support member, which is water insoluble, waterproof and flexible, a moisture activated, adhesive precursor applied to one surface of the support member and an active ingredient applied to the central portion of the support member either directly or dispersed in a matrix. In one embodiment, a recess is provided in the support member to receive the active ingredient. When the dosage form is applied directly to the interior surface of the mouth, contact with saliva activates the adhesive and causes the support member to adhere to the interior surface of the mouth, thereby exposing the active ingredient to a limited area of the oral mucosa while isolating the active ingredient from the remainder of the oral environment.

    摘要翻译： 本公开涉及用于口服给药药物的剂型，并且可直接适用于口腔内表面。 剂型由水不溶性，防水和柔性的支撑构件，施加到支撑构件的一个表面的水分活化的粘合剂前体和直接或分散地施加到支撑构件的中心部分的活性成分组成 在矩阵中。 在一个实施例中，在支撑构件中设置凹部以接收活性成分。 当剂型直接施加到口腔的内表面时，与唾液接触激活粘合剂并使支撑构件粘附到口腔的内表面，从而将活性成分暴露于口腔粘膜的有限区域，同时 将活性成分与口腔环境的其余部分分离。