公开(公告)号：US11875876B2

公开(公告)日：2024-01-16

申请号：US16441647

申请日：2019-06-14

申请人： Massachusetts Institute of Technology

发明人： Timothy Kuan-Ta Lu ,  Manolis Kellis ,  Jicong Cao ,  Eva Maria Novoa Pardo ,  Zhizhuo Zhang

IPC分类号： C12N15/11 ,  G16B20/50 ,  G16B40/00 ,  C12N15/10 ,  C12N15/85

CPC分类号： G16B20/50 ,  C12N15/1089 ,  C12N15/11 ,  C12N15/85 ,  G16B40/00

摘要： Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts. Also disclosed herein are methods of engineering 5′ UTR sequences and methods and kits for screening 5′ UTR sequences for a property of interest.

公开(公告)号：US11869630B2

公开(公告)日：2024-01-09

申请号：US16632071

申请日：2018-07-18

申请人： CONGENICA LTD.

发明人： Nicholas Lench ,  Matt Hurles ,  John McGonigle ,  Alan Martin ,  Suzanne Drury

IPC分类号： G16B20/20 ,  G16B20/50 ,  G16B30/00

CPC分类号： G16B20/20 ,  G16B20/50 ,  G16B30/00

摘要： A prenatal screening system includes a wet-laboratory arrangement and a data processing arrangement to exchange instructions and data with the wet-laboratory arrangement. The data processing arrangement includes a database arrangement storing genetic information accessible to one or more algorithms executable on the data processing arrangement. The wet-laboratory arrangement collects one or more maternal blood samples from a pregnant mother. The wet-laboratory arrangement isolates free fetal DNA fragments present in cell-free DNA derived from plasma of the one or more maternal blood samples. The isolation utilizes baits based upon coordinates of cell-free fetal DNA fragment specific end-points, and the data processing arrangement analyses the isolated free fetal DNA and compares with one or more DNA templates stored in the data processing arrangement for determining an occurrence of one or more biological characteristics of fetal DNA present in the one or more maternal blood samples.

公开(公告)号：US11844812B2

公开(公告)日：2023-12-19

申请号：US16758648

申请日：2018-10-23

申请人： SPHINGOTEC GMBH

发明人： Andreas Bergmann ,  Olle Melander

IPC分类号： A61K33/04 ,  G16B20/50 ,  A61K31/198 ,  G01N33/68

CPC分类号： A61K33/04 ,  A61K31/198 ,  G01N33/6893 ,  G16B20/50 ,  G01N2800/32 ,  G01N2800/50

摘要： Subject of the present invention is a method for assessing a risk for getting a first cardiovascular event or assessing the risk for cardiovascular mortality in a subject, comprising: a) determining the level and/or the amount of Selenoprotein P and/or fragments thereof in a sample of said subject; b) correlating the determined level and/or the amount of Selenoprotein P and/or fragments thereof with the risk for getting a first cardiovascular event or assessing the risk for cardiovascular mortality in said subject.

公开(公告)号：US11827937B2

公开(公告)日：2023-11-28

申请号：US16728333

申请日：2019-12-27

申请人： CELERA CORPORATION

发明人： Dov Shiffman

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12Q1/6883 ,  G16B20/50 ,  G16B20/30 ,  G16B20/20 ,  G16B25/20 ,  A61K31/22 ,  A61K31/366 ,  A61K31/397 ,  A61K31/40 ,  A61K31/405 ,  A61K31/455 ,  A61K31/505 ,  G16B20/00 ,  G16B25/00

CPC分类号： C12Q1/6883 ,  A61K31/22 ,  A61K31/366 ,  A61K31/397 ,  A61K31/40 ,  A61K31/405 ,  A61K31/455 ,  A61K31/505 ,  G16B20/20 ,  G16B20/30 ,  G16B20/50 ,  G16B25/20 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172 ,  G16B20/00 ,  G16B25/00

摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.

公开(公告)号：US20230374527A1

公开(公告)日：2023-11-23

申请号：US18134317

申请日：2023-04-13

申请人： The Broad Institute, Inc. ,  Massachusetts Institute of Technology

发明人： Feng Zhang

IPC分类号： C12N15/74 ,  C12N15/113 ,  C12N9/22 ,  C12N15/63 ,  G16B20/30 ,  G16B30/10 ,  G16B20/20 ,  G16B20/50 ,  G16B20/00 ,  C12N15/85 ,  C12N15/70 ,  C12N15/90

CPC分类号： C12N15/746 ,  C12N15/113 ,  C12N9/22 ,  C12N15/63 ,  G16B20/30 ,  G16B30/10 ,  G16B20/20 ,  G16B20/50 ,  G16B20/00 ,  C12N15/85 ,  C12N15/70 ,  C12N15/74 ,  C12N15/8509 ,  C12N15/907 ,  C12N2310/3519 ,  C12N2310/531 ,  C12N2310/20 ,  C12N15/102

摘要： The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

公开(公告)号：US11810646B2

公开(公告)日：2023-11-07

申请号：US16789993

申请日：2020-02-13

申请人： The Regents of the University of California

发明人： Chunbo Lou ,  Tae Seok Moon ,  Virgil Rhodius ,  Brynne Stanton ,  Alvin Tasmir ,  Karsten Temme ,  Chris Voigt

IPC分类号： C12N5/00 ,  G16B20/30 ,  G16B20/00 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C12N15/63 ,  G16B35/10 ,  G16B30/20 ,  C12N15/70 ,  C12N15/79 ,  G16B20/50

CPC分类号： G16B20/30 ,  C12N15/63 ,  C12N15/635 ,  C12N15/70 ,  C12N15/79 ,  G16B20/00 ,  G16B30/00 ,  G16B30/20 ,  G16B35/00 ,  G16B35/10 ,  G16C20/60 ,  G16B20/50

摘要： Methods for design of genetic circuits are provided.

公开(公告)号：US11804283B2

公开(公告)日：2023-10-31

申请号：US16620389

申请日：2018-06-08

申请人： Just-Evotec Biologics, Inc.

发明人： Jeremy Martin Shaver ,  Randal Robert Ketchem

IPC分类号： G16B20/00 ,  G16B30/00 ,  G16B40/00 ,  G16B20/30 ,  G06F30/20 ,  G16B35/00 ,  G06F111/10 ,  G16B20/50

CPC分类号： G16B20/30 ,  G06F30/20 ,  G16B20/00 ,  G16B30/00 ,  G16B35/00 ,  G16B40/00 ,  G06F2111/10 ,  G16B20/50

摘要： A system for generating a model for predicting a molecular property of a variant of a molecule is provided. For each of a plurality of variants of the molecule, the system for each structural feature, aggregates the values for the structural features of the residues of the molecule that were modified to form the variant to form a feature vector for the variant. The system assigns the value for the molecular property of the variant to the feature vector wherein the feature vector and the assigned value form training data. The system then generates the model for predicting a value for the molecular property using the training data for the plurality of variants.

公开(公告)号：US20230343413A1

公开(公告)日：2023-10-26

申请号：US18055550

申请日：2022-11-15

申请人： Illumina, Inc. ,  Illumina Cambridge Limited

发明人： Tobias HAMP ,  Hong GAO ,  Kai-How FARH

IPC分类号： G16B30/00 ,  G16B20/50 ,  G16B20/20 ,  G16H50/20 ,  G16B15/00 ,  G16B20/00 ,  G16B40/20 ,  G16B5/20

CPC分类号： G16B30/00 ,  G16B20/50 ,  G16B20/20 ,  G16H50/20 ,  G16B15/00 ,  G16B20/00 ,  G16B40/20 ,  G16B5/20

摘要： The technology disclosed relates to determining pathogenicity of nucleotide variants. In particular, the technology disclosed relates to specifying a particular amino acid at a particular position in a protein as a gap amino acid, and specifying remaining amino acids at remaining positions in the protein as non-gap amino acids. The technology disclosed further relates to generating a gaped spatial representation of the protein that includes spatial configurations of the non-gap amino acids, and excludes a spatial configuration of the gap amino acid, and determining a pathogenicity of a nucleotide variant based at least in part on the gaped spatial representation, and a representation of an alternate amino acid coated by the nucleotide variant at the particular position.

公开(公告)号：US20230326552A1

公开(公告)日：2023-10-12

申请号：US18297497

申请日：2023-04-07

申请人： Washington University

发明人： Tae Seok Moon ,  Austin Rottinghaus

IPC分类号： G16B20/50 ,  C12N9/22 ,  C12N15/10

CPC分类号： G16B20/50 ,  C12N9/22 ,  C12N15/102 ,  C12N2310/20

摘要： Among the various aspects of the present disclosure is the provision of systems and methods for producing systems and methods for the computational design of CRISPR guide RNAs for strain-specific control of microbiota consortia.

公开(公告)号：US20230290440A1

公开(公告)日：2023-09-14

申请号：US18168721

申请日：2023-02-14

申请人： BostonGene Corporation

发明人： Natalia Miheecheva ,  Konstantin Chernyshov ,  Aleksandr Vikhorev

IPC分类号： G16B25/00 ,  G16B20/50 ,  G16B30/10 ,  A61K47/68 ,  G16B40/20

CPC分类号： G16B25/00 ,  A61K47/6803 ,  G16B20/50 ,  G16B30/10 ,  G16B40/20

摘要： Aspects of the disclosure relate to methods, systems, computer-readable storage media, and graphical user interfaces (GUIs) that are useful for characterizing subjects having certain cancers, for example bladder cancers or urothelial cancers. The disclosure is based, in part, on methods for determining the urothelial cancer (UC) tumor microenvironment (TME) type of a urothelial cancer subject and the subject’s prognosis and/or likelihood of responding to a therapy based upon the UC TME type determination.