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公开(公告)号：US2336916A
公开(公告)日：1943-12-14
申请号：US35781740
申请日：1940-09-21
申请人： ICI LTD
IPC分类号： C07D333/10
CPC分类号： C07D333/10
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公开(公告)号：US11833129B2
公开(公告)日：2023-12-05
申请号：US17149549
申请日：2021-01-14
申请人： Avoscience, LLC
发明人： Samuel Richard Huber
IPC分类号： A61K31/341 , C07D307/36 , A61K45/06 , C07D333/10 , A61K31/381 , C07D207/32 , A61K31/40 , A61K31/443
CPC分类号： A61K31/341 , A61K31/381 , A61K31/40 , A61K45/06 , C07D207/32 , C07D307/36 , C07D333/10 , A61K31/443
摘要： Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective amount of a compound of Formula I, II, or III, or a pharmaceutically acceptable composition, salt, isotopic analog, prodrug, or combination thereof, to a subject suffering from a cancer, neurological disorder, or fibrotic disorder.
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公开(公告)号：US10889601B2
公开(公告)日：2021-01-12
申请号：US16788027
申请日：2020-02-11
IPC分类号： C07F5/02 , C07C7/12 , C07D333/10
摘要： The invention provides a compound of formula (I): or a salt thereof, wherein R1 and R2 have any of the values defined in the specification, as well as methods of using such compounds and salts to separate an aryl compound from a mixture.
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84.发明申请公开(公告)号：US20200255397A1
公开(公告)日：2020-08-13
申请号：US16833280
申请日：2020-03-27
发明人： Hwan Mook KIM , Kwang Won JEONG , Seung Hyun OH , Sun Ki KIM , Jung Ju KIM , Seong-Won SONG
IPC分类号： C07D333/38 , C07D409/04 , C07D409/14 , A61K31/381 , C07D401/14 , A61K31/426 , C07D333/10 , C07D277/20 , A61P1/16 , C07D417/04
摘要： The present invention relates to a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of autophagy-related diseases.
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公开(公告)号：US10669249B2
公开(公告)日：2020-06-02
申请号：US16309807
申请日：2016-07-21
发明人： Mina Yang , Yongtao Jiang , Ying Meng , Tao Wang , Qian qian Xu , Xin Shao , Chunjie Sha
IPC分类号： C07D333/10
摘要： The present disclosure relates to rotigotine behenate, methods for preparing the same and use of the same for treating diseases associated with dopamine receptor. The rotigotine behenate, the structure of which is shown below, is capable of reducing fluctuation in blood drug concentrations, improving the bioavailability of the drug in vivo, and achieving smooth and extended release of rotigotine.
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公开(公告)号：US10450263B2
公开(公告)日：2019-10-22
申请号：US15892302
申请日：2018-02-08
IPC分类号： C07C233/64 , C07C233/67 , C07C233/75 , C07D231/12 , C07D233/58 , C07D261/08 , C07D277/22 , C07D333/10 , C07D307/36 , C07D213/16 , C07D223/04 , C07D241/12 , C07D271/12 , C07D233/90 , C07D277/56 , C07D261/18 , C07D307/68 , C07D333/38 , C07D241/24 , C07D239/28 , C07C255/41 , C07D213/56 , C07D213/81 , C07D307/85 , C07D309/08 , C07D213/30 , C07D209/46 , C07D223/16 , A61P31/12 , C07D231/14 , C07C255/58 , C07C311/21 , C07C233/29 , C07C233/60 , C07C233/65 , C07C235/48 , C07C255/33
摘要： The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20190210992A1
公开(公告)日：2019-07-11
申请号：US16354011
申请日：2019-03-14
IPC分类号： C07D333/20 , C07D409/14 , C07D275/02 , C07D409/12 , C07D333/10 , A61K35/51 , A61K35/17 , C07D333/24 , A61K35/12 , C07C229/34 , C07C271/22 , C07D317/60 , C07D213/64 , C07C311/08 , C07C271/20 , C07D413/14
CPC分类号： C07D333/20 , A61K35/12 , A61K35/17 , A61K35/51 , C07C229/34 , C07C271/20 , C07C271/22 , C07C311/08 , C07D213/64 , C07D275/02 , C07D317/60 , C07D333/10 , C07D333/24 , C07D409/12 , C07D409/14 , C07D413/14
摘要： A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of α4fβ1, α5β1, α4β7, αvβ3 and αLβ2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.
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88.发明授权公开(公告)号：US10099975B2
公开(公告)日：2018-10-16
申请号：US14913807
申请日：2014-08-11
申请人： MERCK PATENT GMBH
IPC分类号： C07C15/18 , C07C13/47 , C07C13/573 , C07C15/24 , C07C25/24 , C07D213/24 , C07D307/36 , C07D307/38 , C07D333/10 , C07D333/12 , C09K19/18 , C09K19/32 , C09K19/34
摘要： Compounds of formula I their use in liquid-crystalline media, for example, for the phase shifting of microwaves for tunable phased-array antennae, and their use for high-frequency components, in particular antennae, especially for the gigahertz range.
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公开(公告)号：US10071980B2
公开(公告)日：2018-09-11
申请号：US14751431
申请日：2015-06-26
IPC分类号： C07D333/10 , C07D333/20 , C07D275/02 , C07D409/14 , C07C271/20 , C07C311/08 , C07D213/64 , C07D317/60 , A61K35/17 , A61K35/51 , C07D409/12 , C07D413/14 , A61K35/12 , C07C229/34 , C07C271/22 , C07D333/24
摘要： A method of enhancing binding of cells to an integrin-binding ligand comprises treating integrin-expressing cells in vitro with an agonist of integrin, wherein the integrin is selected from the group consisting of α4β1, α5β1, α4β7, αvβ3 and αLβ2, and contacting the treated cells with an integrin-binding ligand; integrin agonist compounds having the general formula I; methods of treating integrin-expressing cells with such agonists to enhance binding; and therapeutic methods comprising administering agonist-treated cells or agonist compounds to a mammal.
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公开(公告)号：US09834537B2
公开(公告)日：2017-12-05
申请号：US14092151
申请日：2013-11-27
IPC分类号： C07C229/56 , C07D333/10 , C07D333/40 , C07C229/58
CPC分类号： C07D333/40 , C07C229/56 , C07C229/58
摘要： Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.
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