公开(公告)号：US20210317106A1

公开(公告)日：2021-10-14

申请号：US17221666

申请日：2021-04-02

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Corinne E. Augelli-Szafran ,  Atefeh Garzan ,  Daniel Steblow ,  Nicole Haese

IPC: C07D403/04 ,  C07D213/74 ,  C07D213/70 ,  C07D213/69 ,  C07D491/052 ,  C07D498/08

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20180230084A1

公开(公告)日：2018-08-16

申请号：US15892302

申请日：2018-02-08

Applicant: Southern Research Institute

Inventor： Ashish Kumar Pathak ,  Syed Kaleem Ahmed ,  Corinne E. Augelli-Szafran ,  Joseph A. Maddry

IPC: C07C233/75 ,  C07D231/14 ,  C07D233/90 ,  C07D277/56 ,  C07D261/18 ,  C07D307/68 ,  C07D333/38 ,  C07D241/24 ,  C07D271/12 ,  C07D239/28 ,  C07C255/41 ,  C07D213/56 ,  C07D213/81 ,  C07D307/85 ,  C07D309/08 ,  C07D213/30 ,  C07D209/46 ,  C07D223/16 ,  A61P31/12

CPC classification number: C07C233/75 ,  A61P31/12 ,  C07C233/29 ,  C07C233/60 ,  C07C233/65 ,  C07C235/48 ,  C07C255/33 ,  C07C255/41 ,  C07C255/58 ,  C07C311/21 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2602/12 ,  C07C2603/74 ,  C07D209/46 ,  C07D213/30 ,  C07D213/56 ,  C07D213/81 ,  C07D223/16 ,  C07D231/14 ,  C07D233/90 ,  C07D239/28 ,  C07D241/24 ,  C07D261/18 ,  C07D271/12 ,  C07D277/56 ,  C07D307/68 ,  C07D307/85 ,  C07D309/08 ,  C07D333/38

Abstract: The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11905306B2

公开(公告)日：2024-02-20

申请号：US18086445

申请日：2022-12-21

Applicant: Southern Research Institute ,  The University of North Carolina at Chapel Hill ,  Vanderbilt University

Inventor： Syed Kaleem Ahmed ,  Shilpa Dutta ,  John Phillip Tillotson ,  Corinne E. Augelli-Szafran ,  Ashish Kumar Pathak ,  Omar Moukha-Chafiq ,  Timothy Patrick Sheahan ,  Ralph S. Baric ,  Amy Catherine Sims ,  Mark R. Denison

IPC: C07F9/58 ,  C07D213/56 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

CPC classification number: C07F9/58 ,  C07D213/56 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20220177452A9

公开(公告)日：2022-06-09

申请号：US17221666

申请日：2021-04-02

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Corinne E. Augelli-Szafran ,  Atefeh Garzan ,  Daniel Steblow ,  Nicole Haese

IPC: C07D403/04 ,  C07D213/74 ,  C07D213/70 ,  C07D213/69 ,  C07D491/052 ,  C07D498/08

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20240182450A1

公开(公告)日：2024-06-06

申请号：US18545749

申请日：2023-12-19

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Corinne E. Augelli-Szafran ,  Atefeh Garzan ,  Daniel Steblow ,  Nicole Haese

IPC: C07D403/04 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D491/052 ,  C07D498/08

CPC classification number: C07D403/04 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D491/052 ,  C07D498/08

Abstract: The present disclosure is concerned with 2-pyrimidone compounds that are capable of inhibiting a viral infection and methods of treating alphavirus viral infections such as, for example, chikungunya, Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), and Venezuelan equine encephalitis using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20230192733A1

公开(公告)日：2023-06-22

申请号：US18086445

申请日：2022-12-21

Applicant: Southern Research Institute ,  The University of North Carolina at Chapel Hill ,  Vanderbilt University

Inventor： Syed Kaleem Ahmed ,  Shilpa Dutta ,  John Phillip Tillotson ,  Corinne E. Augelli-Szafran ,  Ashish Kumar Pathak ,  Omar Moukha-Chafiq ,  Timothy Patrick Sheahan ,  Ralph S. Baric ,  Amy Catherine Sims ,  Mark R. Denison

IPC: C07F9/58 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D417/12

CPC classification number: C07F9/58 ,  C07D213/56 ,  C07D413/12 ,  C07D401/12 ,  C07D417/12

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US10450263B2

公开(公告)日：2019-10-22

申请号：US15892302

申请日：2018-02-08

Applicant: Southern Research Institute

Inventor： Ashish Kumar Pathak ,  Syed Kaleem Ahmed ,  Corinne E. Augelli-Szafran ,  Joseph A. Maddry

IPC: C07C233/64 ,  C07C233/67 ,  C07C233/75 ,  C07D231/12 ,  C07D233/58 ,  C07D261/08 ,  C07D277/22 ,  C07D333/10 ,  C07D307/36 ,  C07D213/16 ,  C07D223/04 ,  C07D241/12 ,  C07D271/12 ,  C07D233/90 ,  C07D277/56 ,  C07D261/18 ,  C07D307/68 ,  C07D333/38 ,  C07D241/24 ,  C07D239/28 ,  C07C255/41 ,  C07D213/56 ,  C07D213/81 ,  C07D307/85 ,  C07D309/08 ,  C07D213/30 ,  C07D209/46 ,  C07D223/16 ,  A61P31/12 ,  C07D231/14 ,  C07C255/58 ,  C07C311/21 ,  C07C233/29 ,  C07C233/60 ,  C07C233/65 ,  C07C235/48 ,  C07C255/33

Abstract: The present disclosure is concerned with benzo annulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, dengue, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20240116972A1

公开(公告)日：2024-04-11

申请号：US18510128

申请日：2023-11-15

Applicant: Southern Research Institute ,  Oregon Health & Science University ,  Washington University in St. Louis ,  Board of Regents, The University of Texas System

Inventor： Omar Moukha-Chafiq ,  Ashish Kumar Pathak ,  Shuklendu D. Karyakarte ,  Larry D. Bratton ,  Corinne E. Augelli-Szafran ,  Michael Diamond ,  Pei Yong Shi ,  Alec Jay Hirsch ,  Jessica Lee Smith ,  Daniel Streblow ,  Nicole Haese ,  Baoling Ying

IPC: C07H19/12 ,  A61P31/14 ,  A61P31/16

CPC classification number: C07H19/12 ,  A61P31/14 ,  A61P31/16

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11858956B2

公开(公告)日：2024-01-02

申请号：US17554979

申请日：2021-12-17

Applicant: Southern Research Institute ,  Oregon Health & Science University ,  Washington University in St. Louis ,  Board of Regents, The University of Texas System

Inventor： Omar Moukha-Chafiq ,  Ashish Kumar Pathak ,  Shuklendu D. Karyakarte ,  Larry D. Bratton ,  Corinne E. Augelli-Szafran ,  Michael Diamond ,  Pei Yong Shi ,  Alec Jay Hirsch ,  Jessica Lee Smith ,  Daniel Streblow ,  Nicole Haese ,  Baoling Ying

IPC: C07H19/12 ,  A61P31/14 ,  A61P31/16

CPC classification number: C07H19/12 ,  A61P31/14 ,  A61P31/16

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11578073B2

公开(公告)日：2023-02-14

申请号：US16905857

申请日：2020-06-18

Applicant: Southern Research Institute ,  Oregon Health and Science University

Inventor： Ashish Kumar Pathak ,  Theresa Ha Nguyen ,  Corinne E. Augelli-Szafran ,  Alec Jay Hirsch ,  Jessica Lee Smith

IPC: C07D473/08 ,  A61P31/14

Abstract: The present disclosure is concerned with xanthine analogs, methods of making xanthine analogs, and methods of treating West Nile virus using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.