公开(公告)号：US20120190714A1

公开(公告)日：2012-07-26

申请号：US13192403

申请日：2011-07-27

Applicant: Michael Graupe ,  John O. Link ,  Michael G. Roepel

Inventor： Michael Graupe ,  John O. Link ,  Michael G. Roepel

IPC: A61K31/4406 ,  A61K31/16 ,  A61P17/06 ,  A61K31/165

CPC classification number: C07C317/48 ,  C07C2601/02 ,  C07D213/32

Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

Abstract translation: 本发明涉及半胱氨酸蛋白酶，特别是组织蛋白酶B，K，L，F和S的抑制剂的化合物，因此可用于治疗由这些蛋白酶介导的疾病。 本发明涉及包含这些化合物的药物组合物及其制备方法。

公开(公告)号：US20100237236A1

公开(公告)日：2010-09-23

申请号：US12408026

申请日：2009-03-20

Applicant: Bruce Thomson ,  Bruce Collings

Inventor： Bruce Thomson ,  Bruce Collings

IPC: B01D59/44

CPC classification number: H01J49/0045 ,  H01J49/4225 ,  H01J49/427

Abstract: A method of processing multiple precursor ions in a tandem mass spectrometer includes generating a plurality of precursor ions with an ion source. At least some of the plurality of precursor ions is trapped in an ion trap. At least two precursor ions of interest are isolated from the plurality of precursor ions with a filtered noise field. Precursor ions of interest are sequentially ejected toward a collision cell. The sequentially ejected precursor ions of interest are fragmented in a collision cell. The mass-to-charge ratio spectra of the fragmented ions are then determined with a mass spectrometer.

Abstract translation: 在串联质谱仪中处理多种前体离子的方法包括用离子源生成多个前体离子。 多个前体离子中的至少一些被捕获在离子阱中。 感兴趣的至少两个前体离子与多个前体离子与已滤波的噪声场分离。 感兴趣的前体离子顺序地朝向碰撞池排出。 感兴趣的顺序排出的前体离子在碰撞池中碎裂。 然后用质谱仪测定碎片离子的质荷比谱。

公开(公告)号：US20090305238A1

公开(公告)日：2009-12-10

申请号：US11921333

申请日：2007-01-22

Applicant: David M. Cox

Inventor： David M. Cox

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: B01L3/5027 ,  B01L3/502738 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0655 ,  B01L2400/0683

Abstract: A fluid processing device is provided that comprises a substrate including a surface and a fluid processing pathway at least partially formed in or on the surface. The fluid processing pathway can comprise a channel, a reaction region in fluid communication with the channel, a microarray in fluid communication with the channel, and optionally a deformable valve. The microarray can comprise binding and/or detection sites, and each site can comprise a binding moiety. A method and a system using the fluid processing device, are also provided.

Abstract translation: 提供一种流体处理装置，其包括基底，该基底包括至少部分地形成在表面中或表面上的表面和流体处理通路。 流体处理途径可以包括通道，与通道流体连通的反应区域，与通道流体连通的微阵列，以及任选的可变形阀。 微阵列可以包含结合和/或检测位点，并且每个位点可以包含结合部分。 还提供了一种使用流体处理装置的方法和系统。

公开(公告)号：US20090163381A1

公开(公告)日：2009-06-25

申请号：US11616110

申请日：2006-12-26

Applicant: James M. Coull ,  Mark J. Fiandaca ,  Mark D. Kristjanson ,  Jens J. Hyldig-Nielsen ,  Theresa S. Creasey

Inventor： James M. Coull ,  Mark J. Fiandaca ,  Mark D. Kristjanson ,  Jens J. Hyldig-Nielsen ,  Theresa S. Creasey

IPC: C40B40/06

CPC classification number: C12Q1/6816 ,  C07B2200/11 ,  C40B20/04 ,  C40B30/04 ,  C40B40/00 ,  C40B40/06 ,  Y10S435/81 ,  C12Q2565/137 ,  C12Q2525/107 ,  C12Q2531/113

Abstract: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.

Abstract translation: 本发明涉及组合寡聚体领域，包括在不存在模板的情况下组合寡聚物的嵌段合成，以及相关方法，试剂盒，文库和其它组合物。

公开(公告)号：US07548818B2

公开(公告)日：2009-06-16

申请号：US11567281

申请日：2006-12-06

Applicant: Byron Kieser

Inventor： Byron Kieser

IPC: B01D59/44

CPC classification number: H01J49/02 ,  H01J49/0031

Abstract: Improved systems, apparatus, methods, and programming useful for the automated analysis of complex compounds using mass spectrometers. Systems, apparatus, methods, and programming according to the invention provide for the automatic determination by a controller 54 of a mass spectrometer 14, 214 of an analysis operation to be implemented using the mass spectrometer, the analysis operation adapted specifically for analysis of one or more substances based contained within a compound based on identification of the compound and/or substances provided by a user of the spectrometer, and a database 66 or other library of information concerning suitable processes or process steps for analyzing substances.

Abstract translation: 改进的系统，设备，方法和编程可用于使用质谱仪自动分析复杂化合物。 根据本发明的系统，装置，方法和编程提供了使用质谱仪来实现的分析操作的质谱仪14,214的控制器54的自动确定，该分析操作专门用于分析一个或 基于化合物和/或由质谱仪的用户提供的物质的鉴定，化合物中所含的更多物质以及数据库66或其他有关分析物质的合适方法或工艺步骤的信息资料库。

公开(公告)号：US20090093062A1

公开(公告)日：2009-04-09

申请号：US11838793

申请日：2007-12-17

Applicant: Ronald J. Graham ,  Ruiming Zou ,  Krishna G. Upadhya ,  Scott C. Benson

Inventor： Ronald J. Graham ,  Ruiming Zou ,  Krishna G. Upadhya ,  Scott C. Benson

IPC: G01N33/00 ,  C07D219/00 ,  C07D221/18 ,  C07H21/00

CPC classification number: C07H21/00 ,  C07D219/06 ,  C09B15/00 ,  C09K11/06 ,  C09K2211/1011 ,  C09K2211/1029 ,  C12Q1/6816 ,  C12Q1/6869 ,  G01N33/582 ,  Y10S436/80 ,  Y10T436/143333

Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.

Abstract translation: 本教导通常涉及荧光染料，荧光染料的可连接形式，能量转移染料，用荧光染料标记的试剂及其用途。

公开(公告)号：US20090063102A1

公开(公告)日：2009-03-05

申请号：US12200636

申请日：2008-08-28

Applicant: Gordana Ivosev ,  Ronald Bonner

Inventor： Gordana Ivosev ,  Ronald Bonner

IPC: G06F19/00

CPC classification number: G06K9/00543 ,  G01N30/72 ,  G01N30/8682 ,  G01N2030/862 ,  H01J49/0036

Abstract: A method for identifying a convolved peak is described. A plurality of spectra is obtained. A multivariate analysis technique is used to assign data points from the plurality of spectra to a plurality of groups. A peak is selected from the plurality of spectra. If the peak includes data points assigned to two or more groups of the plurality of groups, the peak is identified as a convolved peak. Principal component analysis is one multivariate analysis technique that is used to assign data points. A number of principal components are selected. A subset principal component space is created. A data point in the subset principal component space is selected. A vector is extended from the origin of the subset principal component space to the data point. One or more data points within a spatial angle around the vector are assigned to a group.

Abstract translation: 描述了用于识别卷积峰的方法。 获得多个光谱。 多变量分析技术用于将数据点从多个频谱分配到多个组。 从多个光谱中选出峰。 如果峰值包括分配给多个组中的两个或更多个组的数据点，则将该峰识别为卷积峰。 主成分分析是一种用于分配数据点的多变量分析技术。 选择了多个主要组件。 创建子集主体组件空间。 选择子集主体组件空间中的数据点。 向量从子集主体组件空间的起点扩展到数据点。 在矢量周围的空间角度内的一个或多个数据点被分配给一个组。

公开(公告)号：US20090047688A1

公开(公告)日：2009-02-19

申请号：US12126094

申请日：2008-05-23

Applicant: Rouh-Rong Juo ,  John C. Voyta ,  Brooks Edwards

Inventor： Rouh-Rong Juo ,  John C. Voyta ,  Brooks Edwards

IPC: G01N33/53 ,  G01N21/76 ,  C12Q1/42

CPC classification number: G01N33/543 ,  G01N33/533 ,  G01N33/542 ,  G01N33/54313 ,  G01N33/573 ,  G01N33/581 ,  G01N2333/916

Abstract: Reagents, kits and methods for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye such as a J-aggregated dye are described.

Abstract translation: 描述了通过从活性化学发光底物到能量受体染料如J-聚集染料的能量转移来检测生物分子的试剂，试剂盒和方法。

公开(公告)号：US20090036325A1

公开(公告)日：2009-02-05

申请号：US12154294

申请日：2008-05-21

Applicant: Kevin J. McKernan ,  John Andrew Sheridan ,  Douglas R. Smith

Inventor： Kevin J. McKernan ,  John Andrew Sheridan ,  Douglas R. Smith

IPC: C40B50/06 ,  C12P19/34

CPC classification number: C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q2533/107 ,  C12Q2531/113 ,  C12Q2523/101

Abstract: The present teachings relate to improved methods, kits, and compositions for making nucleic acid libraries and sequencing nucleic acids. In some embodiments, directionally defined concatamers are generated, facilitating sequencing efforts.

Abstract translation: 本教导涉及用于制备核酸文库和测序核酸的改进的方法，试剂盒和组合物。 在一些实施例中，生成定向定义的连接器，有利于测序工作。

公开(公告)号：US07486396B2

公开(公告)日：2009-02-03

申请号：US11894829

申请日：2007-08-22

Applicant: Mark F. Oldham ,  Eric S. Nordman ,  Richard T. Reel ,  Janice G. Shigeura, legal representative

Inventor： John S. Shigeura

IPC: G01N21/00

CPC classification number: G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

Abstract: Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

Abstract translation: 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。