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    Method for immunization against and treatment of infection by ectoparasites and endoparasites
    3.
    发明授权
    Method for immunization against and treatment of infection by ectoparasites and endoparasites 失效
    免疫接种和治疗外寄生虫和内寄生虫感染的方法

    公开(公告)号：US4814170A

    公开(公告)日：1989-03-21

    申请号：US839892

    申请日：1986-03-14

    申请人： Stephen L. Karr, Jr.

    发明人： Stephen L. Karr, Jr.

    IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K39/44 ,  A61K47/48 ,  A61P33/02 ,  A61K37/24

    CPC分类号： A61K47/4833 ,  A61K39/0003 ,  A61K39/44 ,  A61K2039/6081

    摘要： This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies formed to said immunogen.

    摘要翻译： 本发明涉及一种针对外寄生虫和内寄生虫的脊椎动物的主动或被动免疫的方法，以及一种治疗由外寄生虫或内寄生虫感染的脊椎动物宿主的方法，包括向脊椎动物施用包含一种或多种外寄生物的内分泌产物的免疫原和 再加上免疫原性载体，或向脊椎动物施用形成于所述免疫原的单克隆抗体。

    Monoclonal Antibodies to Progastrin
    4.
    发明申请
    Monoclonal Antibodies to Progastrin 有权
    促胃泌素的单克隆抗体

    公开(公告)号：US20070248608A1

    公开(公告)日：2007-10-25

    申请号：US11663126

    申请日：2005-09-21

    申请人： Stephen Grimes

    发明人： Stephen Grimes

    IPC分类号： A61K38/00 ,  A01N37/18 ,  A61K39/00 ,  A61K39/395 ,  A61P1/02 ,  C07K16/00 ,  C12N15/00 ,  C12P21/08 ,  G01N33/00 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  A61K2039/505 ,  C07K16/26 ,  C07K2317/34 ,  G01N33/74 ,  G01N2333/595 ,  G01N2800/06

    摘要： The present invention provides progastrin-binding molecules specific for progastrin that do not bind gastrin-17(G17), gastrin-34(G34), glycine-extended gastrin-17(G17-Gly), or glycine-extended gastrin-34(G34-Gly). Further, the invention provides monoclonal antibodies (MAbs) selective for sequences at the N-terminus and the C-terminus of the gastrin precursor molecule, progastrin and the hybridomas that produce these MAbs. Also provided are panels of MAbs useful for the detection and quantitation of progastrin and gastrin hormone species in immuno-detection and quantitation assays. These assays are useful for diagnosing and monitoring a gastrin-promoted disease or condition, or for monitoring the progress of a course of therapy. The invention further provides solid phase assays including immunohistochemical (IHC) and immunofluorescence (IF) assays suitable for detection and visualization of gastrin species in solid samples, such as biopsy samples or tissue slices. The progastrin-binding molecules are useful therapeutically for passive immunization against progastrin in progastrin-promoted diseases or conditions. Also provided are surrogate reference standard (SRS) molecules that are peptide chains of from about 10 to about 35 amino acids, wherein the SRS molecule comprises at least two epitopes found in a protein of interest of greater than about 50 amino acids. Such SRS molecules are useful as standards in place of authentic proteins of interest.

    摘要翻译： 本发明提供了不结合胃泌素-17（G17），胃泌素-34（G34），甘氨酸延长胃泌素-17（G17-Gly）或甘氨酸延长胃泌素-34（G34）的泌乳素特异性的前胃泌素结合分子 -Gly）。 此外，本发明提供对胃泌素前体分子的N-末端和C末端的序列选择性的单克隆抗体（MAb），前导肽和产生这些MAb的杂交瘤。 还提供了用于在免疫检测和定量测定中检测和定量前胃泌素和胃泌素激素物质的MAb的小组。 这些测定法可用于诊断和监测胃泌素促进的疾病或病症，或用于监测治疗过程的进展。 本发明进一步提供固相测定法，包括免疫组织化学（IHC）和免疫荧光（IF）测定法，其适于检测和可视化固体样品例如活检样本或组织切片中的胃泌素种类。 促胃泌素结合分子可用于治疗前列腺素促进的疾病或病症中针对前胃泌素的被动免疫。 还提供了作为约10至约35个氨基酸的肽链的替代参考标准（SRS）分子，其中SRS分子包含在大于约50个氨基酸的目的蛋白中发现的至少两个表位。 这样的SRS分子可用作代替感兴趣的真实蛋白质的标准物。

    Prevention and treatment of hypergastrinemia
    7.
    发明申请
    Prevention and treatment of hypergastrinemia 审中-公开
    预防和治疗高胃泌素血症

    公开(公告)号：US20050187152A1

    公开(公告)日：2005-08-25

    申请号：US10829137

    申请日：2004-04-21

    申请人： Philip Gevas ,  Stephen Grimes ,  Stephen Karr ,  Dov Michaeli ,  Susan Watson

    发明人： Philip Gevas ,  Stephen Grimes ,  Stephen Karr ,  Dov Michaeli ,  Susan Watson

    IPC分类号： A61K39/385 ,  A61K38/00 ,  A61K38/22 ,  A61K47/48 ,  A61P7/00 ,  A61P37/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/595 ,  C07K16/26 ,  C07K16/40 ,  A61K38/17 ,  A61K31/4172 ,  A61K31/4439

    CPC分类号： C07K16/26 ,  A61K38/2207 ,  A61K47/643 ,  A61K2039/505 ,  C07K14/595 ,  C07K2317/34

    摘要： Serum-associated hypergastrinemia is treated by administration of gastrin active or passive immunization. An anti-gastrin immunogenic composition containing a gastrin G17 or G34 peptide fragment which is amino acid spacer-linked to an immunogenic carrier, is administered so as to effectively neutralize the circulating gastrin hormone, and moreover, inhibit autocrine activity by progastrin such as Gly-extended G17, and amidated G17, in patients with pernicious anemia. Moreover, the method includes administration of a therapeutically effective amount of anti-G17 or anti-G34 antibodies which may be in humanized form. Finally, the method provides ameliorating treatment of hypergastrinemic effects of proton pump inhibitors or H2 histamine receptor blocking agents or antagonists, in addition to treatment of hypergastrinemia caused by diseases such as pernicious anemia.

    摘要翻译： 通过施用胃泌素活性或被动免疫来治疗血清相关性高胃泌素血症。 给予含有与免疫原性载体间隔连接的氨基酸的胃泌素G17或G34肽片段的抗胃泌素免疫原性组合物，以有效中和循环的胃泌素激素，此外，抑制前胃泌素如Gly- 延长G17，并与G17阴性，患有恶性贫血患者。 此外，该方法包括施用治疗有效量的可以以人源化形式存在的抗G17或抗G34抗体。 最后，除了治疗由诸如恶性贫血等疾病引起的胃泌素血症外，该方法还提供改善质子泵抑制剂或H 2 H 2组胺受体阻断剂或拮抗剂的高胃肠道作用的改善。

    Method for the treatment of gastroesophageal reflux disease
    9.
    发明申请
    Method for the treatment of gastroesophageal reflux disease 审中-公开
    胃食管反流病的治疗方法

    公开(公告)号：US20030068326A1

    公开(公告)日：2003-04-10

    申请号：US10314057

    申请日：2002-12-06

    申请人： Aphton Corporation

    发明人： Philip C. Gevas ,  Stephen Grimes ,  Stephen Karr ,  Dov Michaeli

    IPC分类号： A61K039/00 ,  A61K038/17

    CPC分类号： A61K39/0005 ,  A61K38/2207 ,  A61K2039/6037 ,  A61K2300/00

    摘要： A method for the treatment of gastroesophageal reflux disease comprising a combination of active immunization with an anti-gastrin immunogenic composition with an antagonist which blocks or inhibits the gastric acid pump activity; or alternatively administering purified anti-gastrin antibodies with a H2 antagonist or proton pump inhibitor of the gastric acid producing enzyme system.

    摘要翻译： 一种治疗胃食管反流病的方法，包括主动免疫与抗胃泌素免疫原性组合物与阻断或抑制胃酸泵活性的拮抗剂的组合; 或者另外用产生胃酸的酶系统的H2拮抗剂或质子泵抑制剂给予纯化的抗胃泌素抗体。