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    MEANS AND METHODS OF CONTROLLING COMMENSALES
    2.
    发明申请
    MEANS AND METHODS OF CONTROLLING COMMENSALES 审中-公开
    手段和控制方法

    公开(公告)号：US20100323996A1

    公开(公告)日：2010-12-23

    申请号：US12867766

    申请日：2009-02-18

    申请人： Dechert Ute ,  Eck Jurgen ,  Krohn Michael

    发明人： Dechert Ute ,  Eck Jurgen ,  Krohn Michael

    IPC分类号： A61K31/122 ,  C07C49/647 ,  A61K31/60 ,  A61K31/17 ,  A61Q19/00 ,  A01P1/00 ,  A01N35/06

    CPC分类号： A61K8/35 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/404 ,  A61Q17/005

    摘要： The present invention relates to a cosmetic composition for the cleaning of the skin, said composition comprising or consisting of one or more compounds of formula (I) wherein represents a single bond or double bond; R1 and R2 are independently selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, linear or branched C1 to C4 alkinyl, and linear or branched C1 to C4 alkanoyl; R4 is selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, and linear or branched C1 to C4 alkinyl; and R3 and R5 are independently selected from H, OH and halogen, or R3 and R5 together are O to form an epoxid, wherein represents a single bond in case R3 and R5 together are O. Also provided are means and methods for the prevention or reduction of biofilm formation on an intracorporeal device and/or for the removal of biofilm from an intracorporeal device, wherein said biofilm comprises or consists of bacteria of the genus Propionibacterium. Furthermore provided is an intracorporeal device which is coated and/or loaded with one or more compounds as defined above.

    摘要翻译： 本发明涉及一种用于清洁皮肤的化妆品组合物，所述组合物包含一种或多种式（I）化合物或其组合，其中代表单键或双键; R 1和R 2独立地选自H，直链或支链C 1至C 4烷基，直链或支链C 1至C 4烯基，直链或支链C 1至C 4炔基，和直链或支链C 1至C 4烷酰基; R4选自H，直链或支链C1至C4烷基，直链或支链C1至C4烯基，直链或支链C1至C4炔基; 并且R 3和R 5独立地选自H，OH和卤素，或者R 3和R 5一起为O以形成环氧化物，其中在R 3和R 5一起为O的情况下表示单键。还提供了用于预防或 在体内装置中减少生物膜形成和/或从体内装置去除生物膜，其中所述生物膜包含丙酸杆菌属的细菌或由其构成。 此外，提供了一种体外装置，其被涂覆和/或加载一种或多种如上所定义的化合物。

    NOVEL GROUP OF ESTERASES FOR THE PRODUCTION OF FINE AND SPECIALITY CHEMICALS
    3.
    发明申请
    NOVEL GROUP OF ESTERASES FOR THE PRODUCTION OF FINE AND SPECIALITY CHEMICALS 有权

    公开(公告)号：US20090221031A1

    公开(公告)日：2009-09-03

    申请号：US12298874

    申请日：2007-04-27

    申请人： Christian Elend ,  Karl-Erich Jaeger ,  Christian Leggewie ,  Christel Vollstedt ,  Wolfgang Streit

    发明人： Christian Elend ,  Karl-Erich Jaeger ,  Christian Leggewie ,  Christel Vollstedt ,  Wolfgang Streit

    IPC分类号： C12P21/00 ,  C12N9/18 ,  C12N15/11 ,  C12N15/00 ,  C12N1/21 ,  C12N15/63 ,  C07K16/18 ,  C07H21/04 ,  C12P7/02

    CPC分类号： C12N9/18

    摘要： The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E.C. 3.1.1.1] activity, wherein the coding sequence is selected from the group consisting of (a) a polynucleotide encoding an amino acid sequence as depicted in any one of SEQ ID NOs: 2, 4, 6 and 8; (b) a polynucleotide having or comprising a nucleotide sequence encoding an enzyme, wherein the nucleic acid sequence is as shown in any one of SEQ ID NOs: 1, 3, 5 and 7; (c) a polynucleotide having or comprising a nucleotide sequence encoding a fragment or derivative of an enzyme encoded by a polynucleotide of (a) or (b), wherein in said derivative one or more amino acid residues are conservatively substituted compared to the amino acid sequence of (a); (d) a polynucleotide encoding an enzyme having carboxyl esterase activity which polynucleotide is at least 65% identical to a polynucleotide encoding an enzyme as shown in one of SEQ ID NOs: 2, 4, 6 and 8; (e) a polynucleotide having or comprising a nucleotide sequence the complementary strand of which hybridizes to a polynucleotide as defined in any one of (a) to (d); and (f) a polynucleotide having or comprising a nucleotide sequence being degenerate to the nucleotide sequence of the polynucleotide of (d) or (e); or the complementary strand of such a polynucleotide of (a) to (f) or fragments thereof useful as specific probes or primers. The present invention also relates to a host, genetically engineered with the polynucleotide of the present invention or the vector of the present invention. The present invention also relates to a polypeptide comprising the amino acid sequence encoded by a polynucleotide of the present invention or which is obtainable by the process of the present invention. Moreover, the present invention relates to a process for producing said polypeptide and for producing bacteria expressing said polypeptide. Finally, the present invention relates to a composition comprising the polynucleotide of the present invention, the vector of the present invention, the host of the present invention, the polypeptide of the present invention, the antibody of the present invention and/or one or more primers of the present invention.

    Isolation and cloning of dna from uncultivated organisms
    4.
    发明申请
    Isolation and cloning of dna from uncultivated organisms 失效
    从未培养的生物体中分离和克隆dna

    公开(公告)号：US20060240423A1

    公开(公告)日：2006-10-26

    申请号：US10525708

    申请日：2003-08-20

    申请人： Achim Quaiser ,  Torsten Ochsenreiter ,  Alexander Treusch ,  Arnulf Kletzin ,  Christa Schleper ,  Patrick Lorenz ,  Jurgen Eck

    发明人： Achim Quaiser ,  Torsten Ochsenreiter ,  Alexander Treusch ,  Arnulf Kletzin ,  Christa Schleper ,  Patrick Lorenz ,  Jurgen Eck

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12N15/1003

    摘要： The present invention relates to a device for the isolation and/or purification of nucleic acid molecules suitable to bind and/or inactivate inhibitors of the activity of reagents or enzymes used for DNA manipulation and to separate a plurality of nucleic acid molecules with respect to their size. Moreover, the invention relates to a method for the isolation of a nucleic acid molecule comprising applying a sample to the device of the invention wherein said nucleic acid molecule preferably represents a fraction of the metagenome of a given habitat. Furthermore, the invention relates to a method for the generation of at least one gene library comprising nucleic acid molecules isolated by the method of the invention and to a nucleic acid molecule isolated by the method of the invention.

    摘要翻译： 本发明涉及用于分离和/或纯化适于结合和/或失活用于DNA操作的试剂或酶的活性抑制剂的核酸分子的装置，并且相对于它们分离多个核酸分子 尺寸。 此外，本发明涉及用于分离核酸分子的方法，包括将样品施用于本发明的装置，其中所述核酸分子优选代表给定栖息地的元素的一部分。 此外，本发明涉及产生至少一种包含通过本发明方法分离的核酸分子的基因文库以及通过本发明的方法分离的核酸分子的方法。

    GROUP OF NOVEL ENANTIOSLEECTIVE MICROBIAL NITRILE HYDRATASES WITH BROAD SUBSTRATE SPECIFICITY
    9.
    发明申请
    GROUP OF NOVEL ENANTIOSLEECTIVE MICROBIAL NITRILE HYDRATASES WITH BROAD SUBSTRATE SPECIFICITY 失效
    具有广泛基质特征的新型强化微生物氮化物组

    公开(公告)号：US20100047863A1

    公开(公告)日：2010-02-25

    申请号：US12296057

    申请日：2007-04-05

    申请人： Jürgen Eck ,  Klaus Liebeton ,  Lutz Fischer ,  Sabine Lutz-Wahl ,  Martina Hensel ,  Christian Ewert ,  Marcus Wälz

    发明人： Jürgen Eck ,  Klaus Liebeton ,  Lutz Fischer ,  Sabine Lutz-Wahl ,  Martina Hensel ,  Christian Ewert ,  Marcus Wälz

    IPC分类号： C12P21/06 ,  C12P13/02 ,  C12N15/74 ,  C12N1/21 ,  C12N15/63 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04

    CPC分类号： C12N9/88 ,  C12P13/02 ,  C12P41/006

    摘要： The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host comprising the disclosed polynucleotide or pair of polynucleotides and methods for the production of the same are provided. Moreover, the invention relates to a pair of polypeptides or a fusion protein having NHase activity, an antibody specifically binding to the pair of polypeptides or fusion protein, a primer or probe, which specifically hybridizes under stringent conditions to the disclosed polynucleotide or either one of the pair of polynucleotides, a composition comprising the polynucleotide or pair of polynucleotides, the pair of polypeptides or fusion protein, the antibody and/or one or more primers or probes of the invention and a method for the production of amides comprising the enantioselective conversion of nitrites.

    摘要翻译： 本发明提供了编码具有腈水合酶（NHase）[E.C.]的酶的多核苷酸或一对多核苷酸。 4.2.1.84]活动。 此外，提供了包含所公开的多核苷酸或一对多核苷酸的载体和宿主及其生产方法。 此外，本发明涉及一对多肽或具有NHase活性的融合蛋白，特异性结合所述一对多肽或融合蛋白的抗体，在严格条件下与所公开的多核苷酸特异性杂交的引物或探针，或者 一对多核苷酸，包含多核苷酸或一对多核苷酸的组合物，一对多肽或融合蛋白，本发明的抗体和/或一种或多种引物或探针以及生产酰胺的方法，其包括对映选择性转化 亚硝酸盐