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公开(公告)号：US10448622B2
公开(公告)日：2019-10-22
申请号：US15298037
申请日：2016-10-19
发明人： Yoshimi Kuroiwa , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
IPC分类号： A01K67/027 , C12N15/85 , C12N15/90 , C07K16/00 , C07K16/24 , C12N15/87 , A61K48/00 , A61K39/00
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
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公开(公告)号：US10155813B2
公开(公告)日：2018-12-18
申请号：US15098627
申请日：2016-04-14
发明人： Jennifer Marie Mataraza , Andrea Van Elsas , Alan J. Korman , Edward L. Halk , Kent B. Thudium , Mark J. Selby , Timothy W. Sproul , Heidi N. Leblanc
摘要： The present invention relates to binding compounds specific for BTLA and uses thereof. More specifically, the invention relates to fully human antibodies that recognize human BTLA and modulate its activity in cancer, inflammatory, and autoimmune disorders.
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公开(公告)号：US20160376370A1
公开(公告)日：2016-12-29
申请号：US15261386
申请日：2016-09-09
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
摘要翻译： 本发明提供了与IFNAR-1结合并且能够抑制I型干扰素的生物活性的分离的人单克隆抗体。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制I型干扰素介导的病症的方法，包括使用本发明的抗体治疗自身免疫疾病，移植排斥或移植物抗宿主病的方法。
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4.发明授权Methods of treating conditions caused by increased expression of nerve growth factor (NGF) or increased sensitivity to NGF using anti-NGF neutralizing antibodies as selective NGF pathway inhibitors 有权使用抗NGF中和抗体作为选择性NGF途径抑制剂治疗由神经生长因子（NGF）表达增加或增加对NGF的敏感性引起的病症的方法公开(公告)号：US09260514B2
公开(公告)日：2016-02-16
申请号：US12576522
申请日：2009-10-09
申请人： Kenneth D. Wild, Jr. , James J.S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
发明人： Kenneth D. Wild, Jr. , James J.S. Treanor , Haichun Huang , Heather Inoue , Tie J. Zhang , Frank Martin
IPC分类号： A61K39/395 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K39/00 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of these antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
摘要翻译： 本发明提供与人神经生长因子（NGF）相互作用或结合的抗体，从而中和NGF的功能。 本发明还提供了这些抗体的药物组合物和中和NGF功能的方法，特别是通过施用药学上有效量的抗NGF抗体来治疗NGF相关疾病（例如慢性疼痛）。 还提供了使用抗NGF抗体检测样品中NGF量的方法。
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公开(公告)号：US10106615B2
公开(公告)日：2018-10-23
申请号：US13900791
申请日：2013-05-23
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.
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公开(公告)号：US09988453B2
公开(公告)日：2018-06-05
申请号：US15048785
申请日：2016-02-19
发明人： Alan J. Korman , Mark J. Selby , Li-Sheng Lu , Alison J. Witte , Haichun Huang
IPC分类号： C12N5/10 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/13 , C12N15/62 , C07K16/28 , C07K16/30 , A61K47/48 , A61K51/10 , A61K47/68 , C07H21/00 , A61K39/00
CPC分类号： C07K16/2827 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07H21/00 , C07K16/30 , C07K16/3015 , C07K2317/14 , C07K2317/21 , C07K2317/40 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2319/55 , C12N15/00 , C12N15/09 , C12N15/62
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
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7.发明授权Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof 有权抗增殖化合物，其缀合物，其方法及其应用公开(公告)号：US09580467B2
公开(公告)日：2017-02-28
申请号：US14939547
申请日：2015-11-12
发明人： Heng Cheng , Sanjeev Gangwar , Qiang Cong
IPC分类号： C07K14/00 , C07K7/06 , A61K47/48 , C07K5/02 , C07K5/078 , C07K5/10 , C07K16/18 , C07C229/14 , C07C229/16 , A61K38/06
CPC分类号： C07K7/06 , A61K38/06 , A61K47/6811 , A61K47/6829 , C07C229/14 , C07C229/16 , C07K5/021 , C07K5/06139 , C07K5/10 , C07K16/18
摘要： Antiproliferative compounds having a structure represented by formula (II), where n, R1, R2, R3, R4, and R5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:
摘要翻译： 具有由式（II）表示的结构的抗增殖化合物，其中n，R 1，R 2，R 3，R 4和R 5如本文所定义，可任选地当与配体例如抗体缀合时用于治疗肿瘤：
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8.发明授权Transgenic animals expressing chimeric antibodies for use in preparing human antibodies 有权表达用于制备人抗体的嵌合抗体的转基因动物公开(公告)号：US09220244B2
公开(公告)日：2015-12-29
申请号：US13540386
申请日：2012-07-02
申请人： Dawn M. Tanamachi , Peter Brams , Amelia Black
发明人： Dawn M. Tanamachi , Peter Brams , Amelia Black
IPC分类号： A01K67/027 , C12N15/13 , C12N15/90 , C07K16/00 , C07K16/12 , C07K16/24 , C07K16/46 , C12N15/85
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/1282 , C07K16/24 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/8509
摘要： The invention provides transgene constructs for expressing chimeric antibodies, and transgenic non-human host animals carrying such constructs, wherein the chimeric antibodies comprise human variable regions and constant regions of the non-human transgenic host animal. The presence of immunoglobulin constant regions of the host animal allows for generation of improved antibodies in such transgenic host animals. Subsequently, the chimeric antibodies can be readily converted to fully human antibodies using recombinant DNA techniques. Thus, the invention provides compositions and methods for generating human antibodies in which chimeric antibodies raised in vivo in transgenic mice are used as intermediates and then converted to fully human antibodies in vitro.
摘要翻译： 本发明提供用于表达嵌合抗体的转基因构建体和携带这种构建体的转基因非人宿主动物，其中嵌合抗体包含人类可变区和非人转基因宿主动物的恒定区。 宿主动物的免疫球蛋白恒定区的存在允许在这些转基因宿主动物中产生改良的抗体。 随后，使用重组DNA技术可以容易地将嵌合抗体转化为完全人抗体。 因此，本发明提供了用于产生人抗体的组合物和方法，其中在转基因小鼠体内产生的嵌合抗体用作中间体，然后在体外转化为完全人抗体。
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公开(公告)号：US09217029B2
公开(公告)日：2015-12-22
申请号：US14080598
申请日：2013-11-14
发明人： Donna M. Ambrosino , Gregory J. Babcock , Teresa Broering , Robert Graziano , Hector Javier Hernandez , Israel Lowy , Robert Mandell , Deborah Molrine , William D. Thomas, Jr. , Hui-Fen Zhang
IPC分类号： C07H21/04 , C07H21/02 , C07H19/00 , C07H21/00 , C12N15/00 , C07K16/12 , A61K39/08 , G01N33/569 , A61K48/00 , C12N15/86 , A61K39/00
CPC分类号： C07K16/1282 , A61K39/08 , A61K48/00 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N15/86 , G01N33/56911 , G01N2333/33 , Y10S424/809 , A61K2300/00
摘要： Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
摘要翻译： 本文提供了特异性结合艰难梭菌毒素的抗体，其抗原结合部分，以及制备和使用抗体及其抗原结合部分的方法。
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公开(公告)号：US20210298277A1
公开(公告)日：2021-09-30
申请号：US17196608
申请日：2021-03-09
发明人： Yoshimi KUROIWA , Kazuma Tomizuka , Hitoshi Yoshida , Isao Ishida
摘要： The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
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