公开(公告)号：US20140243624A1

公开(公告)日：2014-08-28

申请号：US14192605

申请日：2014-02-27

申请人： MicroCHIPS, Inc.

发明人： Robert Farra

IPC分类号： A61M5/142 ,  A61B5/07

CPC分类号： A61M5/14276 ,  A61K9/0097 ,  A61M31/002 ,  A61M2205/0244 ,  A61M2205/04 ,  A61M2205/3515 ,  Y10T29/49128

摘要： In one aspect, containment devices are provided that include a microchip element having one or more containment reservoirs that are configured to be electrically activated to open; an electronic printed circuit board (PCB) or a silicon substrate positioned adjacent to the microchip element; one or more electronic components associated with the microchip element or the PCB/silicon substrate; and a first inductive coupling device associated with the microchip element or the PCB/silicon substrate, wherein the first inductive coupling device is in operable communication with the one or more electronic components. In another aspect, implantable drug delivery devices are provided that include a body housing at least one drug payload for actively controlled release, wherein the ratio of the volume of the at least one drug payload to the total volume of the implantable drug delivery device is from about 75 μL/cc to about 150 μL/cc.

摘要翻译： 在一个方面，提供了包含装置，其包括具有一个或多个容纳储存器的微芯片元件，其被配置为电激活以打开; 位于微芯片元件附近的电子印刷电路板（PCB）或硅衬底; 与微芯片元件或PCB /硅衬底相关联的一个或多个电子部件; 以及与所述微芯片元件或所述PCB /硅衬底相关联的第一感应耦合器件，其中所述第一感应耦合器件与所述一个或多个电子部件可操作地连通。 在另一方面，提供了可植入药物递送装置，其包括容纳用于主动控制释放的至少一种药物有效载荷的主体，其中所述至少一种药物有效载荷的体积与所述可植入药物递送装置的总体积的比率来自 约75μL/ cc至约150μL/ cc。

公开(公告)号：US08679093B2

公开(公告)日：2014-03-25

申请号：US13302863

申请日：2011-11-22

申请人： Robert Farra

发明人： Robert Farra

IPC分类号： A61K9/22

CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61M37/0069

摘要： Drug delivery devices and methods are provided. The device included two or more housing units connected together end-to-end in a fixed, linear orientation, the exterior surfaces of the connected housing units defining a sidewall of the device; discrete drug dose units disposed within the housing units; degradable timing members connected to the housing units and separating the discrete dose units from one another; first and second end pieces defining opposed ends of the device such that the discrete dose units are located between the first and second end pieces within each of the housing units, wherein the device is configured to release in vivo a first of the discrete dose units following rupture of the first or second end piece, and subsequently to release in vivo a second of the discrete dose units following rupture of the degradable timing member separating the first discrete dose unit from the second discrete dose unit.

摘要翻译： 提供给药装置和方法。 该装置包括以固定的线性取向端对端连接的两个或更多个壳体单元，所连接的壳体单元的外表面限定了该装置的侧壁; 设置在所述壳体单元内的离散药物剂量单元; 连接到壳体单元并将离散剂量单元彼此分离的可降解定时构件; 所述第一和第二端部件限定所述装置的相对端，使得所述离散剂量单元位于每个所述壳体单元内的所述第一和第二端片之间，其中所述装置被配置为在体内释放第一离散剂量单位 第一或第二末端件的破裂，并且随后在使第一离散剂量单元与第二离散剂量单元分离的可降解定时构件断裂之后体内释放第二离散剂量单位。

公开(公告)号：US20120035528A1

公开(公告)日：2012-02-09

申请号：US13023370

申请日：2011-02-08

申请人： Jonathan R. Coppeta ,  Kenneth N. Horne ,  John T. Santini, JR. ,  John A. Scholl ,  Gregory J.R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

发明人： Jonathan R. Coppeta ,  Kenneth N. Horne ,  John T. Santini, JR. ,  John A. Scholl ,  Gregory J.R. Spooner ,  Cynthia L. Stevenson ,  Naveed Shams ,  Andrew Poutiatine

IPC分类号： A61M37/00 ,  B65B1/04

CPC分类号： A61F9/0017 ,  A61F9/008 ,  A61K9/0009 ,  A61K9/0051

摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

摘要翻译： 一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。 该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。 第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。 第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。 该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。 第二活性药物成分包含在第二封闭空腔体积中。 该装置还包括包含第一和第二壳单元的包络元件。

公开(公告)号：US07879019B2

公开(公告)日：2011-02-01

申请号：US11925466

申请日：2007-10-26

申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, Jr.

发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, Jr.

IPC分类号： A61M31/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K9/0009 ,  A61K9/0048 ,  A61K9/0097 ,  H01L24/96 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/0102 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/00

摘要： A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to the reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.

摘要翻译： 提供了一种用于选择性地打开容纳储存器的方法。 该方法包括提供一种装置，其包括基板，其中至少一个储存器定位并被储存器盖覆盖; 并将激光引导到储存器盖以使储存器盖分解或变得可渗透。 该装置可以是可植入医疗装置。 储存器可以含有用于控制释放的药物或生物传感器。

公开(公告)号：US07776024B2

公开(公告)日：2010-08-17

申请号：US11925507

申请日：2007-10-26

申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, Jr.

发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer ,  Dennis Ausiello ,  Norman F. Sheppard, Jr.

IPC分类号： A61M31/00

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K9/0009 ,  A61K9/0048 ,  A61K9/0097 ,  H01L24/96 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/0102 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/014 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/12043 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/00

摘要： Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located in the reservoir, and (iii) control circuitry and a power source for disintegrating or permeabilizing the reservoir cap, and (iv) an external interface to receive incident light energy; and directing focused light to the external interface of the implanted device to actuate disintegration or permeabilization of the reservoir cap to release the drug or expose the sensor. The device may implanted onto or into the sclera or other tissue surface of the eye of the patient. The focused light may be laser light, which may be used to transmit power or data to the device.

摘要翻译： 提供了用于治疗或诊断患者的方法。 该方法包括向患者植入一种装置，该装置包括：（i）至少一个储存器定位并被第一储存器盖覆盖的基底，（ii）位于储存器中的药物或传感器，以及（iii）控制电路 以及用于使储存器盖分解或渗透的电源，以及（iv）外部接口以接收入射光能; 并将聚焦的光引导到植入装置的外部界面以致驱动贮存器盖的分解或透化以释放药物或暴露传感器。 该装置可植入患者眼睛的巩膜或其他组织表面上或其中。 聚焦光可以是激光，其可以用于将功率或数据传输到设备。

公开(公告)号：US07599737B2

公开(公告)日：2009-10-06

申请号：US10679763

申请日：2003-10-06

申请人： Barry M. Yomtov ,  Stephen J. Herman ,  John T. Santini, Jr.

发明人： Barry M. Yomtov ,  Stephen J. Herman ,  John T. Santini, Jr.

IPC分类号： A61N1/00

CPC分类号： A61N1/30 ,  A61K9/0097 ,  A61N1/08 ,  A61N1/36071 ,  G06F19/00

摘要： Medical devices and methods are provided for electrical stimulation of neural tissue and controlled drug delivery to a patient. The device includes an implantable drug delivery module which comprises a plurality of reservoirs, a release system comprising at least one drug contained in each of the reservoirs, and control means for selectively releasing a pharmaceutically effective amount of drug from each reservoir; a neural electrical stimulator which comprises a signal generator connected to at least one stimulation electrode for operable engagement with a neural tissue of the patient; and at least one microcontroller for controlling operational interaction of the drug delivery module and the neural electrical stimulator. The microcontroller may control the signal generator and the control means of the drug delivery module. The device may further include a sensor operable to deliver a signal to the microcontroller, for example to indicate when to deliver electrical stimulation, drug, or both.

摘要翻译： 提供医疗装置和方法用于电刺激神经组织和控制药物递送给患者。 该装置包括可植入药物递送模块，其包括多个储存器，包含每个储存器中的至少一种药物的释放系统和用于从每个储存器中选择性释放药学有效量的药物的控制装置; 神经电刺激器，其包括连接到至少一个刺激电极的信号发生器，用于与患者的神经组织可操作地接合; 以及用于控制药物递送模块和神经电刺激器的操作相互作用的至少一个微控制器。 微控制器可以控制药物递送模块的信号发生器和控制装置。 该装置还可以包括可操作以将信号传送到微控制器的传感器，例如以指示何时传递电刺激，药物或两者。

公开(公告)号：US07537590B2

公开(公告)日：2009-05-26

申请号：US11194157

申请日：2005-08-01

申请人： John T. Santini, Jr. ,  Mark A. Staples ,  Stephen J. Herman

发明人： John T. Santini, Jr. ,  Mark A. Staples ,  Stephen J. Herman

IPC分类号： A61K9/22

CPC分类号： A61K9/703 ,  A61F2013/00642 ,  A61K9/0009 ,  A61K9/0021 ,  A61K9/0097 ,  A61K9/7084 ,  A61K9/7092 ,  A61M37/0015 ,  A61M2037/0023 ,  A61N1/30

摘要： Devices and methods are provided for transdermal administration of a pharmaceutical agent to a patient in need thereof. The device includes a substrate, a plurality of discrete reservoirs in the substrate, one or more pharmaceutical agents stored in the reservoirs, discrete reservoir caps that prevent the pharmaceutical agent from passing out from the reservoirs until desired, control means for actuating release of the one or more pharmaceutical agents from one or more of the reservoirs by disintegrating or permeabilizing the reservoir caps, means for securing the device to the skin of the patient, and means for transporting the pharmaceutical agent to the skin following release from the one or more of the reservoirs. In another embodiment, the device is adapted for diagnostic sensing instead of or in addition to drug delivery.

摘要翻译： 提供了用于向有需要的患者透皮施用药剂的装置和方法。 该装置包括衬底，衬底中的多个分立贮存器，储存在储存器中的一个或多个药剂，防止药剂从储存器中流出直到期望的离散贮存器盖，用于致动释放一个 或更多的药剂从一个或多个储存器中分解或渗透储存器盖，用于将装置固定到患者皮肤的装置，以及用于在药物释放之后将药剂运送到皮肤的装置 水库 在另一个实施方案中，该装置适用于代替药物递送或除药物递送之外的诊断感测。

公开(公告)号：US20090112188A1

公开(公告)日：2009-04-30

申请号：US12348609

申请日：2009-01-05

申请人： John T. Santini, JR. ,  Michael J. Cima ,  Scott Albert Uhland

发明人： John T. Santini, JR. ,  Michael J. Cima ,  Scott Albert Uhland

IPC分类号： A61K9/22

CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

摘要： Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.

摘要翻译： 提供了包括衬底的Microchip器件; 在所述基板中的多个储存器，每个储存器限定内部容积; 以及储存器盖，其定位在从外部环境限定内部容积的每个储存器中或每个储存器中，所述储存器盖由在加热时经历相变的材料形成，其中所述内部容积可以在加热所述内部体积时与外部环境连通 储存器盖以使所述储存器盖发生相变和破裂。

公开(公告)号：US20090030404A1

公开(公告)日：2009-01-29

申请号：US12243791

申请日：2008-10-01

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, JR. ,  Stephen J. Herman ,  Barry M. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, JR. ,  Stephen J. Herman ,  Barry M. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物;以及控制电路，用于选择性地分解储存器盖以释放或暴露 水库内容物。 储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。 在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖 水箱盖。

公开(公告)号：US20080083041A1

公开(公告)日：2008-04-03

申请号：US11927316

申请日：2007-10-29

申请人： John Santini ,  Dennis Ausiello

发明人： John Santini ,  Dennis Ausiello

IPC分类号： A61D7/00

CPC分类号： A61B1/041 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/14539 ,  A61K9/0009 ,  A61K9/0051 ,  A61K9/0097 ,  A61M5/14 ,  A61M5/14276 ,  A61M2205/0244 ,  A61M2205/3523 ,  A61M2210/0612 ,  A61M2210/1042

摘要： Devices and methods are provided for wirelessly powering and/or communicating with implanted medical devices used for the controlled exposure and release of reservoir contents, such as drugs or sensors. The device may include a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate the release or exposure of the reservoir contents.

摘要翻译： 提供了用于与用于受控地暴露和释放储存器内容物（例如药物或传感器）的植入式医疗装置的无线供电和/或通信的装置和方法。 该装置可以包括具有多个储存器的基板，该储存器包含用于释放或暴露的储存器内容物; 以及可充电或点播电源，其包括本地组件，其可以从远程发射机无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。