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公开(公告)号：US10518261B2
公开(公告)日：2019-12-31
申请号：US13930772
申请日：2013-06-28
申请人： NEXUS DX, INC.
发明人： Jung Tae Lee , Chung Ung Kim , Young Goun Lee , Jin Beom Hong
摘要： A test apparatus is provided for rapidly detecting abnormal loading of a microfluidic device, and unloading the abnormally-loaded microfluidic device, thereby preventing contamination of the test apparatus by a sample and degradation in reliability of test results. A test system including the test apparatus and a control method for the test apparatus are also provided. The test apparatus includes an optical sensor to photograph an image at a position corresponding to the microfluidic device, and a controller to detect a pattern formed on a surface of the microfluidic device based on the photographed image to determine whether characteristics of the detected pattern are identical to characteristics of a pre-stored pattern, and to determine whether the microfluidic device has not been normally loaded, when the characteristics of the detected pattern are different from the characteristics of the pre-stored pattern.
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公开(公告)号：US09791437B2
公开(公告)日：2017-10-17
申请号：US14739959
申请日：2015-06-15
申请人： Nexus Dx, Inc.
发明人： Richard Laswell Egan , Graham Peter Lidgard , David Dickson Booker , Christopher Johann Johnson , Alexander Belenky , Stan Vukajlovich
IPC分类号： G01N33/543 , B01L3/02 , B01L3/00
CPC分类号： G01N33/54306 , B01L3/0272 , B01L3/5023 , B01L3/5029 , G01N33/54366 , G01N2333/11
摘要： The invention provides compositions, systems and methods for detecting multiple analytes from a sample.
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公开(公告)号：US20120149042A1
公开(公告)日：2012-06-14
申请号：US13276733
申请日：2011-10-19
IPC分类号： G01N33/566 , G01N33/577
CPC分类号： G01N33/6896 , A61B6/501 , G01N2333/988
摘要： The invention describes methods for predicting outcome for patients suffering from traumatic brain injury (TBI) by evaluating levels of markers commonly associated with cellular damage in bodily fluids. Utilization of such methods improves diagnosis and treatment of patients suffering from traumatic brain injury, thus potentially minimizing and/or eliminating long-term adverse effects in these patients.
摘要翻译： 本发明描述了通过评估通常与体液细胞损伤相关的标记物的水平来预测患有创伤性脑损伤（TBI）的患者的结果的方法。 这种方法的使用改善了患有创伤性脑损伤的患者的诊断和治疗，从而可能最小化和/或消除这些患者的长期不良反应。
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公开(公告)号：US20110183436A1
公开(公告)日：2011-07-28
申请号：US13024963
申请日：2011-02-10
申请人： George Jackowski , Tracy Van Lieshout , Brad Thatcher , Rulin Zhang , Jason Yantha , Michele Rasamoelisolo
发明人： George Jackowski , Tracy Van Lieshout , Brad Thatcher , Rulin Zhang , Jason Yantha , Michele Rasamoelisolo
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/325
摘要： The invention provides an assay for the quantification of circulating glycophorin in biological fluid samples. The circulating glycophorin measured by this assay is a truncated glycophorin diagnostic for congestive heart failure (CHF).
摘要翻译： 本发明提供了用于定量生物流体样品中循环血型糖蛋白的测定。 通过该测定测量的循环血型糖蛋白是用于充血性心力衰竭（CHF）的截短的血型糖蛋白诊断。
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公开(公告)号：US07767419B2
公开(公告)日：2010-08-03
申请号：US10359028
申请日：2003-02-04
申请人： Azhar Alvi , William Yajima , Roshana Sikora , George Jackowski , Mee-Ra Hong
发明人： Azhar Alvi , William Yajima , Roshana Sikora , George Jackowski , Mee-Ra Hong
CPC分类号： G01N33/74 , G01N2333/58 , Y10S436/811 , Y10S530/806 , Y10T436/10
摘要： The invention provides a method to efficiently express high levels of a recombinant untagged NT-proBNP for use as a calibrator in NT-proBNP immunoassays.
摘要翻译： 本发明提供了一种在NT-proBNP免疫测定中有效表达高水平重组未标记的NT-proBNP用作校准物的方法。
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公开(公告)号：US20220099687A1
公开(公告)日：2022-03-31
申请号：US17324685
申请日：2021-05-19
申请人： NEXUS DX, INC.
发明人： Michelle Davey , George Jackowski , Peter Kupchak , Eric Stanton
IPC分类号： G01N33/74 , G01N33/535 , C12N5/16 , G01N33/543 , C07K16/26 , G01N33/68
摘要： A specific and sensitive in vitro ELISA assay and diagnostic test kit is disclosed for determining levels of NT-proBNP protein in a variety of bodily fluids, non-limiting examples of which are blood, serum, plasma, urine and the like. The NT-proBNP ELISA assay test employs the sandwich ELISA technique to measure circulating NT-proBNP in human plasma. In order to obtain antibodies with specific binding properties for targeted amino acid sequences within human proBNP, recombinant human proBNP (or rhproBNP) was expressed and purified for use as an immunogen. Polyclonal antibodies (PAb) to specific amino acid sequences were subsequently purified from goat serum by sequential affinity purification. Monoclonal antibodies were raised against specific polypeptides. Recombinant human NT-proBNP (or rhNT-proBNP) was expressed and purified in order to obtain material for use in calibration of a quantitative method for measurement of human NT-proBNP.
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公开(公告)号：US20210053054A1
公开(公告)日：2021-02-25
申请号：US17091692
申请日：2020-11-06
申请人： NEXUS DX, INC.
发明人： Beom Seok LEE
IPC分类号： B01L3/00
摘要： A microfluidic structure in which a plurality of chambers arranged at different positions are connected in parallel and into which a fixed amount of fluid may be efficiently distributed without using a separate driving source, and a microfluidic device having the same. The microfluidic device includes a platform having a center of rotation and including at least one microfluidic structure. The microfluidic structure includes a sample supply chamber configured to accommodate a sample, a plurality of first chambers arranged in a circumferential direction of the platform at different distances from the center of rotation of the platform, and a plurality of siphon channels, each of the siphon channels being connected to a corresponding one of the first chambers.
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公开(公告)号：US09086408B2
公开(公告)日：2015-07-21
申请号：US12596835
申请日：2008-04-30
申请人： Richard Laswell Egan , Graham Peter Lidgard , David Dickson Booker , Christopher Johann Johnson , Alexander Belenky , Stan Vukajlovich
发明人： Richard Laswell Egan , Graham Peter Lidgard , David Dickson Booker , Christopher Johann Johnson , Alexander Belenky , Stan Vukajlovich
IPC分类号： C12Q1/70 , C12M1/34 , G01N33/543 , B01L3/02 , B01L3/00
CPC分类号： G01N33/54306 , B01L3/0272 , B01L3/5023 , B01L3/5029 , G01N33/54366 , G01N2333/11
摘要： The invention provides compositions, systems and methods for detecting multiple analytes from a sample.
摘要翻译： 本发明提供了用于从样品中检测多种分析物的组合物，系统和方法。
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公开(公告)号：US20140370502A1
公开(公告)日：2014-12-18
申请号：US14343483
申请日：2012-09-10
申请人： Ed Brennan , Conan Li , Alexander Belenky
发明人： Ed Brennan , Conan Li , Alexander Belenky
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/54386 , G01N33/6887 , G01N2333/4712 , G01N2800/324 , G01N2800/325
摘要： The present invention provides methods and devices for detecting the presence of two or more threshold levels of an analyte, including markers of myocardial damage such as cardiac troponins, in a sample. In various embodiments, the invention provides convenient point-of-care tests for determining the condition of a patient, so as to guide cost effective health care.
摘要翻译： 本发明提供了用于检测样品中两种或多种阈值水平的分析物（包括心肌损伤标记物如心肌蛋白沉积物）的存在的方法和装置。 在各种实施例中，本发明提供了用于确定患者状况的便利的护理点测试，以便指导成本有效的保健。
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10.发明申请公开(公告)号：US20100315644A1
公开(公告)日：2010-12-16
申请号：US12756157
申请日：2010-04-07
申请人： Richard Egan , Graham Lidgard , David Booker
发明人： Richard Egan , Graham Lidgard , David Booker
IPC分类号： G01N21/55
CPC分类号： G01N21/01 , G01N21/84 , G01N21/8483 , G01N33/487 , G01N2201/0446 , G01N2201/126 , G16H10/40 , Y02A90/26
摘要： A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
摘要翻译： 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。
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