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1.发明授权Hand-held scanner systems and methods for reading point of care test results 有权手持式扫描仪系统和阅读点护理测试结果的方法公开(公告)号：US08638441B2
公开(公告)日：2014-01-28
申请号：US12756157
申请日：2010-04-07
申请人： Richard Egan , Graham Lidgard , David Booker
发明人： Richard Egan , Graham Lidgard , David Booker
IPC分类号： G01N21/55
CPC分类号： G01N21/01 , G01N21/84 , G01N21/8483 , G01N33/487 , G01N2201/0446 , G01N2201/126 , G16H10/40 , Y02A90/26
摘要： A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
摘要翻译： 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。
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2.发明申请Method for Detecting Large Mutations and Duplications Using Control Amplification Comparisons to Paralogous Genes 审中-公开使用对旁系同源基因的对照扩增比较检测大突变和重复的方法公开(公告)号：US20090087846A1
公开(公告)日：2009-04-02
申请号：US12118312
申请日：2008-05-09
申请人： Ray R. Radtkey , Douglas Whitman , Graham Lidgard
发明人： Ray R. Radtkey , Douglas Whitman , Graham Lidgard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/16 , C12Q2600/172
摘要： Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.
摘要翻译： 通过与旁系同源基因共同扩增感兴趣的基因来查询生物样品以检测遗传突变，特别是插入和缺失的方法。 当感兴趣的基因和相应的旁系同源基因选自CYP450家族时，所得到的比例可以预测特定患者如何代谢某些处方药物。
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公开(公告)号：US20050059026A1
公开(公告)日：2005-03-17
申请号：US10694629
申请日：2003-10-27
申请人： Lee Beausang , Graham Lidgard , Thomas Miller
发明人： Lee Beausang , Graham Lidgard , Thomas Miller
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.
摘要翻译： 公开了一种用于检测和定量体液和细胞外介质中可溶性核基质蛋白的方法。 该方法可用于监测细胞和组织的活力，用于评估疾病进展或其治疗，以及评估未知化合物的细胞毒性。 还公开了诱导从细胞释放可溶形式的核基质蛋白质的方法。
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公开(公告)号：US08960026B2
公开(公告)日：2015-02-24
申请号：US13449878
申请日：2012-04-18
申请人： Hemanth Shenoi , Mike Domanico , Graham Lidgard , Joseph E. Schiestle , Scott Castanon , Keith Kopitzke , Martin Bouliane
发明人： Hemanth Shenoi , Mike Domanico , Graham Lidgard , Joseph E. Schiestle , Scott Castanon , Keith Kopitzke , Martin Bouliane
CPC分类号： G01N1/08 , A61B10/0038
摘要： Provided herein is technology relating to collecting samples of soft matter compositions, and particularly, but not exclusively, to devices and methods for collecting stool samples.
摘要翻译： 本文提供了涉及收集软物质组合物的样品的技术，特别地但不排他地涉及用于收集粪便样品的装置和方法。
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5.发明申请Methods for Rapid, Single-Step Strand Displacement Amplification of Nucleic Acids 审中-公开方法快速，单步链放大核酸扩增公开(公告)号：US20080096257A1
公开(公告)日：2008-04-24
申请号：US11838024
申请日：2007-08-13
申请人： Zuxu Yao , Graham Lidgard
发明人： Zuxu Yao , Graham Lidgard
IPC分类号： C12P19/34
CPC分类号： C12Q1/6844 , C12Q2531/119 , C12Q2527/101 , C12Q2547/101 , C12Q2521/301 , C12Q2521/101
摘要： A single-step, isothermal strand displacement amplification method that is conducted without the requirement for heat denaturation of the target nucleic acid. The method is particularly useful for analysis of clinical samples due to the decreased risk of potential contamination of the patient sample.
摘要翻译： 进行不需要靶核酸的热变性的单步等温链置换扩增方法。 该方法对于临床样品的分析特别有用，因为患者样品潜在污染的风险降低。
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公开(公告)号：US20120260748A1
公开(公告)日：2012-10-18
申请号：US13449878
申请日：2012-04-18
申请人： Hemanth Shenoi , Mike Domanico , Graham Lidgard , Joseph E. Schiestle , Scott Castanon , Keith Kopitzke , Martin Bouliane
发明人： Hemanth Shenoi , Mike Domanico , Graham Lidgard , Joseph E. Schiestle , Scott Castanon , Keith Kopitzke , Martin Bouliane
IPC分类号： G01N1/22
CPC分类号： G01N1/08 , A61B10/0038
摘要： Provided herein is technology relating to collecting samples of soft matter compositions, and particularly, but not exclusively, to devices and methods for collecting stool samples.
摘要翻译： 本文提供了涉及收集软物质组合物的样品的技术，特别地但不排他地涉及用于收集粪便样品的装置和方法。
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7.发明申请公开(公告)号：US20100315644A1
公开(公告)日：2010-12-16
申请号：US12756157
申请日：2010-04-07
申请人： Richard Egan , Graham Lidgard , David Booker
发明人： Richard Egan , Graham Lidgard , David Booker
IPC分类号： G01N21/55
CPC分类号： G01N21/01 , G01N21/84 , G01N21/8483 , G01N33/487 , G01N2201/0446 , G01N2201/126 , G16H10/40 , Y02A90/26
摘要： A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
摘要翻译： 描述了包括测试装置和扫描装置的诊断测定系统。 在一个实施方式中，扫描装置包括电磁辐射源，光学组件，检测器和布置在底盘内的微处理器。 测试装置和扫描装置可以被配置为在扫描装置的操作期间可相对于彼此移动。
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8.发明申请Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes 审中-公开使用对旁系同源基因的对照扩增比较检测大突变和重复的方法公开(公告)号：US20070020671A1
公开(公告)日：2007-01-25
申请号：US11485167
申请日：2006-07-12
申请人： Ray Radtkey , Douglas Whitman , Graham Lidgard
发明人： Ray Radtkey , Douglas Whitman , Graham Lidgard
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/16 , C12Q2600/172
摘要： Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.
摘要翻译： 通过与旁系同源基因共同扩增感兴趣的基因来查询生物样品以检测遗传突变，特别是插入和缺失的方法。 当感兴趣的基因和相应的旁系同源基因选自CYP450家族时，所得到的比例可以预测特定患者如何代谢某些处方药物。
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公开(公告)号：US20060127941A1
公开(公告)日：2006-06-15
申请号：US11346457
申请日：2006-02-02
申请人： Lee Beausang , Graham Lidgard , Thomas Miller
发明人： Lee Beausang , Graham Lidgard , Thomas Miller
CPC分类号： G01N33/57488 , C07K14/47 , C07K16/18 , G01N33/5005 , G01N33/5011 , G01N33/574 , G01N33/6875 , G01N2333/525 , G01N2510/00 , Y10S435/961
摘要： Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.
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公开(公告)号：US20090092967A1
公开(公告)日：2009-04-09
申请号：US11768418
申请日：2007-06-26
申请人： Zuxu Yao , Graham Lidgard , Yevgeniy Belousov
发明人： Zuxu Yao , Graham Lidgard , Yevgeniy Belousov
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2521/313 , C12Q2521/307 , C12Q2531/119
摘要： The present invention provides methods of generating target nucleic acids for amplification using nicking enzymes and methods for amplifying the generated target nucleic acids.
摘要翻译： 本发明提供使用切口酶产生用于扩增的靶核酸的方法和用于扩增所产生的靶核酸的方法。
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