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    DNA encoding as human histamine receptor of the H3 subtype
    1.
    发明授权
    DNA encoding as human histamine receptor of the H3 subtype 有权
    编码H3亚型人体组胺受体的DNA

    公开(公告)号：US6136559A

    公开(公告)日：2000-10-24

    申请号：US167354

    申请日：1998-10-07

    申请人： Timothy W. Lovenberg ,  Mark Erlander ,  Arne Huvar ,  Jayashree Pyati

    发明人： Timothy W. Lovenberg ,  Mark Erlander ,  Arne Huvar ,  Jayashree Pyati

    IPC分类号： C07K14/72 ,  C12N15/12 ,  C07K14/47 ,  C07K14/705 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C07K14/723 ,  C12N2799/026

    摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

    摘要翻译： 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

    Lyophilized imaging agent formulation comprising a chemotactic peptide
    2.
    发明授权
    Lyophilized imaging agent formulation comprising a chemotactic peptide 失效
    包含趋化肽的冻干成像剂制剂

    公开(公告)号：US6024938A

    公开(公告)日：2000-02-15

    申请号：US997894

    申请日：1997-12-24

    申请人： Diane C. Corbo ,  Mary Jean M. Link ,  N. Adeyinka Williams ,  Michelle L. Tomsho ,  Michael Bornstein ,  Howard F. Solomon ,  Scott K. Larsen ,  Robert L. Suddith

    发明人： Diane C. Corbo ,  Mary Jean M. Link ,  N. Adeyinka Williams ,  Michelle L. Tomsho ,  Michael Bornstein ,  Howard F. Solomon ,  Scott K. Larsen ,  Robert L. Suddith

    IPC分类号： A61K51/10 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K51/1093

    摘要： A lyophilized imaging agent formulation and methods for making same are disclosed, such formulations comprise a targeting molecule such as antibody or chemotactic peptide, a linker such as diethylenetriaminepentaacetic acid (DTPA) or succinimidyl 6-hydrazinium nicotinate hydrochloride (SHNH), drying protectant such as mannitol, maltose or tricine, and excipient such as polysorbate 80, in citrate buffer. The formulations of the invention are lyophilized and may be stored stably for extended periods of time. Following reconstitution with diluent, the formulations are administered to a subject for scintigraphic imaging or therapeutic use. Also contemplated is a kit comprising a two-vial system wherein a first vial comprises a lyophilized formulation of imaging agent in the form of a lyophilized cake, and a second vial comprises a pharmaceutically acceptable carrier or diluent.

    摘要翻译： 公开了冻干显影剂制剂及其制备方法，该制剂包括靶向分子如抗体或趋化肽，连接体如二亚乙基三胺五乙酸（DTPA）或琥珀酰亚胺基6-肼基烟酸盐酸盐（SHNH），干燥保护剂如 甘露醇，麦芽糖或tricine，以及赋形剂如聚山梨醇酯80，在柠檬酸盐缓冲液中。 本发明的制剂被冻干，并且可以稳定地储存较长时间。 在用稀释剂重构后，将制剂施用于受试者进行闪烁照相成像或治疗用途。 还考虑了一种包含双小瓶系统的试剂盒，其中第一小瓶包含冻干饼形式的成像剂的冻干制剂，第二小瓶包含药学上可接受的载体或稀释剂。

    Dosage regimen container
    3.
    发明授权
    Dosage regimen container 失效
    剂量方案容器

    公开(公告)号：US5833072A

    公开(公告)日：1998-11-10

    申请号：US891234

    申请日：1997-07-10

    申请人： Lawrence E. Lambelet, Jr.

    发明人： Lawrence E. Lambelet, Jr.

    IPC分类号： A61J1/03 ,  A61J7/04 ,  B65D83/04

    CPC分类号： A61J7/04 ,  A61J1/035

    摘要： Generally, this invention relates to dosage containers. More specifically this invention relates to dosage containers which help identify a daily regimen of dosages, or a particular time period of dosages in a day. Most specifically, this invention relates to a dosage container which provides dosages in a linear fashion in a one-to-one relationship for the date or timing of dosages, where such dosages are contained on a card, with a blister package holding the dosages.

    摘要翻译： 通常，本发明涉及剂量容器。 更具体地，本发明涉及有助于确定每日剂量方案或一天的剂量的特定时间段的剂量容器。 最具体地，本发明涉及一种剂量容器，其以剂量的日期或时间以一对一的关系线性地提供剂量，其中这些剂量包含在卡上，其中包含保持剂量的泡罩包装。

    Automatically advancing pill regimen device
    9.
    发明授权
    Automatically advancing pill regimen device 失效
    自动推进药丸装置

    公开(公告)号：US5664697A

    公开(公告)日：1997-09-09

    申请号：US551223

    申请日：1995-10-31

    申请人： Lawrence E. Lambelet, Jr. ,  Thomas A. Frazier

    发明人： Lawrence E. Lambelet, Jr. ,  Thomas A. Frazier

    IPC分类号： A61J7/00 ,  B65D83/04 ,  G07F11/00

    CPC分类号： B65D83/0454 ,  B65D2583/0409

    摘要： The present invention is directed to a self-actuating dispenser for a regimen of pills satisfying the needs discussed herein above. A self-actuating dispenser having the features of the present invention comprises a base, a pill container, and a means for cyclically indexing the pill container with respect to the base. The base has a pill exit aperture. The pill container, which houses the pills in individual compartments or cells, is movably attached to the base such that any pill cell can be aligned with the pill exit aperture. The pill cells are provided with open bottoms for loading and dispensing which are covered over by the base when attached thereto. The means for cyclically indexing provides that each pill cell in turn is brought into alignment with the pill exit aperture thereby singly dropping the resident pills in a series of dispensing cycles.

    摘要翻译： 本发明涉及一种用于满足上文所述需要的药丸剂的自动致动分配器。 具有本发明特征的自动致动分配器包括基座，药丸容器和用于使药丸容器相对于基座循环地分度的装置。 基座具有药丸出口孔。 在单个隔室或细胞中容纳药丸的药丸容器可移动地连接到基部，使得任何药丸可以与药丸出口孔对齐。 药丸细胞设置有用于装载和分配的开放底部，其在附着时被基底覆盖。 用于循环分选的方法提供了每个药丸细胞依次与药丸出口孔对齐，从而在一系列分配循环中单独滴落常规药丸。

    Apparatus and method for automatically processing dried blood spots in HIV-1 testing
    10.
    发明授权
    Apparatus and method for automatically processing dried blood spots in HIV-1 testing 失效
    在HIV-1检测中自动处理干血斑的装置和方法

    公开(公告)号：US5641682A

    公开(公告)日：1997-06-24

    申请号：US514647

    申请日：1995-08-14

    申请人： William Pagels ,  Noel Rolon

    发明人： William Pagels ,  Noel Rolon

    IPC分类号： G01N33/483 ,  G01N35/00 ,  G01N35/02

    CPC分类号： G01N35/02 ,  G01N2035/00108 ,  G01N2035/00752 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/114165 ,  Y10T436/115831 ,  Y10T436/12

    摘要： An apparatus and method for automatically identifying, handling, tracking, and processing dried blood samples in HIV-1 testing are disclosed. Dried blood samples are punched from test cards into incubation receptacles for incubation and further testing. Optionally, the location on the test card to be punched may be manually, semi-automatically or automatically selected, ranked, and punched in order of preference. Test results corresponding to a particular test subject are automatically tracked and reported while maintaining the anonymity of the subject.

    摘要翻译： 公开了一种在HIV-1测试中自动识别，处理，跟踪和处理干血样品的装置和方法。 将干血样品从测试卡打到孵化容器中进行孵育和进一步测试。 可选地，待冲压的测试卡上的位置可以手动，半自动或自动选择，排列和按优先顺序冲压。 自动跟踪和报告与特定测试对象相对应的测试结果，同时保持对象的匿名性。