公开(公告)号：US20240318268A1

公开(公告)日：2024-09-26

申请号：US18572835

申请日：2022-07-07

申请人： BIOMÉRIEUX ,  HOSPICES CIVILS DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON I

发明人： Sophie ASSANT ,  Karen BRENGEL-PESCE ,  Marine MOMMERT

IPC分类号： C12Q1/70 ,  A61B10/00 ,  C12Q1/6851

CPC分类号： C12Q1/701 ,  C12Q1/6851 ,  A61B10/0051 ,  C12Q2600/158

摘要： A method for determining, in vitro or ex vivo, the presence in a patient of an infection by a replicating respiratory virus, including a step i) of determining, in a test sample taken from the mouth or nose of said patient, the level of transcripts of at least one marker gene selected from the interferon-stimulated genes, referred to as ISGs; and associated kits.

公开(公告)号：US20240141406A1

公开(公告)日：2024-05-02

申请号：US18409148

申请日：2024-01-10

申请人： BIOMÉRIEUX

发明人： Chloé BARDET ,  Tiphaine CECCHINI ,  Yannick CHARRETIER ,  Jean-Philippe CHARRIER ,  Christelle COMPAGNON ,  Tanguy FORTIN

IPC分类号： C12Q1/06 ,  G01N33/569 ,  G01N33/68

CPC分类号： C12Q1/06 ,  G01N33/569 ,  G01N33/6848

摘要： A method for quantifying at least one microorganism group via at least one mass spectrometry analysis. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.

公开(公告)号：US20230322804A1

公开(公告)日：2023-10-12

申请号：US18328417

申请日：2023-06-02

申请人： BIOMÉRIEUX ,  UNIVERSITÉ DE CAEN NORMANDIE

发明人： Sylvain URSUEGUI ,  Alain LAURENT ,  Ali LAAYOUN ,  Frédéric FABIS

IPC分类号： C07D498/04 ,  C12Q1/6869

CPC分类号： C07D498/04 ,  C12Q1/6869

摘要： The present invention concerns reagents for the reversible protection of biological molecules. It relates in particular to compounds derived from azaisatoic anhydride and their uses for the protection of biological molecules, particularly enzymes, in order to block their activity. The invention also relates to the biological molecules protected in this manner and to the methods for making use of these reagents.

公开(公告)号：US20230250479A1

公开(公告)日：2023-08-10

申请号：US18014885

申请日：2021-07-05

申请人： BIOMÉRIEUX ,  BIOASTER

发明人： Laurence VACHOT ,  François MALLET ,  Guillaume MONNERET ,  Virginie MOUCADEL ,  Alexandre PACHOT ,  Estelle PERONNET ,  Thomas RIMMELÉ ,  Julien TEXTORIS ,  Fabienne VENET

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158

摘要： An in vitro or ex vivo method for determining the risk of incidence of a care-related infection includes a step of measuring the expression of CD177 in a biological sample from said patient.

公开(公告)号：US20230220477A1

公开(公告)日：2023-07-13

申请号：US18014878

申请日：2021-07-05

申请人： BIOMÉRIEUX ,  BIOASTER

发明人： Laurence VACHOT ,  François MALLET ,  Guillaume MONNERET ,  Virginie MOUCADEL ,  Alexandre PACHOT ,  Estelle PERONNET ,  Thomas RIMMELÉ ,  Julien TEXTORIS ,  Fabienne VENET

IPC分类号： C12Q1/6883 ,  C12Q1/6813 ,  C12Q1/686

CPC分类号： C12Q1/6883 ,  C12Q1/6813 ,  C12Q1/686 ,  C12Q2600/118

摘要： An in vitro or ex vivo method for determining the risk of incidence of a healthcare-associated infection includes a step of measuring the expression of TAP2 in a biological sample from said patient.

公开(公告)号：US20230219797A1

公开(公告)日：2023-07-13

申请号：US18000829

申请日：2021-06-11

申请人： BIOMÉRIEUX

发明人： Michel GUY ,  Nicolas DELEPAUT

IPC分类号： B67B7/10

CPC分类号： B67B7/10

摘要： The subject of the invention relates to a tool for manipulating a plurality of plugs, taking the form of a comb (1) comprising:

a body (7) provided with a row of teeth (4) having pointed distal portions (4p) spaced apart in a linear direction in order to engage with the cavities of the plugs;
a system for separating the plugs from the teeth (4) that comprises a slide returned elastically and guided to slide with respect to the body (7) in a direction parallel to the direction of extension of the teeth, the slide being provided with the fingers of the comb, which are movable by sliding between the teeth (4), and a control (11a) accessible from a first portion (1a) of the comb and which, when pressed to move translationally, causes the fingers of the comb to slide in the direction of the pointed distal portions (4p) in order to eject the plugs from the teeth (4).

公开(公告)号：US11535620B2

公开(公告)日：2022-12-27

申请号：US16833657

申请日：2020-03-29

申请人： Biomérieux

发明人： Yuping Guo ,  Sylvie Cheucle

IPC分类号： C07D475/04 ,  G01N33/82

摘要： Use of a folate derivative to assay in vitro the folate in a sample such as a biological sample.

公开(公告)号：US11104931B2

公开(公告)日：2021-08-31

申请号：US16014665

申请日：2018-06-21

申请人： bioMérieux, Inc.

发明人： Ronnie J. Robinson ,  Mark Joseph Fanning ,  Stanley Michael Philipak ,  Richard Scott Remes ,  James Clement Bishop ,  Gary W. Sommer ,  Lawrence E Guerra ,  Michael A Herron

IPC分类号： G01N35/00 ,  C12Q1/04 ,  C12M1/34 ,  C12Q1/02 ,  G01N35/04 ,  G01N35/02

摘要： A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.

公开(公告)号：US20210254165A1

公开(公告)日：2021-08-19

申请号：US17256811

申请日：2019-06-28

申请人： BIOMÉRIEUX ,  BIOASTER ,  HOSPICES CIVILS DE LYON

发明人： Marine MOMMERT ,  Olivier TABONE ,  Julien TEXTORIS ,  François MALLET

IPC分类号： C12Q1/6883

摘要： A method for determining in vitro or ex vivo the immune status of an individual, preferably a patient, including a step of detecting and/or quantifying the expression of one or more HERV/MaLR sequences in a biological sample of the individual. Also relates to the tools for implementing the method and to the uses thereof.

公开(公告)号：US20210254133A1

公开(公告)日：2021-08-19

申请号：US17246972

申请日：2021-05-03

申请人： bioMérieux

发明人： Stephane Christian Jacques Magro ,  Come Henri Albert Barranger

IPC分类号： C12Q1/686 ,  C12Q1/6851 ,  G16B30/00 ,  C07H21/04 ,  C12M1/26 ,  C12P19/34 ,  C12Q1/6806 ,  C12Q1/70

摘要： Methods, sample vessels, and instruments are provided for quantitative and semi-quantitative amplification.