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28 条记录 (耗时 0.023 秒)

    Bioresorbable spinal implant and related methods
    1.
    发明授权
    Bioresorbable spinal implant and related methods 失效
    生物可吸收脊柱植入物及相关方法

    公开(公告)号：US08282681B2

    公开(公告)日：2012-10-09

    申请号：US12190974

    申请日：2008-08-13

    申请人： Alan McLeod ,  Christopher Reah

    发明人： Alan McLeod ,  Christopher Reah

    IPC分类号： A61F2/44

    CPC分类号： A61F2/442 ,  A61F2/30965 ,  A61F2/4405 ,  A61F2002/30062 ,  A61F2002/30563 ,  A61F2002/30578 ,  A61F2002/30616 ,  A61F2002/30909 ,  A61F2002/4495 ,  A61F2210/0004

    摘要： A prosthesis for the replacement of an intervertebral disc of the spine comprises a block of an elastomeric material, which is held under compression by an encapsulating textile fabric. A preferred version of the invention has flanges that are continuations of the encapsulating fabric forming an interdigitation, with the continuation of the upper fabric passing through a hole in the lower fabric and being attached to the lower vertebral body and the continuation of the lower fabric crossing to its fixation site on the upper vertebral body. Optionally, the flanges are resorbable, over time leaving only the implant core and encapsulation fabric in the intervertebral space.

    摘要翻译： 用于替代脊椎椎间盘的假体包括弹性体材料块，其被包封的纺织织物保持在压缩之下。 本发明的优选形式具有作为形成交叉指向的封装织物的连续的凸缘，上织物的延续通过下织物中的孔并连接到下椎体并且下织物交叉的延续 到其上部椎体的固定位置。 可选地，凸缘可再吸收，随着时间的推移，仅留下植入物芯和包封织物在椎间空间中。

    Cryptate compounds and methods for diagnosis and therapy
    5.
    发明授权
    Cryptate compounds and methods for diagnosis and therapy 有权
    穴位化合物及其诊断和治疗方法

    公开(公告)号：US06869589B1

    公开(公告)日：2005-03-22

    申请号：US09869777

    申请日：2000-01-05

    申请人： Suzanne V. Smith ,  John M. Harrowfield ,  Nadine M. Di Bartolo ,  Alan McLeod Sargeson

    发明人： Suzanne V. Smith ,  John M. Harrowfield ,  Nadine M. Di Bartolo ,  Alan McLeod Sargeson

    IPC分类号： A61K51/10 ,  C07D487/08 ,  A61K51/00 ,  C07D225/00 ,  C07D267/22 ,  A61B5/005

    CPC分类号： C07D487/08 ,  A61K51/1063 ,  A61K51/1072 ,  A61K51/1093 ,  C07B2200/05

    摘要： The present invention relates to cryptate compounds useful as chelating agents. In particular, the present invention relates to functionalized derivatives of certain cryptate compounds. These functionalized derivatives are suitable for use in radiolabelling and similar applications. The present invention also relates to a method for diagnosis or therapy of a disease utilizing functionalized derivatives of cryptase compounds. In one embodiment, the present invention relates to a compound which is capable of being radiolabelled of general formula (I) in which n represents an integer from 2 to 4, where each R4 and R5 is independently selected from —H, CH3, COOH, NO2, CH2OH, H2PO4, HSO3, CN, C═ONH2 and CHO; X and Y are the same or different and are selected from the group of C—R, N, P and C—Z in which R represents a hydrogen or halogen atom or a hydroxyl, nitro, nitroso, amino, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl or cyano group, or a group of the formula —COOR′, COCOOR′, NH—COCH2Br, —NH—CO—CH═CH—COOR′ in which R′ is a hydrogen atom or alkyl group; or, W is selected from the group of NH, S and O; and Z is a functionalized linkage group which is capable of binding said compound of formula (I) to a molecular recognition unit and wherein at least one of X and Y is C—Z; or a pharmaceutically acceptable salt thereof

    摘要翻译： 本发明涉及可用作螯合剂的穴状化合物。 特别地，本发明涉及某些密穴化合物的官能化衍生物。 这些官能化衍生物适用于放射性标记和类似应用。 本发明还涉及利用密切切割酶化合物官能化衍生物诊断或治疗疾病的方法。 在一个实施方案中，本发明涉及能够被放射性标记的通式（I）的化合物，其中n表示2至4的整数，其中每个R 4和R 5独立地选自 - H，CH 3，COOH，NO 2，CH 2 OH，H 2 PO 4，HSO 3，CN，C = ONH 2和CHO; X和Y相同或不同，选自CR，N，P和CZ，其中R表示氢或卤素原子或羟基，硝基，亚硝基，氨基，任选取代的烷基，任选取代的芳基，任选地 取代的芳烷基或氰基，或式-COOR'，COCOOR'，NH-COCH2Br，-NH-CO-CH = CH-COOR'的基团，其中R'为氢原子或烷基; 或者W选自NH，S和O; Z是能够将式（I）化合物与分子识别单元结合的官能化连接基团，其中X和Y中的至少一个为C-Z; 或其药学上可接受的盐

    Textile Prosthesis
    6.
    发明申请
    Textile Prosthesis 审中-公开
    纺织假肢

    公开(公告)号：US20110054610A1

    公开(公告)日：2011-03-03

    申请号：US12942372

    申请日：2010-11-09

    申请人： Julian Ellis ,  Peter Butcher ,  Alan McLeod

    发明人： Julian Ellis ,  Peter Butcher ,  Alan McLeod

    IPC分类号： A61F2/08 ,  A61F2/02

    CPC分类号： A61F2/08 ,  A61B17/7022 ,  A61B17/7055 ,  A61B17/7059 ,  A61B17/8085 ,  A61B2017/00004 ,  A61B2017/00867 ,  A61F2002/183

    摘要： A textile prosthesis comprising a unitary body of predetermined shape having structural integrity, the body including at least one anchorage body portion for attachment to an anatomical body part, the body being composed of a combination of binding yarns and tensile load bearing filaments, the binding yarns being located at least in the or in each of said anchorage body portions and being interconnected to one another by sewn stitches, the tensile load bearing filaments being located inbetween said stitches so as to be constrained to extend through said unitary body along predetermined pathways extending in one or more predetermined directions so as to render the body resistance to stretch when a tensile load is applied in said one or more predetermined directions.

    摘要翻译： 一种织物假体，其包括具有结构完整性的预定形状的整体，所述主体包括用于附接到解剖体部分的至少一个锚固体部分，所述主体由结合纱线和拉伸承载丝线的组合构成，所述结合纱线 至少位于所述锚固体部分中或每个所述锚固体部分中并且通过缝合线迹彼此互连，所述拉伸承载丝线位于所述线圈之间，以便被限制为沿着延伸的预定路径延伸穿过所述整体 一个或多个预定方向，以便当在所述一个或多个预定方向上施加拉伸载荷时使身体抵抗拉伸。

    Textile prosthesis
    7.
    发明授权
    Textile prosthesis 有权
    纺织假体

    公开(公告)号：US07338531B2

    公开(公告)日：2008-03-04

    申请号：US10398883

    申请日：2001-10-11

    申请人： Julian Ellis ,  Peter Butcher ,  Alan McLeod

    发明人： Julian Ellis ,  Peter Butcher ,  Alan McLeod

    IPC分类号： A61F2/02 ,  A61F2/008

    CPC分类号： A61F2/08 ,  A61B17/7022 ,  A61B17/7055 ,  A61B17/7059 ,  A61B17/8085 ,  A61B2017/00004 ,  A61B2017/00867 ,  A61F2002/183

    摘要： A textile prosthesis comprising a unitary body of predetermined shape having structural integrity, the body including at least one anchorage body portion for attachment to an anatomical body part, the body being composed of a combination of binding yarns and tensile load bearing filaments, the binding yarns being located at least in the or in each of said anchorage body portions and being interconnected to one another by sewn stitches, the tensile load bearing filaments being located inbetween said stitches so as to be constrained to extend through said unitary body along predetermined pathways extending in one or more predetermined directions so as to render the body resistance to stretch when a tensile load is applied in said one or more predetermined directions.

    摘要翻译： 一种织物假体，其包括具有结构完整性的预定形状的整体，所述主体包括用于附接到解剖体部分的至少一个锚固体部分，所述主体由结合纱线和拉伸承载丝线的组合构成，所述结合纱线 至少位于所述锚固体部分中或每个所述锚固体部分中并且通过缝合线迹彼此互连，所述拉伸承载丝线位于所述线圈之间，以便被限制为沿着延伸的预定路径延伸穿过所述整体 一个或多个预定方向，以便当在所述一个或多个预定方向上施加拉伸载荷时使身体抵抗拉伸。