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公开(公告)号：US20130330326A1
公开(公告)日：2013-12-12
申请号：US13884842
申请日：2011-11-11
IPC分类号： A61K38/08 , A61K33/24 , A61K31/4745 , A61K39/395 , A61K31/7068 , A61K31/517 , A61K31/519 , A61K31/282 , A61K31/704
CPC分类号： A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors.
摘要翻译： 描述了用叶酸 - 长春花碱缀合物与至少一种其他化学治疗剂联合治疗上皮肿瘤的方法和组合物，其中肿瘤包括卵巢，子宫内膜或非小细胞肺癌肿瘤，包括耐铂性卵巢肿瘤和铂 - 敏感的卵巢肿瘤。
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公开(公告)号：US20120122893A1
公开(公告)日：2012-05-17
申请号：US13294624
申请日：2011-11-11
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors.
摘要翻译： 描述了用叶酸 - 长春花碱缀合物与至少一种其他化学治疗剂联合治疗上皮肿瘤的方法和组合物，其中肿瘤包括卵巢，子宫内膜或非小细胞肺癌肿瘤，包括耐铂性卵巢肿瘤和铂 - 敏感的卵巢肿瘤。
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公开(公告)号：US20120065149A1
公开(公告)日：2012-03-15
申请号：US13199654
申请日：2011-09-07
申请人： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
发明人： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
IPC分类号： A61K31/519 , C07D519/00 , C07H15/26 , A61K31/7068 , A61P35/00 , C07K5/083 , A61K38/06 , C07K5/103 , A61K38/07 , C07K9/00 , A61K38/14 , C07K7/06 , A61K38/08 , C07F7/10 , A61K31/695 , C07D475/04
CPC分类号： A61K47/55 , A61K47/551 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/55
摘要： The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
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公开(公告)号：US20100004276A1
公开(公告)日：2010-01-07
申请号：US12501283
申请日：2009-07-10
申请人： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
发明人： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
IPC分类号： A61K47/48 , A61K31/4745 , A61P35/00
CPC分类号： A61K47/48569 , A61K47/48384 , A61K47/484 , A61K47/48715 , A61K47/551 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/55
摘要： The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
摘要翻译： 本发明描述了维生素受体结合药物递送缀合物及其制备方法。 药物递送缀合物由维生素受体结合部分，二价连接体（L）和药物组成。 维生素受体结合部分包括维生素和维生素受体结合类似物及其衍生物，并且该药物包括其类似物及其衍生物。 维生素受体结合部分与二价连接体共价连接，药物或其类似物或衍生物与二价连接体共价连接，其中二价连接体（L）包括组分如间隔连接子，可释放接头， 和杂原子接头，及其组合。 还描述了使用药物递送缀合物消除致病细胞群的方法和药物组合物。
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公开(公告)号：US07601332B2
公开(公告)日：2009-10-13
申请号：US10765336
申请日：2004-01-27
申请人： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
发明人： Iontcho R. Vlahov , Christopher P. Leamon , Matthew A. Parker , Stephen J. Howard , Hari Krishna Santhapuram , Apparao Satyam , Joseph Anand Reddy
CPC分类号： A61K47/48569 , A61K47/48384 , A61K47/484 , A61K47/48715 , A61K47/551 , A61K47/65 , A61K47/6803 , A61K47/6807 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/55
摘要： The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
摘要翻译： 本发明描述了维生素受体结合药物递送缀合物及其制备方法。 药物递送缀合物由维生素受体结合部分，二价连接体（L）和药物组成。 维生素受体结合部分包括维生素和维生素受体结合类似物及其衍生物，并且该药物包括其类似物及其衍生物。 维生素受体结合部分与二价连接体共价连接，药物或其类似物或衍生物与二价连接体共价连接，其中二价连接体（L）包括组分如间隔连接子，可释放接头， 和杂原子接头，及其组合。 还描述了使用药物递送缀合物消除致病细胞群的方法和药物组合物。
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公开(公告)号：US20080057711A1
公开(公告)日：2008-03-06
申请号：US11511698
申请日：2006-08-29
申请人： Phillip Daniel Matz , Sopa Chevacharoenkul , Ching-Te Lin , Basab Chatterjee , Anand Reddy , Kenneth Joseph Newton , Ju-Ai Ruan
发明人： Phillip Daniel Matz , Sopa Chevacharoenkul , Ching-Te Lin , Basab Chatterjee , Anand Reddy , Kenneth Joseph Newton , Ju-Ai Ruan
IPC分类号： H01L21/44
CPC分类号： H01L21/76834 , H01L21/02063 , H01L21/02164 , H01L21/02274 , H01L21/02282 , H01L21/31116 , H01L21/31608 , H01L21/31625 , H01L21/76802 , H01L21/76814 , H01L21/76883
摘要： A semiconductor device is fabricated while mitigating conductive void formation in metallization layers. A substrate is provided. A first dielectric layer is formed over the substrate. A conductive trench is formed within the first dielectric layer. An etch stop layer is formed over the first dielectric layer. A second dielectric layer is formed over/on the etch stop layer. A resist mask is formed over the device and via openings are etched in the second dielectric layer. The resist mask is removed by an ash process. A clean process is performed that mitigates/reduces surface charge on exposed portions of the etch stop layer. Additional surface charge reduction techniques are employed. The via openings are filled with a conductive material and a planarization process is performed to remove excess fill material.
摘要翻译： 制造半导体器件，同时减轻金属化层中的导电空隙形成。 提供基板。 第一电介质层形成在衬底上。 在第一电介质层内形成导电沟槽。 在第一介电层上形成蚀刻停止层。 在蚀刻停止层上/上形成第二介电层。 在器件上形成抗蚀剂掩模，并且在第二介电层中蚀刻通孔。 抗蚀剂掩模通过灰过程去除。 执行清洁处理，其减轻/减少蚀刻停止层的暴露部分上的表面电荷。 采用附加的表面电荷还原技术。 通孔开口填充有导电材料，并执行平面化处理以去除多余的填充材料。
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公开(公告)号：US08883737B2
公开(公告)日：2014-11-11
申请号：US13884842
申请日：2011-11-11
IPC分类号： A61K38/00 , A61K39/00 , A61K33/24 , A61K31/7068 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K39/395 , A61K38/08 , A61K45/06 , A61K31/517 , A61K31/282 , A61K31/519
CPC分类号： A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors.
摘要翻译： 描述了用叶酸 - 长春花碱缀合物与至少一种其他化学治疗剂联合治疗上皮肿瘤的方法和组合物，其中肿瘤包括卵巢，子宫内膜或非小细胞肺癌肿瘤，包括耐铂性卵巢肿瘤和铂 - 敏感的卵巢肿瘤。
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公开(公告)号：US20150177784A1
公开(公告)日：2015-06-25
申请号：US14139967
申请日：2013-12-24
IPC分类号： G06F1/16
CPC分类号： G06F1/166 , G06F1/1626
摘要： A portable computing device includes a body that has a display. A stand is connected to the body. The stand is operable to place the portable computing device in a viewing orientation in which the portable computing device rests on the stand or a carrying orientation in which the stand acts as a handle for lifting the portable computing device. A rotation device connected to the stand assists in positioning the display in a range of angles for viewing convenience.
摘要翻译： 便携式计算设备包括具有显示器的主体。 一个支架连接到身体。 支架可操作以将便携式计算设备置于便携式计算设备放置在支架上的观察方向或支架方向上，其中支架用作提升便携式计算设备的手柄。 连接到支架的旋转装置有助于将显示器定位在一定范围的角度以便于观看。
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公开(公告)号：US08987281B2
公开(公告)日：2015-03-24
申请号：US13294624
申请日：2011-11-11
IPC分类号： A61K31/4985 , C07D475/04 , A61P35/00 , A61K38/08 , A61K45/06 , A61K31/519 , A61K31/282 , A61K31/4745 , A61K31/517 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/395 , A61K31/337
CPC分类号： A61K38/08 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/517 , A61K31/519 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： Described are methods and compositions for treating epithelial tumors with a folate-vinca conjugate in combination with at least one other chemotherapeutic agent in which the tumors include ovarian, endometrial or non-small cell lung cancer tumors, including platinum-resistant ovarian tumors and platinum-sensitive ovarian tumors.
摘要翻译： 描述了用叶酸 - 长春花碱缀合物与至少一种其他化学治疗剂联合治疗上皮肿瘤的方法和组合物，其中肿瘤包括卵巢，子宫内膜或非小细胞肺癌肿瘤，包括耐铂性卵巢肿瘤和铂 - 敏感的卵巢肿瘤。
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公开(公告)号：US07727885B2
公开(公告)日：2010-06-01
申请号：US11511698
申请日：2006-08-29
申请人： Phillip Daniel Matz , Sopa Chevacharoenkul , Ching-Te Lin , Basab Chatterjee , Anand Reddy , Kenneth Joseph Newton , Ju-Ai Ruan
发明人： Phillip Daniel Matz , Sopa Chevacharoenkul , Ching-Te Lin , Basab Chatterjee , Anand Reddy , Kenneth Joseph Newton , Ju-Ai Ruan
IPC分类号： H01L21/44
CPC分类号： H01L21/76834 , H01L21/02063 , H01L21/02164 , H01L21/02274 , H01L21/02282 , H01L21/31116 , H01L21/31608 , H01L21/31625 , H01L21/76802 , H01L21/76814 , H01L21/76883
摘要： A semiconductor device is fabricated while mitigating conductive void formation in metallization layers. A substrate is provided. A first dielectric layer is formed over the substrate. A conductive trench is formed within the first dielectric layer. An etch stop layer is formed over the first dielectric layer. A second dielectric layer is formed over/on the etch stop layer. A resist mask is formed over the device and via openings are etched in the second dielectric layer. The resist mask is removed by an ash process. A clean process is performed that mitigates/reduces surface charge on exposed portions of the etch stop layer. Additional surface charge reduction techniques are employed. The via openings are filled with a conductive material and a planarization process is performed to remove excess fill material.
摘要翻译： 制造半导体器件，同时减轻金属化层中的导电空隙形成。 提供基板。 第一电介质层形成在衬底上。 在第一电介质层内形成导电沟槽。 在第一介电层上形成蚀刻停止层。 在蚀刻停止层上/上形成第二介电层。 在器件上形成抗蚀剂掩模，并且在第二介电层中蚀刻通孔。 抗蚀剂掩模通过灰过程去除。 执行清洁处理，其减轻/减少蚀刻停止层的暴露部分上的表面电荷。 采用附加的表面电荷还原技术。 通孔开口填充有导电材料，并执行平面化处理以去除多余的填充材料。
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