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公开(公告)号：US20120164126A1
公开(公告)日：2012-06-28
申请号：US13277086
申请日：2011-10-19
IPC分类号： A61K38/46 , A01N37/46 , A61K8/73 , A61P31/04 , C12N1/21 , C12Q1/34 , C12N9/14 , A01P1/00 , C12N15/55 , C12N15/63
CPC分类号： C12N9/2402 , C07K2319/035 , C07K2319/20 , C12N9/50 , C12N9/80
摘要： The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
摘要翻译： 本发明涉及包含如SEQ ID NO：1所示的序列以及该多肽的变体的称为ply_pitti26的多肽。 此外，本发明涉及编码所述多肽及其变体的核酸和载体以及包含这些核酸和/或载体的宿主细胞。 最后，本发明涉及所述多肽，其变体，核酸序列，载体和宿主细胞的用途，特别是用于治疗或预防感染或暴露于葡萄球菌的受试者。
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公开(公告)号：US08557519B2
公开(公告)日：2013-10-15
申请号：US13277086
申请日：2011-10-19
CPC分类号： C12N9/2402 , C07K2319/035 , C07K2319/20 , C12N9/50 , C12N9/80
摘要： The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
摘要翻译： 本发明涉及包含如SEQ ID NO：1所示的序列以及该多肽的变体的称为ply_pitti26的多肽。 此外，本发明涉及编码所述多肽及其变体的核酸和载体以及包含这些核酸和/或载体的宿主细胞。 最后，本发明涉及所述多肽，其变体，核酸序列，载体和宿主细胞的用途，特别是用于治疗或预防感染或暴露于葡萄球菌的受试者。
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公开(公告)号：US08058225B2
公开(公告)日：2011-11-15
申请号：US12194320
申请日：2008-08-19
IPC分类号： C07K14/00
CPC分类号： C12N9/2402 , C07K2319/035 , C07K2319/20 , C12N9/50 , C12N9/80
摘要： The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
摘要翻译： 本发明涉及包含如SEQ ID NO：1所示的序列以及该多肽的变体的称为ply_pitti26的多肽。 此外，本发明涉及编码所述多肽及其变体的核酸和载体以及包含这些核酸和/或载体的宿主细胞。 最后，本发明涉及所述多肽，其变体，核酸序列，载体和宿主细胞的用途，特别是用于治疗或预防感染或暴露于葡萄球菌的受试者。
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4.发明授权Method and means for enrichment, removal and detection of gram-positive bacteria 有权富集，去除和检测革兰氏阳性菌的方法和手段公开(公告)号：US09394534B2
公开(公告)日：2016-07-19
申请号：US12520731
申请日：2007-12-21
IPC分类号： C12Q1/68 , C12N9/00 , G01N33/554 , G01N33/569 , C12N9/96 , C12N1/20 , C12N15/00 , C07H21/04 , C12N9/88 , C07K14/005 , C07K14/195 , C07K14/32
CPC分类号： C12N9/88 , C07K14/005 , C07K14/195 , C07K14/32 , C07K2319/035 , C07K2319/70 , C12N2795/10022 , G01N33/56911 , G01N2469/10
摘要： The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme, and a sequence according to SEQ ID NO: 1 or derivatives thereof, wherein the polypeptide besides the cell wall binding domain comprises no further domains of an endolysin, as well as means for their preparation. The present invention further relates to methods for binding, enriching, removing from a sample, capturing and/or detecting bacteria, particularly gram positive bacteria.
摘要翻译： 本发明涉及包含内溶素或另一细胞壁裂解酶的酶促非活性细胞壁结合结构域的多肽，以及根据SEQ ID NO：1或其衍生物的序列，其中所述多肽除了细胞壁结合结构域包括 没有其他的内溶素域，以及它们的制备方法。 本发明还涉及用于结合，富集，从样品中除去，捕获和/或检测细菌，特别是革兰氏阳性细菌的方法。
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5.发明申请Method and Means for Enrichment, Removal and Detection of Gram-Positive Bacteria 有权富集，去除和检测革兰氏阳性细菌的方法和手段公开(公告)号：US20100092968A1
公开(公告)日：2010-04-15
申请号：US12520731
申请日：2007-12-21
CPC分类号： C12N9/88 , C07K14/005 , C07K14/195 , C07K14/32 , C07K2319/035 , C07K2319/70 , C12N2795/10022 , G01N33/56911 , G01N2469/10
摘要： The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme, and a sequence according to SEQ ID NO: 1 or derivatives thereof, wherein the polypeptide besides the cell wall binding domain comprises no further domains of an endolysin, as well as means for their preparation. The present invention further relates to methods for binding, enriching, removing from a sample, capturing and/or detecting bacteria, particularly gram positive bacteria.
摘要翻译： 本发明涉及包含内溶素或另一细胞壁裂解酶的酶促非活性细胞壁结合结构域的多肽，以及根据SEQ ID NO：1或其衍生物的序列，其中所述多肽除了细胞壁结合结构域包括 没有其他的内溶素域，以及它们的制备方法。 本发明还涉及用于结合，富集，从样品中除去，捕获和/或检测细菌，特别是革兰氏阳性细菌的方法。
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公开(公告)号：US20090202512A1
公开(公告)日：2009-08-13
申请号：US12194320
申请日：2008-08-19
IPC分类号： A61K38/46 , C12N9/14 , C12N9/96 , C12N15/11 , A61L2/00 , A61K31/7088 , C12Q1/34 , A23L3/3463
CPC分类号： C12N9/2402 , C07K2319/035 , C07K2319/20 , C12N9/50 , C12N9/80
摘要： The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in SEQ ID NO:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors. Finally, the present invention relates to the uses of said polypeptide, variants thereof, nucleic acid sequences, vectors and host cells, in particular for the treatment or prophylaxis of a subject infected by or exposed to Staphylococci.
摘要翻译： 本发明涉及包含如SEQ ID NO：1所示的序列以及该多肽的变体的称为ply_pitti26的多肽。 此外，本发明涉及编码所述多肽及其变体的核酸和载体以及包含这些核酸和/或载体的宿主细胞。 最后，本发明涉及所述多肽，其变体，核酸序列，载体和宿主细胞的用途，特别是用于治疗或预防感染或暴露于葡萄球菌的受试者。
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