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1.发明申请Method and Means for Enrichment, Removal and Detection of Gram-Positive Bacteria 有权富集，去除和检测革兰氏阳性细菌的方法和手段公开(公告)号：US20100092968A1
公开(公告)日：2010-04-15
申请号：US12520731
申请日：2007-12-21
CPC分类号： C12N9/88 , C07K14/005 , C07K14/195 , C07K14/32 , C07K2319/035 , C07K2319/70 , C12N2795/10022 , G01N33/56911 , G01N2469/10
摘要： The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme, and a sequence according to SEQ ID NO: 1 or derivatives thereof, wherein the polypeptide besides the cell wall binding domain comprises no further domains of an endolysin, as well as means for their preparation. The present invention further relates to methods for binding, enriching, removing from a sample, capturing and/or detecting bacteria, particularly gram positive bacteria.
摘要翻译： 本发明涉及包含内溶素或另一细胞壁裂解酶的酶促非活性细胞壁结合结构域的多肽，以及根据SEQ ID NO：1或其衍生物的序列，其中所述多肽除了细胞壁结合结构域包括 没有其他的内溶素域，以及它们的制备方法。 本发明还涉及用于结合，富集，从样品中除去，捕获和/或检测细菌，特别是革兰氏阳性细菌的方法。
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2.发明授权Method and means for enrichment, removal and detection of gram-positive bacteria 有权富集，去除和检测革兰氏阳性菌的方法和手段公开(公告)号：US09394534B2
公开(公告)日：2016-07-19
申请号：US12520731
申请日：2007-12-21
IPC分类号： C12Q1/68 , C12N9/00 , G01N33/554 , G01N33/569 , C12N9/96 , C12N1/20 , C12N15/00 , C07H21/04 , C12N9/88 , C07K14/005 , C07K14/195 , C07K14/32
CPC分类号： C12N9/88 , C07K14/005 , C07K14/195 , C07K14/32 , C07K2319/035 , C07K2319/70 , C12N2795/10022 , G01N33/56911 , G01N2469/10
摘要： The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme, and a sequence according to SEQ ID NO: 1 or derivatives thereof, wherein the polypeptide besides the cell wall binding domain comprises no further domains of an endolysin, as well as means for their preparation. The present invention further relates to methods for binding, enriching, removing from a sample, capturing and/or detecting bacteria, particularly gram positive bacteria.
摘要翻译： 本发明涉及包含内溶素或另一细胞壁裂解酶的酶促非活性细胞壁结合结构域的多肽，以及根据SEQ ID NO：1或其衍生物的序列，其中所述多肽除了细胞壁结合结构域包括 没有其他的内溶素域，以及它们的制备方法。 本发明还涉及用于结合，富集，从样品中除去，捕获和/或检测细菌，特别是革兰氏阳性细菌的方法。
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公开(公告)号：US20060172281A1
公开(公告)日：2006-08-03
申请号：US10519259
申请日：2003-06-24
申请人： Michael Schutz , Roman Meyer , Holger Grallert , Stefan Miller
发明人： Michael Schutz , Roman Meyer , Holger Grallert , Stefan Miller
IPC分类号： C12Q1/70
CPC分类号： G01N33/569 , G01N33/566
摘要： The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
摘要翻译： 本发明涉及用噬菌体尾蛋白鉴定内毒素从样品中去除所述内毒素的方法。
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公开(公告)号：US08932580B2
公开(公告)日：2015-01-13
申请号：US12510553
申请日：2009-07-28
申请人： Michael Schutz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
发明人： Michael Schutz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
CPC分类号： C07K14/005 , C12N15/1013 , C12N2795/10222 , Y10S436/802 , Y10T436/10
摘要： The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
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公开(公告)号：US08609348B2
公开(公告)日：2013-12-17
申请号：US13002465
申请日：2009-07-03
申请人： Manfred Biebl , Renate Grassl , Monika Walter , Stefan Miller
发明人： Manfred Biebl , Renate Grassl , Monika Walter , Stefan Miller
CPC分类号： C07K14/005 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C12N2700/00 , C12N2795/10322 , G01N33/56911 , G01N2333/005
摘要： Bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, but lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides, are described, as well as nucleic acid molecules encoding the proteins. In addition, methods for generating the bacteriophage adhesion proteins and their use in detection, purification and enrichment of bacteria are described.
摘要翻译： 描述了与革兰氏阴性细菌的O-抗原结合但是缺乏结合噬菌体和水解脂多糖的能力的噬菌体粘附蛋白以及编码蛋白质的核酸分子。 此外，描述了用于产生噬菌体粘附蛋白的方法及其在细菌的检测，纯化和富集中的用途。
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公开(公告)号：US20100028857A1
公开(公告)日：2010-02-04
申请号：US12510540
申请日：2009-07-28
申请人： Michael Schütz , Roman Meyer , Holger Grallert , Stefan Miller
发明人： Michael Schütz , Roman Meyer , Holger Grallert , Stefan Miller
CPC分类号： G01N33/569 , G01N33/566
摘要： The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
摘要翻译： 本发明涉及用噬菌体尾蛋白鉴定内毒素从样品中去除所述内毒素的方法。
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公开(公告)号：US20070233728A1
公开(公告)日：2007-10-04
申请号：US11396252
申请日：2006-03-30
申请人： Joachim Puteick , Martin Rogge , Hendrik Geipel , Andrea Pluemper , Andreas Huppert , Kai-Uwe Pielka , Ashwin Yeddula , Matthias Schmitt , Toralf Grossmann , Andreas Neumann , Bare Said , Stefan Miller , Michael Neumann , Florian Rehfeld , Ingo Bruss , Horst Schaude , Michael Bauer , Andreas Morsch , Silke Storch , Klaus Bahr , Bernd Schmitt , Michael Meyringer , Dirk Henrich
发明人： Joachim Puteick , Martin Rogge , Hendrik Geipel , Andrea Pluemper , Andreas Huppert , Kai-Uwe Pielka , Ashwin Yeddula , Matthias Schmitt , Toralf Grossmann , Andreas Neumann , Bare Said , Stefan Miller , Michael Neumann , Florian Rehfeld , Ingo Bruss , Horst Schaude , Michael Bauer , Andreas Morsch , Silke Storch , Klaus Bahr , Bernd Schmitt , Michael Meyringer , Dirk Henrich
IPC分类号： G06F7/00
CPC分类号： G06Q10/06
摘要： Methods and apparatus, including systems and computer program products, for a services architecture design that provides enterprise services having foundation layer functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described.
摘要翻译： 用于服务架构设计的方法和装置，包括系统和计算机程序产品，其提供在企业应用级别具有基础层功能的企业服务。 该设计包括一组服务操作，过程组件和可选的部署单元。 还描述了合适的业务对象。
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公开(公告)号：US09534223B2
公开(公告)日：2017-01-03
申请号：US13643900
申请日：2011-04-27
申请人： Stefan Miller
发明人： Stefan Miller
CPC分类号： A61K38/47 , A01N37/46 , A61K45/06 , C12N9/2462 , C12N9/52 , C12N15/62 , C12Y302/01017 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to methods of eliminating, reducing or preventing bacterial biofilms by means of a fusion protein comprising an endolysin, an autolysin or a bacteriocin to which a peptide with membrane or LPS disrupting activity is fused. Further, the present invention relates to fusion proteins for use as a medicament, in particular for the treatment or prevention of Gram-negative and/or Gram-positive bacterial infections associated with bacterial biofilm, as diagnostic means, disinfectant or as cosmetic substance. The present invention also relates to the removal or reduction or prevention of Gram-negative and/or Gram-positive bacterial contamination associated with bacterial biofilm of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to the use of said fusion protein as a diagnostic means in medicinal, food or feed or environmental diagnostic associated with bacterial biofilm.
摘要翻译： 本发明涉及通过融合蛋白消除，减少或预防细菌生物膜的方法，所述融合蛋白包含溶解有膜或LPS破坏活性的肽的细胞内溶素，自溶蛋白或细菌素。 此外，本发明涉及用作药物的融合蛋白，特别是用于治疗或预防与细菌生物膜相关的革兰氏阴性和/或革兰氏阳性细菌感染，作为诊断手段，消毒剂或化妆品物质。 本发明还涉及与食品的细菌生物膜，食品加工设备，食品加工设备，与食品接触的表面的革兰氏阴性和/或革兰氏阳性细菌污染的去除或减少或预防， 医疗设备，医院和手术中的表面。 此外，本发明涉及所述融合蛋白作为与细菌生物膜相关的医药，食品或饲料或环境诊断中的诊断方法的用途。
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公开(公告)号：US08438119B2
公开(公告)日：2013-05-07
申请号：US11396252
申请日：2006-03-30
申请人： Joachim Puteick , Martin Rogge , Hendrik Geipel , Andrea Pluemper , Andreas Huppert , Kai-Uwe Pielka , Ashwin Reddy Yeddula , Matthias Schmitt , Toralf Grossmann , Andreas Neumann , Bare Said , Stefan Miller , Michael Neumann , Florian Rehfeld , Ingo Bruss , Horst Schaude , Michael Bauer , Andreas Morsch , Silke Storch , Klaus Bahr , Bernd Schmitt , Michael Meyringer , Dirk Henrich
发明人： Joachim Puteick , Martin Rogge , Hendrik Geipel , Andrea Pluemper , Andreas Huppert , Kai-Uwe Pielka , Ashwin Reddy Yeddula , Matthias Schmitt , Toralf Grossmann , Andreas Neumann , Bare Said , Stefan Miller , Michael Neumann , Florian Rehfeld , Ingo Bruss , Horst Schaude , Michael Bauer , Andreas Morsch , Silke Storch , Klaus Bahr , Bernd Schmitt , Michael Meyringer , Dirk Henrich
CPC分类号： G06Q10/06
摘要： Methods and apparatus, including systems and computer program products, for a services architecture design that provides enterprise services having foundation layer functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described.
摘要翻译： 用于服务架构设计的方法和装置，包括系统和计算机程序产品，其提供在企业应用级别具有基础层功能的企业服务。 该设计包括一组服务操作，过程组件和可选的部署单元。 还描述了合适的业务对象。
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公开(公告)号：US08329393B2
公开(公告)日：2012-12-11
申请号：US13181199
申请日：2011-07-12
申请人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Grallert
发明人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Grallert
IPC分类号： C12Q1/70 , G01N33/53 , C07K14/005 , C07K17/00
CPC分类号： G01N33/566 , B01D15/08 , C07K1/13 , C07K1/22 , C07K14/005 , C12N7/00 , C12N2795/00022 , C12N2795/00031 , G01N30/00 , G01N33/56911 , G01N33/92 , G01N2333/005 , G01N2400/50
摘要： The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
摘要翻译： 本发明涉及在没有二价阳离子，特别是Ca 2+或Mg 2+的情况下能够结合内毒素的噬菌体尾蛋白及其衍生物和片段。 此外，本发明涉及使用根据本发明的噬菌体尾蛋白从溶液和样品中消耗内毒素的方法以及内毒素的检测方法。
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