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1.发明授权Method for making devices having intermetallic structures and intermetallic devices made thereby 失效制造具有金属间结构和金属间化合物的装置的方法公开(公告)号：US06672502B1
公开(公告)日：2004-01-06
申请号：US09996621
申请日：2001-11-28
IPC分类号： B21D3900
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00835 , B01J2219/0086 , B01J2219/00871 , B01J2219/00873 , B32B15/01 , B32B15/017 , B32B37/00 , B32B37/12 , B32B38/162 , B32B2311/22 , B32B2311/24 , C23C26/00 , Y10S29/904 , Y10T29/303
摘要： A method and system for making a monolithic intermetallic structure are presented. The structure is made from lamina blanks which comprise multiple layers of metals which are patternable, or intermetallic lamina blanks that are patternable. Lamina blanks are patterned, stacked and registered, and processed to form a monolithic intermetallic structure. The advantages of a patterned monolithic intermetallic structure include physical characteristics such as melting temperature, thermal conductivity, and corrosion resistance. Applications are broad, and include among others, use as a microreactor, heat recycling device, and apparatus for producing superheated steam. Monolithic intermetallic structures may contain one or more catalysts within the internal features.
摘要翻译： 提出了一种制造单片金属间结构的方法和系统。 该结构由包括可图案化的多层金属的层状坯料或可图案化的金属间片状坯料制成。 将层状空白图案化，堆叠并记录，并进行加工以形成整体的金属间结构。 图案化整体金属间结构的优点包括熔融温度，导热性和耐腐蚀性等物理特性。 应用广泛，其中包括用作微反应器，热回收装置和用于生产过热蒸汽的设备。 单片金属间化合物可能在内部特征内含有一种或多种催化剂。
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公开(公告)号：US08128822B2
公开(公告)日：2012-03-06
申请号：US11576804
申请日：2005-10-06
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention is related to hemodialysis, and more particularly, to a dialyser with improved efficiency of mass transfer across a dialysis membrane utilizing microchannel separation provided in accordance with embodiments of the present invention. In accordance with an embodiment, a dialyzer is provided comprising a plurality of semipermeable membrane sheets and a plurality of flow separators. The membrane sheets and flow are arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannel layers. Each microchannel layer comprises a plurality of first microchannels and a plurality of second microchannels. The first and second microchannels of each microchannel layer are in fluid communication with each other via one of the plurality of membrane sheets therebetween. The MECS dialyzer is characterized as having a high surface to volume ratio and a high mass transfer coefficient.
摘要翻译： 本发明涉及血液透析，更具体地说，涉及使用根据本发明的实施方案提供的利用微通道分离的透析膜的传质效率提高的透析器。 根据一个实施例，提供一种透析器，其包括多个半透膜和多个分流器。 膜片和流动被布置成交替配置并且耦合到限定多个平行微通道层的薄片叠层中。 每个微通道层包括多个第一微通道和多个第二微通道。 每个微通道层的第一和第二微通道之间通过多个膜片之一彼此流体连通。 MECS透析器的特征在于具有高的表面与体积比和高的传质系数。
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3.发明申请公开(公告)号：US20120074062A1
公开(公告)日：2012-03-29
申请号：US13292903
申请日：2011-11-09
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.
摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成的装置。 这种装置通常包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，这些装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微量加热器等连接。根据本发明制造的装置的实例包括氧合器，透析器，微热交换器等。
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4.发明申请Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法公开(公告)号：US20110253629A1
公开(公告)日：2011-10-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成装置的装置。 通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。 例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。 还公开了包含复合膜的透析器。 为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。 该方法首先形成纳米晶体纤维素的水性分散体。 然后形成包含水分散体和沸点高于水的有机液体的混合物。 然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。
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公开(公告)号：US06793831B1
公开(公告)日：2004-09-21
申请号：US09369679
申请日：1999-08-05
IPC分类号： C25F700
CPC分类号： B23K20/023 , Y10T29/30 , Y10T29/46 , Y10T156/1043 , Y10T156/1057 , Y10T156/12
摘要： A method for fabricating devices in a pre-assembled state comprising forming plural laminae, registering the laminae, and bonding the laminae one to another is described. The plural laminae contain the substructures and structures of the device. The substructures are coupled to structures and other substructures by fixture bridges in the pre-assembled state. The substructures of the device are dissociated by eliminating the fixture bridges. The plural laminae are registered and bonded to form the device either before or after the fixture bridges are eliminated. The fixture bridges can be eliminated in a variety of ways, including vaporization by electrical current, chemical dissolution, or thermochemical dissociation. One method to selectively bond the laminae together is by microprojection welding. Microprojection welding comprises forming laminae with projections that extend from at least one planar surface of the lamina. Bonding together of laminae at selected regions is accomplished by placing the laminae between electrodes and passing a current through the electrodes. The laminae are bonded together selectively at the sites of the projections. Another method for bonding lamina involve diffusion soldering at reduced bonding pressures and temperatures to minimize flow restriction within or to features.
摘要翻译： 描述了一种用于在预组装状态下制造器件的方法，包括形成多个层，对齐层，以及将层彼此粘合。 复数层包含设备的子结构和结构。 子结构通过预组装状态下的夹具桥耦合到结构和其他子结构。 通过消除夹具桥离解器件的子结构。 在夹具桥被消除之前或之后，将多个薄片进行登记和粘结以形成该装置。 夹具桥可以以各种方式消除，包括通过电流蒸发，化学溶解或热化学解离。 通过微喷射焊接选择性地将薄片粘合在一起的一种方法。 微投射焊接包括用从板的至少一个平坦表面延伸的突起形成薄片。 通过将薄片放置在电极之间并使电流通过电极来实现在选定区域处粘合在一起的薄片。 薄片在突出部位选择性地结合在一起。 粘合薄层的另一种方法涉及在降低的粘合压力和温度下的扩散焊接，以最小化在特征内或对特征的流动限制。
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公开(公告)号：US08419945B2
公开(公告)日：2013-04-16
申请号：US13412597
申请日：2012-03-05
CPC分类号： A61M1/16 , A61M2205/0244 , B01D61/28 , B01D63/081 , B01D63/082 , B01D2313/08 , B01D2313/14
摘要： The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.
摘要翻译： 本发明提供了通过血液透析清洗血液的方法和装置，该方法和装置通过膜扩散到透析液中。 这种透析器还可以通过对流过程从血液中除去溶质，其中流体和溶解的溶质通过膜离开血液。 在根据本发明的一个实施方案中，MECS透析器通过多个微通道使用透析液和血液之间的逆流。 所述透析器包括在微通道片之间交错以形成多个流动通道的多个平坦的半透膜。 膜和微通道片的堆叠被对准和固结以形成MECS透析器。 MECS透析器充当具有端口和头部的流量歧管，用于收集血液和透析液，并将其引导到微通道和从微通道引导。
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7.发明授权Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法公开(公告)号：US08137554B2
公开(公告)日：2012-03-20
申请号：US13068037
申请日：2011-04-29
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.
摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成装置的装置。 通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。 例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。 还公开了包含复合膜的透析器。 为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。 该方法首先形成纳米晶体纤维素的水性分散体。 然后形成包含水分散体和沸点高于水的有机液体的混合物。 然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。
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公开(公告)号：US06913877B1
公开(公告)日：2005-07-05
申请号：US10024654
申请日：2001-12-17
申请人： Frank W. R. Chaplen , William H. Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Kevin Paul , Thomas K. Plant , Janine E. Trempy , Corwin Willard
发明人： Frank W. R. Chaplen , William H. Gerwick , Goran Jovanovic , Wojtek Kolodziej , Jim Liburdy , Phil McFadden , Brian Kevin Paul , Thomas K. Plant , Janine E. Trempy , Corwin Willard
CPC分类号： G01N33/542 , C12Q1/04
摘要： Methods of detecting bioactive compounds include exposing compounds to one or more classes of chromatophores and measuring or sensing associated changes in one or more of the chromatophores. Representative methods permit identification and quantification of neurotransmitters, toxins, hormones, and chemical warfare agents with or without prior knowledge of the content of a sample. In some examples, chromatophores based on Betta fish are used. Cytosensor apparatus using such chromatophores include means for exposing chromatophores to a sample and optical detection systems for assessing changes in chromatophore optical properties. Compounds can be identified or quantified based on a red-green-blue or hue saturation-value representations of transmitted or reflected light or based on other characterizations of transmitted or reflected light.
摘要翻译： 检测生物活性化合物的方法包括将化合物暴露于一类或多种色素，并测量或检测一种或多种色素中的相关变化。 代表性的方法允许在有或没有样品内容的知识的情况下鉴定和定量神经递质，毒素，激素和化学战剂。 在一些实例中，使用基于Betta鱼的色素。 使用这种色素的细胞传感器装置包括用于将染色体暴露于样品的装置和用于评估染色质光学性质变化的光学检测系统。 可以基于透射或反射光的红 - 绿 - 蓝或色相饱和度值表示或基于透射或反射光的其它表征来鉴定或量化化合物。
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公开(公告)号：US20120298037A1
公开(公告)日：2012-11-29
申请号：US13489118
申请日：2012-06-05
IPC分类号： B05C11/00
CPC分类号： C07D255/02 , B01F5/0475 , B01F5/0641 , B01F5/0646 , B01F5/0647 , B01F13/0062 , B01F13/0066 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00914 , B01J2219/00916 , B01J2219/00972 , B01L3/502707 , B01L2200/0631 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/0655 , C08L101/005 , G01N27/44791 , G01N30/0005 , G01N30/6095
摘要： Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.
摘要翻译： 公开了用于化学合成和/或分析的装置，系统和方法的实施例。 公开的装置的一个实施例包括限定反应器和分离器的层压的微流体结构。 这种装置或其部分通常具有约1微米至约100微米的尺寸。 为了实现合成方法，所公开的设备的实施例通常包括至少一个单元操作，例如混合器，阀，分离器，检测器及其组合。 单个装置可以串联耦合并联，以形成用于制备化合物的系统。 单独的设备或系统也可以与已知的设备和过程组合使用。
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10.发明授权Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use 有权微流体装置，特别是包括聚合物膜的过滤装置及其制造和使用的方法公开(公告)号：US07955504B1
公开(公告)日：2011-06-07
申请号：US11243937
申请日：2005-10-04
申请人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
发明人： Goran Jovanovic , Sundar V. Atre , Brian Kevin Paul , John Simonsen , Vincent Thomas Remcho , Chih-Hung Chang
CPC分类号： B01D61/18 , A61M1/16 , A61M1/1698 , A61M1/3472 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , B01D63/08 , B01D63/088 , B01D71/10 , B01D71/68 , B01D2313/21 , B01D2313/38
摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed.
摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成装置的装置。 通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 必须开发特定的材料以用于本文公开的装置的某些实施例。 例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。 还公开了包含复合膜的透析器。
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