公开(公告)号：US08304213B2

公开(公告)日：2012-11-06

申请号：US12639045

申请日：2009-12-16

Applicant: Bruce A. Diner ,  Janine Fan

Inventor： Bruce A. Diner ,  Janine Fan

IPC: C12P19/00 ,  C12P7/40 ,  C12P7/18 ,  C12P7/16 ,  C12P7/06 ,  C07H1/08

CPC classification number: C13K1/02 ,  C08H6/00 ,  C08H8/00 ,  C12P2201/00 ,  D21C11/0007 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343

Abstract: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of one of more sulfide (hydrosulfide) salt and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the production of target chemicals by fermentation.

Abstract translation: 在碱性条件下，在一种更多的硫化物（氢硫化物）盐和任选的一种或多种另外的亲核试剂存在下，使用有机溶剂溶液预处理生物质，以将木质素分解和提取。 预处理的生物质被糖化酶联合体进一步水解。 通过糖化释放的发酵糖可用于通过发酵生产目标化学品。

公开(公告)号：US08278070B2

公开(公告)日：2012-10-02

申请号：US12639038

申请日：2009-12-16

Applicant: Bruce A. Diner ,  Janine Fan

Inventor： Bruce A. Diner ,  Janine Fan

IPC: C12P19/00 ,  C12P7/40 ,  C12P7/02 ,  C12P13/04 ,  C12P7/06 ,  C12P7/08 ,  C07H1/08

CPC classification number: C13K1/02 ,  C08H8/00 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  D21C11/0007 ,  Y02E50/16 ,  Y02E50/17

Abstract: Biomass is pretreated using an organic solvent solution, under alkaline conditions, in the presence of one or more organo-mercaptan and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the production of target chemicals by fermentation.

Abstract translation: 在碱性条件下，在一种或多种有机硫醇和任选的一种或多种另外的亲核试剂的存在下，使用有机溶剂溶液对生物质进行预处理以分离和提取木质素。 预处理的生物质被糖化酶联合体进一步水解。 通过糖化释放的发酵糖可用于通过发酵生产目标化学品。

公开(公告)号：US08241880B2

公开(公告)日：2012-08-14

申请号：US12639033

申请日：2009-12-16

Applicant: Bruce A. Diner ,  Janine Fan

Inventor： Bruce A. Diner ,  Janine Fan

IPC: C12P7/06 ,  C12P19/00 ,  C12P7/16 ,  C12P7/18 ,  C12P7/64 ,  C07H1/08

CPC classification number: D21C3/003 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  C13K1/02 ,  D21C3/006 ,  D21C3/20 ,  Y02E50/16 ,  Y02E50/17

Abstract: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of one or more alkylamine and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the production of target chemicals by fermentation.

Abstract translation: 在碱性条件下，在一种或多种烷基胺和任选的一种或多种另外的亲核试剂存在下，使用有机溶剂溶液对生物质进行预处理以分离和提取木质素。 预处理的生物质被糖化酶联合体进一步水解。 通过糖化释放的发酵糖可用于通过发酵生产目标化学品。

公开(公告)号：US08216809B2

公开(公告)日：2012-07-10

申请号：US12639050

申请日：2009-12-16

Applicant: Bruce A. Diner ,  Paul Joseph Fagan ,  Janine Fan

Inventor： Bruce A. Diner ,  Paul Joseph Fagan ,  Janine Fan

IPC: C12P19/00 ,  C12P7/40 ,  C12P7/02 ,  C12P13/04 ,  C12P7/06 ,  C12P7/08 ,  C07H1/08

CPC classification number: C12P7/10 ,  C08H8/00 ,  C10G2300/1014 ,  C10G2300/202 ,  C10G2300/44 ,  C10G2300/805 ,  C10L1/02 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  D21C3/02 ,  D21C3/20 ,  D21C5/00 ,  D21C11/0007 ,  Y02E50/16 ,  Y02E50/17 ,  Y02P30/20

Abstract: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of elemental sulfur and optionally one or more alkylamine and/or one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the production of target chemicals by fermentation.

Abstract translation: 在碱性条件下，在元素硫和任选的一种或多种烷基胺和/或一种或多种另外的亲核试剂的存在下，使用有机溶剂溶液预处理生物质，以片段和提取木质素。 预处理的生物质被糖化酶联合体进一步水解。 通过糖化释放的发酵糖可用于通过发酵生产目标化学品。

公开(公告)号：US07429371B2

公开(公告)日：2008-09-30

申请号：US11069604

申请日：2005-03-01

Applicant: Bruce A. Diner ,  Ming Zheng

Inventor： Bruce A. Diner ,  Ming Zheng

IPC: B82B1/00 ,  H01M4/96 ,  G01N27/26 ,  C25B11/02 ,  C25B11/04 ,  C25B11/06 ,  C25B11/12

CPC classification number: D01F11/10 ,  B82Y10/00 ,  D01F11/12 ,  D01F11/14 ,  D01F11/16 ,  H01G9/2031 ,  H01L51/0048 ,  H01L51/0052 ,  H01L51/4226 ,  H01M8/20 ,  H01M14/005 ,  Y02E10/542 ,  Y02E10/549 ,  Y02E60/528 ,  Y10S977/704 ,  Y10S977/742 ,  Y10S977/745 ,  Y10S977/746 ,  Y10S977/842 ,  Y10S977/847 ,  Y10S977/895 ,  Y10S977/902 ,  Y10S977/948

Abstract: Carbon nanotubes have been reversibly and readily oxidized and reduced with common chemicals in solution, thereby allowing the nanotubes to be used as catalysts for chemical reactions and as stable charge storage devices.

Abstract translation: 碳纳米管已被可逆地容易地用溶液中的普通化学物质氧化和还原，从而允许纳米管用作化学反应的催化剂和稳定的电荷存储装置。

公开(公告)号：US20140094630A1

公开(公告)日：2014-04-03

申请号：US14032328

申请日：2013-09-20

Applicant: DOUGLAS ROBERT ANTON ,  BRUCE A. DINER ,  STEVEN D. DOIG

Inventor： DOUGLAS ROBERT ANTON ,  BRUCE A. DINER ,  STEVEN D. DOIG

IPC: C07C29/86

CPC classification number: C07C29/86 ,  C12P7/04 ,  C12P7/16 ,  C12P21/06 ,  Y02E50/10

Abstract: Provided herein are processes comprising providing a fermentation medium comprising a fermentable carbon source, a recombinant microorganism comprising an engineered butanol biosynthetic pathway, and butanol; contacting said fermentation medium with an extractant composition comprising an effective amount of antioxidant or antioxidant-like compound, whereby at least a portion of the butanol in the fermentation medium partitions into the extractant; recovering at least a portion of the butanol and extractant composition from the fermentation medium; recycling the extractant composition recovered in (c) one or more times in the fermentation medium; optionally adjusting the effective amount of antioxidant or antioxidant-like compound in the extractant composition, whereby the rate of oxidation or effect of oxidized products in the recycled extractant composition is substantially reduced and/or avoided such that the extractant composition may be recycled.

Abstract translation: 本文提供的方法包括提供包含可发酵碳源的发酵培养基，包含工程丁醇生物合成途径的重组微生物和丁醇; 使所述发酵培养基与包含有效量的抗氧化剂或抗氧化剂样化合物的提取剂组合物接触，由此发酵培养基中的至少一部分丁醇分配到提取剂中; 从发酵培养基中回收至少一部分丁醇和提取剂组合物; 在（c）中回收的萃取剂组合物在发酵培养基中回收一次或多次; 任选地调节萃取剂组合物中抗氧化剂或抗氧化剂样化合物的有效量，从而大大降低和/或避免了再循环的萃取剂组合物中的氧化产物的氧化速率或氧化产物的影响，从而可以回收萃取剂组合物。

公开(公告)号：US08651403B2

公开(公告)日：2014-02-18

申请号：US13185572

申请日：2011-07-19

Applicant: Carl E. Camp ,  Jelena Cirakovic ,  Bruce A. Diner ,  Janine Fan

Inventor： Carl E. Camp ,  Jelena Cirakovic ,  Bruce A. Diner ,  Janine Fan

IPC: B02C25/00

CPC classification number: C12P19/00 ,  C08H8/00 ,  C12P7/10 ,  C12P2201/00 ,  D21C3/02 ,  D21C5/00 ,  Y02E50/16 ,  Y02E50/17

Abstract: Mechanical milling of biomass as a pretreatment to render the biomass readily saccharifiable requires high energy input. Preceding mechanical milling by treatment with anhydrous ammonia was found to greatly reduce the energy requirement for fine milling, providing a more economical pretreatment process for commercial use.

Abstract translation: 机械研磨生物质作为预处理以使生物质易于糖化需要高能量输入。 发现用无水氨处理前机械研磨大大降低了精细研磨的能量需求，为商业用途提供了更经济的预处理工艺。

公开(公告)号：US20120264173A1

公开(公告)日：2012-10-18

申请号：US13539555

申请日：2012-07-02

Applicant: BRUCE A. DINER ,  Janine Fan

Inventor： BRUCE A. DINER ,  Janine Fan

IPC: C12P19/00 ,  C12P13/04 ,  C12P7/02

CPC classification number: D21C3/003 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  C13K1/02 ,  D21C3/006 ,  D21C3/20 ,  Y02E50/16 ,  Y02E50/17

Abstract: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of one or more alkylamine and optionally one or more additional nucleophile to fragment and extract lignin. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the production of target chemicals by fermentation.

Abstract translation: 在碱性条件下，在一种或多种烷基胺和任选的一种或多种另外的亲核试剂存在下，使用有机溶剂溶液对生物质进行预处理以分离和提取木质素。 预处理的生物质被糖化酶联合体进一步水解。 通过糖化释放的发酵糖可用于通过发酵生产目标化学品。

公开(公告)号：US08241873B2

公开(公告)日：2012-08-14

申请号：US12639059

申请日：2009-12-16

Applicant: Bruce A. Diner ,  Janine Fan

Inventor： Bruce A. Diner ,  Janine Fan

IPC: C07H1/08 ,  C12P19/00 ,  C12P7/06 ,  C12P7/18

CPC classification number: C12P19/14 ,  C08H8/00 ,  C10G2300/1011 ,  C10G2300/1014 ,  C10G2300/44 ,  C10G2300/805 ,  C10L1/02 ,  C12P7/10 ,  C12P7/16 ,  C12P7/18 ,  C12P19/02 ,  C12P2201/00 ,  C13K1/02 ,  D21C3/024 ,  D21C3/20 ,  D21C11/0007 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343 ,  Y02P30/20

Abstract: Biomass is pretreated using an organic solvent solution under alkaline conditions in the presence of ammonia and optionally an additional nucleophile to fragment and extract lignin without loss of hemicellulose. Pretreated biomass is further hydrolyzed with a saccharification enzyme consortium. Fermentable sugars released by saccharification may be utilized for the production of target chemicals by fermentation.

Abstract translation: 在碱性条件下，在氨和任选另外的亲核试剂存在下，使用有机溶剂溶液对生物质进行预处理，将木质素分解并提取而不损失半纤维素。 预处理的生物质被糖化酶联合体进一步水解。 通过糖化释放的发酵糖可用于通过发酵生产目标化学品。

公开(公告)号：US20100256307A1

公开(公告)日：2010-10-07

申请号：US11951350

申请日：2007-12-06

Applicant: Bruce A. Diner ,  Lech Wilczek

Inventor： Bruce A. Diner ,  Lech Wilczek

IPC: C08F120/06

CPC classification number: B82Y40/00 ,  B82Y30/00 ,  C01B32/174 ,  C01B2202/02 ,  C08F2438/00 ,  Y10S977/748 ,  Y10S977/75 ,  Y10S977/847

Abstract: Novel multiblock polymers are prepared and used to disperse carbon nanotubes in solution.

Abstract translation: 制备新型多嵌段聚合物并用于将碳纳米管分散在溶液中。