公开(公告)号：US20080069904A1

公开(公告)日：2008-03-20

申请号：US11827487

申请日：2007-07-11

申请人： Bryan Oronsky ,  John Sliwa ,  Herbert Berman ,  Carol Tosaya ,  Neil Oronsky ,  Robin Martin

发明人： Bryan Oronsky ,  John Sliwa ,  Herbert Berman ,  Carol Tosaya ,  Neil Oronsky ,  Robin Martin

IPC分类号： A61K33/04 ,  A61K31/04 ,  A61P35/00

CPC分类号： A61K31/04 ,  A61K33/04 ,  A61K45/06 ,  A61K2300/00

摘要： A method is provided for treating cancer in a mammalian subject by inhibiting angiogenesis through the administration to the subject of a therapeutically effective amount of a nitrate-containing compound and a therapeutically effective amount of an inorganic selenium-containing compound. Kits and systems are also disclosed for practicing the subject methods.

摘要翻译： 提供了一种通过向受检者施用治疗有效量的含硝酸盐化合物和治疗有效量的无机硒化合物来抑制血管发生来治疗哺乳动物受试者中的癌症的方法。 还披露了用于实践主题方法的套件和系统。

公开(公告)号：US20070293792A1

公开(公告)日：2007-12-20

申请号：US11818685

申请日：2007-06-15

申请人： John Sliwa ,  Bryan Oronsky

发明人： John Sliwa ,  Bryan Oronsky

IPC分类号： A61B5/103

CPC分类号： A61B5/11 ,  A61B5/0051 ,  A61B5/4381 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6847 ,  A61B2562/0247 ,  A61B2562/046

摘要： Prostate probe systems are disclosed for assessing one or both of BPH or prostate cancer. The prostate probe systems comprise either a force or pressure sensor mounted on or in a rectally insertable probe or a temperature sensor mounted on or in a rectally insertable probe, or both. Also disclosed are probe systems for evaluating a condition of a prostate gland. Finally, force or hardness mapping devices are disclosed for palpation-examination of patient anatomical tissues for abnormalities or assessing states of firmness.

摘要翻译： 公开前列腺探针系统用于评估BPH或前列腺癌中的一种或两种。 前列腺探针系统包括安装在直肠可插入探针上的或安装在直肠可插入探针上或其中的两个或两者的直接插入探针或温度传感器中的力或压力传感器。 还公开了用于评估前列腺状况的探针系统。 最后，公开了力或硬度测绘装置，用于对患者解剖组织进行触诊检查以用于异常或评估硬度状态。

公开(公告)号：US20070224169A1

公开(公告)日：2007-09-27

申请号：US11488945

申请日：2006-07-18

申请人： John Sliwa ,  Carol Tosaya ,  Bryan Oronsky

发明人： John Sliwa ,  Carol Tosaya ,  Bryan Oronsky

IPC分类号： A61K48/00 ,  A61K9/00

CPC分类号： A61K9/06 ,  A61B8/0833 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/3413 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0095 ,  A61K49/226 ,  A61L27/50 ,  A61L27/52 ,  A61N5/02 ,  A61N7/02

摘要： A gel-like material is provided, the gel-like material having an on-demand state-change capability, whether the on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Alternatively, the gel-like material may have a spatially and/or temporally selective state-change, whether on-demand change is to an initial state, a final state or both, at least some of the gel present or delivered undergoing the change. Or, the gel-like material may selectively change state due to gel contacting diseased tissue having a natural thermal or compositional contrast or artificially induced thermal or compositional contrast capable of causing state-change via a state-change parameter, independent of an on-demand nature or a spatial/temporal selective nature.

摘要翻译： 提供凝胶状材料，凝胶状材料具有按需状态变化能力，是否按需改变是初始状态，最终状态或两者，存在或递送的至少一些凝胶 正在经历变化。 或者，凝胶状材料可以具有空间和/或时间选择性状态变化，无论按需改变是初始状态，最终状态还是两者，存在或递送的至少一些凝胶发生变化。 或者，凝胶状材料可以选择性地改变状态，因为凝胶接触具有自然热或组成对比度或人为诱导的热或组成对比度的患病组织，其能够经由状态变化参数引起状态变化，而不依赖于按需 自然或空间/时间选择性。

公开(公告)号：US20060283477A1

公开(公告)日：2006-12-21

申请号：US11155403

申请日：2005-06-16

申请人： Bryan Oronsky ,  Neil Oronsky ,  Denise Oakes-Lottridge ,  Andrew Oakes-Lottridge

发明人： Bryan Oronsky ,  Neil Oronsky ,  Denise Oakes-Lottridge ,  Andrew Oakes-Lottridge

IPC分类号： A61C15/00

CPC分类号： A61C15/041

摘要： The invention features interdental hygiene articles, as well as dispensers for use in conjunction with such and methods of use to promote good oral hygiene practices. In particular the invention is directed to interdental hygiene articles such as flosses, tapes, ribbons, and/or the like, wherein the interdental hygiene articles includes one or more graphics on one ore more sides of the article. The graphic demarcates a recommended length of the article to be used in a single use procedure, and can be provided so as to promote use of the article over different regions of the length used.

摘要翻译： 本发明的特征是牙间卫生用品以及用于与促进良好口腔卫生习惯的这些和使用方法一起使用的分配器。 特别地，本发明涉及牙间卫生用品，例如牙线，带子，带子等，其中所述牙间卫生制品在所述制品的一个更多侧上包括一个或多个图形。 该图形划分了在单次使用程序中使用的制品的推荐长度，并且可以提供以促进在所使用长度的不同区域上使用制品。

公开(公告)号：US20070125677A1

公开(公告)日：2007-06-07

申请号：US11296650

申请日：2005-12-06

申请人： Neil Oronsky ,  Bryan Oronsky ,  Rajan Kumar

发明人： Neil Oronsky ,  Bryan Oronsky ,  Rajan Kumar

IPC分类号： B65D85/20 ,  B65D81/38 ,  B65D25/54

CPC分类号： B01L9/06 ,  B01L3/5082 ,  B01L2200/147 ,  B01L2300/0854 ,  B01L2300/1883

摘要： The invention features a thermal and/or light-protective container assembly that includes a flexible outer and inner layer, as well as a thermoregulatory material disposed between said outer and inner layers. In general, the invention is directed to a thermal and/or light-protective container assembly, such as a form-fitting sleeve, that includes a flexible layered wall having an opened end and a contiguous closed end, wherein the wall defines a centrally located cavity. The wall further includes an outer layer and an inner layer, wherein uniformly disposed between the outer and inner layers is a thermoregulatory material that is configured for insulating an object, and/or for transferring heat or cold to the object, and/or maintaining the temperature of the object disposed within the defined cavity of the sleeve.

摘要翻译： 本发明的特征在于包含柔性外层和内层的热和/或防光容器组件，以及设置在所述外层和内层之间的调温材料。 通常，本发明涉及一种热和/或防光容器组件，例如形状配合套筒，其包括具有开口端和相邻封闭端的柔性分层壁，其中所述壁限定位于中心的位置 腔。 所述壁还包括外层和内层，其中均匀地设置在所述外层和所述内层之间的是配置用于绝缘物体和/或用于将热或冷传递到所述物体的温度调节材料和/或维持 设置在套筒的限定腔内的物体的温度。

公开(公告)号：US20070028941A1

公开(公告)日：2007-02-08

申请号：US11198071

申请日：2005-08-04

申请人： Bryan Oronsky ,  Neil Oronsky

发明人： Bryan Oronsky ,  Neil Oronsky

IPC分类号： A46B11/00 ,  A46B7/02

CPC分类号： A46B5/0041 ,  A46B5/0045 ,  A46B5/005 ,  A46B11/0006 ,  A46B11/0062 ,  A46B15/0071 ,  A46B17/06 ,  A46B2200/1066

摘要： The invention features a dental hygiene article that includes a retractable portion and a chamber portion for use in conjunction with the same, as well as methods of use to promote good oral hygiene practices. In general, the invention is directed to a dental hygiene article, such as a toothbrush, wherein the device includes a retractable proximal portion that contains one or both of a head assembly and a stem portion, a chamber portion that is configured for receiving the retractable proximal portion, and a handle portion, which may be detachable. Accordingly, when the retractable portion is in a retracted configuration the head assembly is encased within the chamber, which may then be filled with an additive, such as a fluid medicament, disinfectant, cleaning solution, or the like, so as to treat the head assembly prior to use.

摘要翻译： 本发明的特征在于一种牙科卫生制品，其包括与其一起使用的可缩回部分和室部分，以及用于促进良好口腔卫生习惯的方法。 通常，本发明涉及一种诸如牙刷的牙齿卫生制品，其中该装置包括可收缩的近端部分，其包含头部组件和杆部分中的一个或两个;室部分，其构造成用于接纳可伸缩的 近端部分和手柄部分，其可以是可拆卸的。 因此，当可缩回部分处于缩回构型时，头部组件被封装在腔室内，然后可以用诸如流体药物，消毒剂，清洁溶液等的添加剂填充，以便治疗头部 组装之前使用。