-
1.发明申请Transgenic Pig in which HO-1 and TNFR1-Fc are Simultaneously Expressed, and Method for Producing Same 有权同时表达HO-1和TNFR1-Fc的转基因猪及其生产方法公开(公告)号：US20120278910A1
公开(公告)日：2012-11-01
申请号：US13520056
申请日：2010-12-21
申请人： Curie Ahn , Byeong Chun Lee , Jong Ik Hwang , Jae Seok Yang , Goo Jang , Bum Rae Cho , Ok Jae Koo , Jung Taek Kang , Dae Kee Kwon
发明人： Curie Ahn , Byeong Chun Lee , Jong Ik Hwang , Jae Seok Yang , Goo Jang , Bum Rae Cho , Ok Jae Koo , Jung Taek Kang , Dae Kee Kwon
IPC分类号： A01K67/027 , C12N5/071
CPC分类号： C07K14/7151 , A01K67/0275 , A01K2207/15 , A01K2217/052 , A01K2217/056 , A01K2217/15 , A01K2227/108 , A01K2267/02 , A01K2267/025 , C07K2319/30 , C12N9/0083 , C12N15/8509 , C12N2710/20051
摘要： The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously expressed. The present invention also relates to a transgenic pig for organ transplantation, which is produced by the method, and in which immune rejection response is inhibited. The present invention also relates to a somatic-cell-donating cell strain for producing the transgenic pig, and to a method for producing organs, from the transgenic pig, in which the immune rejection response is inhibited.
摘要翻译： 本发明涉及抑制免疫排斥反应的转基因猪的制备方法，其中同时表达人HO-1基因和TNFR1-Fe融合基因。 本发明还涉及用于器官移植的转基因猪，其通过该方法产生，并且其中免疫排斥反应被抑制。 本发明还涉及用于产生转基因猪的体细胞供体细胞株以及从其中免疫排斥反应被抑制的转基因猪生产器官的方法。
-
公开(公告)号：US08124832B2
公开(公告)日：2012-02-28
申请号：US11762077
申请日：2007-06-13
申请人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
发明人： Byeong Chun Lee , Sung Keun Kang , Dae Yong Kim , Min Kyu Kim , Goo Jang , Hyun Ju Oh , M. Shamim Hossein , Fibrianto Yuda , Hye Jin Kim , So Gun Hong , Jung Eun Park , Joung Joo Kim
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： C12N15/873 , A01K67/027 , A01K2227/00 , A61D19/04
摘要： Provided is a method for producing a cloned dog by enucleating an oocyte of a dog to produce an enucleated oocyte, transferring a somatic cell of the dog into the enucleated oocyte, carrying out electrofusion under optimized conditions to produce a nuclear transfer embryo, and transferring the nuclear transfer embryo into its surrogate mother.
摘要翻译： 本发明提供了通过将狗的卵母细胞去核以产生去核卵母细胞，将狗的体细胞转移到去核卵母细胞中，在优化条件下进行电融合以产生核转移胚，并转移 核转移胚胎成为其代孕母亲。
-
公开(公告)号：US20050012498A1
公开(公告)日：2005-01-20
申请号：US10791629
申请日：2004-03-03
申请人： Soo-Chan Lee , Young-Kyun Sun , Hyun-Ho Kim , Byeong-Chun Lee , Jun-Ho Lee , Jong-Cheol Lee , Je-Hyoung Ryu , Tae-Gyu Kim , Soon-Kyu Yim
发明人： Soo-Chan Lee , Young-Kyun Sun , Hyun-Ho Kim , Byeong-Chun Lee , Jun-Ho Lee , Jong-Cheol Lee , Je-Hyoung Ryu , Tae-Gyu Kim , Soon-Kyu Yim
CPC分类号： G01R31/2886 , G01R31/2893
摘要： A semiconductor device test apparatus includes a main body and a stacker for stacking devices before and after a test. The stacker includes at least one user tray feeder predesignated with a function for stacking un-tested devices and at least one user tray sender predesignated with a function for stacking tested devices, the user tray functions being interchangeable during stacker operation.
摘要翻译： 半导体器件测试装置包括用于在测试之前和之后堆叠器件的主体和堆叠器。 所述堆垛机包括至少一个用户托盘进料器，所述用户托盘进料器具有用于堆叠未测试的装置的功能，并且至少一个用户托盘发送器预先具有用于堆叠测试的装置的功能，所述用户托盘功能在堆叠器操作期间是可互换的。
-
公开(公告)号：US09357754B2
公开(公告)日：2016-06-07
申请号：US13980846
申请日：2012-01-20
申请人： Curie Ahn , Byeong Chun Lee , Jong Ik Hwang , Jae Seok Yang , Byoung Gon Moon , Goo Jang , Bum Rae Cho , Ok Jae Koo , Sol Ji Park , Jung Taek Kang , Dae Kee Kwon
发明人： Curie Ahn , Byeong Chun Lee , Jong Ik Hwang , Jae Seok Yang , Byoung Gon Moon , Goo Jang , Bum Rae Cho , Ok Jae Koo , Sol Ji Park , Jung Taek Kang , Dae Kee Kwon
IPC分类号： A01K67/027 , C12N15/00 , C12P21/00 , C07K14/705 , C12N15/85 , A61D19/04 , C07K16/18 , C07K14/715 , A61K38/00
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/052 , A01K2227/108 , A01K2267/025 , A61D19/04 , A61K38/00 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K2319/30 , C12N15/8509
摘要： The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-α in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
摘要翻译： 本发明涉及表达sTNFR1-Fc的转基因猪，其中引入编码作为人可溶性肿瘤坏死因子受体（sTNFR1）的细胞外结构域的融合蛋白和免疫球蛋白Fc区的sTNFR1-Fc的基因; 其制备方法; 从转基因猪分离的器官; 插入sTNFR1-Fc基因的体细胞供体细胞系; 制备包含sTNFR1-Fc的血液样品的方法; 以及从转基因猪的血液样品制备人sTNFR1-Fc的方法。 由于转基因猪可以通过分泌抑制血液中TNF-α活性的抑制物质来抑制免疫应答和炎症反应，因此可以有效地用于异种移植。 此外，由于转基因猪具有血型O，所以可以移植以抑制炎性反应，而不管接受者的血型如何。
-
5.发明授权Human embryonic stem cell line prepared by nuclear transfer of a human somatic cell into an enucleated human oocyte 有权人类胚胎干细胞系通过将人体细胞核转移到去核的人类卵母细胞中制备公开(公告)号：US08647872B2
公开(公告)日：2014-02-11
申请号：US13316199
申请日：2011-12-09
申请人： Sung-Il Roh , Woo-Suk Hwang , Byeong-Chun Lee , Sung-Keun Kang , Young-June Ryu , Eu-Gene Lee , Soon-Woong Kim , Dae-Kee Kwon , Hee-Sun Kwon , Ja-Min Koo , Eul-Soon Park , Youn-Young Hwang , Hyun-Soo Yoon , Jong-Hyuk Park , Sun-Jong Kim
发明人： Sung-Il Roh , Woo-Suk Hwang , Byeong-Chun Lee , Sung-Keun Kang , Young-June Ryu , Eu-Gene Lee , Soon-Woong Kim , Dae-Kee Kwon , Hee-Sun Kwon , Ja-Min Koo , Eul-Soon Park , Youn-Young Hwang , Hyun-Soo Yoon , Jong-Hyuk Park , Sun-Jong Kim
CPC分类号： C12N15/87 , C12N5/0606 , C12N5/0619 , C12N5/0623 , C12N15/8776 , C12N2500/25 , C12N2500/38 , C12N2501/115 , C12N2501/13 , C12N2501/235
摘要： An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.
摘要翻译： 通过将人体细胞核转移到去核的人类卵母细胞中制备的来自通过转核的卵母细胞的胚胎干细胞系可以分化成各种所需的细胞类型。
-
公开(公告)号：US20120083032A1
公开(公告)日：2012-04-05
申请号：US13316199
申请日：2011-12-09
申请人： Sung-Il ROH , Woo-Suk HWANG , Byeong-Chun LEE , Sung-Keun KANG , Young-June RYU , Eu-Gene LEE , Soon-Woong KIM , Dae-Kee KWON , Hee-Sun KWON , Ja-Min KOO , Eul-Soon PARK , Youn-Young HWANG , Hyun-Soo YOON , Jong-Hyuk PARK , Sun-Jong KIM
发明人： Sung-Il ROH , Woo-Suk HWANG , Byeong-Chun LEE , Sung-Keun KANG , Young-June RYU , Eu-Gene LEE , Soon-Woong KIM , Dae-Kee KWON , Hee-Sun KWON , Ja-Min KOO , Eul-Soon PARK , Youn-Young HWANG , Hyun-Soo YOON , Jong-Hyuk PARK , Sun-Jong KIM
IPC分类号： C12N5/0735 , C12N5/02
CPC分类号： C12N15/87 , C12N5/0606 , C12N5/0619 , C12N5/0623 , C12N15/8776 , C12N2500/25 , C12N2500/38 , C12N2501/115 , C12N2501/13 , C12N2501/235
摘要： An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.
摘要翻译： 通过将人体细胞核转移到去核的人类卵母细胞中制备的来自通过转核卵母细胞的胚胎干细胞系可以分化成各种所需的细胞类型。
-
7.发明申请Polycarbonate Resin Composition with Improved Transparency and Scratch-Resistance 有权聚碳酸酯树脂组合物具有改善的透明性和耐刮擦性公开(公告)号：US20100152357A1
公开(公告)日：2010-06-17
申请号：US12631018
申请日：2009-12-04
申请人： Kee Hae KWON , Il Jin KIM , Jin Hwa CHUNG , Sang Ki PARK , Ja Kwan KOO , Bok Nam JANG , Jin Hwan CHOI , Tae Uk KIM , Byeong Chun LEE
发明人： Kee Hae KWON , Il Jin KIM , Jin Hwa CHUNG , Sang Ki PARK , Ja Kwan KOO , Bok Nam JANG , Jin Hwan CHOI , Tae Uk KIM , Byeong Chun LEE
CPC分类号： C08L33/08 , C08L31/04 , C08L33/10 , C08L33/24 , C08L35/06 , C08L69/00 , C08L69/005 , C08L2205/02 , C08L2205/03 , C08L2666/18 , C08L2666/02 , C08L2666/04 , C08L33/12
摘要： A polycarbonate resin composition can have improved transparency and scratch resistance of the present invention and comprises about 10 to about 99% by weight of polycarbonate resin (A); and about 1 to about 90% by weight of acrylic copolymer with ultra-low molecular weight and high refractive index (B). The resin composition of the present invention can further comprise acrylic resin (C). The acrylic copolymer with ultra-low molecular weight and high refractive index (B) can have a refractive index of about 1.495 to about 1.590 and a weight average molecular weight of about 3,000 to about 40,000 g/mol.
摘要翻译： 聚碳酸酯树脂组合物可以具有本发明的改善的透明性和耐划伤性，并且包含约10至约99重量％的聚碳酸酯树脂（A）; 和约1至约90重量％的具有超低分子量和高折射率（B）的丙烯酸共聚物。 本发明的树脂组合物还可以包含丙烯酸树脂（C）。 具有超低分子量和高折射率（B）的丙烯酸共聚物可以具有约1.495至约1.590的折射率和约3,000至约40,000g / mol的重均分子量。
-
公开(公告)号：US20070243610A1
公开(公告)日：2007-10-18
申请号：US10584255
申请日：2004-12-30
申请人： Sung-Il Roh , Woo-Suk Hwang , Byeong-Chun Lee , Sung-Keun Kang , Young-June Ryu , Eu-Gene Lee , Soon-Woong Kim , Dae-Kee Kwon , Hee-Sun Kwon , Ja-Min Koo , Eul-Soon Park , Youn-Young Hwang , Hyun-Soo Yoon , Jong-Hyuk Park , Sun-Jong Kim
发明人： Sung-Il Roh , Woo-Suk Hwang , Byeong-Chun Lee , Sung-Keun Kang , Young-June Ryu , Eu-Gene Lee , Soon-Woong Kim , Dae-Kee Kwon , Hee-Sun Kwon , Ja-Min Koo , Eul-Soon Park , Youn-Young Hwang , Hyun-Soo Yoon , Jong-Hyuk Park , Sun-Jong Kim
CPC分类号： C12N15/87 , C12N5/0606 , C12N5/0619 , C12N5/0623 , C12N15/8776 , C12N2500/25 , C12N2500/38 , C12N2501/115 , C12N2501/13 , C12N2501/235
摘要： An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.
摘要翻译： 通过将人体细胞核转移到去核的人类卵母细胞中制备的来自通过转核的卵母细胞的胚胎干细胞系可以分化成各种所需的细胞类型。
-
公开(公告)号：US06590139B1
公开(公告)日：2003-07-08
申请号：US09701839
申请日：2000-12-04
申请人： Byeong-Chun Lee , Tae-Young Shin , Sang-Ho Roh , Jeong-Muk Lim , Jong-Im Park , Jong-Ki Cho , Ki-Yon Kim , Eun-Song Lee , Soo-Jung Shin , Sung-Ki Kim , Kil-Young Song , Woo-Suk Hwang
发明人： Byeong-Chun Lee , Tae-Young Shin , Sang-Ho Roh , Jeong-Muk Lim , Jong-Im Park , Jong-Ki Cho , Ki-Yon Kim , Eun-Song Lee , Soo-Jung Shin , Sung-Ki Kim , Kil-Young Song , Woo-Suk Hwang
IPC分类号： C12N1500
CPC分类号： C12N15/873 , C12N5/0603
摘要： The present invention provides a method for producing cloned cows by employing in vitro maturation of oocytes and nuclear transfer techniques. The method comprises collecting donor somatic cell lines from cows; maturing oocytes extracted from an ovary in vitro; enucleating the oocyte by cutting a portion of the zona pellucida and squeezing out a portion of the cytoplasm, including the first polar body; inserting the donor somatic cell into the oocyte; electrofusing the cells to produce embryos; post-activating the embryos; transferring them into surrogate cows to produce cloned calves.
摘要翻译： 本发明提供了通过使用卵母细胞的体外成熟和核转移技术来生产克隆的牛的方法。 该方法包括从母牛收集供体体细胞系; 成熟卵母细胞从体外提取卵巢; 通过切割透明带的一部分并挤出包括第一极体的细胞质的一部分来摘除卵母细胞; 将供体体细胞插入卵母细胞; 电解细胞产生胚胎; 激活胚胎; 将它们转移到替代奶牛中以产生克隆的小牛。
-
10.发明授权Polycarbonate resin composition with improved transparency and scratch-resistance 有权聚碳酸酯树脂组合物具有改善的透明度和耐擦伤性公开(公告)号：US08940836B2
公开(公告)日：2015-01-27
申请号：US12631018
申请日：2009-12-04
申请人： Kee Hae Kwon , Il Jin Kim , Jin Hwa Chung , Sang Ki Park , Ja Kwan Koo , Bok Nam Jang , Jin Hwan Choi , Tae Uk Kim , Byeong Chun Lee
发明人： Kee Hae Kwon , Il Jin Kim , Jin Hwa Chung , Sang Ki Park , Ja Kwan Koo , Bok Nam Jang , Jin Hwan Choi , Tae Uk Kim , Byeong Chun Lee
CPC分类号： C08L33/08 , C08L31/04 , C08L33/10 , C08L33/24 , C08L35/06 , C08L69/00 , C08L69/005 , C08L2205/02 , C08L2205/03 , C08L2666/18 , C08L2666/02 , C08L2666/04 , C08L33/12
摘要： A polycarbonate resin composition can have improved transparency and scratch resistance of the present invention and comprises about 10 to about 99% by weight of polycarbonate resin (A); and about 1 to about 90% by weight of acrylic copolymer with ultra-low molecular weight and high refractive index (B). The resin composition of the present invention can further comprise acrylic resin (C). The acrylic copolymer with ultra-low molecular weight and high refractive index (B) can have a refractive index of about 1.495 to about 1.590 and a weight average molecular weight of about 3,000 to about 40,000 g/mol.
摘要翻译： 聚碳酸酯树脂组合物可以具有本发明的改善的透明性和耐划伤性，并且包含约10至约99重量％的聚碳酸酯树脂（A）; 和约1至约90重量％的具有超低分子量和高折射率（B）的丙烯酸共聚物。 本发明的树脂组合物还可以包含丙烯酸树脂（C）。 具有超低分子量和高折射率（B）的丙烯酸共聚物可以具有约1.495至约1.590的折射率和约3,000至约40,000g / mol的重均分子量。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.014 秒)
