公开(公告)号：US20190194460A1

公开(公告)日：2019-06-27

申请号：US16310780

申请日：2017-06-19

Applicant: UNIVERSIDAD DE LOS ANDES ,  CELLS FOR CELLS, S.P.A.

Inventor： Javier ENRIONE CÁCERES ,  Paulo DÍAZ-CALDERÓN ,  Alessandro ZAUPA ,  Juan Pablo ACEVEDO COX

IPC: C08L89/06 ,  C08K5/101 ,  C08J3/075

CPC classification number: C08L89/06 ,  B33Y70/00 ,  C07K14/461 ,  C07K14/78 ,  C08H1/00 ,  C08J3/075 ,  C08J2389/06 ,  C08K5/101 ,  C08L2312/00

Abstract: The present invention refers to a composition comprising a solution which in turn comprises an amino acidic chain gelatin polymer derived from natural sources of cold-adapted marine species, at a concentration from 1% to 20% (w/v), which optionally further comprises a polymerizing initiator such as a photoinitiator, and is chemically functionalized to become reactive to polymerization or crosslinking in presence of free radicals. This composition is especially useful for 3D printing, extrusion systems (additive fabrication), spray systems, casting, micro- and nano fibers fabrication systems (electrospinning, solution blow spinning) or microfluidics.

公开(公告)号：US20180304502A1

公开(公告)日：2018-10-25

申请号：US15768161

申请日：2016-10-14

Applicant: Juan Pablo ACEVEDO ,  Camila WILKENS ,  Maroun KHOURY ,  Christopher RIVET ,  UNIVERSIDAD DE LOS ANDES ,  CELLS FOR CELLS, S.P.A

Inventor： Juan Pablo ACEVEDO ,  Camila WILKENS ,  Maroun KHOURY ,  Christopher RIVET

IPC: B29C41/22 ,  B32B1/08 ,  B32B9/02 ,  B29C41/14 ,  A61L27/22 ,  A61L27/54 ,  A61L27/38 ,  A61L27/34 ,  A61L27/18 ,  A61L27/26 ,  A61L27/58 ,  A61L27/50 ,  A61L27/36 ,  A61L27/20 ,  A61F2/04 ,  A61F2/06

CPC classification number: B29C41/22 ,  A61F2/04 ,  A61F2/06 ,  A61F2002/047 ,  A61F2210/0076 ,  A61F2240/001 ,  A61L27/18 ,  A61L27/20 ,  A61L27/222 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3679 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3817 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/3882 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/604 ,  A61L2300/608 ,  A61L2300/64 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/22 ,  A61L2430/32 ,  B29C41/14 ,  B29K2089/00 ,  B29L2031/7534 ,  B32B1/08 ,  B32B9/02 ,  B32B2535/00 ,  C08L67/04 ,  C08L89/06

Abstract: The present invention overcomes all the above drawbacks and provides a versatile method for the fabrication of multilayer hollow tubes that uses a layer-by-layer rod dipping approach using different biomaterials. The device enables fine control over fabrication parameters, such as ascending/descending speeds, rod rotational velocity, and crosslinking or polymerization time. All these technologies allows the generation of more complex multilayer hollow tubes such as vessel-like structures, urethral grafting, prostate grafting and the like.

公开(公告)号：US20190038675A1

公开(公告)日：2019-02-07

申请号：US15768467

申请日：2016-10-13

Applicant: Maroun KHOURY ,  Francisca ALCAYAGA ,  CELLS FOR CELLS, S.P.A.

Inventor： Maroun KHOURY ,  Francisca ALCAYAGA

IPC: A61K35/28 ,  A61K35/14 ,  A61K9/127 ,  A61P35/00

Abstract: The present invention offers a solution to the lack of an effective alternative method to those already known to treat angiogenesis. In particular, the present invention is the first to show that a substantially pure population of exosomes derived from MenSCs have capacity to reduce tumor angiogenesis in diseases such as prostate cancer, breast cancer and pancreatic cancer. In this sense, the present invention shows that a substantially pure population of MenSCs-derived exosomes reduce the endogenous levels of reactive oxygen species (ROS) in cancer cells and the expression of pro-angiogenic factors such as VEGF, NF-KB, FGF and HIFα in the treated tumors. Overall, the invention offers a promising alternative method to treat angiogenesis. Since it is principally composed of exosomes produced by the Stem cells present in menstrual fluid, the invention provides an ease access and repeated sampling in a non-invasive manner. Such attributes allow the rapid production of the treatment.

公开(公告)号：US20180303878A1

公开(公告)日：2018-10-25

申请号：US15768469

申请日：2016-10-14

Applicant: CELLS FOR CELLS, S.P.A.

Inventor： Maroun KHOURY ,  Francisca ALCAYAGA

IPC: A61K35/28 ,  A61P31/04

CPC classification number: A61K35/28 ,  A61K31/198 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/43 ,  A61K31/431 ,  A61K31/496 ,  A61K31/5383 ,  A61K31/546 ,  A61K31/7056 ,  A61K38/14 ,  A61K45/06 ,  A61K2300/00 ,  A61P31/04 ,  Y02A50/473

Abstract: The present invention offers a solution to the lack of effective alternative treatments to fight infectious disease, preferably involving sepsis, comprising active ingredients obtained by non-intrusive and efficient methods. In particular, the present invention is the first to show that mesenchymal stem cells obtained from menstrual fluids (MenSCs) have the capacity to control infectious diseases, especially those leading to a reaction of the host body like sepsis. As shown herein, in vivo experiments illustrate that MenSCs have antibacterial activity in vitro, increase the survival rates of a mouse model for sepsis, regulate several parameters that are altered in sepsis patients and that are related with multi-organ dysfunction, such as the levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), alkaline phosphatase (ALP), glucose in blood, serum albumin, lung injury. Results show that in the mouse model for sepsis, MenScs also regulate the pro- and anti-inflammatory cytokine levels, reduce the loss of lymphocytes during sepsis and systemic bacterial proliferation in blood. The conditioned medium of MenSCs also increases the survival rates of mouse animals affected by sepsis. Overall, the invention offers a promising alternative method to treat infectious diseases. Since it is principally composed of stem cells present in menstrual fluid, the invention provides an ease access and repeated sampling in a non-invasive manner. Such attributes allow the rapid production of the treatment.