公开(公告)号：US08734844B2

公开(公告)日：2014-05-27

申请号：US13109438

申请日：2011-05-17

申请人： Chia-Hung Lee ,  Wei-Neng Liao ,  Shih-Hsun Cheng ,  Jen-Kun Chen ,  Chung-Shi Yang ,  Leu-Wei Lo ,  Yeu-Kuang Hwu ,  Fong-Sian Lin

发明人： Chia-Hung Lee ,  Wei-Neng Liao ,  Shih-Hsun Cheng ,  Jen-Kun Chen ,  Chung-Shi Yang ,  Leu-Wei Lo ,  Yeu-Kuang Hwu ,  Fong-Sian Lin

IPC分类号： A61K9/14

CPC分类号： C07K17/14 ,  B01J19/082 ,  B01J19/084 ,  B01J19/125 ,  B01J19/126 ,  B01J2219/0879 ,  B82Y30/00 ,  B82Y40/00

摘要： A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).

摘要翻译： 公开了一种合成配体结合金纳米粒子（AuNPs）的方法。 该方法包括：a）提供胺改性的二氧化硅颗粒; b）提供包含Au + 3离子的溶液; c）将胺改性的二氧化硅颗粒悬浮在包含Au + 3离子的溶液中; d）允许Au 3+离子被吸附和/或固定在胺改性二氧化硅颗粒的表面上; e）将固定在胺改性的二氧化硅颗粒的表面上的Au 3+离子暴露于辐射以获得吸附和/或固定在胺改性的二氧化硅颗粒的表面上的裸金纳米颗粒（AuNP），其中裸露的AuNP是无机的 表面修饰 和f）将配体与吸附和/或固定在胺修饰的SiNP的表面上的裸AuNP反应，从而获得配体缀合的金纳米颗粒（AuNP）。

公开(公告)号：US08348210B1

公开(公告)日：2013-01-08

申请号：US13306725

申请日：2011-11-29

申请人： Chia-Hung Lee

发明人： Chia-Hung Lee

IPC分类号： E04G3/20

CPC分类号： A47B57/425 ,  A47B57/045 ,  A47B57/22 ,  A47F5/103

摘要： A positioning device for shelves includes a support and a sleeve, the support has a first end and a second end. A tail board extends from the first end and a notch is defined in the tail board. The sleeve has a passage defined axially therethrough and at least one stop extends inward from the inner periphery of the passage. The tail board is inserted into the passage and the stop is engaged with the notch so as to secure the support to the passage. An engaging portion is located in the notch and located corresponding to the stop.

摘要翻译： 用于搁架的定位装置包括支撑件和套筒，所述支撑件具有第一端和第二端。 尾板从第一端延伸，在尾板上限定一个凹口。 套筒具有轴向穿过的通道，并且至少一个止挡件从通道的内周向内延伸。 尾板插入通道中，止动件与凹口接合，以将支撑件固定在通道上。 接合部分位于凹口中并且对应于止挡件定位。

公开(公告)号：US20120130053A1

公开(公告)日：2012-05-24

申请号：US13109438

申请日：2011-05-17

申请人： CHIA-HUNG LEE ,  WEI-NENG LIAO ,  SHIH-HSUN CHENG ,  JEN-KUN CHEN ,  CHUNG-SHI YANG ,  LEU-WEI LO ,  YEU-KUANG HWU ,  FONG-SIAN LIN

发明人： CHIA-HUNG LEE ,  WEI-NENG LIAO ,  SHIH-HSUN CHENG ,  JEN-KUN CHEN ,  CHUNG-SHI YANG ,  LEU-WEI LO ,  YEU-KUANG HWU ,  FONG-SIAN LIN

IPC分类号： B01J19/12 ,  B01J19/10 ,  C07K17/14 ,  C07F19/00 ,  B82Y40/00

CPC分类号： C07K17/14 ,  B01J19/082 ,  B01J19/084 ,  B01J19/125 ,  B01J19/126 ,  B01J2219/0879 ,  B82Y30/00 ,  B82Y40/00

摘要： A method of synthesizing ligand-conjugated gold nanoparticles (AuNPs) is disclosed. The method comprises: a) providing an amine-modified silica particle; b) providing a solution comprising Au+3 ions; c) suspending the amine-modified silica particle in the solution comprising Au+3 ions; d) allowing the Au3+ ions to be adsorbed and/or immobilized onto the surface of the amine-modified silica particle; e) exposing the Au3+ ions immobilized onto the surface of the amine-modified silica particle to radiation to obtain bare gold nanoparticles (AuNPs) adsorbed and/or immobilized onto the surface of the amine-modified silica particle, wherein the bare AuNPs are without organic surface modifications; and f) reacting a ligand with the bare AuNPs adsorbed and/or immobilized onto the surface of the amine-modified SiNP and thereby obtain ligand-conjugated gold nanoparticles (AuNPs).

摘要翻译： 公开了一种合成配体结合金纳米粒子（AuNPs）的方法。 该方法包括：a）提供胺改性的二氧化硅颗粒; b）提供包含Au + 3离子的溶液; c）将胺改性的二氧化硅颗粒悬浮在包含Au + 3离子的溶液中; d）允许Au 3+离子被吸附和/或固定在胺改性二氧化硅颗粒的表面上; e）将固定在胺改性的二氧化硅颗粒的表面上的Au 3+离子暴露于辐射以获得吸附和/或固定在胺改性的二氧化硅颗粒的表面上的裸金纳米颗粒（AuNP），其中裸露的AuNP是无机的 表面修饰 和f）将配体与吸附和/或固定在胺修饰的SiNP的表面上的裸AuNP反应，从而获得配体缀合的金纳米颗粒（AuNP）。

公开(公告)号：US20110080813A1

公开(公告)日：2011-04-07

申请号：US12572254

申请日：2009-10-01

申请人： Chia-Hung Lee ,  Chao-Ming Huang ,  Jui-Hung Yen

发明人： Chia-Hung Lee ,  Chao-Ming Huang ,  Jui-Hung Yen

IPC分类号： G11B21/08

CPC分类号： G11B7/006 ,  G11B7/0945 ,  G11B7/126 ,  G11B20/10009 ,  G11B20/10027 ,  G11B20/10222 ,  G11B27/32 ,  G11B27/36 ,  G11B2020/10898 ,  G11B2020/1277 ,  G11B2220/216 ,  G11B2220/2541 ,  G11B2220/2562

摘要： A method of recording data onto an optical storage medium includes: before starting recording data onto the optical storage medium from an expected link point on the optical storage medium, setting a current recording condition corresponding to the expected link point according to at least one previous recording condition corresponding to the expected link point; and controlling an operation of recording the data onto the optical storage medium according to the current recording condition.

摘要翻译： 一种在光存储介质上记录数据的方法包括：在从光存储介质上的预期链接点开始将数据记录到光存储介质上之前，根据至少一个先前的记录设置与预期链接点对应的当前记录条件 条件对应于预期的链接点; 以及根据当前记录条件控制将数据记录到光存储介质上的操作。

公开(公告)号：US20100104650A1

公开(公告)日：2010-04-29

申请号：US12581965

申请日：2009-10-20

申请人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

发明人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

IPC分类号： A61K47/34 ,  A61K9/14

CPC分类号： A61K9/5115

摘要： A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug.

摘要翻译： 公开了一种带电介孔二氧化硅纳米颗粒（MSN）的药物递送系统，用于控制释放和增强的生物利用度。 该系统包括带正电荷的MSN，其具有二氧化硅基质和基质中的孔和/或纳米通道阵列。 基质，全部表面和孔和/或纳米通道的整个物质包含多个硅烷醇（Si-OH）和季铵官能团。 带负电荷的生物活性化合物的生物利用度可以通过将其加载到孔和/或纳米通道中来增加。 在孔和/或纳米通道壁上的表面上的硅烷醇（Si-OH）官能团可以在pH高于带正电荷的MSN的pI的流体中游离去质子化并导致带负电荷的药物的持续释放 从孔和/或纳米通道，从而提高药物的生物利用度。

公开(公告)号：US20090323487A1

公开(公告)日：2009-12-31

申请号：US12413982

申请日：2009-03-30

申请人： Hsin-Cheng Chen ,  Chao-Yi Wu ,  Chia-Hung Lee ,  Yao-Chun Fang

发明人： Hsin-Cheng Chen ,  Chao-Yi Wu ,  Chia-Hung Lee ,  Yao-Chun Fang

IPC分类号： G11B20/00

CPC分类号： G11B20/1879 ,  G11B20/1217 ,  G11B2020/1221 ,  G11B2020/1297 ,  G11B2220/2537

摘要： The invention provides a method for data recording of an optical disk drive. First, raw data is encoded to obtain a plurality of recording units of encoded data to be stored in a memory. The encoded data stored in the memory is then recorded to an optical disk. A predetermined number of recording units of the encoded data is then reserved in the memory as reserved data without being recorded onto the optical disk. The recorded data read from the optical disk is then compared to the corresponding encoded data stored in the memory to verify correctness of the recorded data. The reserved data is then recorded to the optical disk after correctness verification of the recorded data is completed. Finally, the aforementioned steps are repeated until there is no more raw data left as a source for encoding.

摘要翻译： 本发明提供一种光盘驱动器的数据记录方法。 首先，原始数据被编码以获得要存储在存储器中的多个编码数据的记录单元。 然后将存储在存储器中的编码数据记录到光盘。 然后将编码数据的预定数量的记录单元作为保留数据保留在存储器中，而不被记录在光盘上。 然后将从光盘读取的记录数据与存储在存储器中的相应编码数据进行比较，以验证记录数据的正确性。 然后，在记录数据的正确性验证完成之后，保留的数据被记录到光盘。 最后，重复上述步骤，直到不再有原始数据作为编码源。

公开(公告)号：US08559280B2

公开(公告)日：2013-10-15

申请号：US12413982

申请日：2009-03-30

申请人： Hsin-Cheng Chen ,  Chao-Yi Wu ,  Chia-Hung Lee ,  Yao-Chun Fang

发明人： Hsin-Cheng Chen ,  Chao-Yi Wu ,  Chia-Hung Lee ,  Yao-Chun Fang

IPC分类号： G11B21/08

CPC分类号： G11B20/1879 ,  G11B20/1217 ,  G11B2020/1221 ,  G11B2020/1297 ,  G11B2220/2537

摘要： The invention provides a method for data recording of an optical disk drive. First, raw data is encoded to obtain a plurality of recording units of encoded data to be stored in a memory. The encoded data stored in the memory is then recorded to an optical disk. A predetermined number of recording units of the encoded data is then reserved in the memory as reserved data without being recorded onto the optical disk. The recorded data read from the optical disk is then compared to the corresponding encoded data stored in the memory to verify correctness of the recorded data. The reserved data is then recorded to the optical disk after correctness verification of the recorded data is completed. Finally, the aforementioned steps are repeated until there is no more raw data left as a source for encoding.

摘要翻译： 本发明提供一种光盘驱动器的数据记录方法。 首先，原始数据被编码以获得要存储在存储器中的多个编码数据的记录单元。 然后将存储在存储器中的编码数据记录到光盘。 然后将编码数据的预定数量的记录单元作为保留数据保留在存储器中，而不被记录在光盘上。 然后将从光盘读取的记录数据与存储在存储器中的相应编码数据进行比较，以验证记录数据的正确性。 然后，在记录数据的正确性验证完成之后，保留的数据被记录到光盘。 最后，重复上述步骤，直到不再有原始数据作为编码源。

公开(公告)号：US08252337B2

公开(公告)日：2012-08-28

申请号：US12581965

申请日：2009-10-20

申请人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

发明人： Chia-Hung Lee ,  Leu-Wei Lo ,  Chung-Shi Yang ,  Chung-Yuan Mou

IPC分类号： A61K9/14 ,  A61K47/18

CPC分类号： A61K9/5115

摘要： A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug.

摘要翻译： 公开了一种带电介孔二氧化硅纳米颗粒（MSN）的药物递送系统，用于控制释放和增强的生物利用度。 该系统包括带正电荷的MSN，其具有二氧化硅基质和基质中的孔和/或纳米通道阵列。 基质，全部表面和孔和/或纳米通道的整个物质包含多个硅烷醇（Si-OH）和季铵官能团。 带负电荷的生物活性化合物的生物利用度可以通过将其加载到孔和/或纳米通道中来增加。 在孔和/或纳米通道壁上的表面上的硅烷醇（Si-OH）官能团可以在pH高于带正电荷的MSN的pI的流体中游离去质子化并导致带负电荷的药物的持续释放 从孔和/或纳米通道，从而提高药物的生物利用度。

公开(公告)号：US08009531B2

公开(公告)日：2011-08-30

申请号：US12572254

申请日：2009-10-01

申请人： Chia-Hung Lee ,  Chao-Ming Huang ,  Jui-Hung Yen

发明人： Chia-Hung Lee ,  Chao-Ming Huang ,  Jui-Hung Yen

IPC分类号： G11B20/10

CPC分类号： G11B7/006 ,  G11B7/0945 ,  G11B7/126 ,  G11B20/10009 ,  G11B20/10027 ,  G11B20/10222 ,  G11B27/32 ,  G11B27/36 ,  G11B2020/10898 ,  G11B2020/1277 ,  G11B2220/216 ,  G11B2220/2541 ,  G11B2220/2562

摘要： A method of recording data onto an optical storage medium includes: before starting recording data onto the optical storage medium from an expected link point on the optical storage medium, setting a current recording condition corresponding to the expected link point according to at least one previous recording condition corresponding to the expected link point; and controlling an operation of recording the data onto the optical storage medium according to the current recording condition.

摘要翻译： 一种在光存储介质上记录数据的方法包括：在从光存储介质上的预期链接点开始将数据记录到光存储介质上之前，根据至少一个先前的记录设置与预期链接点对应的当前记录条件 条件对应于预期的链接点; 以及根据当前记录条件控制将数据记录到光存储介质上的操作。

公开(公告)号：US07958625B2

公开(公告)日：2011-06-14

申请号：US12365969

申请日：2009-02-05

申请人： Chia-Hung Lee ,  Jen-Huan Yu ,  Chung-Shao Huang ,  Ching-Feng Hsieh ,  Cheng-Wen Dai ,  Kuo-Ching Chen

发明人： Chia-Hung Lee ,  Jen-Huan Yu ,  Chung-Shao Huang ,  Ching-Feng Hsieh ,  Cheng-Wen Dai ,  Kuo-Ching Chen

IPC分类号： B23P19/00 ,  H05K3/36

CPC分类号： H05K9/0022 ,  H05K13/0447 ,  H05K13/0473 ,  Y10T29/49126 ,  Y10T29/5313 ,  Y10T29/53174 ,  Y10T29/53252 ,  Y10T29/5327

摘要： An assembly device includes a base having a supporting portion upon which an isolation cover and a main body are disposed. A press-fitting mechanism is movably connected to the base, and includes a press-fitting portion facing the supporting portion and disposed corresponding in position to the supporting portion, and further portions for guiding and bending second positioning portions. The further portions are movably disposed on external side faces of the press-fitting portion. The press-fitting mechanism also has first portions for holding the further portions to the external side faces of the press-fitting portion, and has second portions passing through upper ends of the further portions. A drive mechanism is disposed at the base and has a drive portion connected to the press-fitting mechanism, for driving the press-fitting mechanism to move towards the supporting portion via the drive portion, so as to bend and fasten ends of second positioning portions.

摘要翻译： 组装装置包括具有支撑部分的基部，隔离盖和主体设置在该支撑部分上。 压入机构可移动地连接到基座，并且包括面向支撑部分并且相对于支撑部分位置设置的压配部分，以及用于引导和弯曲第二定位部分的另外的部分。 另外的部分可移动地设置在压配部分的外侧面上。 压入机构还具有用于将另外的部分保持在压配部的外侧面的第一部分，并且具有穿过其它部分的上端的第二部分。 驱动机构设置在基座上，具有与压配机构连接的驱动部，驱动压配机构经由驱动部向支撑部移动，从而弯曲并固定第二定位部的端部 。