-
1.发明授权Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders 失效用于治疗血友病和其他疾病的重组基因递送载体的给药方法公开(公告)号：US06818439B1
公开(公告)日：2004-11-16
申请号：US09001039
申请日：1997-12-30
申请人： Douglas J. Jolly , Stephen Chang , James G. Respess , Nicholas J. DePolo , David Chi-Tang Hsu , Carlos E. Ibanez , Judith Greengard , Lee Will
发明人： Douglas J. Jolly , Stephen Chang , James G. Respess , Nicholas J. DePolo , David Chi-Tang Hsu , Carlos E. Ibanez , Judith Greengard , Lee Will
IPC分类号： C12N15867
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C07K14/56 , C07K14/61 , C07K14/705 , C07K14/7455 , C07K14/755 , C07K14/8125 , C07K14/8128 , C12N9/1211 , C12N9/644 , C12N9/6464 , C12N9/647 , C12N2710/10322 , C12N2710/10343 , C12N2740/13043 , C12Y304/21022 , C12Y304/21069
摘要： Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells of greater than 105 cfu/ml, wherein the recombinant retroviral preparation is capable of directing the expression of a protein, nucleic acid molecule, or enzyme which generates an enzymatic product, such that measurable levels of the protein, nucleic acid molecule, or enzymatic product may be obtained in the bodily fluid or cells of the human.
摘要翻译： 提供了用于在体液或人体细胞中获得可测量水平的蛋白质，核酸分子或酶产物的方法，其包括以下步骤：将具有大于10的HT1080细胞滴度的重组逆转录病毒制剂给予人 其中重组逆转录病毒制剂能够引导产生酶产物的蛋白质，核酸分子或酶的表达，使得蛋白质，核酸分子或酶促产物的可测量水平可以 可以在人的体液或细胞中获得。
-
公开(公告)号：US5843723A
公开(公告)日：1998-12-01
申请号：US739167
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and method,, for utilizing recombinant alphavirus vectors.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。
-
公开(公告)号：US20100173412A1
公开(公告)日：2010-07-08
申请号：US12538494
申请日：2009-08-10
申请人： Thomas W. Dubensky, JR. , John M. Polo , Carlos E. Ibanez , Stephen M.W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, JR. , John M. Polo , Carlos E. Ibanez , Stephen M.W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
IPC分类号： C12N5/071
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems
摘要翻译： 本公开提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法
-
公开(公告)号：US06376236B1
公开(公告)日：2002-04-23
申请号：US09236140
申请日：1999-01-22
IPC分类号： C12N1563
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： Disclosed are recombinant alphavirus particles comprising a) an alphavirus vector construct which directs the expression of a heterologous nucleic acid molecule; b) a capsid protein; and c) an envelope glycoprotein from a virus different from said alphavirus vector.
摘要翻译： 公开了重组甲病毒颗粒，其包含a）引导异源核酸分子表达的甲病毒载体构建体; b）衣壳蛋白; 和c）来自不同于所述甲病毒载体的病毒的包膜糖蛋白。
-
公开(公告)号：US07977091B2
公开(公告)日：2011-07-12
申请号：US12538494
申请日：2009-08-10
申请人： Thomas W. Dubensky, Jr. , John M Polo , Carlos E Ibanez , Stephen M. W. Chang , Douglas J Jolly , David A Driver , Barbara A Belli
发明人： Thomas W. Dubensky, Jr. , John M Polo , Carlos E Ibanez , Stephen M. W. Chang , Douglas J Jolly , David A Driver , Barbara A Belli
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本公开提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
-
公开(公告)号：US07572628B2
公开(公告)日：2009-08-11
申请号：US10346880
申请日：2003-01-16
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
-
公开(公告)号：US5789245A
公开(公告)日：1998-08-04
申请号：US741881
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N15/40 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.051 秒)
