-
公开(公告)号：US20100173412A1
公开(公告)日：2010-07-08
申请号：US12538494
申请日：2009-08-10
申请人： Thomas W. Dubensky, JR. , John M. Polo , Carlos E. Ibanez , Stephen M.W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, JR. , John M. Polo , Carlos E. Ibanez , Stephen M.W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
IPC分类号： C12N5/071
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems
摘要翻译： 本公开提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法
-
公开(公告)号：US07572628B2
公开(公告)日：2009-08-11
申请号：US10346880
申请日：2003-01-16
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
-
公开(公告)号：US5843723A
公开(公告)日：1998-12-01
申请号：US739167
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and method,, for utilizing recombinant alphavirus vectors.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。
-
公开(公告)号：US5789245A
公开(公告)日：1998-08-04
申请号：US741881
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N15/40 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
-
公开(公告)号：US6015686A
公开(公告)日：2000-01-18
申请号：US404796
申请日：1995-03-15
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N15/11
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
-
公开(公告)号：US5814482A
公开(公告)日：1998-09-29
申请号：US739158
申请日：1996-10-30
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12P21/00 , C07H21/04
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
-
7.发明授权Method for stimulating an immune response utilizing recombinant alphavirus particles 失效利用重组甲病毒颗粒刺激免疫应答的方法
公开(公告)号：US6015694A
公开(公告)日：2000-01-18
申请号：US931869
申请日：1997-09-16
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12P21/06
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
-
8.发明授权Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders 失效使用重组基因递送载体来治疗或预防溶酶体储存障碍公开(公告)号：US06730297B1
公开(公告)日：2004-05-04
申请号：US09580820
申请日：2000-05-26
申请人： Beverly Davidson , Douglas J. Jolly , Sybille L. Sauter , Colleen S. Stein , Thomas W. Dubensky, Jr. , Jason A. Heth
发明人： Beverly Davidson , Douglas J. Jolly , Sybille L. Sauter , Colleen S. Stein , Thomas W. Dubensky, Jr. , Jason A. Heth
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K48/00 , C12N9/2434 , C12N2740/15043 , C12Y302/01018 , C12Y302/01031
摘要： Gene delivery vectors, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of the brain associated with lysosomal storage disorders.
摘要翻译： 提供基因递送载体，例如重组FIV载体，以及使用这些载体的方法用于治疗或预防眼睛的视网膜疾病和与溶酶体储存障碍相关的脑部疾病。
-
9.发明授权公开(公告)号：US07034010B2
公开(公告)日：2006-04-25
申请号：US10356272
申请日：2003-01-31
申请人： Beverly Davidson , Douglas J. Jolly , Sybille L. Sauter , Colleen S. Stein , Thomas W. Dubensky, Jr. , Jason A. Heth
发明人： Beverly Davidson , Douglas J. Jolly , Sybille L. Sauter , Colleen S. Stein , Thomas W. Dubensky, Jr. , Jason A. Heth
CPC分类号： C12N15/86 , A61K48/00 , C12N9/2434 , C12N2740/15043 , C12Y302/01018 , C12Y302/01031
摘要： Gene delivery vectors, such as, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of the brain associated with lysosomal storage disorders.
-
10.发明授权Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders 失效用于治疗血友病和其他疾病的重组基因递送载体的给药方法公开(公告)号：US06818439B1
公开(公告)日：2004-11-16
申请号：US09001039
申请日：1997-12-30
申请人： Douglas J. Jolly , Stephen Chang , James G. Respess , Nicholas J. DePolo , David Chi-Tang Hsu , Carlos E. Ibanez , Judith Greengard , Lee Will
发明人： Douglas J. Jolly , Stephen Chang , James G. Respess , Nicholas J. DePolo , David Chi-Tang Hsu , Carlos E. Ibanez , Judith Greengard , Lee Will
IPC分类号： C12N15867
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C07K14/56 , C07K14/61 , C07K14/705 , C07K14/7455 , C07K14/755 , C07K14/8125 , C07K14/8128 , C12N9/1211 , C12N9/644 , C12N9/6464 , C12N9/647 , C12N2710/10322 , C12N2710/10343 , C12N2740/13043 , C12Y304/21022 , C12Y304/21069
摘要： Methods are provided for obtaining measurable levels of a protein, nucleic acid molecule, or enzymatic product in a bodily fluid or cells of a human, comprising the step of administering to a human a recombinant retroviral preparation having a titer on HT1080 cells of greater than 105 cfu/ml, wherein the recombinant retroviral preparation is capable of directing the expression of a protein, nucleic acid molecule, or enzyme which generates an enzymatic product, such that measurable levels of the protein, nucleic acid molecule, or enzymatic product may be obtained in the bodily fluid or cells of the human.
摘要翻译： 提供了用于在体液或人体细胞中获得可测量水平的蛋白质，核酸分子或酶产物的方法，其包括以下步骤：将具有大于10的HT1080细胞滴度的重组逆转录病毒制剂给予人 其中重组逆转录病毒制剂能够引导产生酶产物的蛋白质，核酸分子或酶的表达，使得蛋白质，核酸分子或酶促产物的可测量水平可以 可以在人的体液或细胞中获得。
-
-
-
-
-
-
-
-
-
搜索结果
50 条记录 (耗时 0.056 秒)
