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公开(公告)号：US20100173412A1
公开(公告)日：2010-07-08
申请号：US12538494
申请日：2009-08-10
申请人： Thomas W. Dubensky, JR. , John M. Polo , Carlos E. Ibanez , Stephen M.W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, JR. , John M. Polo , Carlos E. Ibanez , Stephen M.W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
IPC分类号： C12N5/071
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present disclosure provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems
摘要翻译： 本公开提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法
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公开(公告)号：US5843723A
公开(公告)日：1998-12-01
申请号：US739167
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and method,, for utilizing recombinant alphavirus vectors.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。
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公开(公告)号：US07572628B2
公开(公告)日：2009-08-11
申请号：US10346880
申请日：2003-01-16
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver , Barbara A. Belli
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
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公开(公告)号：US5789245A
公开(公告)日：1998-08-04
申请号：US741881
申请日：1996-10-30
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Carlos E. Ibanez , Stephen M. W. Chang , Douglas J. Jolly , David A. Driver
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N15/40 , C12N5/10
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
摘要翻译： 本发明提供了利用重组甲病毒载体的组合物和方法。 还公开了用于制备和利用真核分层载体引发系统的组合物和方法。
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公开(公告)号：US06376236B1
公开(公告)日：2002-04-23
申请号：US09236140
申请日：1999-01-22
IPC分类号： C12N1563
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N9/2402 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , C12Y302/01045 , Y02A50/388 , Y02A50/396 , Y02A50/466 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： Disclosed are recombinant alphavirus particles comprising a) an alphavirus vector construct which directs the expression of a heterologous nucleic acid molecule; b) a capsid protein; and c) an envelope glycoprotein from a virus different from said alphavirus vector.
摘要翻译： 公开了重组甲病毒颗粒，其包含a）引导异源核酸分子表达的甲病毒载体构建体; b）衣壳蛋白; 和c）来自不同于所述甲病毒载体的病毒的包膜糖蛋白。
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公开(公告)号：US6015686A
公开(公告)日：2000-01-18
申请号：US404796
申请日：1995-03-15
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12N15/11
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
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公开(公告)号：US5814482A
公开(公告)日：1998-09-29
申请号：US739158
申请日：1996-10-30
IPC分类号： A61K38/00 , A61K48/00 , C07K14/02 , C07K14/045 , C07K14/075 , C07K14/155 , C07K14/16 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N5/16 , C12N9/24 , C12N15/00 , C12N15/113 , C12N15/33 , C12N15/63 , C12N15/86 , C12N15/861 , C12P21/02 , C12P21/00 , C07H21/04
CPC分类号： C12N15/113 , C07K14/005 , C07K14/47 , C07K14/705 , C07K14/755 , C07K14/82 , C12N15/1131 , C12N15/86 , C12N9/2402 , C12Y302/01045 , A61K2039/5256 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2710/16722 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2770/36122 , C12N2830/002 , C12N2830/42 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12N2840/85 , Y10S977/773 , Y10S977/804 , Y10S977/808 , Y10S977/918 , Y10S977/92 , Y10S977/924
摘要： The present invention provides compositions and methods for utilizing recombinant alphavirus vectors. Also disclosed are compositions and methods for making and utilizing eukaryotic layered vector initiation systems.
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8.发明申请RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACRO-MOLECULAR SYNTHESIS 审中-公开基于重组腺病毒的载体，具有减少细胞宏观分子合成的抑制作用公开(公告)号：US20100330121A1
公开(公告)日：2010-12-30
申请号：US12845516
申请日：2010-07-28
申请人： Thomas W. Dubensky, JR. , John M. Polo , Barbara A. Belli , Sergey A. Dryga , Sondra Schlessinger , Ilya Frolov
发明人： Thomas W. Dubensky, JR. , John M. Polo , Barbara A. Belli , Sergey A. Dryga , Sondra Schlessinger , Ilya Frolov
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子，其包含甲病毒非结构蛋白基因，当可操作地并入重组甲病毒颗粒中时，与野生型相比，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平 类型，以及与野生型重组甲病毒颗粒相比，从病毒连接区启动子转录的RNA编码的相同或更高水平的蛋白质。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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9.发明授权Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis 失效基于重组甲病毒的载体具有抑制细胞大分子合成的作用公开(公告)号：US07811812B2
公开(公告)日：2010-10-12
申请号：US10391441
申请日：2003-03-17
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Drvga , Ilya Frolov
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Drvga , Ilya Frolov
IPC分类号： C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
摘要翻译： 公开了分离的核酸分子，其包含甲病毒非结构蛋白基因，当可操作地并入重组甲病毒颗粒中时，与野生型相比，真核分子载体启动系统或RNA载体复制子具有降低的载体特异性RNA合成水平 类型，以及与野生型重组甲病毒颗粒相比，从病毒连接区启动子转录的RNA编码的相同或更高水平的蛋白质。 还公开了RNA载体复制子，甲病毒载体构建体和含有上述核酸分子的真核分子载体启动系统。
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10.发明授权公开(公告)号：US06451592B1
公开(公告)日：2002-09-17
申请号：US08944465
申请日：1997-10-06
申请人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
发明人： Thomas W. Dubensky, Jr. , John M. Polo , Barbara A. Belli , Sondra Schlesinger , Sergey A. Dryga , Ilya Frolov
IPC分类号： C12N1500
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/79 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/005 , C12N2830/006 , C12N2830/42 , C12N2830/48 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.
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