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公开(公告)号：US5320139A
公开(公告)日：1994-06-14
申请号：US40320
申请日：1993-03-30
CPC分类号： G01N35/1097 , B01J19/0046 , B01J4/02 , F16K11/22 , G01N1/31 , B01J2219/00286 , B01J2219/00306 , B01J2219/00398 , C40B60/14 , Y10T137/86163 , Y10T137/87249 , Y10T137/87684
摘要： A fluid delivery system is provided to deliver precise volumes of a plurality of fluid in sequence to one or more treatment reservoirs. Fluid channels are formed in a plate structure to provide a means for delivering fluids from a plurality of fluid reservoirs to one or a plurality of treatment reservoirs. Each fluid is delivered by a system comprising a pneumatically or electrically activated inlet valve in fluid communication with a fluid reservoir, a positive displacement pump in fluid communication with the inlet valve and a pneumatically or electrically activated outlet valve in fluid communication with the positive displacement pump.
摘要翻译： 提供流体输送系统以将精确体积的多个流体顺序地输送到一个或多个处理储存器。 流体通道形成为板结构，以提供用于将流体从多个流体储存器输送到一个或多个处理储存器的装置。 每个流体由包括与流体储存器流体连通的气动或电活动入口阀的系统输送，与进气阀流体连通的容积式泵和与所述正排量泵流体连通的气动或电活动的出口阀 。
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公开(公告)号：US06993958B2
公开(公告)日：2006-02-07
申请号：US10424326
申请日：2003-04-28
申请人： Carlton H. Paul
发明人： Carlton H. Paul
IPC分类号： G01N11/04
CPC分类号： G01N30/6095 , B01J20/285 , B01J2220/54 , B01J2220/82 , B01J2220/84 , G01N30/466 , G01N30/50 , G01N30/6004 , G01N30/6043 , G01N30/7233 , G01N2030/528 , G01N2030/565 , G01N2030/746 , G01N2030/8813
摘要： A microfluidic system is provided for separating components of many fluid samples in a parallel fashion through an array of capillary conduits. The system includes capillary conduits for receiving fluid samples, and for effecting separation of substituents of the sample by passing the sample through a corresponding array of capillary separation conduits containing a solid separation medium. The microfluidic circuit is made of three or more substrate layers and preferably includes etched channels in different layers that are dimensioned relative to one another to provide for retaining the solid composition within the capillary separation conduits. The system also includes an array of detector flow cells in fluid communication with the capillary separation conduits, and an array of high pressure connectors for connecting discrete capillary tubes to the fluid passages in the microfluidic circuit for introducing and removing the fluid samples from the system. The connections for the capillary tubes have a small footprint, are readily reversible (allowing ease of maintenance and replacement), and can seal against high pressures.
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公开(公告)号：US06581441B1
公开(公告)日：2003-06-24
申请号：US10061612
申请日：2002-02-01
申请人： Carlton H. Paul
发明人： Carlton H. Paul
IPC分类号： G01N3000
CPC分类号： G01N30/6095 , B01J20/285 , B01J2220/54 , B01J2220/82 , B01J2220/84 , G01N30/466 , G01N30/50 , G01N30/6004 , G01N30/6043 , G01N30/7233 , G01N2030/528 , G01N2030/565 , G01N2030/746 , G01N2030/8813
摘要： A microfluidic system is provided for separating components of many fluid samples in a parallel fashion through an array of capillary conduits. The system includes capillary conduits for receiving fluid samples, and for effecting separation of substituents of the sample by passing the sample through a corresponding array of capillary separation conduits containing a solid separation medium. The microfluidic circuit is made of three or more substrate layers and preferably includes etched channels in different layers that are dimensioned relative to one another to provide for retaining the solid composition within the capillary separation conduits. The system also includes an array of detector flow cells in fluid communication with the capillary separation conduits, and an array of high pressure connectors for connecting discrete capillary tubes to the fluid passages in the microfluidic circuit for introducing and removing the fluid samples from the system. The connections for the capillary tubes have a small footprint, are readily reversible (allowing ease of maintenance and replacement), and can seal against high pressures.
摘要翻译： 提供了一种微流体系统，用于通过一系列毛细管道以平行的方式分离许多流体样品的组分。 该系统包括用于接收流体样品的毛细管道，以及通过使样品通过包含固体分离介质的相应阵列的毛细管分离导管来实现样品取代基的分离。 微流体电路由三个或更多个衬底层制成，并且优选地包括相对于彼此尺寸设置的不同层中的蚀刻通道，以便将固体组合物保持在毛细管分离导管内。 该系统还包括与毛细管分离管道流体连通的检测器流动池阵列，以及用于将离散毛细管连接到微流体回路中的流体通道的高压连接器阵列，用于从系统引入和移除流体样品。 毛细管的连接部分占地面积小，容易可逆（允许维护和更换），并可以对高压进行密封。
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公开(公告)号：US5325889A
公开(公告)日：1994-07-05
申请号：US40321
申请日：1993-03-30
CPC分类号： F15C3/04 , B01J19/0046 , B01J4/02 , B01J2219/00286 , B01J2219/00306 , B01J2219/00398 , C40B60/14 , Y10T137/87153 , Y10T137/87684
摘要： A laminated plate structure including conduit and regent delivery means for a fluid delivery system is provided to deliver precise volumes of a plurality of fluids in sequence to a treatment reservoir. Fluid channels are formed in the plate structure to provide a means for delivering fluids from a plurality of fluid reservoirs attached to the plate structure to one or a plurality of treatment reservoirs attached to the plate structure. Each fluid is delivered by a system comprising a fluid reservoir, an inlet valve in fluid communication with the fluid reservoir, a positive displacement pump in fluid communication with the inlet valve and an outlet valve in fluid communication with the positive displacement pump all of which are attached to the plate structure. The means for delivering fluid and the fluid reservoirs are positioned on opposing surfaces of the plate structure. The plate structure is provided with vent holes for venting vapors that may be produced during formation of the plate structure.
摘要翻译： 提供了包括用于流体输送系统的管道和输送装置的层压板结构，以将精确量的多个流体按顺序输送到处理储存器。 流体通道形成在板结构中以提供用于将附着到板结构的多个流体储存器的流体输送到连接到板结构的一个或多个处理储存器的装置。 每个流体由包括流体储存器，与流体储存器流体连通的入口阀，与入口阀流体连通的容积泵和与所述正位移泵流体连通的出口阀的系统输送， 连接到板结构。 用于输送流体和流体储存器的装置定位在板结构的相对表面上。 板结构设置有用于排出可能在板结构形成期间产生的蒸气的通气孔。
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公开(公告)号：US5641270A
公开(公告)日：1997-06-24
申请号：US509472
申请日：1995-07-31
CPC分类号： G01N30/32 , F04B17/04 , F04B43/04 , F04B49/065 , G01N2030/027 , G01N2030/326
摘要： A magnetostrictive pump is provided which makes use of a magnetostrictive element which, when an alternating magnetic field is applied to it, compresses a chamber containing a working fluid. A bellows located within the working fluid is repeatedly compressed by the compression of the chamber, and pumps a fluid to be pumped in and out of the bellows. Since the magnetostrictive element does not directly contact the bellows, the bellows life is greatly extended. Valves are provided to direct the fluid flow in a desired manner. The pump may be combined with other pumps in various series or parallel arrangements to create a pump system. The pump may be pre-biased to make its response more linear by either mechanical or magnetic biasing. A permanent magnet may be used to magnetically bias the pump and create an "at-rest" initial extension of the magnetostrictive element. Similarly, a spring may be used to mechanically load the magnetostrictive element. A controller is used to detect feedback signals from pressure and pump displacement transducers, and thereby provide active control of the pump or pump system. It is especially useful for high performance liquid chromatography.
摘要翻译： 提供了一种利用磁致伸缩元件的磁致伸缩泵，该磁致伸缩元件当施加交变磁场时，压缩包含工作流体的腔室。 位于工作流体内的波纹管通过腔室的压缩被反复压缩，并将要泵入的流体泵入和流出波纹管。 由于磁致伸缩元件不直接接触波纹管，因此波纹管寿命大大延长。 提供阀以以期望的方式引导流体流动。 泵可以与各种串联或并联装置的其它泵组合以产生泵系统。 泵可以被预偏置以通过机械或磁偏置使其响应更线性。 可以使用永磁体来磁偏置泵并产生磁致伸缩元件的“静止”初始延伸。 类似地，可以使用弹簧来机械地加载磁致伸缩元件。 控制器用于检测来自压力和泵位移传感器的反馈信号，从而提供泵或泵系统的主动控制。 它对高效液相色谱特别有用。
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6.发明授权Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits 失效用于控制微流体电路中较高压力的可编程跟踪压力调节器公开(公告)号：US06662818B2
公开(公告)日：2003-12-16
申请号：US10061985
申请日：2002-02-01
IPC分类号： G05D1113
CPC分类号： G01N30/36 , G01L9/0001 , G05D16/2026 , Y10T137/0396 , Y10T137/2076 , Y10T137/2514 , Y10T137/2529 , Y10T137/8326
摘要： Regulator for precision control of pressure based on a means of measuring pressure differentials. More specifically, the present invention provides a pressure control that tracks a relatively high background pressure, and applies a positive or negative offset to create the small pressure differentials that can be utilized to transport fluids within a capillary network. The present invention is also directed to a method of controlling microfluidic elements (such as donut cavities) with a high degree of precision. In high performance liquid chromatography applications, this is accomplished using tracking pressure regulators to measure and respond to the difference between the liquid pump pressure and the regulated pneumatic pressure.
摘要翻译： 基于测量压力差的方法精确控制压力的调节器。 更具体地说，本发明提供了一种跟踪相对高的背景压力的压力控制，并且施加正或负偏移以产生可用于输送毛细管网内的流体的小压力差。 本发明还涉及以高精度控制微流体元件（例如，环形腔）的方法。 在高效液相色谱应用中，使用跟踪压力调节器来测量和响应液体泵压力和调节气压之间的差异。
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7.发明授权公开(公告)号：US06193471B1
公开(公告)日：2001-02-27
申请号：US09345072
申请日：1999-06-30
申请人： Carlton H. Paul
发明人： Carlton H. Paul
IPC分类号： F04B1924
CPC分类号： B01L3/502738 , B01F11/0071 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/146 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0688 , G01N35/1095
摘要： A process and system are provided for forming and transporting precise small volumes of liquid samples by means of controlled gas pressures. As the controlled gas pressures are changed at a multiplicity of control points in the fluid circuit, transitions take place involving the transport of small liquid samples. This transport is arrested by the geometry of the fluid circuit to produce a new state, which state remains stable until another transition is initiated by a change in the multiplicity of controlled gas pressures. Various combinations of control elements are described for effecting formation of fixed liquid volumes, transporting, mixing, and removing entrained bubbles from small liquid samples.
摘要翻译： 提供了一种工艺和系统，用于通过可控的气体压力形成和输送精确的小体积的液体样品。 由于受控气体压力在流体回路中的多个控制点处发生变化，涉及到小液体样品的输送。 这种运输被流体回路的几何形状阻止以产生新的状态，该状态保持稳定，直到通过受控气体压力的多重性的变化开始另一转变为止。 描述了控制元件的各种组合，用于实现固定液体体积的形成，运输，混合和从小液体样品中除去夹带的气泡。
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