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1.发明申请SYSTEMS AND METHODS FOR BIOFILM REMOVAL, INCLUDING A BIOFILM REMOVAL ENDOSCOPE FOR USE THEREWITH 有权用于生物膜去除的系统和方法，包括用于其中的生物膜去除内窥镜公开(公告)号：US20120253125A1
公开(公告)日：2012-10-04
申请号：US13495564
申请日：2012-06-13
CPC分类号： A61B17/3203 , A61B1/00091 , A61B1/012 , A61B1/0125 , A61B1/015 , A61B1/12 , A61B1/227 , A61B1/233 , A61M1/0039
摘要： Systems and methods of removing bacterial biofilm from a target site using a biofilm removal endoscope. The endoscope has an insertion portion including an imaging channel terminating at a viewing window and an irrigation channel terminating at a nozzle. The imaging and irrigation channels are permanently affixed relative to one another. The insertion portion is inserted into the patient, with a working end thereof being disposed proximate the target site. The target site is imaged and a flow of fluid is dispensed via the nozzle to mechanically remove bacterial biofilm from the target site.
摘要翻译： 使用生物膜去除内窥镜从靶位点去除细菌生物膜的系统和方法。 内窥镜具有包括终端于观察窗口的成像通道和终止于喷嘴的冲洗通道的插入部分。 成像和灌溉通道相对于彼此永久地固定。 插入部分被插入患者体内，其工作端设置在目标部位附近。 成像目标部位，并通过喷嘴分配流体流，以从靶位置机械去除细菌生物膜。
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公开(公告)号：US07785337B2
公开(公告)日：2010-08-31
申请号：US10657915
申请日：2003-09-09
申请人： Kenneth M. Adams , Cecil O. Lewis
发明人： Kenneth M. Adams , Cecil O. Lewis
IPC分类号： A61B17/32
CPC分类号： A61B17/1688 , A61B17/24 , A61B17/32002 , A61B2217/005 , A61B2217/007
摘要： A surgical micro-burring instrument including an outer tubular member coaxially maintaining an inner tubular member. The outer tubular member defines a proximal section, a distal section, and a central lumen extending from the proximal section to the distal section. The distal section forms a pocket and an elevator tip. The pocket has a bottom wall and an opposed upper opening. The elevator tip extends distal the pocket. The inner tubular member forms a bur received within the pocket. Upon final assembly, at least a portion of the bur is exposed relative to the outer tubular member via the upper opening of the pocket. The elevator tip is configured to facilitate lifting of soft tissue, such as mucosa, while positioning the bur, via the pocket, in an appropriate location for cutting contacted harder tissue, such as turbinate bone or septal bone/cartilage.
摘要翻译： 一种手术微型毛刺装置，其包括同轴地保持内部管状构件的外部管状构件。 外部管状构件限定近端部分，远端部分和从近端部分延伸到远端部分的中心腔。 远侧部分形成一个口袋和一个电梯提示头。 口袋具有底壁和相对的上开口。 电梯尖端在口袋的远端延伸。 内部管状构件形成容纳在口袋内的毛刺。 在最终组装时，毛坯的至少一部分经由袋的上部开口相对于外管状构件露出。 电梯提示头构造成便于软组织（例如粘膜）的提升，同时通过口袋将毛囊定位在合适的位置，用于切割接触较硬的组织，例如鼻骨骨或间隔骨/软骨。
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公开(公告)号：US20080249483A1
公开(公告)日：2008-10-09
申请号：US11697789
申请日：2007-04-09
申请人： Dale E. Slenker , John R. Prisco , Cecil O. Lewis , Gerould W. Norman , Robert K. Vaccaro , Isaac C. Perry
发明人： Dale E. Slenker , John R. Prisco , Cecil O. Lewis , Gerould W. Norman , Robert K. Vaccaro , Isaac C. Perry
CPC分类号： A61B1/0055 , A61B1/015 , A61B1/2275 , A61B1/233 , A61B17/24 , A61B2017/00314 , A61B2017/242 , A61B2217/007 , A61M1/0058 , A61M3/0258 , A61M3/0279 , A61M25/0147
摘要： Systems and methods for removal of bacterial biofilm from a target site of a human patient includes a surgical instrument having an introducer for bodily insertion and maintaining an irrigation duct and a nozzle. A distal portion of the introducer is transitionable between a plurality of bend angles relative to a proximal portion thereof. In particular, the instrument is adapted to independently maintain the distal portion at each of the plurality of bend angles relative to the proximal portion. The nozzle is maintained relative to the distal portion of the introducer and is adapted to dispense pressurized irrigant from the irrigation duct toward a layer of bacterial biofilm.
摘要翻译： 用于从人类患者的靶位点去除细菌生物膜的系统和方法包括具有用于身体插入并保持冲洗管道和喷嘴的导引器的外科器械。 引导器的远端部分可相对于其近端部分在多个弯曲角度之间转变。 特别地，该仪器适合于相对于近端部分在多个弯曲角度的每一个处独立地保持远端部分。 喷嘴相对于导引器的远端部分保持，并且适于将加压冲洗液从冲洗管道分配到细菌生物膜层。
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4.发明申请公开(公告)号：US20070264310A1
公开(公告)日：2007-11-15
申请号：US11739528
申请日：2007-04-24
IPC分类号： A61F11/08
CPC分类号： A61F11/002 , A61K9/0046
摘要： Chronic Otitis Media with Effusion (COME), Recurrent Acute Otitis Media (RAOM), cholesteatoma, and other bacterial ear conditions may be treated by applying a solvating system containing greater than 0.2 wt. % surfactant to a bacterial biofilm in the middle or inner ear, disrupting the biofilm, and applying a protective layer of a polymeric film-forming medical sealant.
摘要翻译： 慢性中耳炎（COME），复发性急性中耳炎（RAOM），胆脂瘤和其他细菌耳朵病症可以通过使用包含大于0.2wt。 ％表面活性剂与中耳或内耳中的细菌生物膜，破坏生物膜，以及施加聚合物成膜医用密封剂的保护层。
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公开(公告)号：US20120184926A1
公开(公告)日：2012-07-19
申请号：US13323636
申请日：2011-12-12
CPC分类号： A61L26/0047 , A61L24/0015 , A61L24/0042 , A61L24/108 , A61L26/0014 , A61L26/0019 , A61L26/0023 , A61L26/0066 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2400/04 , C09J133/14 , C09J139/06 , C09J167/00 , C09J167/04 , C09J169/00 , C09J175/04 , C09J177/00 , C09J179/02 , C09J185/02
摘要： The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.
摘要翻译： 本发明提供一种聚合物医用密封剂。 医用密封剂可用于扁桃体和腺样体，其中密封剂具有以下功能中的至少一个：a）抑制细菌的定居，b）抑制细菌与组织的结合，c）减少组织发病率， d）止血，e）愈合过程中涂层和保护组织。 f）促进愈合，g）减轻疼痛。
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公开(公告)号：US20110009699A1
公开(公告)日：2011-01-13
申请号：US12886215
申请日：2010-09-20
CPC分类号： A61B1/015 , A61B1/00091 , A61B1/00135 , A61B1/0051 , A61M1/0064 , A61M3/0283
摘要： A method of removing bacterial biofilm from a target site of a human patient. A bacterial biofilm removal system is provided that includes an endoscope, an irrigation duct and an aspiration duct. The endoscope includes a working end. The irrigation duct includes an outlet. The aspiration duct includes an inlet. The endoscope working end, the irrigation duct outlet and the aspiration duct inlet are disposed proximate a target site that includes a layer of bacterial biofilm. The target site is imaged with the endoscope working end. The fluid is dispensed through the irrigation duct outlet toward the target site to mechanically remove at least a portion of the layer of bacterial biofilm. The removed bacterial biofilm and the dispensed fluid are collected with the aspiration duct inlet.
摘要翻译： 从人类患者的靶位点去除细菌生物膜的方法。 提供了一种细菌生物膜去除系统，其包括内窥镜，冲洗管道和抽吸管道。 内窥镜包括工作端。 灌溉管道包括一个出口。 抽吸管包括入口。 内窥镜工作端，冲洗管道出口和抽吸管道入口设置在包括细菌生物膜层的靶位置附近。 目标部位用内窥镜工作端成像。 将流体通过冲洗管出口分配到目标部位以机械地去除细菌生物膜层的至少一部分。 去除的细菌生物膜和分配的液体被抽吸管道入口收集。
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7.发明申请EXTRACELLULAR POLYSACCHARIDE SOLVATING SYSTEM FOR TREATMENT OF BACTERIAL EAR CONDITIONS 有权用于治疗细菌性耳朵的细胞多糖溶解系统公开(公告)号：US20070264353A1
公开(公告)日：2007-11-15
申请号：US11739508
申请日：2007-04-24
摘要： Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.
摘要翻译： 可以通过将含有金属离子螯合剂和表面活性剂的溶剂化体系应用于中耳或内耳的细菌生物膜来治疗慢性中耳炎和其它细菌耳朵病症。 溶剂化系统破坏生物膜并有助于其去除。
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公开(公告)号：US09326665B2
公开(公告)日：2016-05-03
申请号：US11697789
申请日：2007-04-09
申请人： Dale E. Slenker , John R. Prisco , Cecil O. Lewis , Gerould W. Norman , Robert K. Vaccaro , Isaac C. Perry
发明人： Dale E. Slenker , John R. Prisco , Cecil O. Lewis , Gerould W. Norman , Robert K. Vaccaro , Isaac C. Perry
IPC分类号： A61M1/00 , A61B1/00 , A61M31/00 , A61B1/005 , A61M25/01 , A61B1/015 , A61B1/227 , A61B1/233 , A61M3/02 , A61B17/24 , A61B17/00
CPC分类号： A61B1/0055 , A61B1/015 , A61B1/2275 , A61B1/233 , A61B17/24 , A61B2017/00314 , A61B2017/242 , A61B2217/007 , A61M1/0058 , A61M3/0258 , A61M3/0279 , A61M25/0147
摘要： Systems and methods for removal of bacterial biofilm from a target site of a human patient includes a surgical instrument having an introducer for bodily insertion and maintaining an irrigation duct and a nozzle. A distal portion of the introducer is transitionable between a plurality of bend angles relative to a proximal portion thereof. In particular, the instrument is adapted to independently maintain the distal portion at each of the plurality of bend angles relative to the proximal portion. The nozzle is maintained relative to the distal portion of the introducer and is adapted to dispense pressurized irrigant from the irrigation duct toward a layer of bacterial biofilm.
摘要翻译： 用于从人类患者的靶位点去除细菌生物膜的系统和方法包括具有用于身体插入并保持冲洗管道和喷嘴的导引器的外科器械。 引导器的远端部分可相对于其近端部分在多个弯曲角度之间转变。 特别地，该仪器适合于相对于近端部分在多个弯曲角度的每一个处独立地保持远端部分。 喷嘴相对于导引器的远端部分保持，并且适于将加压冲洗液从冲洗管道分配到细菌生物膜层。
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公开(公告)号：US09119896B2
公开(公告)日：2015-09-01
申请号：US13323636
申请日：2011-12-12
CPC分类号： A61L26/0047 , A61L24/0015 , A61L24/0042 , A61L24/108 , A61L26/0014 , A61L26/0019 , A61L26/0023 , A61L26/0066 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2400/04 , C09J133/14 , C09J139/06 , C09J167/00 , C09J167/04 , C09J169/00 , C09J175/04 , C09J177/00 , C09J179/02 , C09J185/02
摘要： The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.
摘要翻译： 本发明提供一种聚合物医用密封剂。 医用密封剂可用于扁桃体和腺样体，其中密封剂具有以下功能中的至少一个：a）抑制细菌的定居，b）抑制细菌与组织的结合，c）减少组织发病率， d）止血，e）愈合过程中涂层和保护组织。 f）促进愈合，g）减轻疼痛。
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公开(公告)号：US08313489B2
公开(公告)日：2012-11-20
申请号：US12852834
申请日：2010-08-09
申请人： Kenneth M. Adams , Cecil O. Lewis
发明人： Kenneth M. Adams , Cecil O. Lewis
IPC分类号： A61B17/00
CPC分类号： A61B17/1688 , A61B17/24 , A61B17/32002 , A61B2217/005 , A61B2217/007
摘要： A surgical micro-burring instrument including an outer tubular member coaxially maintaining an inner tubular member. The outer tubular member defines a proximal section, a distal section, and a central lumen extending from the proximal section to the distal section. The distal section forms a pocket and an elevator tip. The pocket has a bottom wall and an opposed upper opening. The elevator tip extends distal the pocket. The inner tubular member forms a bur received within the pocket. Upon final assembly, at least a portion of the bur is exposed relative to the outer tubular member via the upper opening of the pocket. The elevator tip is configured to facilitate lifting of soft tissue, such as mucosa, while positioning the bur, via the pocket, in an appropriate location for cutting contacted harder tissue, such as turbinate bone or septal bone/cartilage.
摘要翻译： 一种手术微型毛刺装置，其包括同轴地保持内部管状构件的外部管状构件。 外部管状构件限定近端部分，远端部分和从近端部分延伸到远端部分的中心腔。 远侧部分形成一个口袋和一个电梯提示头。 口袋具有底壁和相对的上开口。 电梯尖端在口袋的远端延伸。 内部管状构件形成容纳在口袋内的毛刺。 在最终组装时，毛坯的至少一部分经由袋的上部开口相对于外管状构件露出。 电梯提示头构造成便于软组织（例如粘膜）的提升，同时通过口袋将毛囊定位在合适的位置，用于切割接触较硬的组织，例如鼻骨骨或间隔骨/软骨。
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