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1.发明授权Dirofilaria and onchocerca larval L3 cysteine protease proteins and uses thereof 失效Dirofilaria和onchocerca幼虫L3半胱氨酸蛋白酶蛋白及其用途
公开(公告)号：US5792624A
公开(公告)日：1998-08-11
申请号：US482282
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/64 , G01N33/50 , G01N33/53 , G01N33/569 , C12P21/06 , C12N15/00 , C12P21/04
CPC分类号： G01N33/5091 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , C12N9/641 , G01N33/5008 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US06419923B1
公开(公告)日：2002-07-16
申请号：US08768619
申请日：1996-12-18
IPC分类号： A61K3846
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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3.发明授权公开(公告)号：US06365392B1
公开(公告)日：2002-04-02
申请号：US09005298
申请日：1998-01-09
IPC分类号： C12N701
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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4.发明授权Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof 失效丝状线虫半胱氨酸蛋白酶蛋白，核酸分子及其用途
公开(公告)号：US5795768A
公开(公告)日：1998-08-18
申请号：US486036
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K35/68 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P33/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N7/00 , C12N9/64 , C12N15/57 , C12Q1/37 , G01N33/50 , G01N33/53 , G01N33/569 , C12N1/20
CPC分类号： C12N9/641 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , G01N33/5008 , G01N33/5091 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US5750391A
公开(公告)日：1998-05-12
申请号：US463989
申请日：1995-06-05
IPC分类号： C12N15/09 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/002 , A61K39/395 , A61K48/00 , A61P5/12 , A61P33/00 , A61P33/02 , A61P33/10 , A61P43/00 , C07H21/04 , C07K14/44 , C12N1/21 , C12N5/10 , C12N9/50 , C12N9/64 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C12N9/48
CPC分类号： C12N9/641 , C12N9/6416 , A61K39/00
摘要： The present invention relates to parasite astacin metalloendopeptidase and filariid cysteine protease proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases or cysteine proteases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm.
摘要翻译： 本发明涉及寄生虫星细胞金属内肽酶和丝状半胱氨酸蛋白酶蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体以及可抑制寄生虫星形金属内毒肽酶或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物以及它们用于保护动物免受由寄生虫如心脏病引起的疾病的用途。
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公开(公告)号：US5691186A
公开(公告)日：1997-11-25
申请号：US463262
申请日：1995-06-05
IPC分类号： C12N15/09 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/002 , A61K39/395 , A61K48/00 , A61P5/12 , A61P33/00 , A61P33/02 , A61P33/10 , A61P43/00 , C07H21/04 , C07K14/44 , C12N1/21 , C12N5/10 , C12N9/50 , C12N9/64 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , C12N15/63
CPC分类号： C12N9/641 , C12N9/6416 , A61K39/00
摘要： The present invention relates to parasite astacin metalloendopeptidase and filariid cysteine protease proteins, nucleic acid molecules having sequences that encode such proteins, antibodies raised against such proteins and compounds that can inhibit the activities of parasite astacin metalloendopeptidases or cysteine proteases. The present invention also includes methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitors. The present invention also includes therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites, such as heartworm.
摘要翻译： 本发明涉及寄生虫星细胞金属内肽酶和丝状半胱氨酸蛋白酶蛋白质，具有编码这种蛋白质的序列的核酸分子，针对这种蛋白质产生的抗体以及可抑制寄生虫星形金属内毒肽酶或半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种核酸分子，蛋白质，抗体和抑制剂的方法。 本发明还包括包含这种核酸分子，蛋白质，抗体和抑制剂的治疗组合物以及它们用于保护动物免受由寄生虫如心脏病引起的疾病的用途。
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公开(公告)号：US6114142A
公开(公告)日：2000-09-05
申请号：US473034
申请日：1995-06-06
CPC分类号： C07K14/4354 , C07K16/20
摘要： The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, and/or antibodies as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及约39kD（即P39蛋白）的寄生蠕虫蛋白; 包括寄生蠕虫P39核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US5977306A
公开(公告)日：1999-11-02
申请号：US487031
申请日：1995-06-06
CPC分类号： A61K38/27 , G01N33/5308 , G01N33/56905 , C12N2799/021
摘要： The present invention relates to parasitic helminth proteins of about 39 kD (i.e., P39 proteins); to parasitic helminth P39 nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules, and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, and/or antibodies as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及约39kD（即P39蛋白）的寄生蠕虫蛋白; 包括寄生蠕虫P39核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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9.发明授权Compositions of parasitic helminth PLA2 nucleic acid molecules and uses thereof 失效寄生蠕虫PLA2核酸分子的组成及其用途公开(公告)号：US06673916B1
公开(公告)日：2004-01-06
申请号：US09391270
申请日：1999-09-07
IPC分类号： C07H2104
CPC分类号： G01N33/502 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K39/39533 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , A61K2300/00
摘要： The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫PLA2蛋白; 包括寄生虫的PLA2核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制寄生蠕虫磷脂酶A2活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。 本发明还包括含有这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US06391569B1
公开(公告)日：2002-05-21
申请号：US08715628
申请日：1996-09-18
IPC分类号： G01N3353
CPC分类号： C07K14/4354 , G01N33/569 , G01N2333/4353
摘要： The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in a host animal using a D. immitis anti-Di33 protein to detect Di33 proteins in a bodily fluid of the animal. The present invention also relates to D. immitis detection kits that include either a Di33 protein or an anti-Di33 antibody; such kits also include a composition to detect an immunocomplex between the anti-Di33 antibody and D. immitis Di33 protein. The present invention also includes Di33 proteins, nucleic acid molecules encoding such proteins, as well as recombinant molecules and recombinant cells comprising such nucleic acid molecules, and anti-Di33 antibodies. Also included are methods to produce such proteins, nucleic acid molecules and antibodies.
摘要翻译： 本发明包括使用D.Imitmiti Di33蛋白检测宿主动物中的D. immitis感染以检测抗-D的方法。 immitis Di33抗体在动物的体液中。 还包括在宿主动物中使用D.emmitis抗-Di33蛋白检测动物体内的Di33蛋白的方法。 本发明还涉及包含Di33蛋白或抗-Di33抗体的D.IMIITIS检测试剂盒; 这样的试剂盒还包括用于检测抗Di33抗体和D.Imitmiti Di33蛋白之间的免疫复合物的组合物。 本发明还包括Di33蛋白，编码这种蛋白质的核酸分子，以及重组分子和包含这种核酸分子的重组细胞和抗Di33抗体。 还包括产生这种蛋白质，核酸分子和抗体的方法。
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