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1.发明授权Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof 失效寄生虫蠕虫巨噬细胞迁移抑制因子蛋白质，核酸分子及其用途公开(公告)号：US06207158B1
公开(公告)日：2001-03-27
申请号：US08906480
申请日：1997-08-05
IPC分类号： A61K3900
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子， 针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US5789194A
公开(公告)日：1998-08-04
申请号：US450944
申请日：1995-05-23
申请人： Cynthia Ann Tripp , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Nancy Wisnewski
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P33/00 , C07K14/435 , C07K14/44 , C07K16/18 , C07K16/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/00 , C12P21/02 , C12P21/00 , C07H21/04 , C07K1/00
CPC分类号： C07K16/18 , C07K14/4354 , A61K38/00 , A61K39/00
摘要： The present invention relates to parasitic helminth venom allergen antigen 5-like proteins; to parasitic helminth venom allergen antigen 5-like nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules and/or antibodies, as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫毒液变应原抗原5样蛋白; 对寄生蠕虫毒素变应原抗原5样核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。 本发明还包括获得这些蛋白质，核酸分子和抗体的方法。 本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US06419923B1
公开(公告)日：2002-07-16
申请号：US08768619
申请日：1996-12-18
IPC分类号： A61K3846
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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4.发明授权Parasitic helminth macrophage inhibitory factor nucleic acid molecules and uses thereof 失效寄生蠕虫巨噬细胞抑制因子核酸分子及其用途
公开(公告)号：US5681724A
公开(公告)日：1997-10-28
申请号：US558735
申请日：1995-11-16
IPC分类号： G01N33/53 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/002 , A61P33/00 , A61P33/02 , A61P33/10 , C07K14/44 , C07K14/52 , C07K16/20 , C12N7/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/10 , H01G9/04 , H01G9/055 , C07H21/04
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子， 针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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5.发明授权Anti-parasitic helminth macrophage migration inhibitory factor antibodies and uses thereof 有权抗寄生虫蠕虫巨噬细胞迁移抑制因子抗体及其用途公开(公告)号：US06455039B2
公开(公告)日：2002-09-24
申请号：US09774377
申请日：2001-01-30
IPC分类号： C12Q168
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译： 本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子， 针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。 本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及使用这些治疗组合物来保护动物免受寄生蠕虫引起的疾病。
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6.发明授权公开(公告)号：US06365392B1
公开(公告)日：2002-04-02
申请号：US09005298
申请日：1998-01-09
IPC分类号： C12N701
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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7.发明授权Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof 失效丝状线虫半胱氨酸蛋白酶蛋白，核酸分子及其用途
公开(公告)号：US5795768A
公开(公告)日：1998-08-18
申请号：US486036
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K35/68 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P33/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N7/00 , C12N9/64 , C12N15/57 , C12Q1/37 , G01N33/50 , G01N33/53 , G01N33/569 , C12N1/20
CPC分类号： C12N9/641 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , G01N33/5008 , G01N33/5091 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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8.发明授权Dirofilaria and onchocerca larval L3 cysteine protease proteins and uses thereof 失效Dirofilaria和onchocerca幼虫L3半胱氨酸蛋白酶蛋白及其用途
公开(公告)号：US5792624A
公开(公告)日：1998-08-11
申请号：US482282
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/64 , G01N33/50 , G01N33/53 , G01N33/569 , C12P21/06 , C12N15/00 , C12P21/04
CPC分类号： G01N33/5091 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , C12N9/641 , G01N33/5008 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译： 本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。 本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。 本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。
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公开(公告)号：US07208589B2
公开(公告)日：2007-04-24
申请号：US10855541
申请日：2004-05-27
申请人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
发明人： Nancy Wisnewski , Anna M. Becher , Eric Jarvis
CPC分类号： C07K14/4359 , C07K14/721 , Y10S530/858
摘要： We claim a flea ultraspiracle nucleic acid molecule encoding an ultraspiracle protein, and a composition comprising the isolated nucleic acid molecule. Also, we claim a method of recombinantly producing the ultraspiracle protein thereof.
摘要翻译： 我们要求编码超尖锐蛋白的跳蚤超尖锐核酸分子和包含分离的核酸分子的组合物。 此外，我们要求重组产生其超蛋白质蛋白的方法。
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公开(公告)号：US06506784B1
公开(公告)日：2003-01-14
申请号：US09606986
申请日：2000-06-29
申请人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Dimitris Agrafiotis , Nancy Wisnewski , Gary M. Silver , Dan T. Stinchcomb , R. Lee Seward
发明人： Daljit S. Dhanoa , Dario Doller , Sanath Meegalla , Richard M. Soll , Dimitris Agrafiotis , Nancy Wisnewski , Gary M. Silver , Dan T. Stinchcomb , R. Lee Seward
IPC分类号： A01N4356
CPC分类号： A01N43/56
摘要： The present invention is directed to inhibiting pest GABA receptors by contacting said receptors with a compound of Formula I: The invention is also directed to methods of controlling pests, especially insects and arachnids such as fleas and ticks, and to novel compounds within the scope of Formula I.
摘要翻译： 本发明涉及通过使所述受体与式I化合物接触来抑制病虫害GABA受体：本发明还涉及防治害虫，特别是昆虫和蜘蛛如跳蚤和蜱的方法，以及在本发明范围内的新化合物 一级方程式
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