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24 条记录 (耗时 0.018 秒)

    Biodegradable bursting release system
    3.
    发明授权
    Biodegradable bursting release system 失效
    可生物降解爆破释放系统

    公开(公告)号：US5429822A

    公开(公告)日：1995-07-04

    申请号：US852372

    申请日：1992-03-13

    申请人： Joseph D. Gresser ,  Donald L. Wise ,  Abdul G. Jimoh ,  Don C. Augenstein ,  Dean O. Kuethe ,  Debra J. Trantolo

    发明人： Joseph D. Gresser ,  Donald L. Wise ,  Abdul G. Jimoh ,  Don C. Augenstein ,  Dean O. Kuethe ,  Debra J. Trantolo

    IPC分类号： A61K9/00 ,  A61F2/00

    CPC分类号： A61K9/0024

    摘要： A biodegradable polymeric multiphasic release system of one or more biodegradable bursting units capable of delivering biologically active substances in a burst or pulse at predetermined times and a method for constructing those units is disclosed. The individual bursting units of the system may take the form of a biodegradable, membrane coated capsule surrounding a core material which may include an active agent. The membrane ruptures after a predetermined time upon exposure to water or bodily, or other aqueous environmental fluids. The bursting units may be used in any situation in which a controlled pulsed release of an active substance is desired. The predetermined time release of each bursting unit is controlled by the composition of the core material, the initial radius and wall thickness of the membrane and the porosity of the membrane. The core material may also contain a chemical composition which generates gas as fluid is drawn into the bursting unit thus adding an additional design variable for predetermining bursts.

    摘要翻译： 公开了一种可生物降解的聚合多相释放系统，该系统能够在预定时间内以突发或脉冲递送生物活性物质，以及用于构建这些单元的方法。 系统的各个破裂单元可以采用围绕可以包含活性剂的核心材料的可生物降解的膜包膜的形式。 暴露于水或身体或其他含水环境液体之后，膜会在预定时间后破裂。 爆破单元可以用于需要活性物质的受控脉冲释放的任何情况。 每个破裂单元的预定时间释放由芯材料的组成，膜的初始半径和壁厚度以及膜的孔隙度来控制。 核心材料还可以包含当流体被拉入破裂单元时产生气体的化学组成，从而为预先确定的脉冲串添加额外的设计变量。

    Use of aromatic salts for simultaneously removing SO.sub.2 and NO.sub.x pollutants from exhaust of a combustion system
    4.
    发明授权
    Use of aromatic salts for simultaneously removing SO.sub.2 and NO.sub.x pollutants from exhaust of a combustion system 失效
    使用芳香盐同时从燃烧系统排气中除去SO2和NOx污染物

    公开(公告)号：US5352423A

    公开(公告)日：1994-10-04

    申请号：US39853

    申请日：1993-03-30

    申请人： Yiannis A. Levendis ,  Donald L. Wise

    发明人： Yiannis A. Levendis ,  Donald L. Wise

    IPC分类号： B01D53/60 ,  B01J20/04 ,  B01D53/34

    CPC分类号： B01D53/60 ,  B01J20/041 ,  B01J20/28021 ,  B01J20/3078 ,  B01J20/3085

    摘要： A method is disclosed for removing pollutants from the exhaust of combustion systems burning fuels containing substantial amounts of sulfur and nitrogen. An exemplary method of the invention involves the formation and reaction of a sorbent comprising calcium benzoate. The calcium benzoate is either dry-sprayed (in the form of a fine powder) or wet-sprayed in an aqueous solution in a high temperature environment such as a combustion chamber. The latter technique is feasible since calcium benzoate is a water-soluble form of calcium. When the dispersed particles of calcium benzoate are heated to a high temperature, the organic benzoate burns off and fine calcium oxide particles are formed. These particles are cenospheric (hollow) and have thin and highly porous walls, thus, affording optimum external and internal accessibility for reacting with toxic gaseous emissions such as SO.sub.2. Further, the combustion of the organic benzoate portion of the sorbent results in the conversion of NO.sub.x to N.sub.2.

    摘要翻译： 公开了一种从燃烧系统的排气中除去燃烧含有大量硫和氮的燃料的污染物的方法。 本发明的示例性方法涉及包含苯甲酸钙的吸附剂的形成和反应。 苯甲酸钙可以在高温环境如燃烧室中喷雾（以细粉末的形式）或在水溶液中湿喷雾。 后一种技术是可行的，因为苯甲酸钙是水溶性形式的钙。 当苯甲酸钙的分散颗粒被加热到高温时，有机苯甲酸盐被烧掉并形成细小的氧化钙颗粒。 这些颗粒是空心的（空心的）并且具有薄且高度多孔的壁，因此，提供最佳的外部和内部可接近性以与诸如SO 2的有毒气体排放物反应。 此外，吸附剂的有机苯甲酸酯部分的燃烧导致NOx转化为N 2。

    Resorbable interbody spinal fusion devices
    5.
    发明授权
    Resorbable interbody spinal fusion devices 失效
    可再生体内脊柱融合装置

    公开(公告)号：US07077866B2

    公开(公告)日：2006-07-18

    申请号：US09785593

    申请日：2001-02-16

    申请人： Joseph D. Gresser ,  Debra J. Trantolo ,  Robert S. Langer ,  Kai-Uwe Lewandrowski ,  Alexander M. Klibanov ,  Donald L. Wise

    发明人： Joseph D. Gresser ,  Debra J. Trantolo ,  Robert S. Langer ,  Kai-Uwe Lewandrowski ,  Alexander M. Klibanov ,  Donald L. Wise

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4455 ,  A61F2/30965 ,  A61F2/442 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30112 ,  A61F2002/30133 ,  A61F2002/30153 ,  A61F2002/30179 ,  A61F2002/30217 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30868 ,  A61F2002/30904 ,  A61F2002/30957 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0015 ,  A61F2230/0019 ,  A61F2230/0058 ,  A61F2230/0067 ,  Y10S623/926

    摘要： A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25–100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.

    摘要翻译： 公开了一种用于脊柱固定的可再吸收体内融合装置。 该装置由25-100％的生物可吸收或可再吸收材料组成。 本发明的体内融合装置可以是任何方便的形式，例如楔形物，螺钉或笼子。 优选地，本发明的可再吸收装置是锥形楔形或锥形的形状，其进一步期望地包括诸如锯齿或线的结构特征，以更好地将装置锚定在相邻的椎骨中。 优选的装置还包括多个周边空隙，并且更期望地为其中的中心空隙空间，其可期望地填充有用于促进骨发育和/或脊柱融合的接枝材料，例如自体移植材料。 作为制造可再吸收的体内融合装置的优选材料最可能是在水解降解时可以产生酸性产物的聚合物，该装置优选还包含足够高浓度的中和化合物或缓冲剂，以降低 pH值随器械降解而改变，以防止在植入物区域积聚无缓冲酸性产物引起的无菌性脓肿形成。

    Sustained release of pharmaceuticals from polyester matrices
    8.
    发明授权
    Sustained release of pharmaceuticals from polyester matrices 失效
    从聚酯基质中持续释放药物

    公开(公告)号：US3978203A

    公开(公告)日：1976-08-31

    申请号：US487886

    申请日：1974-07-12

    申请人： Donald L. Wise

    发明人： Donald L. Wise

    IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K31/74

    CPC分类号： A61K9/204

    摘要： A novel class of polymer-based products for use in physiological environment, e.g. for use as sutures or implanted, medicine-bearing compositions for use in controlled-rate medication, or the like. The advantageous polymers on which these products are based are condensation polymers formed of Krebs cycle acid-type compounds and a physiologically-tolerable polyol type compound such as glycerol or the like.

    Method of making biopolymer-based nonlinear optical materials
    10.
    发明授权
    Method of making biopolymer-based nonlinear optical materials 失效
    制备基于生物聚合物的非线性光学材料的方法

    公开(公告)号：US5512218A

    公开(公告)日：1996-04-30

    申请号：US217312

    申请日：1994-03-24

    申请人： Joseph D. Gresser ,  Debra J. Trantolo ,  Donald L. Wise ,  Gary E. Wnek

    发明人： Joseph D. Gresser ,  Debra J. Trantolo ,  Donald L. Wise ,  Gary E. Wnek

    IPC分类号： B29D7/01 ,  C08G69/10 ,  G02F1/361 ,  B29D11/00 ,  G02F1/37

    CPC分类号： C08G69/10 ,  B29D7/01 ,  G02F1/3615 ,  B29K2093/00 ,  B29K2105/0079

    摘要： A biopolymer film and other materials that exhibit nonlinear optical (NLO) properties and a method for making this film. Alignment of biopolymer molecules, which is required for NLO phenomena, is achieved by application of an electric field parallel to the surface of a biopolymer solution as the film is formed. In one embodiment, a solution of poly(.gamma.-benzyl-L-glutamate), PBLG, in methylene chloride is employed. Upon application of an electric field, laminar structures perpendicular to both the field direction and to the film surface are formed. These ordered structures are captured in the film upon evaporation of the biopolymer solvent.

    摘要翻译： 展示非线性光学（NLO）性质的生物聚合物膜和其它材料以及制备该膜的方法。 NLO现象所需的生物聚合物分子的对准通过在形成膜时施加与生物聚合物溶液的表面平行的电场来实现。 在一个实施方案中，使用聚（γ-苄基-L-谷氨酸酯），PBLG在二氯甲烷中的溶液。 在施加电场时，形成垂直于场方向和膜表面的层状结构。 当生物聚合物溶剂蒸发时，这些有序结构被捕获在膜中。