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    Resorbable interbody spinal fusion devices
    2.
    发明授权
    Resorbable interbody spinal fusion devices 失效
    可再生体内脊柱融合装置

    公开(公告)号：US07077866B2

    公开(公告)日：2006-07-18

    申请号：US09785593

    申请日：2001-02-16

    申请人： Joseph D. Gresser ,  Debra J. Trantolo ,  Robert S. Langer ,  Kai-Uwe Lewandrowski ,  Alexander M. Klibanov ,  Donald L. Wise

    发明人： Joseph D. Gresser ,  Debra J. Trantolo ,  Robert S. Langer ,  Kai-Uwe Lewandrowski ,  Alexander M. Klibanov ,  Donald L. Wise

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4455 ,  A61F2/30965 ,  A61F2/442 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30112 ,  A61F2002/30133 ,  A61F2002/30153 ,  A61F2002/30179 ,  A61F2002/30217 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30868 ,  A61F2002/30904 ,  A61F2002/30957 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0015 ,  A61F2230/0019 ,  A61F2230/0058 ,  A61F2230/0067 ,  Y10S623/926

    摘要： A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25–100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.

    摘要翻译： 公开了一种用于脊柱固定的可再吸收体内融合装置。 该装置由25-100％的生物可吸收或可再吸收材料组成。 本发明的体内融合装置可以是任何方便的形式，例如楔形物，螺钉或笼子。 优选地，本发明的可再吸收装置是锥形楔形或锥形的形状，其进一步期望地包括诸如锯齿或线的结构特征，以更好地将装置锚定在相邻的椎骨中。 优选的装置还包括多个周边空隙，并且更期望地为其中的中心空隙空间，其可期望地填充有用于促进骨发育和/或脊柱融合的接枝材料，例如自体移植材料。 作为制造可再吸收的体内融合装置的优选材料最可能是在水解降解时可以产生酸性产物的聚合物，该装置优选还包含足够高浓度的中和化合物或缓冲剂，以降低 pH值随器械降解而改变，以防止在植入物区域积聚无缓冲酸性产物引起的无菌性脓肿形成。

    Method of making biopolymer-based nonlinear optical materials
    3.
    发明授权
    Method of making biopolymer-based nonlinear optical materials 失效
    制备基于生物聚合物的非线性光学材料的方法

    公开(公告)号：US5512218A

    公开(公告)日：1996-04-30

    申请号：US217312

    申请日：1994-03-24

    申请人： Joseph D. Gresser ,  Debra J. Trantolo ,  Donald L. Wise ,  Gary E. Wnek

    发明人： Joseph D. Gresser ,  Debra J. Trantolo ,  Donald L. Wise ,  Gary E. Wnek

    IPC分类号： B29D7/01 ,  C08G69/10 ,  G02F1/361 ,  B29D11/00 ,  G02F1/37

    CPC分类号： C08G69/10 ,  B29D7/01 ,  G02F1/3615 ,  B29K2093/00 ,  B29K2105/0079

    摘要： A biopolymer film and other materials that exhibit nonlinear optical (NLO) properties and a method for making this film. Alignment of biopolymer molecules, which is required for NLO phenomena, is achieved by application of an electric field parallel to the surface of a biopolymer solution as the film is formed. In one embodiment, a solution of poly(.gamma.-benzyl-L-glutamate), PBLG, in methylene chloride is employed. Upon application of an electric field, laminar structures perpendicular to both the field direction and to the film surface are formed. These ordered structures are captured in the film upon evaporation of the biopolymer solvent.

    摘要翻译： 展示非线性光学（NLO）性质的生物聚合物膜和其它材料以及制备该膜的方法。 NLO现象所需的生物聚合物分子的对准通过在形成膜时施加与生物聚合物溶液的表面平行的电场来实现。 在一个实施方案中，使用聚（γ-苄基-L-谷氨酸酯），PBLG在二氯甲烷中的溶液。 在施加电场时，形成垂直于场方向和膜表面的层状结构。 当生物聚合物溶剂蒸发时，这些有序结构被捕获在膜中。

    Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements
    6.
    发明授权
    Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements 有权
    用于内固定装置和骨水泥的生物可降解聚合物半互穿网络合金

    公开(公告)号：US06486232B1

    公开(公告)日：2002-11-26

    申请号：US09663612

    申请日：2000-09-18

    申请人： Donald L. Wise ,  Joseph D. Gresser ,  Debra J. Trantolo ,  Yung-Yueh Hsu

    发明人： Donald L. Wise ,  Joseph D. Gresser ,  Debra J. Trantolo ,  Yung-Yueh Hsu

    IPC分类号： A61L2408

    CPC分类号： A61L27/58 ,  A61B17/80 ,  A61B17/866 ,  A61B17/8833 ,  A61B2017/00004 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/30004 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2210/0004 ,  A61F2250/0014 ,  A61L24/0042 ,  A61L24/0094 ,  A61L24/043 ,  A61L27/26 ,  A61L27/48 ,  A61L2430/02 ,  C08L67/04 ,  C08L35/02

    摘要： A bioerodible polymeric material, and in particular a semi-interpenetrating network (“semi-IPN”) alloy, is disclosed. A beneficial end use of this material is in the form of internal fixation devices (IFDs) (such as bone supports, plates, and pins) and as cured bone cements for bone repair. A multi-part bioerodible cement system, which, upon mixing of the system parts, forms a cured bioerodible cement, includes, in one part, a first bioerodible polymer (e.g., PLGA) capable of producing acidic products upon hydrolytic degradation, and, in another part, a second bioerodible scaffolding polymer (e.g., PPF) which upon crosslinking provides a biopolymeric scaffolding or internal reinforcement for the cured cement. In another aspect, a bone cement system of the invention includes a bioerodible scaffolding polymer (such as PPF), which when polymerized provides a hardened bone cement, the cement system further including a gas generating agent in stabilized form for providing the cured bone cement with pores for facilitating inward cell migration.

    摘要翻译： 公开了一种生物可腐蚀的聚合物材料，特别是半互穿网络（“半IPN”）合金。 这种材料的有益的最终用途是内固定装置（IFD）（例如骨支撑件，板和销）以及用于骨修复的固化骨水泥的形式。 多部分生物可腐蚀水泥体系，其在系统部件混合后形成固化的生物可侵蚀水泥，其中一部分包括能够在水解降解时产生酸性产物的第一生物可腐蚀聚合物（例如PLGA） 另一部分，第二生物可蚀解脚手架聚合物（例如，PPF），其在交联时为固化的水泥提供生物聚合物脚手架或内部增强。 在另一方面，本发明的骨水泥系统包括生物可蚀解脚手架聚合物（例如PPF），当聚合时提供硬化的骨水泥，所述水泥系统还包括稳定形式的气体发生剂，用于提供固化的骨水泥， 用于促进内向细胞迁移的孔。

    Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
    10.
    发明授权
    Method for making a bioerodible material for the sustained release of a medicament and the material made from the method 失效
    用于制备药物持续释放的生物腐蚀性材料的方法和由该方法制成的材料

    公开(公告)号：US5456917A

    公开(公告)日：1995-10-10

    申请号：US180914

    申请日：1994-01-12

    申请人： Donald L. Wise ,  Debra J. Trantolo ,  Joseph D. Gresser

    发明人： Donald L. Wise ,  Debra J. Trantolo ,  Joseph D. Gresser

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/52 ,  A61K47/30

    CPC分类号： A61K9/1647

    摘要： A method for making an implantable bioerodible material for the sustained release of a medicament and the material made from the method. The method comprises the formulation of a biomaterial polymeric carrier into particles of predetermined density and size. The particles are then are mixed with the desired medicament and extruded into the desired shape for implantation or reground to a predetermined size distribution for injection as a suspension. In an alternative embodiment, the particles of polymeric carrier are immersed in a solvent containing a medicament, and the pores of the particles are filled with medicament through alternate application and release of vacuum.

    摘要翻译： 一种用于制造用于药物的持续释放和由该方法制成的材料的可植入生物腐蚀性材料的方法。 该方法包括将生物材料聚合物载体配制成预定密度和尺寸的颗粒。 然后将颗粒与期望的药物混合并挤出成所需的形状，用于植入或再循环至作为悬浮液注射的预定尺寸分布。 在替代实施方案中，将聚合物载体的颗粒浸入含有药物的溶剂中，并且通过交替施加和释放真空来填充颗粒的孔。