Surface treatment
    1.
    发明授权
    Surface treatment 有权
    表面处理

    公开(公告)号:US09110056B2

    公开(公告)日:2015-08-18

    申请号:US12540526

    申请日:2009-08-13

    IPC分类号: C12M3/00 G01N33/543

    CPC分类号: G01N33/54366

    摘要: A biosensor comprising surface treated with a method for producing a monolayer of molecules on a surface, the method comprising loading a stamp with seed molecules, transferring seed molecules from the stamp to the surface, wherein transferring comprises transferring a fraction of the seed molecules loaded on the stamp to the surface and adsorbing the seed molecules to the stamp and adsorbing the seed molecules to the surface, the adsorption of the seed molecules to the stamp being stronger than the adsorption of the seed molecules to the surface, self-completing amplification of the seed molecules via an amplifying reaction to produce the monolayer on a flat surface, wherein self-completing amplification comprises producing a homogeneous area, wherein the homogeneous area comprises a monolayer of molecules on the surface, and wherein the monolayer of molecules on the surface has no diffusive component that can relocate and destroy amplification accuracy.

    摘要翻译: 一种生物传感器,包括用在表面上产生单层分子的方法进行表面处理的方法,所述方法包括用种子分子加载印模,将种子分子从印模转移到表面,其中转印包括转移一部分加载的种子分子 将表面吸附并将种子分子吸附到印模上并将种子分子吸附到表面,种子分子对印模的吸附比种子分子吸附到表面更强,自我完成的扩增 种子分子通过扩增反应在平坦表面上产生单层,其中自我完成扩增包括产生均匀区域,其中均匀区域包括表面上的单分子层,并且其中表面上的单分子层没有 扩散成分可以重新定位并破坏放大精度。

    MICROFLUIDIC DEVICE WITH AUXILIARY AND BYPASS CHANNELS
    3.
    发明申请
    MICROFLUIDIC DEVICE WITH AUXILIARY AND BYPASS CHANNELS 有权
    具有辅助和旁路通道的微流体装置

    公开(公告)号:US20130337578A1

    公开(公告)日:2013-12-19

    申请号:US13881975

    申请日:2011-08-03

    IPC分类号: B01L3/00

    摘要: The invention is directed to a microfluidic device having a flow inlet and outlet, generally defining a flow direction. A bypass channel (11) and an auxiliary channel (21) are provided which respectively defines a first and a second flow path toward the same outlet (102). The auxiliary channel connects to a reagent area (215), i.e., designed to receive a reagent (e.g., chemical or biological, such as detection antibodies). It further joins the bypass channel at the level of a junction (J1) downstream the reagent area, with respect to the second flow path, e.g., like a T-junction. Such a solution provides a simple way of adapting the dissolution rate of the reagent.

    摘要翻译: 本发明涉及一种具有通常限定流动方向的流入口和出口的微流体装置。 提供旁路通道(11)和辅助通道(21),其分别限定朝向相同出口(102)的第一和第二流动路径。 辅助通道连接到试剂区域(215),即被设计成接收试剂(例如化学或生物学检测抗体)。 它还在试剂区域下游的连接点(J1)的水平处,相对于第二流动路径,例如类似于T形接头连接旁路通道。 这种溶液提供了使试剂的溶解速率适应的简单方法。

    METHOD FOR PROCESSING A SURFACE
    4.
    发明申请
    METHOD FOR PROCESSING A SURFACE 失效
    处理表面的方法

    公开(公告)号:US20120255930A1

    公开(公告)日:2012-10-11

    申请号:US13525843

    申请日:2012-06-18

    IPC分类号: B05D5/00 B44C1/22

    摘要: A method for processing a surface involves depositing at least one class of enzymes (2) onto the surface (1); introducing at least a reactant (3) into an environment of the surface (1), and causing interaction between the enzymes (2) and the reactant (3), thereby to cause processing of a region of the surface (1), the processed region of the surface (1) being defined with respect to a region thereof that is proximate (4) to where the enzymes (3) have been deposited.

    摘要翻译: 一种用于处理表面的方法包括将至少一类酶(2)沉积在表面(1)上; 将至少一种反应物(3)引入到表面(1)的环境中,并引起酶(2)和反应物(3)之间的相互作用,从而导致表面(1)的区域的加工,经处理 表面(1)的区域相对于其已经沉积有酶(3)的(4)的区域而定义。

    Method for processing a surface
    5.
    发明授权
    Method for processing a surface 失效
    处理表面的方法

    公开(公告)号:US08202438B2

    公开(公告)日:2012-06-19

    申请号:US11959190

    申请日:2007-12-18

    摘要: A method for processing a surface involves depositing at least one class of enzymes (2) onto the surface (1); introducing at least a reactant (3) into an environment of the surface (1), and causing interaction between the enzymes (2) and the reactant (3), thereby to cause processing of a region of the surface (1), the processed region of the surface (1) being defined with respect to a region thereof that is proximate (4) to where the enzymes (3) have been deposited.

    摘要翻译: 一种用于处理表面的方法包括将至少一类酶(2)沉积在表面(1)上; 将至少一种反应物(3)引入到表面(1)的环境中,并引起酶(2)和反应物(3)之间的相互作用,从而导致表面(1)的区域的加工,经处理 表面(1)的区域相对于其已经沉积有酶(3)的(4)的区域而定义。

    MICROORGANISM CULTURE DEVICE AND METHOD OF OPERATION THEREOF
    7.
    发明申请
    MICROORGANISM CULTURE DEVICE AND METHOD OF OPERATION THEREOF 审中-公开
    微生物文化装置及其操作方法

    公开(公告)号:US20120034677A1

    公开(公告)日:2012-02-09

    申请号:US13257320

    申请日:2010-03-04

    摘要: The invention is directed to a microorganism culture device (100), such as a micro fluidic cell culture device. The device comprises an open chamber (10), wherein microorganisms are likely to be deposited within a liquid for subsequent study. The open chamber simplifies the deposition of the microorganisms. The chamber is further provided with retention features (11), whereby microorganisms can be retained therein. In addition, the device comprises an overflow area (20), wherein capillary structures (22) are configured to retain excess liquid overflowing from the open chamber, e.g. when covering the device with a cover. As such, it allows for confining microorganism in the chamber, while excess fluid is captured externally, e.g. to seal the device with a cover.

    摘要翻译: 本发明涉及微生物培养装置(100),例如微流体细胞培养装置。 该装置包括开放室(10),其中微生物可能沉积在液体中用于随后的研究。 开放室简化了微生物的沉积。 该室还具有保留特征(11),由此微生物可被保留在其中。 此外,该装置包括溢流区域(20),其中毛细管结构(22)构造成保持从开放室溢出的多余液体,例如, 当用盖子覆盖设备时。 因此,它允许将微生物限制在室中,而过量的流体被外部捕获,例如, 用盖子密封设备。

    Magnetic valves for performing multi-dimensional assays using one microfluidic chip
    8.
    发明授权
    Magnetic valves for performing multi-dimensional assays using one microfluidic chip 失效
    用于使用一个微流控芯片进行多维测定的磁阀

    公开(公告)号:US08051878B2

    公开(公告)日:2011-11-08

    申请号:US12329551

    申请日:2008-12-06

    IPC分类号: F15C1/04

    摘要: An apparatus for performing multi-dimensional assays using a microfluidic chip is presented. The apparatus comprises of two crossing series of micro-channels on the microfluidic chip. The apparatus further comprises of a plurality of magnetic valves placed at the crossings and a guiding magnet. When an operator places the guiding magnet in a vicinity of the chip, the guiding magnet produces a proximal magnetic field gradient at a location of each of the plurality of magnetic valves. At the first micro-channel crossing, a magnetic valve controls fluid flow in the first micro-channel, and another magnetic valve controls fluid flow in the second micro-channel at the first micro-channel crossing. Each magnetic valve comprises a magnetic bead and a cavity on the chip next to a corresponding micro-channel section.

    摘要翻译: 提出了使用微流控芯片进行多维测定的装置。 该装置包括微流体芯片上的两个交叉的微通道系列。 该装置还包括放置在交叉处的多个电磁阀和导向磁体。 当操作者将引导磁体放置在芯片附近时,引导磁体在多个电磁阀的每个位置产生近端磁场梯度。 在第一微通道交叉处,磁阀控制第一微通道中的流体流动,另一个电磁阀在第一微通道交叉处控制第二微通道中的流体流动。 每个电磁阀包括位于相应微通道部分旁边的芯片上的磁珠和腔。

    Display element
    9.
    发明授权
    Display element 有权
    显示元素

    公开(公告)号:US07907330B2

    公开(公告)日:2011-03-15

    申请号:US12271135

    申请日:2008-11-14

    IPC分类号: G02B26/00

    摘要: A display element having circuitry adapted to at least partially electrochemically dissolve a first layer by means of supplying an electrical current through the first layer. The first layer separates a first reservoir filled with a liquid from a second reservoir. By dissolving the first layer at least partially, at least a portion of the liquid can flow from the first to the second reservoir. Consequently, the display element transitions from a first to a second optical state.

    摘要翻译: 一种显示元件,其具有适于通过提供电流通过第一层至少部分地电化学溶解第一层的电路。 第一层将装有液体的第一容器与第二储存器分开。 通过至少部分地溶解第一层,液体的至少一部分可以从第一储存器流到第二储存器。 因此,显示元件从第一光学状态转变到第二光学状态。