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公开(公告)号:US20080254532A1
公开(公告)日:2008-10-16
申请号:US11981155
申请日:2007-10-30
Applicant: Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
Inventor: Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
IPC: C12M1/02
CPC classification number: G01N21/75 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00871 , B01J2219/00873 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/505 , B01L3/508 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
Abstract: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the rigid frame to form at least one major wall of the chamber. In preferred embodiments, two sheets or films are attached to opposite sides of the rigid frame to form two opposing major walls of the chamber, the major walls being connected to each other by the minor walls.
Abstract translation: 具有用于保持样品的反应室的反应容器通过制造具有限定室的小壁的刚性框架的壳体来制造。 壳体还限定了用于将流体引入腔室的端口。 至少一个片或薄膜连接到刚性框架以形成腔室的至少一个主壁。 在优选实施例中,两个片或膜连接到刚性框架的相对侧面以形成腔室的两个相对的主壁,主壁通过次壁彼此连接。
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公开(公告)号:US06878540B2
公开(公告)日:2005-04-12
申请号:US10006904
申请日:2001-11-07
Applicant: Farzad Pourahmadi , William A. Mcmillan , Jesus Ching , Ronald Chang , Christel A. Lee , Gregory T.A. Kovacs , Northrup M. Allen , Petersen E. Kurt
Inventor: Farzad Pourahmadi , William A. Mcmillan , Jesus Ching , Ronald Chang , Christel A. Lee , Gregory T.A. Kovacs , Northrup M. Allen , Petersen E. Kurt
CPC classification number: C12M47/06 , B01L2400/0622 , B01L2400/0644
Abstract: A device for use with an ultrasonic transducer to lyse components of a fluid sample comprises a cartridge having a lysing chamber, an inlet port in fluid communication with the lysing chamber, and an outlet port for exit of the sample from the lysing chamber. The inlet and outlet ports are positioned to permit flow of the sample through the lysing chamber, and the chamber contains at least one solid phase for capturing the sample components to be lysed as the sample flows through the chamber. The lysing chamber is defined by at least one wall having an external surface for contacting the transducer to effect the transfer of ultrasonic energy to the chamber.
Abstract translation: 用于与超声换能器一起用于裂解流体样品的组分的装置包括具有裂解室,与裂解室流体连通的入口端口和用于将样品从裂解室排出的出口的筒。 入口端口和出口端口被定位成允许样品流过裂解室,并且室包含至少一个固相,用于在样品流过室时捕获要裂解的样品组分。 裂解室由至少一个具有用于接触换能器的外表面的壁限定,以实现将超声波能量传递到腔室。
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公开(公告)号:US20130018590A1
公开(公告)日:2013-01-17
申请号:US13371183
申请日:2012-02-10
Applicant: David A. BORKHOLDER , Gregory T.A. KOVACS , Jeffrey ROGERS
Inventor: David A. BORKHOLDER , Gregory T.A. KOVACS , Jeffrey ROGERS
CPC classification number: A61B5/4064 , A61B5/1112 , A61B5/165 , A61B5/6803 , A61B5/7275 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , F41H1/02 , F41H1/04 , F42D5/00 , G06F19/00 , Y10T29/49002
Abstract: A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.
Abstract translation: 剂量测定装置包括壳体中的至少一个传感器和具有存储器的剂量测定处理装置。 所述剂量调节处理装置联接到所述壳体中的所述至少一个传感器。 剂量测定处理装置被配置为执行存储在存储器中的编程指令,包括:从传感器获得读数; 存储读数; 对存储的读数进行分析以确定伤害风险评估; 并且输出所确定的伤害风险评估或存储的读数的进行分析中的至少一个。
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公开(公告)号:US08200320B2
公开(公告)日:2012-06-12
申请号:US11367992
申请日:2006-03-03
Applicant: Gregory T.A. Kovacs
Inventor: Gregory T.A. Kovacs
IPC: A61B5/0402
CPC classification number: A61B5/04325 , A61B5/0205 , A61B5/0809 , A61B5/1118 , A61B5/14551 , A61B5/4866 , A61B5/6831 , A61B2560/0412 , A61B2562/0219 , G06F19/00
Abstract: In some embodiments, a wearable physiologic monitor comprises a mixed analog and digital application-specific integrated circuit (ASIC) including signal conditioning circuitry, an A/D converter, a real-time clock, and digital control logic. The signal conditioning circuitry includes analog amplification circuitry, analog (continuous-time or switched capacitor) filtering circuitry before the A/D converter, and in some embodiments digital (DSP) filtering circuitry after the A/D converter. The monitor includes sensors such as electrocardiogram (ECG) electrodes, accelerometers, and a temperature sensor, some of which may be integrated on the ASIC. The digital control logic receives digital physiologic data sampled at different rates, assembles the data into physiologic data packets, time-stamps at least some of the packets, and periodically stores the packets in a digital memory. The monitor may include a disposable patch including the ASIC, and a reusable, removable digital memory such as flash memory card. Applications include ambulatory monitoring and quantitative titration of care.
Abstract translation: 在一些实施例中,可穿戴的生理监视器包括包括信号调节电路,A / D转换器,实时时钟和数字控制逻辑的混合模拟和数字应用专用集成电路(ASIC)。 信号调理电路包括模拟放大电路,A / D转换器之前的模拟(连续时间或开关电容)滤波电路,以及A / D转换器之后的一些实施例数字(DSP)滤波电路。 显示器包括诸如心电图(ECG)电极,加速度计和温度传感器的传感器,其中一些可以集成在ASIC上。 数字控制逻辑接收以不同速率采样的数字生理数据,将数据组装成生理数据分组,对至少一些分组进行时间戳,并将分组周期性地存储在数字存储器中。 显示器可以包括包括ASIC的一次性贴片,以及诸如闪存卡的可重复使用的可拆卸数字存储器。 应用包括动态监测和定量滴定护理。
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公开(公告)号:US20160228045A1
公开(公告)日:2016-08-11
申请号:US15130074
申请日:2016-04-15
Applicant: David A. Borkholder , Gregory T.A. Kovacs , Jeffrey Rogers
Inventor: David A. Borkholder , Gregory T.A. Kovacs , Jeffrey Rogers
CPC classification number: A61B5/4064 , A61B5/1112 , A61B5/165 , A61B5/6803 , A61B5/7275 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , F41H1/02 , F41H1/04 , F42D5/00 , G06F19/00 , Y10T29/49002
Abstract: A method including a dosimetry device having at least one sensor in a housing and a dosimetry processing device with a memory. The dosimtery processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.
Abstract translation: 一种包括在壳体中具有至少一个传感器的剂量测定装置和具有存储器的剂量测定处理装置的方法。 所述剂量调节处理装置联接到所述壳体中的所述至少一个传感器。 剂量测定处理装置被配置为执行存储在存储器中的编程指令,包括:从传感器获得读数; 存储读数; 对存储的读数进行分析以确定伤害风险评估; 并且输出所确定的伤害风险评估或存储的读数的进行分析中的至少一个。
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公开(公告)号:US20120295269A1
公开(公告)日:2012-11-22
申请号:US13552950
申请日:2012-07-19
Applicant: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
Inventor: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
CPC classification number: C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Abstract translation: 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室,其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径,所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室,从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径,将捕获的分析物从萃取室洗脱。
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公开(公告)号:US20110165562A1
公开(公告)日:2011-07-07
申请号:US13042203
申请日:2011-03-07
Applicant: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
Inventor: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
CPC classification number: C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Abstract translation: 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室,其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径,所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室,从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径,将捕获的分析物从萃取室洗脱。
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公开(公告)号:US20100068706A1
公开(公告)日:2010-03-18
申请号:US12370527
申请日:2009-02-12
Applicant: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
Inventor: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
CPC classification number: C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Abstract translation: 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室,其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径,所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室,从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径,将捕获的分析物从萃取室洗脱。
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